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Neural Regeneration Research 2023年第9期18卷 1968-1975页

作者： He-Mei Huang Gui-Sheng Chen Zhong-Yi Liu Qing-Lin Meng Jia-Hong Li Han-Wen Dong Yu-Chen Chen Fei Zhao Xiao-Wu Tang Jin-Liang Gao Xi-Ming Chen Yue-Xin Cai Yi-Qing Zheng Department of Otolaryngology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Institute of hearing and Speech-Language Science Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Otolaryngology Shenzhen-Shanwei Central HospitalSun Yat-sen Memorial HospitalSun Yat-sen UniversityShanweiGuangdong ProvinceChina Department of Radiology Guangdong Provincial Work Injury Rehabilitation HospitalGuangzhouGuangdong ProvinceChina Acoustics Lab of School of Physics and Optoelectronics and State Key Laboratory of Subtropical Building Science South China University of TechnologyGuangzhouGuangdong ProvinceChina Department of Radiology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Speech and Language Therapy and hearing Science Cardiff Metropolitan UniversityCardiffUK Department of Otolaryngology Shenzhen Baoan Maternal and Child Health HospitalShenzhenGuangdong ProvinceChina

Patients with age-related hearing loss face hearing difficulties in daily life.The causes of age-related hearing loss are complex and include changes in peripheral hearing,central processing,and cognitive-related abilities.Furthermore,the factors by which aging relates to hearing loss via changes in audito ry processing ability are still unclear.In this cross-sectional study,we evaluated 27 older adults(over 60 years old) with age-related hearing loss,21 older adults(over 60years old) with normal hearing,and 30 younger subjects(18-30 years old) with normal hearing.We used the outcome of the uppe r-threshold test,including the time-compressed thres h old and the speech recognition threshold in noisy conditions,as a behavioral indicator of auditory processing ability.We also used electroencephalogra p hy to identify presbycusis-related abnormalities in the brain while the participants were in a spontaneous resting state.The timecompressed threshold and speech recognition threshold data indicated significant diffe rences among the groups.In patients with age-related hearing loss,information masking(babble noise) had a greater effect than energy masking(speech-shaped noise) on processing difficulties.In terms of resting-state electroencephalography signals,we observed enhanced fro ntal lobe(Brodmann’s area,BA11) activation in the older adults with normal hearing compared with the younger participants with normal hearing,and greater activation in the parietal(BA7) and occipital(BA19) lobes in the individuals with age-related hearing loss compared with the younger adults.Our functional connection analysis suggested that compared with younger people,the older adults with normal hearing exhibited enhanced connections among networks,including the default mode network,sensorimotor network,cingulo-opercular network,occipital network,and frontoparietal network.These results suggest that both normal aging and the development of age-related hearing loss have a negative effect on advanced audito ry processing capabilities and t

关键词： age-related hearing loss aging electroencephalography fast-speech comprehension functional brain network functional connectivity restingstate sLORETA source analysis speech reception threshold

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Expression ofα2-Na/K-ATPase in C57BL/6J Mice Inner Ear and Its Relationship with age-related hearing loss

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Current Medical Science 2021年第1期41卷 153-157页

作者： Yun LIU Han-qi CHU Yan-bo SUN Dan BING Liang-qiang ZHOU Jin CHEN Qing-guo CHEN Zhi-hui DU Department of Otolaryngology-Head and Neck Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Otolaryngology-Head and Neck Surgery the Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

K^(+)cycling in the cochlea is critical to maintain hearing.Many sodium-potassium pumps are proved to participate in K^(+)cycling,such as Na/K-ATPase.Theα2-Na/K-ATPase is an important isoform of Na/K-ATPase.The expression ofα2-Na/K-ATPase in the cochlea is not clear.In this study,we used C57BL/6 mice as a model of presbycusis and implemented immunohistochemistry staining and quantitative real time-PCR,and theα2-Na/K-ATPase expression pattern was confirmed in the inner ear.It was foundα2-Na/K-ATPase was expressed widely in cochlea and its mRNA and protein expression was gradually reduced with aging(4-,14-,26-and 48-weeks old mice).We suspected that,the down-regulation ofα2-Na/K-ATPase expression might be associated with the remodeling of K^(+)cycling,degeneration of morphological structure and decrease of hearing function in aging C57 mice.In conclusion,we speculated that the reduction ofα2-Na/K-ATPase might play an important role in the pathogenesis of age-related hearing loss.

