Anti-apoptotic treatment in mouse models of age-related hearing loss

作     者：Fengchan Han Oumei Wang Quanxiang Cai 

作者机构：Key Laboratory for Genetic Hearing Disorders in Shandong Binzhou Medical University Institute of Neurobiology School of Special Education Binzhou Medical University 

出 版 物：《Journal of Otology》 (中华耳科学杂志（英文版）)

年 卷 期：2016年第11卷第1期

页      面：7-12页

核心收录：

学科分类：1002[医学-临床医学] 100213[医学-耳鼻咽喉科学] 10[医学] 

基　　金：supported by National Natural Science Foundation of China (No. 81271092, 81570927) Scientific and Technological Developing Grant in Shandong Province (2014GSF118083) Scientific and Technological Developing Grant for Medicine and Health in Shandong Province (2015WS0507) Research Initiation Grant of Binzhou Medical University (BY2012KYQD01, BY2013KYQD15) 

主　　题：Age-related hearing loss Mouse model Apoptosis Oxidative stress 

摘      要：Age-related hearing loss (AHL), or presbycusis, is the most common neurodegenerative disorder and top communication deficit of the aged population. Genetic predisposition is one of the major factors in the development of AHL. Generally, AHL is associated with an age-dependent loss of sensory hair cells, spiral ganglion neurons and stria vascularis cells in the inner ear. Although the mechanisms leading to genetic hearing loss are not completely understood, caspase-family proteases function as important signals in the inner ear pathology. It is now accepted that mouse models are the best tools to study the mechanism of genetic hearing loss or AHL. Here, we provide a brief review of recent studies on hearing improvement in mouse models of AHL by anti-apoptotic treatment.