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Relationship between dietary macronutrient intake and the risk of age-related cataract in middle-aged and elderly patients in northeast China

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International Journal of Ophthalmology(English edition) 2013年第6期6卷 805-810页

作者： Zhi-Quan Lu Jia Yan Wen-Hui Sun Teng-Xuan Jiang Shu-Na Zhai Yan Li Guang-Dong Gao Department of Epidemiology Liaoning Medical University Department of Ophthalmology the First Affiliated Hospitalof Liaoning Medical University

AIM:To examine the association between dietary macronutrient intake and the risk of age-related cataract(ARC)in middle-aged and elderly ***:A hospital-based case-control study was conducted from December 2009 to November ***(n=360)were patients with cataract aged 45-85years old,and controls(n=360)were patients who had been admitted to the same hospital for diseases not related with *** subjects were interviewed using a structured interviewer-administrated questionnaire that included information on socio-demographic characteristics,lifestyle habits and detailed medical history,simultaneously,the dietary intakes of nutrients were collected via a valid semi-quantitative food frequency questionnaire(FFQ).The odds ratios(OR)and corresponding 95%confidence intervals(CI)of three types of ARC were estimated using multiple logistic regression ***:After adjusting for multiple potential confounders,total dietary intake of carbohydrate was positively associated with cortical cataract,compared to controls in the lowest quartile,and the OR for cases in the highest quartile of intake was 2.471(95%CI:1.348-6.043,P=0.027).Higher dietary intakes of protein were protective for posterior subcapsular cataract(PSC)(OR=0.528,95%CI:0.148-0.869,P=0.023).Dietary fat intake was not associated with any type of cataract,however,participants in the highest quartile of polyunsaturated fatty acids intake had 2.7 times the risk of nuclear cataract as did those in the lowest quartile(OR=2.742,95%CI:1.790-4.200,P=0.033).CONCLUSION:A high intake of carbohydrate and polyunsaturated fatty acid may increase the odds of cortical and nuclear cataract,respectively,whereas high intake of protein,especially animal protein,may protect against PSC *** is possible that dietary changes of target population may reduce the risk of ARC.

关键词： age-related cataract carbohydrate protein polyunsaturated fatty acid

DNA hypermethylation of COL4A1 in ultraviolet-Binduced age-related cataract models in vitro and in vivo

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International Journal of Ophthalmology(English edition) 2024年第10期17卷 1791-1799页

作者： Li Wang Dan Zhu Yang Yang Yuan He Jing Sun Yi-Ming Li Zi-Jing Wang Peng Li Department of Optometry Xi’an Medical UniversityXi’an 710021Shaanxi ProvinceChina Department of Ophthalmology the Second Affiliated Hospital of Xi’an Medical UniversityXi’an 710038Shaanxi ProvinceChina Department of Ophthalmology Xijing 986 HospitalFourth Military Medical UniversityXi’an 710054Shaanxi ProvinceChina

AIM:To explore the DNA methylation of COL4A1 in ultraviolet-B(UVB)-induced age-related cataract(ARC)models in vitro and in ***:Human lens epithelium B3(HLEB3)cells and Sprague Dawley rats were exposure to UVB *** MTT assay was utilized to evaluate cell *** cytometry was employed for analysis of cell apoptosis and cell ***4A1 expression in HLEB3 cells and anterior lens capsules were assessed using Western blot and reverse transcription-polymerase chain reaction(RTPCR).The localization of COL4A1 in HLEB3 cells was determined by *** methylation status of CpG islands located in COL4A1 promoter was verified using bisulfite-sequencing PCR(BSP).DNMTs and TETs mRNA levels was examined by ***:UVB exposure decreased HLEB3 cells proliferation,while increased the apoptosis rate and cells were arrested in G0/G1 ***4A1 expression was markedly inhibited in UVB treated cells compared to the *** status was detected in the CpG islands within COL4A1 promoter in HLEB3 cells subjected to UVB *** of DNMTs including DNMT1/2/3 were elevated in UVB treated HLEB3 cells compared to that in the controls,while expressions of TETs including TET1/2/3 showed the opposite *** from the UVB treated rat model further confirmed the decreased expression of COL4A1,hypermethylation status of the CpG islands at promoter of COL4A1 and abnormal expression of DNMT1/2/3 and TET1/2/in UVB exposure ***:DNA hypermethylation of COL4A1 promoter CpG islands is correlated with decreased COL4A1 expression in UVB induced HLEB3 cells and anterior lens capsules of rats.

