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Identification of novel biomarkers for adult-onset-immunodeficiency(AOID)syndrome using serum proteomics

Asian Pacific Journal of Tropical Medicine 2017年第5期10卷 445-452页

作者： Jeerang Wongtrakul Thananya Thongtan Sittiruk Roytrakul Jutarat Praparattanapan Jiraprapa Wipasa Benjawan Kumrapich Khuanchai Supparatpinyo Research Institute for Health Sciences Chiang Mai University110 Intavaroros RoadSriphumMuang DistrictChiang Mai 50200Thailand Department of Biochemistry Faculty of MedicineChulalongkorn University1873 Rama 4 RoadPathumwanBangkok 10330Thailand Proteomics Research Laboratory Genome InstituteNational Center for Genetic Engineering and Biotechnology113 Thailand Science ParkPhahonyothin RoadKhlong NuengKhlong LuangPathumthani 12120Thailand Department of Medicine Faculty of MedicineChiang Mai University110 Intavaroros RoadSriphumMuang DistrictChiang Mai 50200Thailand

Objective:To identify the candidate protein biomarkers of adult-onset-immunodeficiency(AOID) syndrome using serum proteomics. Methods:Screening and verification phases were performed in the study. A total of 97 serum samples were classified into three groups:AOID patients with opportunistic infections(active AOID),AOID patients without opportunistic infections(inactive AOID),and healthy control. In the screening phase,pooled sera collected from patients and healthy control in each group were separated by 2D-gel electrophoresis,analyzed for differentially expressed proteins and identified for biomarkers using LC/MS. In the verification phase,the protein candidates were selected for confirmation by western blotting. Results:The analysis revealed 35 differentially expressed proteins. Three proteins including haptoglobin,gelsolin,and transthyretin,were selected for verification. The results showed that the levels of haptoglobin in both active and inactive AOID groups were significantly higher than that in the control group,while the levels of gelsolin in the active AOID group were significantly lower than that in the inactive AOID group. The level of transthyretin in the active AOID group was also significantly lower than that in the control group. Conclusions:The comparison of serum proteins between the three groups revealed three candidates which are related to chronic inflammatory diseases. Haptoglobin and transthyretin biomarkers could be applied in clinical assessment for monitor of disease outcome,including for the study of AOID pathogenesis.

关键词： adult-onset immunodeficiency syndrome Anti-interferon-gamma autoantibody Haptoglobin Gelsolin Transthyretin Biomarkers

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Intracranial infection accompanied sweet’s syndrome in a patient with anti-interferon-γautoantibodies:A case report

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World Journal of Clinical Cases 2023年第32期11卷 7926-7934页

作者： Jun-Hui Zheng Dan Wu Xiao-Yun Guo General Internal Medicine Affiliated Cancer Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Intensive Care Unit Affiliated Cancer Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Several reports of adult-onset immunodeficiency syndrome have been associated with anti-interferon-gamma(IFN-γ)autoantibodies(AIGAs).However,it is rare to find AIGAs with intracranial *** SUMMARY In this case study,we report a case of an AIGAs with intracranial infection and hand rashes considered Sweet’s *** patient presented to our hospital with a persistent cough,a fever that had been going on for 6 mo,and a rash that had been going on for a *** patient started losing consciousness gradually on the fourth day after admission,with neck stiffness and weakened limb *** upper lobe of the left lung had a high-density mass with no atypia and a few inflammatory cells in the *** magnetic resonance imaging and cerebrospinal fluid suggest intracranial *** pathology of the skin damage on the right upper extremity revealed an infectious lesion that was susceptible to Sweet’s *** has an anti-IFN-γautoantibody titer of 1:*** was given empirical anti-non-tuberculous mycobacterial and antifungal *** patient had no fever,obvious cough,headache,or rash on the *** got out of bed and took care of herself following hospitalization and discharge with *** adults with severe and recurrent infections of several organs should be considered for AIGAs if no other known risk factors *** are susceptible to subsequent intracranial infections and Sweet’s syndrome.

关键词： adult-onset immunodeficiency syndrome Anti-interferon-gamma autoantibodies Intracranial infection Sweet disease Case report

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