检索结果-南通市图书馆

adaptive response of resistant cancer cells to chemotherapy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2020年第4期17卷 842-863页

作者： Yi-Jye Chern Isabella T.Tai Division of Gastroenterology Department of MedicineUniversity of British ColumbiaVancouverBritish Columbia V5Z1L3Canada Michael Smith Genome Sciences Center British Columbia Cancer AgencyVancouverBritish Columbia V5Z1L3Canada

Despite advances in cancer therapeutics and the integration of personalized medicine,the development of chemoresistance in many patients remains a significant contributing factor to cancer mortality.Upon treatment with chemotherapeutics,the disruption of homeostasis in cancer cells triggers the adaptive response which has emerged as a key resistance mechanism.In this review,we summarize the mechanistic studies investigating the three major components of the adaptive response,autophagy,endoplasmic reticulum(ER)stress signaling,and senescence,in response to cancer chemotherapy.We will discuss the development of potential cancer therapeutic strategies in the context of these adaptive resistance mechanisms,with the goal of stimulating research that may facilitate the development of effective cancer therapy.

关键词： Cancer adaptive response chemoresistance chemotherapy autophagy ER stress signaling senescence

adaptive response of thymocyte apoptosis induced by X-irradiation with 75 mGy

在线全文

学校读者我要写书评

暂无评论

吉林大学学报(医学版) 1998年第2期 111-114页

作者： Gong Shouliang Liu Shuchun Liu Jianxiang Zhang Yinchun Liu Shuzheng (MH Radiobiology Research Unit) (Supported by a grant from the National Natural science Foundation,PRC,39170275)

目的：本研究观察胸腺细胞凋亡小体（TAB）以评价低剂量辐射诱导的胸腺细胞凋亡的适应性反应。方法：实验用X射线全身照射Kunmin雄性小鼠，诱导剂量75mGy（D1），攻击剂量1．5或2．0Gy（D2），D1和D2间隔6h，D2照后20h检测TAB百分数。... 详细信息

目的：本研究观察胸腺细胞凋亡小体（TAB）以评价低剂量辐射诱导的胸腺细胞凋亡的适应性反应。方法：实验用X射线全身照射Kunmin雄性小鼠，诱导剂量75mGy（D1），攻击剂量1．5或2．0Gy（D2），D1和D2间隔6h，D2照后20h检测TAB百分数。结果：D1+D2组TAB百分数明显低于D2组（P＜0．05）。此外，将75mGy照射的脾细胞外液加入2Gy照射的胸腺细胞悬液中，在培养72h明显低于2Gy照射组（P<0．05）。结论：低剂量辐射（75mGy）可改变免疫细胞的外环境，降低其凋亡，并且可诱导其后大剂量（1．5或2．Gy）照射的小鼠胸腺细胞凋亡的适应性反应。

关键词： adaptive response thymocyte apoptosis X-rays irradiation

Interplay between ethylene and nitrogen nutrition:How ethylene orchestrates nitrogen responses in plants

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2023年第2期65卷 399-407页

作者： Biao Ma Tian Ma Wenhao Xian Bin Hu Chengcai Chu Guangdong Laboratory for Lingnan Modern Agriculture State Key Laboratory for Conservation and Utilization of Subtropical Agro-BioresourcesCollege of AgricultureSouth China Agricultural UniversityGuangzhou 510642China

The stress hormone ethylene plays a key role in plant adaptation to adverse environmental conditions.Nitrogen(N)is the most quantitatively required mineral nutrient for plants,and its availability is a major determinant for crop production.Changes in N availability or N forms can alter ethylene biosynthesis and/or signaling.Ethylene serves as an important cellular signal to mediate root system architecture adaptation,N uptake and translocation,ammonium toxicity,anthocyanin accumulation,and premature senescence,thereby adapting plant growth and development to external N status.Here,we review the ethylenemediated morphological and physiological responses and highlight how ethylene transduces the N signals to the adaptive responses.We specifically discuss the N-ethylene relations in rice,an important cereal crop in which ethylene is essential for its hypoxia survival.

关键词： adaptive response cellular signal ethylene nitrogen acquisition and utilization

Long-term high fructose and saturated fat diet affects plasma fatty acid profile in rats

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第4期13卷 307-317页

作者： Fabrice TRANCHIDA Léopold TCHIAKPE Zo RAKOTONIAINA Valérie DEYRIS Olivier RAVION Abel HIOL Institute of Molecular Sciences of Marseilles iSm2 UMR 7313CNRSAix-Marseille University13397 Marseilles Cedex 20France Laboratory of Nutrition-Dietetics Faculty of PharmacyAix-Marseille University13385 Marseilles Cedex 5France Food Sciences Department of Biotechnology EngineeringInstitute of TechnologyUniversity of the French West Indies and GuianaSaint-Claude 97120France

