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Gene-Gene Interaction between PPARd and PPARy Is Associated with ABDOMINAL OBESITY in a Chinese Population

Journal of Genetics and Genomics 2012年第12期39卷 625-631页

作者： Yi Ding Zhi-Rong Guo Ming Wu Qiu Chen Hao Yu Wen-Shu Luo Department of Epidemiology School of Public HealthSoochow University Center for Diseases Control of Jiangsu Province Center for Disease Control of Changzhou

The peroxisome proliferator-activated receptors （PPARs） -α, -δ/β and -γ are the ligand-activated transcription factors that function as the master regulators of glucose, fatty acid and lipoprotein metabolism, energy balance, cell proliferation and differentiation, inflarn- marion, and atherosclerosis. The objective of the current study was to examine the main and interactive effect of seven single nucleotide polymorphisms （SNPs） of PPARδ/γ, in contribution to ABDOMINAL OBESITY. A total of 820 subjects were randomly selected and no indi- viduals were related. The selected S NPs in PPARδ （rs2016520 and rs9794） and PPARγ （rs10865710, rs 1805192, rs709158, rs3856806, and rs4684847） were genotyped. Mean difference and 95% confident interval were calculated. Interactions were explored by the method of generalized multifactor dimensionality reduction. After adjustment for gender, age, and smoking status, it was found that the carriers of the C allele （TC ＋ CC） of rs2016520 were associated with a decreased risk of ABDOMINAL OBESITY compared to the carriers of the TT genotype （mean difference = -2.63, 95% CI = -3.61-1.64, P 〈 0.000t）. A significant two-locus model （P = 0.0107） involving rs2016520 and rs 10865710 and a significant three-locus model （P = 0.0107） involving rs2016520, rs9794, and rs 1805192 were observed. Overall, the three-locus model had the highest level of testing accuracy （59.85%） and showed a better cross-validation consistency （9/10） than two-locus model. Therefore, for ABDOMINAL OBESITY defined by waist circumference, we chose the three-locus model as the best interaction model. In conclusion, the C allele in rs2016520 was significantly associated with a lower ABDOMINAL OBESITY. Moreover, an interaction among rs2016520, rs1805192, and rs9794 on incident ABDOMINAL OBESITY could be demonstrated.

关键词： PPARs gene Polymorphism ABDOMINAL OBESITY Interaction

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ABDOMINAL OBESITY in females： a problem in South Asia receiving insufficient attention

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Chinese Medical Journal 2011年第22期124卷 3824-3827页

作者： Jeevan Prasanga Marasinghe Carukshi Arambepola Chandrika Wijeyaratne Department of Obstetrics and Gynaecology James Paget University Hospitals Foundation Trusts Lowestoft road Goreston Great Yarmouth Norfolk NR31 6LA UK

ABDOMINAL OBESITY （AO） has become a major health problem to most of the Asian communities. The severity and consequences of AO are higher among females. It has virtually become an epidemic in most South Asian countries and the health care systems in this region are likely to be challenged by one of the biggest health issues in the near future. Yet, the recognition of the magnitude of the problem by health authorities is poor. The purpose of this paper is to motivate health care professionals, planners and policy makers towards better control of the epidemic of AO while highlighting the paucity of evidence on clinical manaclement of AO from the South Asian reqion.

关键词： ABDOMINAL OBESITY female South Asia

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Study on intestinal flora of acupoint catgut embedding intervention in female patients with ABDOMINAL OBESITY: study protocol for a randomized controlled trial

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TMR Integrative Medicine 2022年第10期6卷 1-9页

作者： Qi-Fu Li Jia-Lei Feng Xing-He Zhang Li Li Xuan-Xiang Zeng Si-Wen Zhao Meng Kong Yun-Qiu Zheng Chong-Hui Xing Tai-Pin Guo School of Second Clinical medicine/The Second Affiliated Hospital of Yunnan University of Chinese Medicine Kunming 650500China Institute for History of Medicine and Medical Literature China Academy of Chinese Medical SciencesBeijing 100700China The Third Affiliated Hospital Yunnan University of Chinese MedicineKunming 650500China The sports Trauma Specialist Hospital of Yunnan Province Kunming 650000China

