Cytogenetic Characteristics of Childhood Acute Lymphoblastic Leukemia:A Study of 1541 Chinese Patients Newly Diagnosed between 2001 and 2014

作     者：Meng-meng YIN Rui-chi WU Jing GAO Shao-yan HU Xiao-ming LIU Xiao-fan ZHU Shu-hong SHEN Jing-yan TANG Jing CHEN Qun HU Meng-meng YIN;Rui-chi WU;Jing GAO;Shao-yan HU;Xiao-ming LIU;Xiao-fan ZHU;Shu-hong SHEN;Jing-yan TANG;Jing CHEN;Qun HU

作者机构：Department of Pediatric HematologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Hematology/OncologyShanghai Children’s Medical CenterShanghai Jiaotong University School of MedicineShanghai 200000China Children’s Hospital of Soochow UniversitySuzhou 215000China State Key Laboratory of Experimental HematologyNational Clinical Research Center for Blood DiseasesInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300000China 

出 版 物：《Current Medical Science》 (当代医学科学（英文）)

年 卷 期：2022年第42卷第1期

页      面：201-209页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：This study was supported by grants from the National Natural Science Foundation of China(No.81670136) VIVA-China Children's Cancer Foundation. 

主　　题：cytogenetics characteristics childhood Chinese acute lymphoblastic leukemia. 

摘      要：Objective:Cytogenetic abnormalities have been proven to be the most valuable parameter for risk stratification of childhood acute lymphoblastic leukemia(ALL).However,studies on the prevalence of cytogenetic abnormalities and their correlation to clinical features in Chinese pediatric patients are limited,especially large-scale studies.Methods:We collected the cytogenetics and clinical data of 1541 children newly diagnosed with ALL between 2001 and 2014 in four Chinese hospitals,and retrospectively analyzed their clinical features,prognosis and risk factors associated with pediatric ALL.