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A review on cocrystal of active ingredients in traditional chinese medicine

traditional medicine Research 2023年第4期8卷 1-13页

作者： Xiao-Qin Ma Ye Peng Jian Cui Tong-Xiang Liu School of Pharmacy Minzu University of ChinaBeijing 100081China Key Laboratory of Ethnomedicine Minority of EducationMinzu University of ChinaBeijing 100081China

In the development of new drugs products,especially the development of traditional chinese medicine active ingredients,solubility and oral bioavailability are the main factors which are restricting the development of new drugs,whereas the physicochemical properties of active ingredients are the key element to affecting these *** cocrystal provides an excellent opportunity to develop new drugs with excellent physical and chemical properties such as melting point,solubility,stability and bioavailability while retaining the pharmacological properties of individuals active pharmaceutical ingredients among pharmaceutical cocrystal *** chinese herbal medicine has the characteristics of multiple pathways and multiple targets,mainly because it contains many active ingredients,like cocrystals thereof with many *** active ingredients extracted from traditional chinese herbal medicine have a wide range of pharmacological activities,but most of the active ingredients affect the development of traditional chinese medicine active ingredients due to their physical and chemical properties such as *** chinese medicine pharmaceutical cocrystals can not only improve the physical and chemical properties of drugs without changing the internal structure of drugs,so as to provide a new scheme for the development of traditional chinese medicine active *** paper reviews the research progress of active ingredients of traditional chinese medicine pharmaceutical *** preparation methods of cocrystals are summarized and the advantages of cocrystals are illustrated with examples.

关键词： pharmaceutical cocrystal active ingredients of traditional chinese medicine cocrystal production advantages of cocrystal

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Impacts of active ingredients of Three traditional chinese medicine on Immune Effect of PCV2 Vaccine

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Animal Husbandry and Feed Science 2017年第6期9卷 402-406页

作者： Yao Jing Li Kai Jiang Chunmao Zhang Bin Wu Caihong Sheng Yu Yu Lianqin Service Center of Agriculture Information Wuxi Council of Agriculture Jiangsu Agri-animal Husbandry Vocational College Animal Diseases Control & Prevention Centre of Wuxi Animal Diseases Control & Prevention Centre of Yixing

[ Objective ] The paper was to screen the active ingredients of traditional chinese medicine （ TCM）, which significantly enhanced the immune effect of porcine circovirus type 2 （PCV2） vaccine. [Method]Sixty-six 14-day-old piglets were randomly divided into 11 groups, including immune control group, blank control group and nine drug groups. Piglets that were reared for 21 d were intramuscularly injected with 2 mL of inactivated vaccine in cervical region expect for blank control group. Piglets in nine drug groups were administrated with 5 mL of matrine, scutellarin and astragalus polysaecharide （ASP） at three doses （ high dose 12 mg, medium dose 8 nag, low dose 4 mg） three days before and after immunization; piglets in blank control group and irmnune control group were administrated with equal volume of normal saline. Five piglets were randomly selected from each group to collect venous blood at 7, 14, 21 and 28 d post immunization, and the PCV2 antibody level, the concentration of specific immunoglobulin [gG, the changes in peripheral blood lymphocyte subsets, and the content of serum IL-2 and IFN-γ were determined. [ Result] The immunological effects of active ingredients of three TCM on PCV2 vaccine all enhanced at different degree. The effects of scutellarin middle dose group was the best. [ Conclusion ] Scutellarin could be used as a candidate drug for PCV2 vaccine immunoenhancer.

关键词： active ingredients of traditional chinese medicine PCV2 vaccine Humoral immunity Cellular immunity

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Recent advances of traditional chinese medicine on the prevention and treatment of COVID-19

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chinese Journal of Natural medicines 2020年第12期18卷 881-889页

作者： DAI Yu-Jie WAN Shi-Yao GONG Shuai-Shuai LIU Jin-Cheng LI Fang KOU Jun-Ping Jiangsu Key Laboratory of TCM Evaluation and Translational Research School of Traditional Chinese PharmacyDepartment of Pharmacology of Chinese Materia MedicaChina Pharmaceutical UniversityNanjing 211198China

Coronavirus disease-2019(COVID-19)is a new highly infectious disease caused by a novel ***,the number of new cases infected pneumonia in the world continues to increase,which has aroused great concern from the international *** present,there are no small-molecule specific anti-viral drugs for the *** high mortality rate seriously threatens human *** chinese medicine(TCM)is a unique health resource in *** combination of TCM and Western medicine has played a positive and important role in combating COVID-19 in *** this review,through literature mining and analysis,it was found that TCM has the potential to prevent and treat the ***,the network pharmacological studies demonstrated that TCM played roles of anti-virus,anti-inflammation and immunoregulation in the management of COVID-19 via multiple components acting on multiple targets and multiple ***,clinical researches also confirmed the beneficial effects of TCM on the treatment of *** review may provide meaningful and useful information on further drug development of COVID-19 and other viral infectious diseases.

关键词： Novel coronavirus pneumonia Prescription of traditional chinese medicine Single chinese herb active ingredients of traditional chinese medicine Viral infection

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