关键词： human lens epithelium cells age-related cataract COL4A1 hypermethylation ultraviolet-B rat

Cigarette smoking,body mass index associated with the risks of age-related cataract in male patients in northeast China

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International Journal of Ophthalmology(English edition) 2012年第3期5卷 317-322页

作者： Zhi-Quan Lu Wen-Hui Sun Jia Yan Teng-Xuan Jiang Shu-Na Zhai and Yan Li Department of Epidemiology Liaoning Medical University Jinzhou 121001 Liaoning Province China

AIM: To determine the association between cigarettes smoking, body mass index (BMI) and the risk of age-related cataract (ARC) in middle-aged and elderly men in Northeast China. METHODS: A hospital-based case control study was conducted. Cases (n =362) were men who had surgically treated ARC, 45-85 years old; controls frequency-matched (n=362) were men who had been admitted to the same hospital as cases for other diseases not related with eye diseases. Cases and controls were matched with 1:1. The cases and controls were interviewed during their hospital stay, using a structured interviewer-administrated questionnaire that included information on sociodemographic characteristics, socioeconomic, lifestyle habits (tobacco smoking and alcohol consumption, etc.), anthropometric measures, personal medical history, and family history of ARC in first-degree relatives, and simultaneously BMI was calculated. The odds ratios (OR) and 95% confidence intervals (CI) of ARC were estimated using multiple logistic regression models. RESULTS: After adjusting for age and multiple potential confounders, higher BMI was associated with an increased risk of ARC. Cigarette smoking, years smoking or moderate cigarette smoking (1-29 cigarettes per day) had no relation with the risk of ARC (P>0.05), although patients smoking >= 30 cigarettes per day had an elevated risk of ARC as compared with the non-smokers (OR=1.55, 95% CI; 1.16-2.85, P=0.026). Higher BMI was associated with an increased risk of ARC. Both overweight and obesity was associated with an obviously increased risk for surgically ARC (OR=1.55, 95% CI:1.02-1.98, P=0.015 and OR=1.71, 95% CI:1.32-2.39, P=0.013 respectively) compared to normal BMI. Then participants were grouped into quartiles of BMI (Q1 to Q4), compared to controls in the lowest quartile, the ORfor cases in the highest quartile of BMI was 1.54 (OR=1.54, 95% CI: 1.08-2.46, P=0.022). The results of univariate analysis showed cigarette smoking was not associated with

关键词： age-related cataract male smoking body mass index risk

Upregulation of histone H3 caused by CRYAA may contribute to the development of age-related cataract

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BIOCELL 2023年第1期47卷 143-154页

作者： CHAO WANG JUNWEI WANG FANQIAN SONG HANRUO LIU LIYAO SUN XI WEI TAO ZHENG HUA QIAN XIAOGUANG LI WEIHUA ZHANG XIANLING TANG PING LIU Eye Hospital First Affiliated HospitalHarbin Medical UniversityHarbin150001China Department of Pharmacology College of PharmacyHarbin Medical Universityand Heilongjiang Academy of Medical SciencesHarbin150081China Beijing Institute of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&Visual Science Key LabBeijing100000China Department of Pathophysiology Harbin Medical UniversityHarbin150081China

Objective:age-relate cataract(ARC)is a disease of the eyes with no effective drugs to prevent or treat *** aim of the present study is to determine whether histone H3,αA-crystallin(CRYAA),β-galactosidase(GLB1),and p53 are involved in the pathogenesis of ***:A total of 99 anterior lens capsules(ALCs)of patients with ARC of various nuclear grades,ultraviolet models of ALCs,and two human lens epithelial cell lines(FHL-124 and SRA01/04)were used,and the expression of histone H3,CRYAA,GLB1,and p53 were detected by immunoblotting and reverse transcription and real time-quantitative polymerase chain *** association between CRYAA with histone H3,GLB1,and p53 was assessed in FHL-124 and SRA01/04 cells following CRYAA ***:Histone H3 and p53 in ALCs of patients with ARC were up-regulated in a grade-dependent manner,and the expression of CRYAA showed a positive association with histone H3,p53,and *** UV models of ALCs and human lens epithelial cell lines,the expression levels of histone H3,cell apoptosis factors(Bax/Bcl-2,cleaved caspase-3),and inflammation factors(interleukin-6,tumor necrosis factor-α)were all ***,transfection of CRYAA in FHL-124 cells induced overexpression of histone ***:CRYAA-mediated upregulation of histone H3 may be involved in the pathogenesis of ARC.p53 may also have a role in ARC development,but not via the CRYAA-histone H3 *** results of the present study may assist in improving our understanding of the pathogenesis of ARC and in identifying potential targets for treatment.

