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Study of Differential Serum Metabolites in Patients with adenomatous polyps of Colon and Yang-Deficiency Constitution Based on Ultra-Performance Liquid Chromatography-Mass Spectrometry

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Chinese Journal of Integrative Medicine 2022年第5期28卷 403-409页

作者： DU Wen-zhang ZHANG Ai-hua REN Jun-ling LYU Kun TUO Lu-yao XU Wei Department of Integrated Traditional Chinese and Western Medicine First Affiliated Hospital of Harbin Medical UniversityHarbin(150001)China Metabolomics Laboratory Heilongjiang University of Chinese MedicineHarbin(150001)China

Objective:To study the differences between the serum metabolites in patients with adenomatous polyps of the colon and yang-deficiency constitution and those without colon polyps and with balanced constitution,and look for biomarkers that can be used to distinguish between the two ***:General patient information was gathered,and Chinese medicine constitutions were collected in 940 patients who underwent electronic colonoscopy.A total of 119 patients with adenomatous polyps of the colon and yang-deficiency constitution were included in the experimental group,and 150 patients without colon polyps and with balanced constitution were included in the control *** analysis was performed on the fasting venous blood obtained from each patient in both *** component analysis and orthogonal partial least squares discriminant analysis were performed on the detection results,potential biomarkers were screened,metabolic pathway changes were determined,and the metabolic processes involved were ***:A total of 59 differential biomarkers between the experimental group and the control group were *** differential metabolites were found mainly in the glycerophospholipid metabolism pathway,and the bile acid 3-oxo-4,6-choladienoic acid was the biomarker that distinguished the experimental group from the control ***:With the help of metabolomics analysis,the differential metabolites in patients with adenomatous polyps of the colon and yang-deficiency constitution and those in patients without colon polyps and with balanced constitution could be *** biomarker 3-oxo-4,6-choladienoic acid may have potential diagnostic value in patients with adenomatous polyp of the colon and yang-deficiency constitution.(Trial Registration ***02986308)

关键词： ultra-performance liquid chromatography-mass spectrometry adenomatous polyps yang-deficiency constitution Chinese medicine metabolomics biomarkers

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Fecal metabolomic profiles: A comparative study of patients with colorectal cancer vs adenomatous polyps

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World Journal of Gastroenterology 2021年第38期27卷 6430-6441页

作者： Giulia Nannini Gaia Meoni Leonardo Tenori Maria Novella Ringressi Antonio Taddei Elena Niccolai Simone Baldi Edda Russo Claudio Luchinat Amedeo Amedei Department of Clinical and Experimental Medicine University of FlorenceFlorence 50134Italy Department of Chemistry“Ugo Schiff” University of FlorenceFlorence 50134Italy Department of Chemistry&Magnetic Resonance Center(CERM) University of FlorenceFlorence 50134Italy

BACKGROUND Colorectal cancer(CRC),the third most common cause of death in both males and females worldwide,shows a positive response to therapy and usually a better prognosis when detected at an early ***,the survival rate declines when the diagnosis is late and the tumor spreads to other ***,the measures widely used in the clinic are fecal occult blood test and evaluation of serum tumor markers,but the lack of sensitivity and specificity of these markers restricts their use for CRC *** to its high sensitivity and precision,colonoscopy is currently the gold-standard screening technique for CRC,but it is a costly and invasive ***,the implementation of custom-made methodologies including those with minimal invasiveness,protection,and reproducibility is highly *** regard to other screening methods,the screening of fecal samples has several benefits,and metabolomics is a successful method to classify the metabolite shift in living systems as a reaction to pathophysiological influences,genetic modifications,and environmental *** To characterize the variation groups and potentially recognize some diagnostic markers,we compared with healthy controls(HCs)the fecal nuclear magnetic resonance(NMR)metabolomic profiles of patients with CRC or adenomatous polyposis(AP).METHODS Proton nuclear magnetic resonance spectroscopy was used in combination with multivariate and univariate statistical approaches,to define the fecal metabolic profiles of 32 CRC patients,16 AP patients,and 38 HCs well matched in age,sex,and body mass *** NMR metabolomic analyses revealed that fecal sample profiles differed among CRC patients,AP patients,and HCs,and some discriminatory metabolites including acetate,butyrate,propionate,3-hydroxyphenylacetic acid,valine,tyrosine and leucine were *** In conclusion,we are confident that our data can be a forerunner for future studies on CRC management,especially the di

