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Incidence of adverse reactions to COVID-19 vaccination:A meta-analysis of randomized controlled trials

Journal of Acute Disease 2022年第1期11卷 1-11页

作者： Xin-Xin Wu Jin-Jian Yao Jin Qian Qi-Feng Huang Tang Deng Shuang-Qin Xu Hang-Fei Wang Qi Li Ji-Chao Peng Yang Yi Nan Li Yue Huang Xiao-Ran Liu School of Public Health Hainan Medical UniversityHaikou 570100China Emergency Department Hainan General Hospital Affiliated to Hainan Medical UniversityHaikou 570100China Emergency and Trauma College Hainan Medical UniversityKey Laboratory of Emergency and Trauma of Ministry of EducationHaikou 570100China Department of Intensive Care Medicine The First Affiliated Hospital of Hainan Medical UniversityHaikou 570100China Emergency Department The First Affiliated Hospital of Hainan Medical UniversityHaikou 570100China

Objective:To systematically evaluate the incidence of adverse reactions to coronavirus disease 2019(COVID-19)***:We systematically searched PubMed,Embase,The Cochrane Library,Web of Science,CNKI,WanFang Data,and VIP Database from the inception of each database to August 31,*** controlled clinical trials(RCTs)on the safety of different types of COVID-19 vaccines were retrieved and analyzed.A random or fixed-effects model was used with an odds ratio as the effect *** quality of each reference was *** incidence of the adverse reactions of the placebo group and the vaccination group was *** and publication bias were taken care of by meta-regression and sub-group ***:A total of 13 articles were included,with 81287 *** with the placebo group,the vaccination group showed a higher combined risk ratio(RR)of total adverse reactions(RR=1.67,95%CI:1.46-1.91,Padverse reactions(RR=2.86,95%CI:2.11-3.87,Padverse reactions(RR=1.25,95%CI:0.92-1.72,P=0.16),pain(RR=2.55,95%CI:1.75-3.70,Padverse reactions of the vaccination group after injection of the three COVID-19 vaccines(inactivated viral vaccines,mRNA vaccines and adenovirus vector vaccines)was higher than that of the placebo group,and the difference between the placebo group and the vaccination group in the mRNA vaccine subgroup and the adenovirus vector vaccine subgroup was statistically significant(Padverse reactions after injection of COVID-19 vaccine in subgroups of different ages was significantly higher than that in the placebo group(Padverse reactio

关键词： COVID-19 adverse reactions Safety Randomized controlled trials

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Protective Effect of Oral Steroid Premedication: adverse reactions to Nonionic Iodine Contrast Media for Computed Tomography

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Open Journal of Radiology 2022年第3期12卷 102-112页

作者： Norikazu Koori Akiko Maeda Mayumi Yasui Hiroki Kamekawa Yusuke Yoshida Akari Noda Yuta Shiraki Kazuya Yokoi Yudai Suzuki Kazuma Kurata Hiroko Nishikawa School of Health Sciences Ibaraki Prefectural University of Health Sciences Ibaraki Japan Division of Health Sciences Graduate School of Medical Sciences Kanazawa University Kanazawa Japan Department of Radiology Komaki City Hospital Komaki Japan Department of Neurology Komaki City Hospital Komaki Japan

This study aimed to investigate the protective effect of oral steroid premedication in terms of adverse reactions to non-ionic contrast media. We investigated the incidence of adverse reactions among patients who underwent contrast-enhanced computed tomography. Patients in the premedication group took 30 mg of prednisolone orally the night before and on the morning of the scheduled computed tomography. Sixty-five patients received the same contrast media. Among them, 56 took prednisolone orally prior to the procedure (premedication without change of contrast media group) and nine without premedication (no premedication and no change of contrast media group). In total, 379 patients received different contrast media. Among them, 340 took prednisolone orally (premedication with change of contrast media group), while 39 did not take the premedication (no premedication with change of contrast media group). The adverse reaction rates in the premedication with change of contrast media and no premedication with change of contrast media groups were 1.8% (6/340 cases) and 2.6% (1/39 cases) (P = 0.54), respectively. The incidence of adverse reaction after the administration of non-ionic iodinated contrast media did not differ significantly based on whether an oral steroid was administered prior to compute tomography. Our evaluation is limited due to the small sample size of the contrast media-changed group. However, even if premedication with steroids is effective, it may only result in an adverse reaction reduction rate of ≤3%.