关键词： age-related cataract Histone H3 αA-crystallin Anterior lens capsules Basement membrane

A pilot exome-wide association study of age-related cataract in Koreans

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The Journal of Biomedical Research 2016年第3期30卷 186-190页

作者： Sang-Yong Eom Dong-Hyuk Yim Jung-Hyun Kim Joo-Byung Chae Yong-Dae Kim Heon Kim Center for Farmer's Safety and Health Chungbuk National University Hospital Department of Preventive Medicine College of MedicineChungbuk National University Department of Optometry Daejeon Health Science College Department of Ophthalmology College of MedicineChungbuk National University

age-related cataract （ARC） is the most common cause of visual impairment and blindness worldwide. A previous study reported that genetic factors could explain approximately 50% of the heritability of cataract. However, a genetic predisposition to ARC and the contributing factors have not yet been elucidated in the Korean population. In this study, we assessed the influence of genetic polymorphisms on the risk of ARC in Koreans, including 156 cataract cases and 138 healthy adults. We conducted an exome-wide association study using Illumina Human Exome-12v1.2 platform to screen 244,770 single nucleotide polymorphisms （SNPs）. No SNPs reached exome-wide significance level of association （P 〈 l x 10 6）. B3GNT4 rs7136356 showed the most significant association with ARC （P = 6.54x 10 5）. Two loci （MUC16 and P2RY2） among the top 20 ARC-associated SNPs were recognized as probably linked to cata- ractogenesis. Functions of these genes were potentially related to regulating dehydration or homeostasis of the eyes, and showed a potential association with dry eye disease. This finding suggests that mucin- and dry eye disease-related genes may play a significant role in cataractogenesis. Our study provides insight into the genetic predisposition of ARC in Koreans. Additional studies with larger sample sizes are required to confirm the results of this study.

关键词： age-related cataract exome-wide association study single nucleotide polymorphism genetic predispo-sition dry eye disease

Characterization of N6-methyladenosine long non-coding RNAs in sporadic congenital cataract and age-related cataract

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International Journal of Ophthalmology(English edition) 2024年第11期17卷 1973-1986页

作者： Hong-Fei Ye Xiang Zhang Zhen-Nan Zhao Ce Zheng Ping Fei Yu Xu Jiao Lyu Ji-Li Chen Xun-Xiang Guo Huang Zhu Pei-Quan Zhao Department of Ophthalmology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Ophthalmology and Vision Science Eye Ear Nose and Throat Hospital of Fudan UniversityShanghai 200031China Department of Ophthalmology Shanghai Shibei Hospital of Jing’an DistrictShanghai 200040China Key Laboratory of Systems Biomedicine(Ministry of Education) Shanghai Center for Systems BiomedicineShanghai Jiao Tong UniversityShanghai 200030China

AIM:To characterize the N6-methyladenosine(m6A)modification patterns in long non-coding RNAs(lncRNAs)in sporadic congenital cataract(CC)and age-related cataract(ARC).METHODS:Anterior capsule of the lens were collected from patients with CC and *** RNA immunoprecipitation with next-generation sequencing and RNA sequencing were performed to identify m6A-tagged lncRNAs and lncRNAs *** Encyclopedia of Genes and Genomes pathway enrichment analyses and Gene Ontology annotation were used to predict potential functions of the ***:Large amount of m6A peaks within lncRNA were identified for both CC and ARC,while the level was much higher in ARC(49870 peaks)than that in CC(18688 peaks),yet those difference between ARC in younger age group(ARC-1)and ARC in elder age group(ARC-2)was quite slight.A total of 1305 hypermethylated and 1178 hypomethylated lncRNAs,as well as 182 differential expressed lncRNAs were exhibited in ARC compared with *** the other hand,5893 hypermethylated and 5213 hypomethylated lncRNAs,as well as 155 significantly altered lncRNA were identified in ARC-2 compared with *** lncRNAs in ARC were mainly associated with the organization and biogenesis of intracellular organelles,as well as nucleotide excision ***:Our results for the first time present an overview of the m6A methylomes of lncRNA in CC and ARC,providing a solid basis and uncovering a new insight to reveal the potential pathogenic mechanism of CC and ARC.

关键词： congenital cataract age-related cataract N6-methyladenosine RNA modification long non-coding RNA epigenetics

Study on the association between polymorphisms in gap junction protein-alpha 8 gene and age-related cataract

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Study on the association between polymorphisms in gap juncti...

miR-211 regulates the antioxidant function of lens epithelial cells affected by age-related cataracts

湖北省遗传学会第八次代表大会暨学术讨论会

作者： Yuanyuan Liu~1,Min Ke~2,Fang Zheng~(1*),Guohua Yang~1,Shuren Guo~1,Qiang Chen~1,Xin Zhou~1. 1.Center for Gene Diagnosis,Zhongnan Hospital,Wuhan University,Wuhan,Hubei,430071,P.R. China 2.Department of Ophthalmology,Zhongnan Hospital,Wuhan University.Wuhan,Hubei,430071,P.R. China.

