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Enhancing cartilage regeneration and repair through bioactive and biomechanical modification of 3D acellular dermal matrix

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Regenerative Biomaterials 2024年第3期3卷 105-121页

作者： Wei Gao Tan Cheng Zhengya Tang Wenqiang Zhang Yong Xui Min Han Guangdong Zhou Chunsheng Tao Ning Xu Huitang Xia Weijie Sun Qingdao Medical College of Qingdao University Qingdao266071China Department of Infectious Diseases The First Affliated Hospital of Anhui Medical UniversityShushanHefei230022China Department of Orthopaedic Surgery Shanghai Sixth People's Hospital Affliated to Shanghai jiao Tong University School of MedicineShanghai200025China Department of Orthopedic Surgery Shanghai Eighth People's HospitalShanghai200235China Department of PlasticSurgery&Jinan ClinicalResearch Center for Tissue Engineering Skin Regeneration and Wound Repair The First Affliated Hospital of Shandong First Medical UniversityJinan266299China Department of Orthopaedics Ninety-seventh Hospital of the Chinese People's Liberation Army NavyQingdao266071China Department of Orthopaedics The First Affliated Hospital of Shandong First Medical UniversityJinan266299China Department of Plastic surgery Shanghai Key Laboratory of Tissue EngineeringShanghai Ninth People's HospitalShanghai jiao Tong University School of MedicineShanghai200023China Department of Thoracic Surgery Shanghai Children's HospitalShanghai Jiao Tong University School of MedicineShaghai200040China Department of Thoracic Surgery Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai200433China

acellular dermal matrix(ADM)shows promise for cartilage regeneration and ***,an effective decellularization technique that removes cellular components while preserving the extracellular matrix,the transformation of 2D-ADM into a suitable 3D scaffold with porosity and the enhancement of bioactive and biomechanical properties in the 3D-ADM scaffold are yet to be fully *** this study,we present an innovative decellularization method involving 0.125%trypsin and 0.5%SDS and a 1%Triton X-100 solution for preparing ADM and converting 2D-ADM into 3D-ADM *** scaffolds exhibit favorable physicochemical properties,exceptional biocompatibility and significant potential for driving cartilage regeneration in vitro and in *** further enhance the cartilage regeneration potential of 3D-ADM *** incorporated porcine-derived small intestinal submucosa(SIS)for bioactivity and calcium sulfate hemihydrate(CSH)for biomechanical *** resulting 3D-ADM+SIS scaffolds displayed heightened biological activity,while the 3D-ADM+CSH scaffolds notably bolstered biomechanical *** scaffold types showed promise for cartilage regeneration and repair in vitro and in vivo,with considerable improvements observed in repairing cartilage defects within a rabbit articular cartilage *** summary,this research introduces a versatile 3D-ADM scaffold with customizable bioactive and biomechanical properties,poised to revolutionize the field of cartilageregeneration.

关键词： acellular dermal matrix three-dimensional scaffolds cartilage regeneration small intestinal submucosa calcium sulfate hemihydrate

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Factors influencing Frey syndrome after parotidectomy with acellular dermal matrix

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World Journal of Clinical Cases 2024年第9期12卷 1578-1584页

作者： Xian-Da Chai Huan Jiang Ling-Ling Tang Jing Zhang Long-Fei Yue Department of Oral and Maxillofacial Surgery People’s Hospital of AnshunAnshun 561000Guizhou ProvinceChina Department of General Practice People’s Hospital of AnshunAnshun 561000Guizhou ProvinceChina

BACKGROUND Frey syndrome,also known as ototemporal nerve syndrome or gustatory sweating syndrome,is one of the most common complications of parotid gland *** condition is characterized by abnormal sensations in the facial skin accompanied by episodes of flushing and sweating triggered by cognitive processes,visual stimuli,or *** To investigate the preventive effect of acellular dermal matrix(ADM)on Frey syndrome after parotid tumor resection and analyzed the effects of Frey syndrome across various surgical methods and other factors involved in parotid tumor *** Retrospective data from 82 patients were analyzed to assess the correlation between sex,age,resection sample size,operation time,operation mode,ADM usage,and occurrence of postoperative Frey *** Among the 82 patients,the incidence of Frey syndrome was 56.1%.There were no significant differences in sex,age,or operation time between the two groups(P>0.05).However,there was a significant difference between ADM implantation and occurrence of Frey syndrome(P<0.05).ADM application could reduce the variation in the incidence of Frey syndrome across different operation *** ADM can effectively prevent Frey syndrome and delay its onset.