Background:obesity,as an epidemic public health issue in the world today,not only brings a heavy medical burden to society but also seriously affects people’s quality of life.In the context of new evidence for the efficacy of acupoint catgut embedding(ACE)in ABDOMINAL OBESITY(AO),it is necessary to elucidate the mechanism of ACE for AO.The intestinal flora is closely associated with obesity,and the study of its intestinal flora may provide evidence to clarify the mechanism of obesity treatment by ACE.Methods:75 participants will be recruited in this study,including 60 eligible female patients diagnosed with AO and 15 healthy female participants.60 female AO patients will be randomized to ACE group,sham ACE group,and waiting list(WL)group in a ratio of 1:1:1.Patients in two ACE groups will receive one ACE treatment per week for 12 consecutive weeks,and in the WL group will not receive any treatment;only their data will be extracted.The primary outcome is the mean change in body mass index.Secondary effects include waist circumference,body weight,the visual analog score of appetite,and the Gastrointestinal Symptom Rating Scale.High-throughput 16S ribosomal ribonucleic acid gene sequencing will be used to detect intestinal flora in each group before and after the intervention.Conclusion:The results of this trial are expected to identify the critical intestinal flora causing AO and the target intestinal flora of AO regulated by ACE,providing further theoretical support for ACE in the clinical treatment of obesity.

关键词： acupoint catgut embedding ABDOMINAL OBESITY intestinal flora 16S rRNA female randomized controlled trial

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A pilot study of radiologic measures of abdominal adiposity:weighty contributors to early pancreatic carcinogenesis worth evaluating?

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Cancer Biology & Medicine 2017年第1期14卷 66-73页

作者： Jennifer B.Permuth Jung W.Choi Dung-Tsa Chen Kun Jiang Gina DeNicola Jian-Nong Li Domenico Coppola Barbara A.Centeno Anthony Magliocco Yoganand Balagurunathan Nipun Merchant Jose G.Trevino Daniel Jeong Departments of Cancer Epidemiology Gastrointestinal Oncology Diagnostic Imaging and Interventional Radiology Biostatistics and Bioinformatics Anatomic Pathology Cancer Imaging and Metabolism Moffitt Cancer Center and Research InstituteTamPa 33612FLUSA Department of Surgery Sylvester Comprehensive Cancer Center at the University of Miami Miller School of MedicineMiami 33136FLUSA Department of Surgery Division of General SurgeryUniversity of Florida Health Sciences CenterGainesville 32611FLUSA

Objective:Intra-abdominal fat is a risk factor for pancreatic cancer(PC),but little is known about its contribution to PC precursors known as intraductal papillary mucinous neoplasms(IPMNs).Our goal was to evaluate quantitative radiologic measures of abdominal/visceral obesity as possible diagnostic markers of IPMN severity/pathology.Methods:In a cohort of 34 surgically-resected,pathologically-confirmed IPMNs(17 benign;17 malignant) with preoperative abdominal computed tomography(CT) images,we calculated body mass index(BMI) and four radiologic measures of obesity:total abdominal fat(TAF) area,visceral fat area(VFA),subcutaneous fat area(SFA),and visceral to subcutaneous fat ratio(V/S).Measures were compared between groups using Wilcoxon two-sample exact tests and other metrics.Results:Mean BMI for individuals with malignant IPMNs(28.9 kg/m^2) was higher than mean BMI for those with benign IPMNs(25.8 kg/m^2)(P=0.045).Mean VFA was higher for patients with malignant IPMNs(199.3 cm^2) compared to benign IPMNs(120.4cm^2),P=0.092.V/S was significantly higher(P=0.013) for patients with malignant versus benign IPMNs(1.25 vs.0.69 cm^2),especially among females.The accuracy,sensitivity,specificity,and positive and negative predictive value of V/S in predicting malignant IPMN pathology were 74%,71%,76%,75%,and 72%,respectively.Conclusions:Preliminary findings suggest measures of visceral fat from routine medical images may help predict IPMN pathology,acting as potential noninvasive diagnostic adjuncts for management and targets for intervention that may be more biologically-relevant than BMI.Further investigation of gender-specific associations in larger,prospective IPMN cohorts is warranted to validate and expand upon these observations.

