Study of Differential Serum Metabolites in Patients with Adenomatous Polyps of Colon and Yang-Deficiency Constitution Based on Ultra-Performance Liquid Chromatography-Mass Spectrometry

作     者：DU Wen-zhang ZHANG Ai-hua REN Jun-ling LYU Kun TUO Lu-yao XU Wei 

作者机构：Department of Integrated Traditional Chinese and Western MedicineFirst Affiliated Hospital of Harbin Medical UniversityHarbin(150001)China Metabolomics LaboratoryHeilongjiang University of Chinese MedicineHarbin(150001)China 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2022年第28卷第5期

页      面：403-409页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Jiangxi University of Traditional Chinese Medicine  JXUTCM 

主　　题：ultra-performance liquid chromatography-mass spectrometry adenomatous polyps yang-deficiency constitution Chinese medicine metabolomics biomarkers 

摘      要：Objective:To study the differences between the serum metabolites in patients with adenomatous polyps of the colon and yang-deficiency constitution and those without colon polyps and with balanced constitution,and look for biomarkers that can be used to distinguish between the two ***:General patient information was gathered,and Chinese medicine constitutions were collected in 940 patients who underwent electronic colonoscopy.A total of 119 patients with adenomatous polyps of the colon and yang-deficiency constitution were included in the experimental group,and 150 patients without colon polyps and with balanced constitution were included in the control *** analysis was performed on the fasting venous blood obtained from each patient in both *** component analysis and orthogonal partial least squares discriminant analysis were performed on the detection results,potential biomarkers were screened,metabolic pathway changes were determined,and the metabolic processes involved were ***:A total of 59 differential biomarkers between the experimental group and the control group were *** differential metabolites were found mainly in the glycerophospholipid metabolism pathway,and the bile acid 3-oxo-4,6-choladienoic acid was the biomarker that distinguished the experimental group from the control ***:With the help of metabolomics analysis,the differential metabolites in patients with adenomatous polyps of the colon and yang-deficiency constitution and those in patients without colon polyps and with balanced constitution could be *** biomarker 3-oxo-4,6-choladienoic acid may have potential diagnostic value in patients with adenomatous polyp of the colon and yang-deficiency constitution.(Trial Registration ***02986308)