关键词： Colorectal cancer adenomatous polyps Nuclear magnetic resonance metabolomics Fecal samples Fecal metabolomics

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Sex-influenced association of non-alcoholic fatty liver disease with colorectal adenomatous and hyperplastic polyps

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World Journal of Gastroenterology 2017年第28期23卷 5206-5215页

作者： Qin-Fen Chen Xiao-Dong Zhou Yang-Jie Sun Dan-Hong Fang Qian Zhao Jun-Hua Huang Yin Jin Jian-Sheng Wu Department of Gastroenterology The First Affiliated Hospital of Wenzhou Medical University Department of Cardiovascular Medicine The First Affiliated Hospital of Wenzhou Medical University Medical and Health Care Center The First Affiliated Hospital of Wenzhou Medical University

AIM To investigate the relationship between non-alcoholic fatty liver disease(NAFLD) and colorectal adenomatous and hyperplastic *** A retrospective cross-sectional study was conducted on 3686 individuals undergoing health checkups(2430 males and 1256 females). All subjects underwent laboratory testing,abdominal ultrasonography,colonoscopy,and an interview to ascertain the baseline characteristics and general state of health. Multinomial logistic regression analysis was performed to examine the association between NAFLD and the prevalence of colorectal adenomatous and hyperplastic ***,the relationship was analyzed in different sex groups. Subgroup analysis was performed based on number,size,and location of colorectal *** The prevalence of colorectal polyps was 38.8% in males(16.2% for adenomatous polyps and 9.8% for hyperplastic polyps) and 19.3% in females(8.4% for adenomatous polyps and 3.9% for hyperplastic polyps). When adjusting for confounding variables,NAFLD was significantly associated with the prevalence of adenomatous polyps(OR = 1.28,95%CI: 1.05-1.51,P polyps(OR = 1.35,95%CI: 1.01-1.82,P adenomatous and hyperplastic polyps in different sex groups,the significant association remained in males(OR = 1.53,95%CI: 1.18-2.00,P 0.05; OR = 1.18,95%CI: 0.50-2.78,P > 0.05). CONCLUSION NAFLD is specifically associated with an increased risk of colorectal adenomatous and hyperplastic polyps in men. However,NAFLD may not be a significant factor in the prevalence of colorectal polyps in women.

关键词： Non-alcoholic fatty liver disease Healthcheck adenomatous polyps Hyperplastic polyps

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Role of high definition colonoscopy in colorectal adenomatous polyp detection

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World Journal of Gastroenterology 2011年第35期17卷 4001-4006页

作者： Tolga Erim John M Rivas Evelio Velis Fernando Castro Department of Gastroenterology Cleveland Clinic FloridaWestonFL 33331United States Department of Internal Medicine Cleveland Clinic FloridaWestonFL 33331United States Health Services Administration Master Program Barry UniversityMiami ShoresFlorida 33161United States

AIM:To investigate the rates of polyp detection in a mixed risk population using standard definition (SDC) vs high definition colonoscopes (HDC).METHODS:This was a retrospective cohort comparative study of 3 colonoscopists who each consecutively performed 150 SDC (307,200 pixel) and 150 HDC (792,576 pixels) in a community teaching ***:A total of 900 colonoscopies were evaluated (mean age 56,46.8% men),450 with each *** of any type were detected in 46.0% of patients using SDC and 43.3% with HDC (P=0.42).There was no significant difference between the overall number of polyps,HDC (397) and SDC (410),detected among all patients examined,(P=0.73).One or more adenomatous polyps were detected in 24.2% of patients with HDC and 24.9% of patients with SDC colonoscopy (P=0.82).There was no significant difference between HDC (M=0.41) and SDC (M=0.42) regarding adenomatous polyp (P=0.88) or advanced adenoma (P=0.56) detection rate among all patients ***:HDC did not improve yield of adenomatous polyp,advanced adenoma or overall polyp detection in a population of individuals with mixed risk for colorectal cancer.

