检索结果-南通市图书馆

Intraoperative sudden arrhythmias in cervical spine surgery adjacent to the stellate ganglion:A case report

在线全文

学校读者我要写书评

暂无评论

世界临床病例杂志 2023年第24期11卷 5789-5796页

作者： Jong-Hun Seo Su-Yeon Cho Ji-Hwan Park Jin-Young Seo Hyun-Young Lee Dong-Joon Kim Department of Neurosurgery Chosun University HospitalGwangju 61453South Korea Department of Anesthesiology and Pain Medicine Chosun University HospitalGwangju 61453South Korea Department of Anesthesiology and Pain Medicine College of MedicineChosun UniversityGwangju 61453South Korea

BACKGROUND Atrial arrhythmias such as paroxysmal supraventricular tachycardia(PSVT)and atrial flutter(AF)are common in the perioperative *** commonly resolve ***,occasionally,they may continually progress to fatal arrhythmias or cause ***,prompt and appropriate management is *** SUMMARY A 46-year-old female patient diagnosed with cervical C6-7 radiculopathy characterized by decreased sensation in the right third,fourth and fifth fingers underwent C6-7 anterior cervical disc fusion *** showed PSVT and ventricular tachycardia during C6-7 disc ***,the patient remained *** treatment with esmolol and lidocaine for ventricular tachycardia was *** massage and Valsalva maneuver were attempted but PSVT did not *** surgery was paused,and the patient’s fraction of inspired oxygen was set to 100%.adenosine was administered for pharmacological management of *** arrhythmia temporarily ***,it then transformed into *** was administered,which briefly decreased blood pressure,which immediately *** resumed while the patient was in normal sinus *** was discharged safely on postoperative day 6 without complications or ***,she is living a healthy life without arrhythmia *** Ganglia associated with cardiac arrhythmias in the surgical site should be identified during cervical spine surgery.

关键词： Supraventricular tachycardia Atrial flutter Stellate ganglion adenosine Diltiazem Case Report

ATP结合盒家族G蛋白亚家族2单核苷酸多态性与高尿酸血症的关系

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华内科杂志 2017年第11期56卷 833-838页

作者：张冰清方卫纲张昀刘淑芬曾学军中国医学科学院北京协和医学院北京协和医院普通内科100730 中国医学科学院北京协和医学院北京协和医院物理康复理疗科100730

目的研究在不同年龄、性别中ATP结合盒家族G蛋白亚家族2（ABCG2）单核苷酸多态性rs2231142（C〉A）与高尿酸血症的相关性.方法选北京协和医院职工体检人群为研究对象,男性血尿酸〉416.4μmol/L、女性血尿酸〉359.6μmol/L者纳入高尿... 详细信息

目的研究在不同年龄、性别中ATP结合盒家族G蛋白亚家族2（ABCG2）单核苷酸多态性rs2231142（C〉A）与高尿酸血症的相关性.方法选北京协和医院职工体检人群为研究对象,男性血尿酸〉416.4μmol/L、女性血尿酸〉359.6μmol/L者纳入高尿酸血症组,另选血尿酸水平正常者为对照组.采用扩增耐突变系统-聚合酶链反应检测ABCG2基因型,分析ABCG2 rs2231142与高尿酸血症的相关性,以及基因与性别的交互作用.结果高尿酸血症组ABCG2 rs2231142A等位基因频率高于对照组（38.38%比26.62%,P〈0.001）,OR=2.89（95%CI 1.91-4.37,P〈0.001）,调整高血压、高血糖、高血脂后,OR=2.99（95%CI 1.94-4.62,P〈0.001）.亚组分析显示,男性高尿酸血症的相对风险高于女性,OR值分别为3.83（95%CI 2.03-7.24,P〈0.001）、2.30（95%CI 1.32-4.00,P=0.003）.年龄≥55岁者,男性和女性ABCG2 rs2231142 A等位基因携带者发生高尿酸血症的相对风险相仿;而年龄〈55岁者,男性ABCG2 rs2231142 A等位基因携带者发生高尿酸血症的相对风险高于女性,OR值分别为4.11（95%CI 1.92-8.79,P〈0.001）、1.73（95%CI 0.80-3.76,P=0.165）,交互性分析未达统计学意义.结论我院职工体检人群中,ABCG2 rs2231142 A等位基因是发生高尿酸血症的独立危险因素.