关键词： Iodine Contrast Media Oral Steroid Premedication Breakthrough Reaction Prednisolone adverse reactions

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Research Progress on Pharmacology and adverse reactions of hirudin

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Asian Toxicology Tesearch 2021年第3期3卷 18-26页

作者： Y u-Qiang Lu Guo-Cheng Zhang Hui Ding Zhao-Lin Shi Ru-Ying Li Shaanxi University of Chinese Medicine Xianyang 712046China The Second Affiliated Hospital of Shaanxi University of Chinese Medicine Xianyang 712046China.

Hirudin is an active ingredient extracted from leeches(Hirudo).At present,there are many hirudin preparations on the market,which are roughly divided into three categories,the first is natural hirudin,the second is hirudin derivatives such as lepirudin,desirudin and bivalirudin,and the third is new hirudin preparations such as hirudin-bovine serum albumin(BSA)nanoparticles,polydopamine fitted titanium dioxide nanoparticles systems and recombinant hirudins-2(rhv2)-loaded *** pharmacological effects and adverse reactions of hirudin were reviewed to evaluate its safety,efficacy and quality *** has obvious pharmacological effects on cardio-cerebrovascular diseases(coronary atherosclerotic heart disease,myocardial infarction,hyperlipidemia,cerebral infarction,arteriosclerosis obliterans of lower extremities),angiogenesis(fracture,skinflaptransplantation),tissue fibrosis,tumor,ophthalmopathy,hyperuricemia and female ***,attention should be paid to clinical adverse reactions(bleeding,allergic reaction,infection,cutaneous pseudolymphoma).

关键词： Hirudin Pharmacology Clinical application adverse reactions

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Analysis of the adverse reactions of atezolizumab: A real-world study based on FAERS database

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Oncology and Translational Medicine 2021年第2期7卷 88-94页

作者： Hao Liu Yujing Zhang Jingyi Li Rong Yan Department of Surgical Oncology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061China College of Stomatology Xi'an Jiaotong UniversityXi'an 710061China

Objective In this study,we aimed to determine the incidence of adverse drug reactions(ADRs)of atezolizumab,identify ADR signals that are significantly related to atezolizumab,and provide a reference for the rational use of atezolizumab in the clinic through the statistical analysis of its adverse drug events(ADEs)reported in the American Food and Drug Administration(FDA)adverse Event Reporting System(FAERS)*** In total,4796 cases of atezolizumab ADEs reported in the American FAERS database from 2017 to 2019 were retrospectively *** The top three ADEs were febrile neutropenia(3.7%),anemia(2.9%),and acute renal failure(2.3%).In addition,the incidence rates of some ADEs were significantly different according to sex and *** systematic organ classification of atezolizumab ADEs involved 32 systems,among which the top three were blood and lymphatic system disorders(585 cases,12.2%),gastrointestinal disorders(433 cases,9.0%),and infections and infestations(401 cases,8.4%).The reporting odds ratio(ROR)method was used to detect the ADR signals of *** ROR(95%confidence interval)of the top ADE,febrile neutropenia,was 39.236(33.757–45.604).In addition,we found 121 cases of complications associated with immune-related *** The ADRs of atezolizumab reported in the FAERS database were consistent with those mentioned in the instructions for atezolizumab use,suggesting that atezolizumab has an acceptable and controllable drug effect.

关键词： atezolizumab adverse reactions Food and Drug Administration(FDA)adverse Event Reporting System(FAERS)database rational drug use

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Genetic Polymorphisms Contribute to the Individual Variations of Imatinib Mesylate Plasma Levels and adverse reactions in Chinese GIST Patients

Genetic Polymorphisms Contribute to the Individual Variation...

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石河子大学2017年“一带一路”核心区创新驱动发展博士...