关键词： High definition colonoscopy Colon cancer screening adenomatous polyps

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Screening colonoscopy:The present and the future

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World Journal of Gastroenterology 2021年第3期27卷 233-239页

作者： Chelsea V Hayman Dinesh Vyas College of Medicine California Northstate UniversityElk GroveCA 95757United States Department of Surgery San Joaquin General HospitalFrench CampCA 95231United States

In the United States,colorectal cancer(CRC)is the second leading cause of mortality in men and *** are now seeing an increasing number of patients with advanced-stage diagnosis and mortality from colorectal cancer before 50 years of age,which requires earlier *** the increasing need for CRC screening through colonoscopy,and thus endoscopists,easier and simpler techniques are needed to train proficient *** most widely used approach by endoscopists is air insufflation colonoscopy,where air distends the colon to allow visualization of the colonic *** technique is uncomfortable for patients and requires an anesthetist to administer *** addition,patients commonly complain about discomfort post-op as air escapes into the small bowel and cannot be adequately *** research into the use of water insufflation colonoscopies has proved promising in reducing the need for sedation,decreasing discomfort,and increasing the visibility of the colonic *** direction into water insufflation colonoscopies which have shown to be simpler and easier to teach may increase the number of proficient endoscopists in training to serve our aging population.

关键词： Colorectal cancer Water-insufflation colonoscopy Air-insufflation colonoscopy adenomatous polyps Adenoma detection rate

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Colorectal cancer disparities: Issues, controversies and solutions

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World Journal of Gastroenterology 2014年第4期20卷 869-876页

作者： Venkata S Tammana Adeyinka O Laiyemo Division of Gastroenterology Department of Medicine Howard University College of Medicine

Colorectal cancer(CRC)is the second leading cause of cancer related deaths in the United *** are significant differences in CRC incidence and mortality by race with the highest burden occurring among *** underlying factors contributing to CRC disparities are multiple and *** have suggested that a higher prevalence of putative risk factors for CRC,limited access to healthcare services,lower utilization of healthcare resources and increased biological susceptibilities contribute to this disparity by *** article reviews the factors associated with the disproportionally higher burden of CRC among blacks;addresses the controversies regarding the age to begin CRC screening and the screening modality to use for blacks;and proffers solutions to eliminate CRC disparity by race.

关键词： Colorectal cancer disparities adenomatous polyps Colon cancer Colonoscopy Screening

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Should we perform sigmoidoscopy for colorectal cancer screening in people under 45 years?

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1248-1255页

作者： Waiian Leong Jia-Qi Guo Chun Ning Fei-Fei Luo Rui Jiao Dong-Ye Yang Division of Gastroenterology&Hepatology The University of Hong Kong-Shenzhen HospitalShenzhen 518053Guangdong ProvinceChina Department of Accident&Emergency The University of Hong Kong-Shenzhen HospitalShenzhen 518053Guangdong ProvinceChina Department of Anatomical Pathology The University of Hong Kong-Shenzhen HospitalShenzhen 518053Guangdong ProvinceChina Endoscopy Center The University of Hong Kong-Shenzhen HospitalShenzhen 518053Guangdong ProvinceChin