关键词： ABDOMINAL OBESITY pre-malignant lesions pancreatic cancer computed tomography

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Clustering of Cardiovascular Risk Factors and Diabetes： A Prospective Cohort Study on the Inner Mongolian Population in China

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Biomedical and Environmental Sciences 2018年第10期31卷 749-756页

作者： WANG Ting Ting LIN Bo CUI Wen Xiu ZHANG Ming Zhi ZHANG Yong Hong ZHANG Shao Yan Department of Epidemiology School of Public Health andJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases Medical College of Soochow University Suzhou 215123 Jiangsu China Harbin Center for Disease Control and Prevention Harbin 150000 Heilongjiang China

Objective To evaluate the effect of clustering of cardiovascular risk factors（CVRFs） on type 2 diabetes mellitus（T2 DM） incidence and identify some high predictive clusters in the Inner Mongolian population in China. Methods A total of 1,884 Mongolian individuals aged 20 years or above were followed up from 2002 to 2013 and included in the final analysis. We categorized the participants into two subgroups according to the study outcome event. A Cox proportional hazards model was used to evaluate the effect of clustering of CVRFs on the incidence of T2 DM. Areas under the curve were used to compare the effect of every cluster on T2 DM and identify those having higher predictive value. Results We found 203 persons with T2 DM. Subjects with incident T2 DM tended to be older, had a higher prevalence of drinking, had higher systolic and diastolic pressures; total cholesterol, triglyceride, low-density lipoprotein cholesterol, and C-reactive protein levels; waist circumference; body mass index; and heart rate and lower HDL-C level than did those without T2 DM. The multivariable adjusted hazard ratio（95% confidence interval） of T2 DM was calculated based on comparisons with subjects with 0 CVRFs; in participants with 2 and ≥ 3 factors, the adjusted hazard ratios were 2.257（1.448, 3.518） and 3.316（2.119, 5.188）, respectively. Conclusion The clustering of CVRFs increased the risk of T2 DM. On the basis of fast heart rate, the cluster of ABDOMINAL OBESITY and other CVRFs had higher predictive value for T2 DM than the other three CVRF clusters.

关键词： Type 2 diabetes Cardiovascular risk factors ABDOMINAL OBESITY Heart rate

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Effects of Endurance and Endurance-strength Exercise on Renal Function in abdominally Obese Women with Renal Hyperfiltration：A Prospective Randomized Trial

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Biomedical and Environmental Sciences 2016年第10期29卷 706-712页

作者： Monika Szulińska Damian Skrypnik Marzena Ratajczak Joanna Karolkiewicz Edyta Madry Katarzyna Musialik Jaroslaw Walkowiak Hieronim Jakubowski Pawel Bogdański Department of Education and obesity Treatment and Metabolic Disorders Poznań University of Medical Sciences ul. Szamarzewskiego 82 60-569 Poznań Poland Department of Internal Medicine Metabolic Disorders and Hypertension Poznań University of Medical Sciences ul. Szamarzewskiego 82 60-569 Poznań Poland Department of Physiology Biochemistry and Hygiene Poznań University School of Physical Education ul. Kr61owej Jadwigi 27/39 61-871 Poznań Poland Department of Physiology Poznań University of Medical Sciences ul. Swiecickiego 6 60-781 Poznań Poland Department of Pediatric Gastroenterology and Metabolic Diseases Poznań University of Medical Sciences ul. Szpitalna 27/33 60-572 Poznań Poland Department of Microbiology Biochemistry and Molecular Genetics Rutgers University New Jersey Medical School International Center for Public Health 225 Warren Street Room E230P Newark New Jersey 07103-3535 USA Department of Biochemistry and Biotechnology Poznań University of Life Sciences Dojazd Str. 11 60-632 Poznań Poland Institute of Bioorganic Chemistry Polish Academy of Sciences Noskowskiego Str. 12/14 61-704 Poznań Poland