作者： Jing Liu Zhiyu Chen Hanmei Chen Yingyong Hou Weiqi Lu Junyi He Hanxing Tong Yuhong Zhou Weimin Cai Department of Clinical Pharmacy School of Pharmacy Fudan University Department of Medical Oncology Shanghai Cancer Center Fudan University Department of Pathology Zhongshan Hospital Fudan University Department of General Surgery Zhongshan Hospital Fudan University Department of Medical Oncology Zhongshan Hospital Fudan University

Imatinib mesylate（IM） has dramatically improved the outcomes of gastrointestinal stromal tumor（GIST） patients. However, the clinical responses of IM may considerably vary among single individuals. This study aimed to investigate the influences of genetic polymorphisms of drug-metabolizing enzyme（CYP3A4）, transporters（ABCB1, ABCG2）, and nuclear receptor（Pregnane X Receptor（PXR, encoded by NR1I2）） on IM plasma levels and related adverse reactions in Chinese GIST patients. A total of 68 Chinese GIST patients who have received IM 300–600 mg/day were genotyped for six single nucleotide polymorphisms（SNPs）（CYP3A4 rs2242480;ABCB1 rs1045642;ABCG2 rs2231137;NRI12 rs3814055, rs6785049, rs2276706）, and the steady-state IM trough plasma concentrations were measured by a validated HPLC method. There were statistically significant variances in the steady-state IM trough plasma concentrations（from 272.22 to 4365.96 ng/m L）. Subjects of GG in rs2242480, T allele carriers in rs1045642 and CC in rs3814055 had significantly higher steady-state IM dose-adjusted trough plasma concentrations. Subjects of CC in rs3814055 had significantly higher incidence rate of edema. The genetic polymorphisms of rs2242480, rs1045642, rs3814055 were significantly associated with IM plasma levels, and the genetic variations of rs3814055 were significantly associated with the incidence rate of edema in Chinese GIST patients. The current results may serve as valuable fundamental knowledge for IM therapy in Chinese GIST patients.

关键词： imatinib mesylate gastrointestinal stromal tumor genetic polymorphisms plasma levels adverse reactions Chinese

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Clinical Efficacy and adverse reactions of Photodynamic Therapy in the Treatment of Malignant Skin Tumors and Precancerous Skin Diseases

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Advances in Modern Oncology Research 2019年第5期5卷 6-8页

作者： Andrew L.Mason Chadia Chourabi Department of Genetics University of North CarolinaChapel HillNC Alliance Protocol Operations Office University of ChicagoChicagoIL

The purpose of the study was to investigate the efficacy and safety of photodynamic therapy in the treatment of malignant skin tumors and precancerous skin *** of all,100 patients with malignant skin tumor and pre-cancer skin disease admitted to our hospital from January 20,2018 to September 18,2018 were selected,and all of them adopted photodynamic *** 100 patients included 40 cases of basal cell carcinoma,14 cases of squamous cell carcinoma,7 cases of proliferative erythema,9 cases of Bowen’s disease and 39 cases of solar *** the 100 patients,77 cases had excellent curative effect,18 cases had good effect and 5 cases had poor effect,and the overall effective rate was 95%(95/100).After 6 months of follow-up,5 cases of basal cell carcinoma,2 cases of squamous cell carcinoma,0 cases of proliferative erythra,1 case of Bowen’s disease and 3 cases of solar keratosis recurred,with an overall recurrence rate of 14%(14/100).The adverse reactions of pruritus were 90%(90/100),81%(81/100),90%(90/100)and 3%(3/100).Therefore,the application of photodynamic therapy in the treatment of malignant skin tumors and precancerous skin diseases is not only effective,but also safe and not easy to relapse.

关键词： Malignant skin tumor Precancerous skin disease Photodynamic therapy adverse reactions

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Research progress on pharmacology and adverse reactions of gastrodin

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Asian Toxicology Tesearch 2020年第4期2卷 170-175页

作者： Peng Lu Ke Xiong Ming Huang Bing Zhang Xian-Bin Kong State Key Laboratory of Component-based Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin301617China Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique Ministry of EducationTianjin301617China School of Food and Biology Engineering Xuzhou University of TechnologyJiangsu221018China College of traditional Chinese medicine Tianjin University of traditional Chinese MedicineTianjin301617China

Gastrodin(4-hydroxymethylphenyl-β-d-glucopyranoside)is an active ingredient with high content,which is isolated from the rhizome of Gastrodia *** injections,tablets and capsules are currently the main gastrodin-related preparations in clinical practice,and gastrodin injections are the most widely *** article will summarize pharmacology and adverse reactions of gastrodin to evaluate its safety,effectiveness and quality *** has pharmacological effects on central nervous system(vertigo,headache,insomnia,neurasthenia,convulsions and epilepsy,etc.),cardiovascular system and other diseases(osteoporosis,osteoarthritis and bone injury,etc.),but we still need to pay attention to its clinical adverse reactions(some patients may have dry mouth and nose,dizziness and stomach discomfort).In addition,further research is needed in other fields,such as health products,food,cosmetics,*** also need to further develop and explore the new pharmacological effects of gastrodin and expand its medicinal value.

