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Design, Synthesis and Activities of aziridine Derivatives of N^5-Methyltetrahydrofolate Against Methionine Synthase

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Chemical Research in Chinese Universities 2015年第5期31卷 742-745页

作者： DENG Xiling GUO Ying TIAN Chao LIU Junyi WANG Xiaowei ZHANG Zhili School of Pharmaceutical Sciences Beijing 100191 P R. China State Key Laboratory of Natural and Biomimetic Drugs Peking University Beijing 100191 P R. China School of Pharmaceutical Sciences Shihezi University Shihezi 832000 P R. China

aziridine derivatives of N^5-methyltetrahydrofolate were designed and synthesized based on the mechanism of methionine synthase, and their biological activities were investigated as well. The aziridine derivatives 1 and 6 exhibited superior inhibitory activities（IC50：5.05 and 4.15 μmol/L, respectively） compared to the corresponding chain analogue 4（IC55=24.42 μmol/L）. The results suggest that the aziridine derivatives can get potential activities against nucleophilic methionine synthase.

关键词： aziridine Methionine synthase Ring closure reaction N^5-Methyltetrahydrofolate

CURING KINETICS AND PROPERTIES OF ACRYLIC RESIN CURED WITH aziridine CROSSLINKER

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Chinese Journal of Polymer Science 2002年第1期20卷 65-70页

作者：魏德卿 Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 China

A kind of aziridine crosslinkers was synthesized and used to crosslink acrylate copolymers. The crosslinking properties and curing kinetics of the resin were studied. It was found that with the increase of the content of crosslinker in the emulsion, the mechanical properties and solvent resistance of the resin will be apparently improved, but its glass transition temperature (T.) is very low. The lowest amount of crosslinker used in the acrylic resin emulsion is 0.25%. Curing kinetics studied by DSC show that this curing reaction occurs readily because the apparent activation energy of the reaction is low (65.1 kJ/mol). These results demonstrate that the aziridine crosslinker is indeed a low temperature crosslinking agent and can be used at room temperature.

关键词： aziridine acrylic resin crosslink curing kinetics differential scanning calorimetry (DSC)

SYNTHESIS　AND　CHARACTERIZATION　OF　C_（60）NAr，THE　FIRST　aziridine　FULLERENE　DERIVATIVE

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Chinese Chemical Letters 1995年第7期6卷 569-572页

作者： Feng, J Li, JS Dong, GX Ji, GJ Acad Sinica Inst Chem Beijing 100080 Peoples R China

Fullerene deriwtives C60NAr 2 were opthesized by the reaction of fullerene C60 with pstituted Pbenyl andes in refluxing chlorobenzene. The structure of each product was elucidated on the basis of FD-MS. UV-Vis. IR. H... 详细信息

关键词： FIRST aziridine DERIVATIVE AND FULLERENE NAr OF SYNTHESIS THE

Diastereoselective synthesis of functionalized tetrahydro-γ-carbolines via a[3+3] cycloaddition of 2,2’-diester aziridines with β-(indol-2-yl)-α,β-unsaturated ketones

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Chinese Chemical Letters 2020年第5期31卷 1293-1296页

作者： Xuejie Zou Yangzi Liu Shaojing Shang Wulin Yang Weiping Deng Shanghai Key Laboratory of New Drug Design and School of Pharmacy East China University of Science and TechnologyShanghai 200237China

A Sc(OTf)3-catalyzed[3+3]cycloaddition of 2,2’-diester aziridines withβ-(indol-2-yl)-α,β-unsaturated ketones was developed,affording polysubstituted tetrahydro-y-carbolines in single diastereoisomers in good to ex... 详细信息

关键词： aziridine Tetrahydro-γ-carboline [3+3]cycloaddition Sc(OTf)3 Diastereoselectivity

Hydrolysis of epoxides and aziridines catalyzed by polymer-supported quarternary ammonium bisulfate

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Chinese Chemical Letters 2008年第2期19卷 146-148页

作者： Wan Xuan Zhang Kang Ye Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules Hubei University Wuhan 430062 China

Macroporous resin （D201）-supported quartemary ammonium bisulfate （D201-HSO4） was prepared and effectively used in catalyzing the hydrolysis of epoxides or aziridines under mild and non-metal conditions to give the... 详细信息

关键词： Resin-supported quartemary ammonium bisulfate Catalysis Hydrolysis aziridine Epoxide

Fe(OTf)_(3) Catalyzed Annulation of 2,3-Disubstituted Indoles with aziridines

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Chinese Journal of Chemistry 2014年第8期32卷 709-714页

作者： Hua Liu Chao Zheng Shu-Li You State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

A Fe(OTf)_(3) catalyzed[3+2]annulation reaction between 2,3-disubstituted indoles and N-Ts aziridines is described herein.A series of hexahydropyrrolo[3,4-b]indole derivatives bearing two consecutive quaternary carbon... 详细信息

关键词： annulation indole aziridine Lewis acid catalysis

Mild,convenient and efficient synthesis of novel 2,2-dichloro-1,3-diarylaziridines from Schiff bases by phase transfer CTAB catalysis under low concentration alkaline conditions

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Chinese Chemical Letters 2011年第11期22卷 1273-1276页

作者： Hossein Naeimi Khadijeh Rabiei Department of Organic Chemistry Faculty of Chemistry University of Kashan

A mild and efficient method for preparation of novel 2,2-dichloro-1,3-diarylaziridines from Schiff base compounds in the presence of Ar-cetyl-N,N,N-trimethyl ammonium bromide（CTAB） as phase transfer catalyst has been *** reaction is dramatically enhanced in the presence of quaternary ammonium *** corresponding products have been obtained in excellent yields,high purity and short reaction times.

关键词： aziridine Synthesis Schiff base CTAB Phase transfer catalyst

Tri-n-butylphosphine Mediated Ring-Opening Reactions of aziridines or Epoxides with Diphenyl Diselenide

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Chinese Journal of Chemistry 2007年第11期25卷 1758-1761页

作者：张万轩叶康阮珊陈祖兴夏清华 Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules Hubei University Wuhan Hubei 430062 China

aziridines and epoxides were reacted with diphenyl diselenide in the presence of a stoichiometric amount of （n-Bu）3P, respectively, giving β-amino- or β-hydroxy selenides in moderate to excellent yields under mild conditions. In the reactions the （n-Bu）3P might act as a reductant though it was a nucleophilic catalyst in other similar ring-opening reactions.

关键词： aziridine epoxide ring opening selenide reduction

A Three-Component Reaction for the Synthesis of Multifunctionalized Isoxazolidines and aziridines

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A Three-Component Reaction for the Synthesis of Multifunctio...