关键词： Parotid gland tumor Frey syndrome acellular dermal matrix acellular allogenic dermal matrix

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Application of acellular dermal matrix for intestinal elongation in animal models

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World Journal of Gastroenterology 2010年第16期16卷 2023-2027页

作者： Xu, Hui-Min Wang, Zhen-Jun Han, Jia-Gang Ma, Hua-Chong Zhao, Bo Zhao, Bao-Cheng Capital Med Univ Beijing Chaoyang Hosp Dept Gen Surg Beijing 100020 Peoples R China

AIM:To investigate the eff icacy of acellular dermal matrix(ADM) for intestinal elongation in animal ***:Japanese white big-ear rabbits(n = 9) and Wuzhishan miniature pigs(n = 5) were used in the ***-made and commercial ADM materials were used as grafts,respectively.A 3-cm long graft was interposed in continuity with the small bowel and a sideto-side anastomosis,distal to the graft about 3-4 cm,was *** animals were sacrificed at 2 wk,4 wk,8 wk and 3 mo after surgery and the histological changes were evaluated under light microscope and electron ***:The animals survived after the operation with no evidence of peritonitis and *** ad-hesions were found between the graft and surrounding *** grafts were completely absorbed within postoper ative two or three months except *** observ ation showed inflammation in the grafts with fibrinoid necroses,infiltration of a large amount of neutrophils and leukomonocytes,and the degree varied in different *** neointestine with wellformed structures was not observed in the ***:It is not suitable to use acellular dermal matrix alone as a scaffold for the intestinal elongation in animal models.

关键词： acellular dermal matrix Intestine Elongation

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Randomized controlled trial of minimally invasive surgery using acellular dermal matrix for complex anorectal fistula

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World Journal of Gastroenterology 2010年第26期16卷 3279-3286页

作者： Ma-Mu-Ti-Jiang A ba-bai-ke-re Er-Ha-Ti Ai Anorectal Surgical Department First Aff iliated Hospital of Xinjiang Medical University

AIM: To compare the efficacy and safety of acellular dermal matrix (ADM) bioprosthetic material and endorectal advancement flap (ERAF) in treatment of complex anorectal fistula. METHODS: Ninety consecutive patients with complex anorectal fistulae admitted to Anorectal Surgical Department of First Affi liated Hospital, Xinjiang Medical University from March 2008 to July 2009, were enrolled in this study. Complex anorectal fistula was diagnosed following its clinical, radiographic, or endoscopic diagnostic criteria. Under spinal anesthesia, patients underwent identification and irrigation of the fistula tracts using hydrogen peroxide. ADM was securely sutured at the secondary opening to the primary opening using absorbable suture. Outcomes of ADM and ERAF closure werecompared in terms of success rate, fecal incontinence rate, anorectal deformity rate, postoperative pain time, closure time and life quality score. Success was defined as closure of all external openings, absence of drainage without further intervention, and absence of abscess formation. Follow-up examination was performed 2 d, 2, 4, 6, 12 wk, and 5 mo after surgery, respectively. RESULTS: No patient was lost to follow-up. The overall success rate was 82.22% (37/45) 5.7 mo after surgery. ADM dislodgement occured in 5 patients (11.11%), abscess formation was found in 1 patient, and fistula recurred in 2 patients. Of the 13 patients with recurrent fistula using ERAF, 5 (11.11%) received surgical drainage because of abscess formation. The success rate, postoperative pain time and closure time of ADM were significantly higher than those of ERAF (P < 0.05). However, no difference was observed in fecal incontinence rate and anorectal deformity rate after treatment with ADM and ERAF. CONCLUSION: Closure of fistula tract opening with ADM is an effective procedure for complex anorectal fistula. ADM should be considered a first line treatment for patients with complex anorectal fistula.