关键词： α2-Na/K-ATPase C57BL/6J mouse inner ear age-related hearing loss K^(+)cycling

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Anti-apoptotic treatment in mouse models of age-related hearing loss

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Journal of Otology 2016年第1期11卷 7-12页

作者： Fengchan Han Oumei Wang Quanxiang Cai Key Laboratory for Genetic hearing Disorders in Shandong Binzhou Medical University Institute of Neurobiology School of Special Education Binzhou Medical University

age-related hearing loss (AHL), or presbycusis, is the most common neurodegenerative disorder and top communication deficit of the aged population. Genetic predisposition is one of the major factors in the development of AHL. Generally, AHL is associated with an age-dependent loss of sensory hair cells, spiral ganglion neurons and stria vascularis cells in the inner ear. Although the mechanisms leading to genetic hearing loss are not completely understood, caspase-family proteases function as important signals in the inner ear pathology. It is now accepted that mouse models are the best tools to study the mechanism of genetic hearing loss or AHL. Here, we provide a brief review of recent studies on hearing improvement in mouse models of AHL by anti-apoptotic treatment.

关键词： age-related hearing loss Mouse model Apoptosis Oxidative stress

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Subclinical hearing loss associated with aging

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Journal of Otology 2023年第3期18卷 111-117页

作者： Cristian Aedo-Sanchez Jose Oliveros Constanza Aranguiz Camila Munoz Claudia Lazo-Maturana Enzo Aguilar-Vidal Departamento de Tecnología Médica Facultad de MedicinaUniversidad de ChileChile Escuela de Tecnología Médica Facultad de MedicinaUniversidad de ChileChile

Objective:Contribute to clarifying the existence of subclinical hearing deficits associated with aging.Design:In this work,we study and compare the auditory perceptual and electrophysiological performance of normal-hearing young and adult subjects(tonal audiometry,high-frequency tone threshold,a triplet of digits in noise,and click-evoked auditory brainstem response).Study sample:45 normal hearing volunteers were evaluated and divided into two groups according to age.27 subjects were included in the“young group”(mean 22.1 years),and 18 subjects(mean 42.22 years)were included in the“adult group.”Results:In the perceptual tests,the adult group presented significantly worse tonal thresholds in the high frequencies(12 and 16 kHz)and worse performance in the digit triplet tests in noise.In the electrophysiological test using the auditory brainstem response technique,the adult group presented significantly lower I and V wave amplitudes and higher V wave latencies at the supra-threshold level.At the threshold level,we observed a significantly higher latency in wave V in the adult group.In addition,in the partial correlation analysis,controlling for the hearing level,we observed a relationship(negative)between age and speech in noise performance and high-frequency thresholds.No significant association was observed between age and the auditory brainstem response.Conclusion:The results are compatible with subclinical hearing loss associated with aging.

关键词： age-related hearing loss Cochlear synaptopathy Auditory electrophysiology Speech perception Aging

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Correlation of PDCD5 and Apoptosis in Hair Cells and Spiral Ganglion Neurons of Different age of C57BL/6J Mice

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2012年第1期32卷 113-118页

作者：王燕褚汉启周良强高贺云熊浩陈请国陈金黄孝文崔永华 Department of Otorhinolaryngology Head and Neck Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology Department of Pediatric Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology

This study examined the expression pattern of programmed cell death 5 (PDCD5) in co-chlear hair cells and spiral ganglion neurons (SGNs) and its association with age-related hearing loss in mice.Sixty C57BL/6J (C57) mice at different ages were divided into four groups (3,6,9 or 12 months).PDCD5 expression was detected by using immunohistochemistry,real-time PCR and Western blot.Morphological change of the cochleae was also evaluated by using immunoassay.The results showed that the expression of PDCD5 had a gradual increase with ageing in both protein and RNA levels in C57 mice,as well as gradually increased apoptosis of cochlear hair cells and SGNs.In addition,we also found that caspase-3 activity was enhanced and its expression was enhanced with ageing.It is implied that overexpression of PDCD5 causes the increase in caspase-3 activity and the subsequent increase of apoptosis in cochlear hair cells and SGNs,and thereby plays a role in the pathogenesis of presbycusis.Thus,PDCD5 may be a new target site for the treatment and prevention of age-related hearing loss.