Objective obesity is associated with kidney defects.Physical activity is a key element in the treatment of obesity.The aim of this study was to compare the effect of endurance and endurance-strength training on kidney function in abdominally obese women.Methods Forty-four abdominally obese women were randomized to endurance training or endurance-strength training,three times a week for 3 months.Before and after the intervention,kidney function was assessed by measuring blood creatinine,urine creatinine,and urine albumin levels,and the albumin-to-creatinine ratio and glomerular filtration rate（GFR） were calculated.Results Renal hyperperfusion was present in both groups before the study.Following both types of physical activity,similar modifications of the investigated parameters were observed,but with no significant between-group differences.Both courses of training led to a significant increase in blood creatinine and a subsequent decrease in the GFR.A significant increase in urine creatinine and album levels,though not exceeding the range for microalbuminuria,was not accompanied by any difference in the albumin-to-creatinine ratio after endurance-strength training alone.Conclusion Three months of either endurance or endurance-strength training has a favorable and comparable effect on renal function in abdominally obese women with renal hyperfiltration.

关键词： ABDOMINAL OBESITY Renal function Physical exercise

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Effects of Altered Intra-abdominal Pressure on the Upper Airway Collapsibility in a Porcine Model

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Chinese Medical Journal 2015年第23期128卷 3204-3210页

作者： Shu-Lin Ren Yan-Ru Li Ji-Xiang Wu Jing-Ying Ye Rachel Jen Department of General Surgery Beijing Tongren Hospital Capital Medical University Beijing 100730 China Department of Otolaryngology Head and Neck Surgery Beijing Tongren Hospital Capital Medical University Beijing 100730 China Department of Otolaryngology Head and Neck Surgery Beijing Tsinghua Changgung Hospital Tsinghua University Beijing 102218 China Department of Medicine Respiratory Division University of British Columbia Vancouver BC Canada

Background： Obstructive sleep apnea is strongly associated with obesity, particularly ABDOMINAL OBESITY common in centrally obese males. Previous studies have demonstrated that intra-abdominal pressure （IAP） is increased in morbid obesity, and tracheal traction forces may influence pharyngeal airway collapsibility. This study aimed to investigate that whether IAP plays a role in the mechanism of upper airway （UA） collapsibility via IAP-related caudal tracheal traction. Methods： An abdominal wall lifting （AWL） system and graded CO2 pneumoperitoneum pressure was applied to four supine, anesthetized Guizhou miniature pigs and its effects on tracheal displacement （TD） and airflow dynamics of UA were studied. Individual run data in 3 min obtained before and after AWL and obtained before and after graded pneumoperitoneum pressure were analyzed. Differences between baseline and AWL/graded pneumoperitoneum pressure data of each pig were examined using a Student＇s t-test or analysis of variance. Results： Application of AWL resulted in decreased IAP and significant caudal TD. The average displacement amplitude was 0.44 mm （P 〈 0.001 ）. There were three subjects showed increased tidal volume （TV）（P 〈 0.01 ） and peak inspiratory airflow （P 〈 0.01 ）; however, the change of flow limitation inspiratory UA resistance （Rua） was not significant. Experimental increased lAP by pneumoperitoneum resulted in significant cranial TD. The average displacement amplitude was 1.07 mm （P 〈 0.001） when lAP was 25 cmH2O compared to baseline. There were three subjects showed reduced Rua while the TV increased （P 〈 0.01 ）. There was one subject had decreased TV and elevated Rua （P 〈 0.001）. Conclusions： Decreased IAP significantly increased caudal TD, and elevated lAP significantly increased cranial TD. However, the mechanism of UA collapsibility appears primarily mediated by changes in lung volume rather than tracheal traction effect. TV plays an independent role in the mechanism of UA collapsibility.

关键词： ABDOMINAL OBESITY Intra-abdominal Pressure Lung Volume Obstructive Sleep Apnea Trachea Traction

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obesity in China： its characteristics, diagnostic criteria, and implications

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Frontiers of Medicine 2015年第2期9卷 129-133页

作者： Weiping Jia Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai Clinical Centerfor Diabetes Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes Mellitus Shanghai Key Clinical Center for MetabolicDisease Shanghai 200233 China

The rising prevalence of overweight and obesity in several countries has been described as a global pandemic. obesity and obesity-related diseases are increasing dramatically and have become a massive burden on world economy and global health. In 2010, overweight and obesity were estimated to cause 3.4 million deaths, with 4% of years of life lost and 4% of disability-adjusted life-years worldwide [1]. ABDOMINAL OBESITY, also known as central obesity, refers to the presence of excess fat in the abdominal area. Epidemiological studies have demonstrated that obesity, especially central obesity,