As the consumption of fructose and saturated fatty acids(FAs) has greatly increased in western diets and is linked with an increased risk of metabolic syndrome,the aim of this study was to investigate the effects of a mod-erate(10 weeks) and a prolonged(30 weeks) high fructose and saturated fatty acid(HFS) diet on plasma FA com-position in rats.The effects of a few weeks of HFS diet had already been described,but in this paper we tried to es-tablish whether these effects persist or if they are modified after 10 or 30 weeks.We hypothesized that the plasma FA profile would be altered between 10 and 30 weeks of the HFS diet.Rats fed with either the HFS or a standard diet were tested after 10 weeks and again after 30 weeks.After 10 weeks of feeding,HFS-fed rats developed the metabolic syndrome,as manifested by an increase in fasting insulinemia,total cholesterol and triglyceride levels,as well as by impaired glucose tolerance.Furthermore,the plasma FA profile of the HFS group showed higher proportions of monounsaturated FAs like palmitoleic acid [16:1(n-7)] and oleic acid [18:1(n-9)],whereas the proportions of some polyunsaturated n-6 FAs,such as linoleic acid [18:2(n-6)] and arachidonic acid [20:4(n-6)],were lower than those in the control group.After 30 weeks of the HFS diet,we observed changes mainly in the levels of 16:1(n-7)(decreased) and 20:4(n-6)(increased).Together,our results suggest that an HFS diet could lead to an adaptive response of the plasma FA profile over time,in association with the development of the metabolic syndrome.

关键词： High fructose and saturated fatty acid diet Metabolic syndrome Plasma fatty acids adaptive response Rats

Plant hormesis and Shelford’s tolerance law curve

在线全文

学校读者我要写书评

暂无评论

Journal of Forestry Research 2021年第5期32卷 1789-1802页

作者： Elena A.Erofeeva Department of Ecology Lobachevsky State University of Nizhny Novgorod23 Gagarina PrNizhni NovgorodRussian Federation 603950

Shelford’s law of tolerance is illustrated by a bell-shaped curve depicting the relationship between environmental factor/factors’intensity and its favorability for species or populations.It is a fundamental basis of ecology when considering the regularities of environment impacts on living systems,and applies in plant biology,agriculture and forestry to manage resistance to environmental limiting factors and to enhance productivity.In recent years,the concept of hormesis has been increasingly used to study the dose-response relationships in living organisms of different complexities,including plants.This requires the need for an analysis of the relationships between the hormetic dose-response model and the classical understanding of plant reactions to environments in terms of Shelford’s law of tolerance.This paper analyses various dimensions of the relationships between the hormetic model and Shelford’s tolerance law curve under the influence of natural environmental factors on plants,which are limiting for plants both in deficiency and excess.The analysis has shown that Shelford’s curve and hormetic model do not contradict but instead complement each other.The hormetic response of plants is localized in the stress zone of the Shelford’s curve when adaptive mechanisms are disabled within the ecological optimum.At the same time,in a species range,the ecological optimum is the most favorable combination of all or at least the most important environmental factors,each of which usually deviates slightly from its optimal value.adaptive mechanisms cannot be completely disabled in the optimum,and hormesis covers optimum and stress zones.Hormesis can modify the plant tolerance range to environmental factors by preconditioning and makes limits of plant tolerance to environmental factors flexible to a certain extent.In turn,as a result of tolerance range evolution,quantitative characteristics of hormesis(width and magnitude of hormetic zone)as well as the range of stimulating doses,may significantly differ in various plan

关键词： Hormetic dose-response Environmental limiting factor Plant stress Phenotypic plasticity adaptive response

Comparison of physiological responses to oxidative and heavy metal stress in seedlings of rice paddy, Oryza sativa L.

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2000年第4期12卷 458-462页

作者： YU Guo\|ying, WANG Guo\|ping, HE Chi\|quan (Lab for Wetland Process and Environment, Changchun Institute of Geography, The Chinese Academy of Sciences, Changchun 130021,China E\|mail: yuguoying@***) 中科院长春地理所湿地环境开放实验室吉林长春 1 3 0 0 2

Physiological responses on the bases of activities of antioxidant enzymes: peroxidase, catalase, superoxide dismutase and glutathione reductase as well as estimation of total protein, lipid peroxidation and thiols in the form of protein, non\|protein, glutathione and phytochelatin measured in growing seedlings of paddy, Oryza sativa L., from day 2 to 8 were compared following treatment of seeds for 5h with oxidative agents, paraquat 5 × 10 -5 , 10 -4 , 10 -3 mol/L, H 2O 2 10 -3 , 5×10 -3 , 10 -2 mol/L, and CdCl 2 10 -5 , 10 -4 , 5×10 -3 mol/L. A significant induction of all antioxidant enzymes along with an increase in the levels of protein, lipid peroxidation and glutathione was noted in response to oxidative stress, CdCl 2 induced significant peroxidase and catalase activities but not superoxide dismutase. In a marked contrast from oxidative stress, CdCl 2 decreased glutathione reductase activity as well as glutathione levels but increased phytochelatin level. The different physiological responses thus underlined the crucial involvement of glutathione and phytochelatin in the oxidative and heavy metal\|linduced adaptive responses respectively.

