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Cytogenetic Characteristics of Childhood acute lymphoblastic leukemia.A Study of 1541 Chinese Patients Newly Diagnosed between 2001 and 2014

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Current Medical Science 2022年第1期42卷 201-209页

作者： Meng-meng YIN Rui-chi WU Jing GAO Shao-yan HU Xiao-ming LIU Xiao-fan ZHU Shu-hong SHEN Jing-yan TANG Jing CHEN Qun HU Department of Pediatric Hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Hematology/Oncology Shanghai Children’s Medical CenterShanghai Jiaotong University School of MedicineShanghai 200000China Children’s Hospital of Soochow University Suzhou 215000China State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300000China

Objective:Cytogenetic abnormalities have been proven to be the most valuable parameter for risk stratification of childhood acute lymphoblastic leukemia.ALL).However,studies on the prevalence of cytogenetic abnormalities and their correlation to clinical features in Chinese pediatric patients are limited,especially large-scale ***:We collected the cytogenetics and clinical data of 1541 children newly diagnosed with ALL between 2001 and 2014 in four Chinese hospitals,and retrospectively analyzed their clinical features,prognosis and risk factors associated with pediatric ALL.

关键词： cytogenetics characteristics childhood Chinese acute lymphoblastic leukemia.

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Spatial-spectral identication of abnormal leukocytes based on microscopic hyperspectral imaging technology

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Journal of Innovative Optical Health Sciences 2020年第2期13卷 44-56页

作者： Xueqi Hu Jiahua Ou Mei Zhou Menghan Hu Li Sun Song Qiu Qingli Li Junhao Chu Shanghai Key Laboratory of Multidimensional Information Processing East China Normal University Shanghai 200241 P.R.China

Screening and diagnosing of abnormal Leukocytes are crucial for the diagnosis of immune diseases and acute lymphoblastic leukemia.ALL).As the deterioration of abnormal leukocytes is mainly due to the changes in the chromatin distribution,which signicantly affects the absorption and reflection of light,the spectral feature is proved to be important for leukocytes classication and *** paper proposes an accurate identication method for healthy and abnormal leukocytes based on microscopic hyperspectral imaging(HSI)technology which combines the spectral *** segmentation of nucleus and cytoplasm is obtained by the morphological watershed ***,the spectral features are extracted and combined with the spatial *** on this,the support vector machine(SVM)is applied for classication ofve types of leukocytes and abnormal *** with different classication methods,the proposed method utilizes spectral features which highlight the differences between healthy leukocytes and abnormal leukocytes,improving the accuracy in the classication and identication of *** paper only selects one subtype of ALL for test,and the proposed method can be applied for detection of other leukemia.in the future.

关键词： Leukocyte microscopic hyperspectral imaging nucleus segmentation acute lymphoblastic leukemia.

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