关键词： INTIMA-MEDIA THICKNESS BODY-MASS INDEX WAIST CIRCUMFERENCE CUTOFFS CORONARY-ARTERY-DISEASE METABOLIC RISK-FACTORS ABDOMINAL OBESITY VISCERAL FAT CARDIOVASCULAR-DISEASE ADULT OVERWEIGHT ADIPOSE-TISSUE

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Effects of television viewing on body fatness among Chinese children and adolescents

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Chinese Medical Journal 2012年第8期125卷 1500-1503页

作者： WANG Ning XU Feng ZHENG Li-qiang ZHANG Xin-gang LI Yang SUN Guo-zhe GUO Xiao-fan YU Sha-sha SUN Ying-xian Department of C~diology the First Hospital of China MedicalUniversity Shenyang Liaoning 110001 China Department of Cardiology Shengjing Hospital of China MedicalUniversity Shenyang Liaoning 110004 China

Background Numerous studies have shown that time spent on television （TV） viewing is positively associated with obesity. The aim of this study was to examine the potential association between excessive TV viewing and obesity, especially ABDOMINAL OBESITY, among children and adolescents in mainland of China. Methods A total of 4708 children and adolescents aged 6 to 16 years were recruited for the study. Anthropometric measures were conducted by trained personnels. A self-report questionnaire was designed to gather information on TV time, physical activity, diet habits, maternal body mass index （BMI）, birth weight, and on general demographics, including age and gender, and socio-economic status. Results The prevalence of obesity in this group was 6.5%. Linear regression analysis indicated that high TV viewing time （〉1.5 h/d） was significantly associated with higher BMI, waist circumference （WC）, and waist-to-height ratio （WHtR）. In addition, the high TV time group had 1.3 times the odds of obesity as compared to the low TV time group. Likewise, high TV viewing time increased the OR value 1.32 and 1.21 times higher in WC- and WHtR-defined obesity. Within the non-obesity group, high TV viewing time was also positively associated with higher WC and WHtR. All these correlations remained significant after adjustment for the confounding variables. Conclusions Excessive TV viewing might increase the risk of obesity among Chinese youth. Reducing TV viewing time may be beneficial to improve health outcomes, both in the short- and long term. This finding should be taken into account in future designs of intervention policies to prevent childhood and adolescent obesity in China.

关键词： obesity ABDOMINAL OBESITY television children

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Postprandial triglyceride metabolism in elderly men with subnormal testosterone levels

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Asian Journal of Andrology 2008年第4期10卷 542-549页

作者： Ingvild Agledahl John-Bjarne Hansen Johan Svartberg Department of Medicine University Hospital of North Norway TromsO 9038 Norway Center for Atherothrombotic Research in TromsФ （CART） Institute of Clinical Medicine University of TromsФ TromsФ 9037 Norway institute of Clinical Medicine University of TromsФ TromsФ 9037 Norway

Aim： To investigate the level of postprandial triglycerides （TG）s in elderly men with subnormal testosterone level （≤ 11.0 nmol/L） compared to men with normal testosterone level （〉 11.0 nmol/L）. Methods： Thirthy-seven men with subnormal and 41 men with normal testosterone aged 60-80 years underwent an oral fat load and TG levels were measured fasting and 2, 4, 6 and 8 h afterwards. Results： Men with subnormal testosterone had significantly higher body mass index （BMI） and waist circumference （P 〈 0.001） than men with normal testosterone. They had significantly higher area under curve （AUC, P = 0.037）, incremental area under curve （AUCi, P = 0.035） and TG response （TGR, P = 0.014） for serum-TG and significantly higher AUC （P = 0.023）, AUCi （P = 0.023） and TGR （P = 0.014） for chylomicron-TG compared to men with normal testosterone level. Adjusting for waist circumference erased the significant differences between the groups in postprandial triglyceridemia. Conclusion： Men with subnormal testosterone have increased postprandial TG levels indicating an impaired metabolism of postprandial TG-rich lipoproteins （TRL）, which may add to an unfavourable lipid profile and promote development of atherosclerosis.

关键词： testosterone sex hormone-binding globulin postprandial triglycerides ABDOMINAL OBESITY waist circumference

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