Postprandial triglyceride metabolism in elderly men with subnormal testosterone levels
Postprandial triglyceride metabolism in elderly men with subnormal testosterone levels作者机构：Department of Medicine University Hospital of North Norway TromsO 9038 Norway Center for Atherothrombotic Research in TromsФ （CART） Institute of Clinical Medicine University of TromsФ TromsФ 9037 Norway institute of Clinical Medicine University of TromsФ TromsФ 9037 Norway
出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)
年 卷 期：2008年第10卷第4期
页 面：542-549页
核心收录：
基 金：AnindependentgrantfromtheCenterforResearchintheElderlyinTromsФ Norway
主 题：testosterone sex hormone-binding globulin postprandial triglycerides abdominal obesity waist circumference
摘 要：Aim： To investigate the level of postprandial triglycerides （TG）s in elderly men with subnormal testosterone level （≤ 11.0 nmol/L） compared to men with normal testosterone level （〉 11.0 nmol/L）. Methods： Thirthy-seven men with subnormal and 41 men with normal testosterone aged 60-80 years underwent an oral fat load and TG levels were measured fasting and 2, 4, 6 and 8 h afterwards. Results： Men with subnormal testosterone had significantly higher body mass index （BMI） and waist circumference （P 〈 0.001） than men with normal testosterone. They had significantly higher area under curve （AUC, P = 0.037）, incremental area under curve （AUCi, P = 0.035） and TG response （TGR, P = 0.014） for serum-TG and significantly higher AUC （P = 0.023）, AUCi （P = 0.023） and TGR （P = 0.014） for chylomicron-TG compared to men with normal testosterone level. Adjusting for waist circumference erased the significant differences between the groups in postprandial triglyceridemia. Conclusion： Men with subnormal testosterone have increased postprandial TG levels indicating an impaired metabolism of postprandial TG-rich lipoproteins （TRL）, which may add to an unfavourable lipid profile and promote development of atherosclerosis.
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