关键词： Gastrodin Pharmacology Clinical application adverse reactions Effectiveness

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Study on the Management Effect of Pharmaceutical Care on adverse reactions of Traditional Chinese Medicines in Joint Surgery and Neurology

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Food Therapy and Health Care 2021年第1期3卷 1-5页

作者： Kun Qian Juan Wang Xue-Mei Gao Li-Li Liu Jie Zhong Wen-Ming Cao Changle People's Hospital Weifang 262400ShandongChina

Objective:In general hospitals,pharmaceutical care was carried out to reduce the incidence of adverse drug reactions(ADR),and this effect was *** can significantly reduce the incidence of adverse drug reactions and improve the safety of drug *** Joint Surgery Department and the Department of Neurology of Changle County People's Hospital in Shandong province were investigated for the effect of pharmaceutical care on reducing adverse drug ***:120 patients were selected from the Department of Joint Surgery and Neurology,Changle County People's Hospital,Shandong Province from May 2015 to May *** to the random table method,the patients were divided into experimental group(60 cases)and control group(60 cases).Control group:routine drug *** group:pharmaceutical care treatment was carried out jointly,and the incidence of adverse reactions was compared between the two ***:The incidence of adverse reactions in experimental group was lower than that in control ***:In general hospitals,pharmaceutical care is effective in reducing adverse drug reactions,which can significantly reduce the incidence of adverse drug *** the same time,this improves the safety of drug treatment,which is worthy of clinical promotion.

关键词： Pharmaceutical care adverse reactions Management effect

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Progress in the treatment of advanced hepatocellular carcinoma with immune combination therapy

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 273-286页

作者： Di Pan Hao-Nan Liu Peng-Fei Qu Xiao Ma Lu-Yao Ma Xiao-Xiao Chen Yu-Qin Wang Xiao-Bing Qin Zheng-Xiang Han Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of General Surgery The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

Advanced hepatocellular carcinoma(HCC)is a severe malignancy that poses a serious threat to human *** to challenges in early diagnosis,most patients lose the opportunity for radical treatment when ***,recent advancements in cancer immunotherapy provide new directions for the treatment of *** instance,monoclonal antibodies against immune check-point inhibitors(ICIs)such as programmed cell death protein 1/death ligand-1 inhibitors and cytotoxic t-lymphocyte associated antigen-4 significantly improved the prognosis of patients with ***,tumor cells can evade the immune system through various *** the rapid development of genetic engineering and molecular biology,various new immunotherapies have been used to treat HCC,including ICIs,chimeric antigen receptor T cells,engineered cytokines,and certain cancer *** review summarizes the current status,research progress,and future directions of different immunotherapy strategies in the treatment of HCC.

关键词： Hepatocellular carcinoma Immunotherapies Immune checkpoint inhibitor Clinical efficacy adverse reactions

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Effectiveness of Comprehensive Nursing Management in Enhancing Blood Donation Outcomes and Donor Experience: A Comparative Study

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Journal of Clinical and Nursing Research 2024年第5期8卷 277-282页

作者： Yumiao Zhang Suzhou Wujiang Blood Station Suzhou 215200Jiangsu ProvinceChina

Objective:To assess the management effect of comprehensive nursing management on blood donation services in blood ***:Sixty-four individuals who donated blood at a blood station between September 2021 and September 2023 were selected and randomly assigned into two groups of 32 *** first group received comprehensive nursing management,while the second group received routine nursing *** donation indexes and observational indexes such as adverse reactions were compared between the ***:The total blood donation volume and qualified blood donation volume were higher in the first group than in the second *** amount of discarded blood and the rate of blood discards were lower in the first group compared to the second group(Padverse reaction rate in the first group was lower,the blood donation comfort scores were higher,the psychological state scores were lower,and the quality of care scores were higher than those in the second group(Padverse reactions,alleviate negative psychological states of blood donors,and enhance both the comfort level of blood donation and the quality of care provided.

关键词： Comprehensive nursing management Blood donation service at blood stations adverse reactions Comfort Quality of care

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