关键词：高尿酸血症 ATP结合盒家族G蛋白亚家族2 多态性单核苷酸雌激素类 adenosine triphosphate binding cassette subfamily G member-2

Neuroimaging of inflammation in alcohol use disorder: a review

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2020年第7期63卷 19-37页

作者： Dana E.FELDMAN Katherine L.MCPHERSON Catherine L.BIESECKER Corinde E.WIERS Peter MANZA Nora D.VOLKOW Gene-Jack WANG National Institute on Alcohol Abuse and Alcoholism National Institute on Drug Abuse

Alcohol use disorder(AUD) is a global health concern associated with several *** health problems related to AUD, such as cognitive deficits, have been linked to *** use has been associated with changes in neuroimmune activity, although current literature has yielded mixed results. For example, markers of gliosis, including translocator protein 18-kDa(TSPO), proinflammatory cytokines, glutamate(Glu), and myo-inositol(mI), are disrupted in the alcohol-dependent brain. Further, neuroinflammatory-related phenomena including membrane turnover, blood brain barrier(BBB) permeability, and adenosine release have also shown alterations in AUD. However, current literature remains inconclusive about the directionality of these changes. Both in vivo and in vitro studies have provided insight on the relationship between alcohol use and neuroinflammatory processes, suggesting considerable treatment potential for alcohol use disorder and its inflammatory comorbidities. Here, we review current neuroimaging literature assessing the impacts of alcohol use on neuroimmune activity in the brain.

关键词： acetate adenosine alcohol use disorder blood brain barrier choline gliosis glutamate myoinositol neuroimaging neuroinflammation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

腺苷中6-甲胺基杂质的发现与合成

中国医药工业杂志 2014年第10期45卷 923-924页

作者：张超陈道新李总领浙江海正药业股份有限公司浙江台州318000

腺苷（adenosine,1）,化学名为6-氨基-9-β-D-呋喃核糖嘌呤,是一种普遍存在于人体细胞的内源性物质。1有广泛的心脏效应和扩血管作用,可用于治疗心绞痛、心肌梗死、动脉硬化等症。1也是一种重要的医药原料,可以制备许多核苷类药物如嘌... 详细信息

腺苷（adenosine,1）,化学名为6-氨基-9-β-D-呋喃核糖嘌呤,是一种普遍存在于人体细胞的内源性物质。1有广泛的心脏效应和扩血管作用,可用于治疗心绞痛、心肌梗死、动脉硬化等症。1也是一种重要的医药原料,可以制备许多核苷类药物如嘌呤霉素、赖氨酰氨基腺苷、8-氯腺苷等,因此具有广阔的市场和发展前景。

关键词：生物合成法呋喃核糖核苷类药物扩血管作用苦味酸盐嘌呤霉素内源性物质甲胺 adenosine 发展前景

Purines:From Diagnostic Biomarkers to Therapeutic Agents in Brain Injury

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2020年第11期36卷 1315-1326页

作者： Bruno G.Frenguelli Nicholas Dale School of Life Sciences The University WarwickCoventry CV47ALUK

The purines constitute a family of inter-related compounds that serve a broad range of important intracellular and extracellular biological *** particular,adenosine triphosphate(ATP)and its metabolite and precursor,adenosine,regulate a wide variety of cellular and systems-level physiological processes extending from ATP acting as the cellular energy currency,to the adenosine arising from the depletion of cellular ATP and responding to reduce energy demand and hence to preserve ATP during times of metabolic *** inter-relationship provides opportunities for both the diagnosis of energy depletion during conditions such as stroke,and the replenishment of ATP after such *** this review we address these opportunities and the broad potential of purines as diagnostics and restorative agents.