关键词： acellular dermal matrix Surgery Transsphincteric complex fistula

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Differentiation of mesenchymal stem cells into neuronal cells on fetal bovine acellular dermal matrix as a tissue engineered nerve scaffold

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Neural Regeneration Research 2014年第22期9卷 1968-1978页

作者： Yuping Feng Jiao Wang Shixin Ling Zhuo Li Mingsheng Li Qiongyi Li Zongren Ma Sijiu Yu Animal Medicine College of Gansu Agriculture University Gansu Provincial Animal Cell Engineering Center Key Laboratory of Bioengineering & Technology of State Ethnic Affairs Commission Life Science and Engineering College of Northwest University for Nationalities Laboratory of Molecular Neurobiology Institute of Systems BiologyShanghai University

The purpose of this study was to assess fetal bovine acellular dermal matrix as a scaffold for supporting the differentiation of bone marrow mesenchymal stem cells into neural cells fol-lowing induction with neural differentiation medium. We performed long-term, continuous observation of cell morphology, growth, differentiation, and neuronal development using several microscopy techniques in conjunction with immunohistochemistry. We examined speciifc neu-ronal proteins and Nissl bodies involved in the differentiation process in order to determine the neuronal differentiation of bone marrow mesenchymal stem cells. The results show that bone marrow mesenchymal stem cells that differentiate on fetal bovine acellular dermal matrix display neuronal morphology with unipolar and bi/multipolar neurite elongations that express neuro-nal-speciifc proteins, includingβIII tubulin. The bone marrow mesenchymal stem cells grown on fetal bovine acellular dermal matrix and induced for long periods of time with neural differen-tiation medium differentiated into a multilayered neural network-like structure with long nerve ifbers that was composed of several parallel microifbers and neuronal cells, forming a complete neural circuit with dendrite-dendrite to axon-dendrite to dendrite-axon synapses. In addition, growth cones with filopodia were observed using scanning electron microscopy. Paraffin sec-tioning showed differentiated bone marrow mesenchymal stem cells with the typical features of neuronal phenotype, such as a large, round nucleus and a cytoplasm full of Nissl bodies. The data suggest that the biological scaffold fetal bovine acellular dermal matrix is capable of supporting human bone marrow mesenchymal stem cell differentiation into functional neurons and the subsequent formation of tissue engineered nerve.

关键词： nerve regeneration peripheral nerve defects fetal bovine acellular dermal matrix biological scaffold bone marrow mesenchymal stem cells neuronal differentiation neurons tissue engineered nerve neural regeneration

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Optimal Bioprinting Parameters and Experimental Investigation of acellular dermal matrix Scaffold

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Journal of Renewable Materials 2021年第1期9卷 1-16页

作者： Qingxi Hu Yiming Wang Dongchao Yang Haiguang Zhang Zhicheng Song Yan Gu Rapid Manufacturing Engineering Center School of Mechatronic Engineering and AutomationShanghai UniversityShanghaiChina Shanghai Key Laboratory of Intelligent Manufacturing and Robotics Shanghai UniversityShanghaiChina National Demonstration Center for Experimental Engineering Training Education Shanghai UniversityShanghaiChina Shanghai Ninth People’s Hospital Shanghai JiaoTong University School of MedicineShanghai200011China

acellular dermal matrix(ADM)as a biomaterial is currently believed to be promising tissue repair *** the development of tissue engineering,ADM is increasingly used as biological *** explored the feasibility and performance of ADM biological scaffolds that fabricated by 3D *** paper presented our study on the printability of 3D printed ADM scaffolds,with a focus on identifying the influence of printing parameters/conditions on *** characterize the printability,we examined the fiber morphology,pore size,strand diameter,and mechanical property of the printed *** results revealed that the printability could be affected by a number of factors and among them,the most considerable one was related to the nozzle diameter and the composition of *** then evaluated the biocompatibility in terms of cytotoxicity,cell proliferation and *** vitro evaluation of the ADM scaffolds was carried out and the experimental results indicated that cells were viable and proliferative during the period of *** vivo results also indicated that the defect area was well repaired without any noticeable infection,hematoma and other *** conclusion,ADM could be reconstructed with 3D printing technology and ADM biological scaffold has potential applications for tissue engineering.