BACKGROUND The strategy for preventing colorectal cancer is screening by colonoscopy,which offers a direct way for detection and removal of adenomatous polyps(APs).American College of Gastroenterology guidelines recommend that people aged≥45 years should undergo colonoscopy;however,how to deal with people aged≤45 years is still *** To compare the prevalence of APs and high-grade neoplasia between the left and right colon in patients≤45 *** A retrospective observational study was conducted at a single tertiary III hospital in *** study included patients aged 18-45 years with undergoing initial colonoscopy dissection and pathological diagnosis AP or high-grade neoplasia between February 2014 and January *** number of APs in the entire colon while screening and post-polypectomy surveillance in following 1-3 years were *** A total of 3053 cases were *** prevalence of APs in the left and right colon was 55.0%and 41.6%,respectively(OR 1.7,95%CI 1.6-2.4;Ppolyps(52.0%)and 46 cases had>3 polyps(14.1%;OR 0.3,95%CI 0.1-0.6;P<0.05).CONCLUSION This study suggests that flexible sigmoidoscopy would be an optimal approach for initial screening in people aged≤45 years and would be a more cost-effective and safe strategy.

关键词： adenomatous polyps High-grade neoplasia Colonoscopy Flexible sigmoidoscopy

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Incidence of colorectal neoplasms among male pilots

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World Journal of Gastroenterology 2014年第27期20卷 9116-9120页

作者： Menachem Moshkowitz Ohad Toledano Lior Galazan Aharon Hallak Nadir Arber Erwin Santo Integrated Cancer Prevention Center and Department of Gastroenterology Tel-Aviv Sourasky Medical Center and Sackler Faculty of Medicine Tel-Aviv University

AIM: To assess the prevalence of colorectal neoplasms (adenomas, advanced adenomas and colorectal cancers) among Israeli military and commercial airline pilots.

关键词： Colorectal cancer adenomatous polyps Colon neoplasms Hyperplastic polyps

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Expanding endoscopic boundaries:Endoscopic resection of large appendiceal orifice polyps with endoscopic mucosal resection and endoscopic submucosal dissection

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World Journal of Gastrointestinal Endoscopy 2023年第5期15卷 386-396页

作者： Ankur P Patel Mai A Khalaf Margarita Riojas-Barrett Tara Keihanian Mohamed O Othman Department of Internal Medicine Baylor College of MedicineHoustonTX 77030United States Department of Tropical Medicine Tanta UniversityTanta 31527Egypt Department of Gastroenterology Baylor College of MedicineHoustonTX 77030United States

BACKGROUND Large appendiceal orifice polyps are traditionally treated ***,endoscopic mucosal resection(EMR)and endoscopic submucosal dissection(ESD)have been utilized as alternative resection *** To evaluate the efficacy and safety of endoscopic resection techniques for the management of large appendiceal orifice *** This was a retrospective observational study conducted to assess the feasibility and safety of EMR and ESD for large appendiceal orifice *** project was approved by the Baylor College of Medicine Institutional Review *** who underwent endoscopic resection of appendiceal orifice polyps≥1 cm from 2015 to 2022 at a tertiary referral endoscopy center in the United States were *** main outcomes of this study included en bloc resection,R0 resection,post resection adverse events,and polyp *** A total of 19 patients were *** patients were female(53%)and Caucasian(95%).The mean age was 63.3±10.8 years,and the average body mass index was 28.8±*** mean polyp size was 25.5±14.2 mm.74%of polyps were localized to the appendix(at or inside the appendiceal orifice)and the remaining extended into the cecum.68%of polyps occupied≥50%of the appendiceal orifice *** mean procedure duration was 61.6±37.9 *** were resected via endoscopic mucosal resection,endoscopic submucosal dissection,and hybrid procedures in 5,6,and 8 patients,*** pathology was remarkable for tubular adenoma(n=10)[one with high grade dysplasia],sessile serrated adenoma(n=7),and tubulovillous adenoma(n=2)[two with high grade dysplasia].En bloc resection was achieved in 84%with an 88%R0 resection *** the large polyp sizes and challenging procedures,89%(n=17)of patients were discharged on the same day as their *** patients were admitted for post-procedure observation for conservative pain *** patients underwent repeat colonoscopy without evide

关键词： Appendiceal orifice polyps Endoscopic mucosal resection Endoscopic submucosal dissection Polyp resection adenomatous polyps En bloc resection

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