关键词： Purines adenosine ATP Biomarker Stroke Cerebral ischemia Traumatic brain injury Adenine D-ribose

Distinctive quality control method for solid-state fermented Isaria cicadae from strain Ic-17-7 and application in a rat model of type 2 diabetes

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2021年第12期19卷 921-929页

作者： SUN Chang-Sheng WANG Yu-Qin ZHANG Zhong-Liang LIOU Yuligh ZHOU Hong-Hao Department of Clinical Pharmacology Xiangya HospitalCentral South UniversityChangsha 410008China Institute of Clinical Pharmacology Central South UniversityHunan Key Laboratory of PharmacogeneticsChangsha 410078China Engineering Research Center of Applied Technology of Pharmacogenomics Ministry of EducationChangsha 410078China National Clinical Research Center for Geriatric Disorders Changsha 410008China China Zhejiang Bioasia Life Science Institute Pinghu 314200China

This work was aimed to establish a quality control method for evaluating the effects on glucose and lipids of the fruiting body of Isaria cicadae Miquel from strain Ic-17-7(Ic-17-7fb) using a rat model of type 2 diabetes(T2DM). Random amplified polymorphic DNA, sequence-characterized amplified region, and high-performance liquid chromatography(HPLC) were used for the quality control of Ic-17-7fb. The pharmacological effects on streptozocin(STZ)-induced high fat diet(HFD)-fed Albino Wistar rats were evaluated. The rats underwent the following treatments: control, metformin, Ic-17-7fb(0.166 and 0.5 g·kg;) or without treatment. The fasting blood glucose(FBG), blood glucose, total cholesterol(TC), triglyceride(TG), high-density lipoprotein(HDL-c), and low-density lipoprotein(LDL-c) were measured. Ic-17-7fb amplified a single specific band by S11-2-F3 and S11-2-R3 primers. An HPLC-based quality and quantity method was established for industrial application. The contents of adenosine and N;-(2-hydroxyethyl) adenosine(HEA) of the cultivated Ic-17-7fb were analyzed. All of the validation lots of cultured Ic-17-7fb passed the quantity control of the training set(0.90 mg·g;of adenosine and 0.89 mg·g;of HEA). After two weeks of administration, the average FBG was 4.89 ± 0.42(control), 26.10 ± 5.77(model), 23.63 ± 6.15(metformin), 17.96 ± 9.36(Ic-17-7fb for 0.166 g·kg;), and 19.69 ±8.71 mmol·L;(Ic-17-7fb for 0.5 g·kg;). The FBG of Ic-17-7fb(0.166 g·kg;) treatment significantly reduced by 31.19%, compared with the model after two weeks of administration(P < 0.01). Metformin, Ic-17-7fb(0.166 g·kg;), and Ic-17-7fb(0.5 g·kg;) reduced TC, TG, HDL-c, and LDL-c compared with the T2DM model treatment at the 6 th week of treatment(P < 0.05). This study established the first quality standard for Ic-17-7fb, which can be effectively applied in the treatment of T2DM. The reliable quality control method and pharmacological effect will broaden its application space.

关键词： Isaria cicadae Quality control adenosine HEA Type 2 diabetes model Blood glucose and lipid

Development of an eco-friendly and fast HPLC method for quantitative analysis of four nucleosides in Cordyceps and related products

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Natural Medicines 2021年第12期19卷 954-960页

作者： QIAN Zheng-Ming WU Zi HUANG Qi WANG Chuan-Xi TAN Guo-Yin LI Wen-Jia SUN Wan-Yang LV Gen-Pin GAO Hao Institute of Traditional Chinese Medicine and Natural Products College of PharmacyJinan UniversityGuangzhou 510632China Ruyuan HEC Pharm Co. Ltd.Shaoguan 512700China

An eco-friendly and fast HPLC method was developed for the determination of adenosine, inosine, guanosine and uridine in Cordyceps and related products(fermented mycelia of Hirsutella sinensis and Paecilomyces hepiali). The sample was ultrasonically extracted using 0.5% phosphoric acid solutions for 2.5 min. Sample separation was performed on a Poroshell SB-Aq column(50 mm × 4.6 mm, 2.7 μm) using eco-friendly mobile phase consisting of formic acid and ammonium formate aqueous solution at a flow rate of 1.0 m L·min;. The detection wavelength was 260 nm. The developed HPLC method showed good linearity with correlation coefficients of 1.0000 in the test range. Good precision, repeatability and stability of this method were also observed(RSD ≤ 2.81%).The recovery ranged from 91.84%-105.19%(RSD ≤ 2.59%). Compared with reported methods, the current method did not use harmful organic solvent and took only 10.5 min. It obtained a high eco-score of 91 by the "Analytical Eco-Scale" tool. The developed method is eco-friendly and fast, which is suitable for the quality evaluation of Cordyceps and related products.