关键词： Bioprinting acellular dermal matrix scaffolds printability tissue engineering

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Treatment of oral lichen planus by surgical excision and acellular dermal matrix grafting:Eleven case reports and review of literature

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World Journal of Clinical Cases 2021年第6期9卷 1446-1454页

作者： Zhen-Zhen Fu Li-Qiang Chen Yao-Xiang Xu Jin Yue Qian Ding Wen-Lin Xiao Department of Stomatology Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina School of Stomatology Qingdao UniversityQingdao 266003Shandong ProvinceChina

BACKGROUND Oral lichen planus(OLP)is a chronic inflammatory disorder,and it can affect normal oral *** conventional treatments for OLP are not always effective,and relapse easily ***,treatment of OLP is difficult and *** this study,we evaluated over a long period the clinical efficacy of surgical excision and acellular dermal matrix(ADM)grafting in patients with refractory *** SUMMARY Eleven patients with refractory OLP underwent a standardized protocol of surgical excision and ADM *** condition of the area of the grafted wound,the intraoperative maximum mouth opening,pain,and clinical healing were assessed at postoperative follow-up *** patients had a flat surgical area with similar mucosal tissue coverage and local scar *** had no irritation and pain in their mucous membranes when eating acidic and spicy *** patients’mouth openings returned to normal within 2-6 mo after *** follow-up,none of the patients had recurrence of OLP after *** longest follow-up was 11 yr and the shortest was 6 mo,and none of the patients relapsed during *** Surgical excision and ADM grafting could be an effective method to treat refractory OLP.

关键词： Lichen planus Surgical excision acellular dermal matrix Case report Oral

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Application of acellular dermal matrix in breast reconstruction

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Chinese Medical Journal 2013年第13期126卷 2548-2552页

作者： QI Yue YOU Wei-tao LI Dong LI Jian-ning Plastic Surgery Hospital Chinese Academy of Medical Sciences B eijing 100041 China Department of Plastic Surgery Peking University Third Hospital Beijing 100191 China

In the past 10 years, acellular dermal matrix （ADM） has .been widely used in various fields of surgery, includingcleft palate repair, abdominal wall repair, tendon repair, hernia repair, facial and eyelid soft tissue augmentation surgery, ulcer repair, and vaginal sling repair, among others.1-3 ADM not only provides initial structural strength and bulk, but also allows relatively rapid vascular growth and serves as a scaffold for ＂new＂ tissue formation.4 These properties have led to its application to resolving surgical problems where tissue deficiency remains an issue. Many surgeons have begun to use ADM-assisted breast reconstruction techniques. Compared with ADM, the traditional method of implant-based breast reconstruction is more straightforward but is more prone to postoperative complications. Generally speaking, breast revision surgery procedures are complex, challenging, and unpredictable as the potential for the development of serious complications, such as capsular contracture （CC）, must be addressed. CC has plagued plastic surgeons as the most common complication of reconstructive breast surgery for many yearsY The application of ADM addresses these problems, and as a result, its popularity is growing： in the United States 73% of surgeons have some experience in the use of xenogeneic or allogeneic ADM in breast reconstruction.8 Furthermore, the use of ADM in nipple and areola reconstruction can achieve a more natural appearance and avoids complications of other more traditional techniques.~ In cases of breast reconstruction, techniques that incorporate the use of ADM have been used to treat and reduce the incidence of CC, determine the position of the inframammary fold and final breast contour, enhance the use of available mastectomy skin, and increase the thickness of the soft tissue to reduce implant visibility or palpability. These goals can be achieved by replacing or extending the tissue with ADM or using ADM as a supplement. In addition to the advan

关键词： acellular dermal matrix breast reconstruction nipple reconstruction

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MRI tracking of human Wharton’s jelly stem cells seeded onto acellular dermal matrix labeled with superparamagnetic iron oxide nanoparticles in burn wounds

