Glial decline and loss of homeostatic support rather than inflammation defines cognitive aging

作     者：Alexei Verkhratsky Natalia Lazareva Alexey Semyanov Alexei Verkhratsky;Natalia Lazareva;Alexey Semyanov

作者机构：Faculty of BiologyMedicine and HealthThe University of ManchesterManchesterUK Achucarro Center for NeuroscienceIKERBASQUEBasque Foundation for ScienceBilbaoDepartment of NeurosciencesUniversity of the Basque Country UPV/EHU and CIBERNEDLeioaSpain Sechenov First Moscow State Medical UniversityMoscowRussia Shemyakin-Ovchinnikov Institute of Bioorganic ChemistryRussian Academy of SciencesFaculty of BiologyMoscow State UniversityMoscowRussia 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第3期

页      面：565-566页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：supported by the Russian Science Foundation No.20-14-00241。 

主　　题：inflammation senile aging 

摘      要：The preservation of cognitive longevity and arresting the pandemic of senile dementia engulfing the modern world is arguably the major challenge faced by biomedical research in the 21st century.Age is the leading risk factor for neurodegenerative diseases and vascular dementia,and yet there is a clear distinction between physiological and pathological brain aging.