The gap junction protein-alpha 8(GJA8)plays an important role in lens growth and transparency and it is associated with hereditary congenital ***,the association of GJA8 gene to age-related cataract has rarely been pr... 详细信息

关键词： Single nucleotide polymorphism gap junction protein-alpha 8 age-related cataract linkage disequilibrium polymorphic information content

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International Journal of Ophthalmology(English edition) 2018年第3期11卷 349-353页

作者： Bo Lu Ian T. Christensen Li-Wei Ma Tao Yu Ling-Feng Jiang Chun-Xia Wang Li Feng Jin-Song Zhang Qi-Chang Yan Xin-Ling Wang Department of Ophthalmology the Fourth Affiliated Hospital of China Medical University Key Laboratory of Lens Research of Liaoning Province Eye Hospital of China Medical University Shenyang 110005 Liaoning Province China University of Utah School of Medicine Salt Lake City Utah 84132 USA Department of Medical Imaging Cancer Hospital of China Medical University Liaoning Cancer Hospital & Institute Shenyang 110042 Liaoning Province China

AIM： To investigate the effects and mechanism of miR-211 in mediating the antioxidant function of lens epithelial cells affected by age-related cataracts. METHODS： Real-time quantitative polymerase chain reaction （RT-qPCR） was used to detect miR-211 expression in the anterior lens capsules of healthy people, the anterior lens capsules of patients with age-related cataracts, and human epithelial cell line （SRA01/04） cells exposed to oxidative stress. A 2＇, 7＇-dichloro-fluorescein diacetate （DCFH-DA） probe was used to measure the levels of endogenous reactive oxygen species （ROS） in human lens epithelial cells （hLECs） exposed to 400 pmol/L H2O2 for lh. SRA01/04 cells were transfected with either miR-211 mimics, mimic controls, miR-211 inhibitors or inhibitor controls. After 72h, these cells were exposed to 400 IJmollL H2O2 for lh, then p53 and Bax mRNA expression were measured using RT-qPCR. p53 and Bax protein expression were also measured by Western blotting analysis. Finally, cell viability was assessed using an MTS assay. RESULTS： Compared to the control group, expression of miR-211 in the anterior lens capsules of age-related cataract patients and in SRA01/04 cells exposed to oxidative stress was significantly increased （P〈0.001）. Levels of endogenous ROS were significantly elevated in hLECs exposed to oxidative stress （P〈0.001）. Compared to the mimic control group, the hLECs in the miR-211 mimic group expressed significantly higher levels of p53 and Bax mRNA and protein while cell viability was significantly reduced （P〈0.001）. Conversely, p53 and Bax mRNA and protein expression were significantly reduced in the miR-211 inhibitor group as compared to the control group, while the cells in this group had much higher levels of call viability （P〈0.001）. CONCLUSION： miR-211 is upregulatsd in the anterior lens capsules of age-related cataract patients, miR-211 decreased the antioxidative stress capacity of lens epithelial cells by upregulating p53 and Bax, while inhib

关键词： KEYWORDS: miR-211 p53 Bax age-related cataract oxi-dative stress

Comparison of dynamic defocus curve Checkfor updates on cataract patients implanting extended depth of focus and monofocal intraocular

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Eye and Vision 2024年第4期10卷 32-40页

作者： Tingyi Wu Yuexin Wang jiazhi Yu Xiaotong Ren Yuanting Li Weigiang Qiu Xuemin Li Department of Ophthalmology Peking University Third Hospital49 North Garden RoadHaidian DistrictBeijing 100191People's Republic of China Bejing Key Laboratory of Restoration of Damaged Ocular Nerve PekingUniversity Third HospitalBeijingPeople's Republic of China Peking University Health Science Center BeijingPeople's Republicof China.

Background:The aim of the study was to compare the dynamic defocus curve on patients post-implantation of the extended depth-of-focus(EDOF)and monofocal intraocular lens(IOL).Methods:A total of 62 age-related cataract patients receiving phacoemulsification with implantation of TECNIS Symfony(ZXRoO)or monofocal IOLs were *** binocular static and dynamic defocus curves with corrected distance visual acuity were evaluated at one month ***:The ZXR00 group achieved signifcantly better intermediate(P=0.044)and near(P=0.017)visual acuity(VA)than the monofocal *** groups had similar uncorrected and corrected distance VA(P>0.05,respectively).The dynamic defocus curve revealed a smoother decline from 0.0 D to-2.0 D in the ZXRo0 *** dynamic VA in the ZXR00 group was significantly better(Pcataract surgery.

关键词： Dynamic defocus curve age-related cataract Extended depth-of-focus intraocular lens Monofocal intraocularlens