关键词： age-related hearing loss apoptosis programmed cell death 5 hair cells spiral ganglion neurons

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Mechanism of aseptic inflammation upon the inner ear injury

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Journal of Bio-X Research 2020年第2期3卷 72-77页

作者： Wang Yanmei Ren Dongdong ENT Institute and Otorhinolaryngology Department Affiliated Eye and ENT Hospital of Fudan UniversityShanghaiChina Shanghai Auditory Medical Center ShanghaiChina Key Laboratory of hearing Science Ministry of HealthShanghaiChina

Many factors can cause inner ear injury,such as noise exposure,chemicals,viral infection,and radiation.The main pathological manifestations of inner ear injury are local hypoxia-ischemia,micro-trauma,and an increased level of reactive oxygen species and inflammatory mediators.The contribution of the inflammatory response to the mediation of cochlear and vestibular pathologies has received increasing attention in recent years.Aseptic inflammation can devastate audition and balance,which can lead to many typical clinical inner ear diseases.In this review,we will discuss the most pertinent and recent research on inflammatory mechanisms in inner ear injury.We will also discuss the pathophysiology of some common and significant ear diseases,such as sudden sensorineural hearing loss,age-related hearing loss,noise-induced hearing loss,and Meniere’s disease.

关键词： age-related hearing loss immune response inflammatory response macrophages sudden sensorineural hearing loss

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Early on Set Presbyacusis in Gwagwalada Area Council of Federal Capital Territory, Abuja

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International Journal of Otolaryngology and Head & Neck Surgery 2021年第3期10卷 238-249页

作者： David Femi Folorunso Enoch Auta Dahilo Ibeneche Onyemuchechi Gbujie Fredrick M. Damtong Oladeji Raheem Quadri Basil E. Nwankwo Titus Sunday Ibekwe Onyekwere George Nwaorgu Department of ENT/Head & Neck Surgery University of Abuja Teaching Hospital Gwagwalada-Abuja Nigeria Department of ENT Federal Teaching Hospital Gombe Gombe State Nigeria Chukwuemeka Odumegwu Ojukwu University Teaching Hospital Awka Anambra State Nigeria Department of Otorhinolaryngology University College Hospital Ibadan & College of Medicine University of Ibadan Oyo State Nigeria

Background: Presbyacusis is a major cause of hearing loss among seniors. The condition attracts attention following the prediction of World Health Organization that elderly population is expected to hit 1.2 billion by 2025 out of which more than 500 million of them will suffer from sensorineural hearing loss(SHL) worldwide. The studies have shown that this begins to reflect on audiograms as from the third decade, mainly in the high frequencies. Aim/objective: This study evaluated the early on-set presbyacusis at Gwagwalada Area Council of the Federal capital territory-Abuja. Method: It was a multi-stage sampling, prospective, cross-sectional study done in FCT, Abuja. Participants from age 20 years and above were recruited into the study after signing informed consent. The presumed risk factors as highlighted in the questionnaire were screened out. Results: Two hundred and two participants were recruited into the study, out of which twelve were excluded from the analysis on account of various exclusion criteria. The age range of the participants was 20 to 79 years, with an average age of 54.8 ± 5.6 years. One hundred and fourteen (60.0%) males and seventy-six (40.0%) females participated in the study. The commonly reported associated symptom was tinnitus. About 32.0% of the participants had moderate sensorineural hearing loss. However, the prevalence of presbyacusis was 28.2% for age below 65 years and 78.8% for 65 years and above. The cumulative prevalence was 54.2%. Conclusion: The study has shown that presbyacusis occur as early as the third decade of life, possibly subclinical before age 65 years. The prevalence was 28.2% before age 65 years and 78.8% from age 65 years, there was a steady increase in percentage of participants with SNHL from age 20 years, and a significant sudden increase from 65 years was observed with a sloping tracing at high frequency.

关键词： Presbyacusis age-related hearing loss Young Adults Sensorineural hearing loss and Pure Tone Audiometry

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