关键词： adaptive response oxidative stress heavy metal antioxidant enzymes glutathione phytochelatin

Detecting and adaptive responding mechanism for mobile WSN

在线全文

学校读者我要写书评

暂无评论

High Technology Letters 2020年第3期26卷 323-334页

作者：赵敏 Qin Danyang Guo Ruolin Xu Guangchao Key Laboratory of Electronic and Communication Engineering Heilongjiang UniversityHarbin 150080P.R.China

Mobile wireless sensor network(WSN)composed by mobile terminals has a dynamic topology and can be widely used in various fields.However,the lack of centralized control,dynamic topology and limited energy supply make the network layer of mobile WSN be vulnerable to multiple attacks,such as black hole(BH),gray hole(GH),flooding attacks(FA)and rushing attacks(RU).Existing researches on intrusion attacks against mobile WSN,currently,tend to focus on targeted detection of certain types of attacks.The defense methods also have clear directionality and is unable to deal with indeterminate intrusion attacks.Therefore,this work will design an indeterminate intrusion attack oriented detecting and adaptive responding mechanism for mobile WSN.The proposed mechanism first uses a test sliding window(TSW)to improve the detecting accuracy,then constructs parameter models of confidence on attack(COA),network performance degradation(NPD)and adaptive responding behaviors list,finally adaptively responds according to the decision table,so as to improve the universality and flexibility of the detecting and adaptive responding mechanism.The simulation results show that the proposed mechanism can achieve multiple types of intrusion detecting in multiple attack scenarios,and can achieve effective response under low network consumption.

关键词： mobile wireless sensor network(WSN) network security intrusion detection adaptive response

Many-lined Sun Skinks(Mabuya multifasciata) Shift Their Thermal Preferences Downwards When Fasted

在线全文

学校读者我要写书评

暂无评论

Asian Herpetological Research 2010年第1期1卷 36-39页

作者： LI Hong MAO Luxi SHI Linqiang JI Xiang Jiangsu Key Laboratory for Biodiversity and Biotechnology College of Life SciencesNanjing Normal University Hangzhou Key Laboratory for Animal Adaptation and Evolution Hangzhou Normal University

We maintained adult many-lined sun skinks(Mabuya multifasciata; 12 females and 12 males) collected from Hainan(southern China) in September 2006 in two outdoor enclosures to examine the effect of feeding condition on selected body temperature(Tsel).Skinks shifted their thermal preferences when fasted.Temporal variation in Tsel was not found within each sex feeding condition combination,and neither in fed nor in fasted skinks did the mean values for Tsel differ between sexes.Body temperatures selected by fed skinks fell within the range from 30.2 to 33.9 C,and those selected by fasted skinks within the range from 25.1 to 31.8 C.Body temperatures(31.8 0.3 C) selected by fed skinks were on average 4.0 C higher than those(27.8 0.4 C) selected by fasted skinks.Fasted skinks had no difficulty in attaining higher body temperatures,but they voluntarily shift their thermal preferences downwards to save energy.This finding suggests an adaptive mechanism adopted by many-lined sun skinks to enhance their fitness during the periods when food availability is low.

关键词： Scincidae feeding condition selected body temperature adaptive response food deprivation

New understanding of the low-dose radiation-induced hormesis

在线全文

学校读者我要写书评

暂无评论

Radiation Medicine and Protection 2020年第1期1卷 2-6页

作者： Shunzi Jin Hongyu Jiang Lu Cai School of Public Health Jilin UniversityNHC Key Laboratory of Radiobiology(Jilin University)ChangchunJilin130021China Department of Health Examination Center The First Hospital of Jilin UniversityChangchunJilin130021China Pediatric Research Institute Departments of PediatricsRadiation OncologyPharmacology and ToxicologyThe University of LouisvilleSchool of MedicineLouisvilleKY40202USA

Dr.Liu Shuzheng as a well-known educator and radiobiologist has started to work on the physiological benefits of low-dose radiation since 1970s.His research on the distinct effects of low-dose radiation from those of high-dose radiation has nationally and internationally impacted radiobiology,medicine and oncology.Therefore,here we briefly review the research from his research team from early years to last two decades.Two important facts related to LDR biological effects are the hormesis and adaptive response,both have been the main focuses of Dr.Liu Shuzheng early research.In the last couple of decades Dr.Liu Shuzheng have further investigated how to apply these important mechanisms into clinical translational research,such as the potential to application of LDRhormesis to enhance tumor’s chemo-or radio-therapy and LDR-induced adaptive response to protect normal tissue from chemo-or radio-therapy related side toxic effects.Therefore,Dr.Liu has provided important guidance and role model for his trainees in the continue of their research career in radiation biology,medicine and oncology.

关键词： LDR Hormesis adaptive response LDR antitumor effect Immune stimulation