关键词： adenosine Inosine Guanosine Uridine Cordyceps

Current status of assessment of fractional flow reserve

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2009年第6期122卷 725-731页

作者： FANG Yi-min Grisana Grootenhuijs-Triyasut Pieter A. Doevendans Yolande Appelman Department of Cardiology Affiliated Yantai Yuhuangding Hospital of Medical College Qingdao University Yantai Shandong 264000 China Radi Medical Systems BV Eindhoven The Netherlands epartmentof Cardiology Utrecht University Hospital Utrecht The Netherlands Department of Cardiology VU University Medical Center Amsterdam The Netherlands

Coronary angiography presently remains the main method tor the diagnosis and instruction of epicardial coronary disease. However, precise characterization of the significance for any given stenosis is limited by the inability to identify intermediate coronary lesions responsible for ischemia. In clinical practice, in addition to the assessment of the anatomical details of vessel narrowing, a more impediment to coronary precise assessment of the blood flow has become extremely important. At present, several physiological parameters have been introduced to improve discrimination in functional coronary lesion severity during cardiac catheterization. Of these parameters, myocardial fractional flow reserve （FFR） has been the most frequently used and is being increasingly applied to assess the functional significance of intermediate lesions. FFR can provide important information, both for decision making in diagnostic angiography and for monitoring and evaluating coronary interventions.

关键词： coronary angiography fractional flow reserve stent adenosine

Treadmill training improves neurological deficits and suppresses neuronal apoptosis in cerebral ischemic stroke rats

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2019年第8期14卷 1387-1393页

作者： Li-Mei Cao Zhi-Qiang Dong Qiang Li Xu Chen Department of Neurology Shanghai No.8 People’s Hospital

RehabilNation training is believed to be beneficial to patients with stroke, but its molecular mechanism is still unclear. Rat models of cerebral ischemic stroke were established by middle cerebral artery occlusion/reperfusion, and then received treadmill training of different intens让ies, twice a day for 30 minutes for 1 week. Low-intensity training was conducted at 5 m/min, with a 10-minute running, 10-minute rest, and 10-minute running cycle. In the moderate-intensity training, the intensity gradually increased from 5 m/min to 10 m/min in 5 minutes, with the same rest cycle as above. In high-intensity training, the intensity gradually increased from 5 m/min to 25 m/min in 5 minutes, with the same rest cycle as above. The Bederson scale was used to evaluate the improvement of motor function. Infarct volume was detected using 2,3,5-triphenyltetrazolium chloride staining. Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining was applied to detect the apoptosis of nerve cells in brain tissue. Western blot assay was employed to analyze the activation of cyclic adenosine monophosphate (cAMP)/protein kinase A and Akt/glycogen synthase kinase-3卩 signaling pathways in rat brain tissue. All training intensities reduced the neurological deficit score, infarct volume, and apoptosis in nerve cells in brain tissue of stroke rats. Training intensities activated the cAMP/protein kinase A and Akt/glycogen synthase kinase-3 beta signaling pathways. This activation was more obvious with higher training intensities. These changes were reversed by intracerebroventricular injection of protein kinase A inhibitor Rp-cAMP. Our findings indicate that the neuroprotective effect of rehabilitation training is achieved via activation of the cAMP/ protein kinase A and Akt/glycogen synthase kinase-3 beta signaling pathways. This study was approved by the Ethics Committee of Animal Experimentation in Shanghai No. 8 Peoples Hospital, China.

关键词： nerve regeneration ischemic stroke treadmill training neuronal deficit apoptosis cyclic adenosine monophosphate protein kinase A glycogen synthase kinase-3^ neuroprotective effect neural regeneration