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Burns & Trauma 2022年第1期10卷 129-141页

作者： Davood Mehrabani Mehra Nazempour Rouhollah Mehdinavaz-Aghdam Seyedeh-Sara Hashemi Reza Jalli Mahdi Saeedi Moghadam Shahrokh Zare Iman Jamhiri Javad Moayedi Feridoun Karimi-Busheri Stem Cell Technology Research Center Shiraz University of Medical SciencesShirazFars T6G 2E171348-14336Iran Burn and Wound Healing Research Center Shiraz University of Medical SciencesShirazFars 71987-74731Iran Comparative and Experimental Medicine Center Shiraz University of Medical SciencesShirazFars 71348-14336Iran Li Ka Shing Center for Health Research and Innovation University of AlbertaEdmontonAlbertaCanada Department of Biomedical and Tissue Engineering Science and Research BranchIslamic Azad UniversityTehranIran School of Metallurgy and Materials Engineering College of EngineeringUniversity of TehranTehran ***Iran Medical Imaging Research Center Department of RadiologyShiraz University of Medical SciencesShirazFars 71348-14336Iran Department of Biochemistry School of Biotechnology and AgricultureShiraz BranchIslamic Azad UniversityShirazFars 71987-74731Iran Department of Oncology Faculty of MedicineUniversity of AlbertaEdmontonAlbertaT6G 1Z2Canada

Background:In vivo cell tracking after transplantation in regenerative medicine remains an unmet challenge and limits current understanding of the wound healing mechanism through cell-based *** study investigated tracking of human Wharton’s jelly stem cells(hWJSCs)seeded onto an acellular dermal matrix(ADM)and labeled with superparamagnetic iron oxide nanoparti-cles(SPIONs)by magnetic resonance imaging(MRI)in burn ***:The hWJSCs were characterized and assessed for growth kinetics.A total of 30 rats were enrolled in three equal *** 1 underwent scald burn injury left without treatment,the group 2 was treated by an ADM that was prepared from cosmetic surgery skin samples and the group 3 received hWJSCs labeled with SPIONs seeded onto an *** strength was evaluated before and after interventions,real time PCR assessed apoptosis,and Prussian blue staining,scanning electron microscopy(SEM)and MRI were used for the tracking of labeled ***:The hWJSCs exhibited mesenchymal stem cell *** doubling time was 40.1 *** did not show any toxic *** hWJSCs seeded onto an ADM decreased Bax and increased Bcl-2 gene *** of SPIONs within hWJSCs was confirmed by Prussian blue staining,SEM and MRI until day *** was a significant difference between the Young’s moduli of normal skin and the group receiving hWJSCs seeded onto an *** observations and SEM imaging confirmed that MRI is an accurate method to track SPION-labeled hWJSCs in ***:This study showed that SPION labeling coupled with MRI can be used to further understand the fate of stem cells after transplantation in a burn model.

关键词： Wharton’s jelly stem cells Superparamagnetic iron oxide nanoparticles acellular dermal matrix Magnetic resonance imaging Healing Burn

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Meshed acellular dermal matrix:technique and application in implant based breast reconstruction

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Plastic and Aesthetic Research 2016年第1期3卷 254-256页

作者： Dino Zammit Jonathan Kanevsky Fan-Yi Meng Tassos Dionisopoulos Plastic Surgery Faculty of MedicineMcGill UniversityMontrealQuebec H3G 1A4Canada Montreal General Hospital McGill UniversityMontrealQuebec H3G 1A4Canada Jewish General Hospital McGill UniversityMontrealQuebec H3G 1A4Canada

Alloderm was the first acellular dermal matrix used and remains a popular choice among plastic ***,while the overall surgical outcome of breast reconstruction using alloderm has been a success,the economic burden on the health care system makes it a subject of frequent re-evaluations in *** by the high price of$3,700 USD for a 6 cm×16 cm area,our group proposes the meshing of AlloDerm to decrease the total amount needed for breast reconstruction,while achieving comparable surgical outcomes as using unmeshed alloderm.

关键词： Alloderm acellular dermal matrix breast reconstruction meshing breast cancer

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