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5-hydroxytryptamine:a potential therapeutic target in amyotrophic lateral sclerosis

Neural Regeneration Research 2023年第9期18卷 2047-2055页

作者： Shi-Shi Jiang Meng-Ni Gong Wei Rao Wen Chai Wen-Zhi Chen Xiong Zhang Hong-Bing Nie Ren-Shi Xu Medical College of Nanchang University Department of NeurologyJiangxi Provincial People’s HospitalThe First Affiliated Hospital of Nanchang Medical CollegeClinical College of Nanchang Medical CollegeNanchangJiangxi ProvinceChina Department of Neurology The First Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Department of Neurology Maoming People’s HospitalMaomingGuangdong ProvinceChina

Previous studies have indicated that the pathogenesis of amyotrophic lateral sclerosis(ALS) is closely linked to 5-hydroxytryptamine(5-HT).To investigate this further,we administered 5-HT receptor antagonists to SOD1*G93A transgenic(ALS mouse model) and wide-type *** involved intraperitoneal injections of either granisetron,piboserod,or ritanserin,which inhibit the 5-HT3,5-HT4,and 5-HT2 receptors,*** transgenic mice were found to have fewer5-HT-positive cells in the spinal cord compared with wide-type *** found that the administration of granisetron reduced the body weight of the transgenic mice,while piboserod and ritanserin worsened the motor functioning,as assessed using a hanging wire ***,none of the 5-HT receptor antagonists affected the disease *** analyzed the distribution and/or expression of TAR DNA binding protein 43(TDP-43) and superoxide dismutase 1 G93A(SOD1-G93A),which fo rm abnormal aggregates in *** found that the expression of these proteins increased following the administration of all three 5-HT receptor *** addition,the disease-related mislocalization of TD P-43 to the cytoplasm increased markedly for all three *** ce rtain anatomical regions,the 5-HT receptor antagonists also led to a marked increase in the number of astrocytes and microglia and a decrease in the number of *** results indicate that 5-HT deficiency may play a role in the pathogenesis of amyotrophic lateral sclerosis by inducing the abnormal expression and/or distribution of TDP-43 and SOD1-G93A and by activating glial cells.5-HT co uld therefore be a potential therapeutic target for amyotrophic lateral sclerosis.

关键词： 5-hydroxytryptamine amyotrophic lateral sclerosis astrocytes granisetron microglia neuron piboserod ritanserin SOD1-G93A TAR DNA-binding protein 43

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Herbal medicines for insomnia through regulating 5-hydroxytryptamine receptors:a systematic review

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Chinese Journal of Natural Medicines 2023年第7期21卷 483-498页

作者： WANG Haoran GU Yanqiu KHALID Rahman CHEN Xiaofei HAN Ting School of Pharmacy Naval Medical University(Second Military Medical University)Shanghai 200433China School of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China Department of Pharmacy Shanghai Ninth People's HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 201999China Faculty of Science School of Pharmacy and Biomolecular SciencesLiverpool John Moores UniversityLiverpoolEngland

Insomnia is a common sleep disorder without effective therapy and can affect a person's *** mechanism of the disease is not completely ***,there is a need to understand the targets related to insomnia,in order to develop innovative therapies and new ***,increasing interest has been focused on complementary and alternative medicines for treating or preventing *** into their molecular components has revealed that their sedative and sleep-promoting properties rely on the interactions with various neurotransmitter systems in the *** this review,the role of 5-hydroxytryptamine(5-HT)in insomnia development is summarized,while a systematic analysis of studies is conducted to assess the mechanisms of herbal medicines on different 5-HT receptors subtypes,in order to provide reference for subsequent research.

关键词： 5-hydroxytryptamine 5-HT receptors Insomnia Herbal medicine

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Non-cholinergic late slow excitatory postsynaptic potential, 5-hydroxytryptamine and substance P

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Chinese Science Bulletin 1996年第9期41卷 762-765页

作者：孔德虎黄振信马如纯蔡圣荣裴文芬 Department of Physiology Anhui Medical University Hefei 230032 China

It has been recognized that substance P (SP) and 5-hydroxytryptamine (5-HT) maybe the transmitters mediating non-cholinergic late slow excitatory postsynaptic potential(LS-EPSP) in the neurons of guinea pig inferior m... 详细信息

关键词： late slow excitatory postsynaptic potential 5-hydroxytryptamine substance P inferior mesenteric ganglion.

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5-hydroxytryptamine-mediated apnea caused by the habenular nucleus

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Neural Regeneration Research 2011年第20期6卷 1554-1558页

作者： Min Wang Weihong Lin Jinghua Wang Min Huang Chunyong Wang Mingxian Li Shao Wang Department of Pneumology First Hospital of Jilin University Changchun 130021 Jilin Province China Department of Neurology First Hospital of Jilin University Changchun 130021 Jilin Province China Department of Physiology Norman Bethune College of Medicine Jilin University Changchun 130021 Jilin Province China School of Public Health Jilin University Changchun 130021 Jilin Province China

5-hydroxytryptamine contributes to the control of activities of the dilator muscle in the upper respiratory tract, and is derived from the raphe nuclei, in which the habenular nucleus exerts a sustaJned inhibitory effect. In the present study, respiratory motion curve of the genJoglossus muscle and peripheral 5-hydroxytryptamine changes were observed following L-glutamate stimulation of the habenular nucleus of adult Wistar rats. Results showed that the rats had apnea and decreased plasma 5-hydroxytryptamine content after the neurons in habenular nucleus were excited. Genioglossus muscle electromyogram amplitude and integral were significantly reduced. The genioglossus myoelectric activity and respiratory motion curve were similar to obstructive sleep apnea syndrome, thus confirming that the habenular nucleus is the key nucleus involved in the pathogenesis of obstructive sleep apnea syndrome, and is the primary regulated center in the raphe nuclei. Stimulation of the habenular nucleus may suppress 5-hydroxytryptamine release and result in apnea, which is similar to obstructive sleep apnea syndrome.

关键词： sleep apnea habenular nucleus 5-hydroxytryptamine genioglossus neural electrophysiology neural regeneration

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Effect of the pineal gland on 5-hydroxytryptamine and γ-aminobutyric acid secretion in the hippocampus of male rats during the summer and winter

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Journal of Traditional Chinese Medical Sciences 2020年第3期7卷 283-290页

作者： Ting Li Hailu Wang Hewei Zhang Leilei Liu Peipei Li Shuran Ma School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing100029China The First Affiliated Hospital of Soochow University Suzhou215006China

Objective:The present study aimed to investigate the effect of seasonal variation on neurotransmitter release in the hippocampus of normal rats and rats with pineal ***:Two time points,the summer and winter solstice,which are the longest and shortest days of the year,respectively,were *** Spraguee Dawley rats that underwent a sham operation without pineal excision were included as a control *** concentrations of 5-hydroxytryptamine(5-HT)andγ-aminobutyric acid(GABA)were determined by radioimmunoassays and enzyme-linked immunosorbent assays,***:In the winter,the 5-HT and GABA levels in normal rats exhibited a significant difference compared with those in the operation group(P5).The concentrations of 5-HT and GABA in the hippocampal tissues of the normal group exhibited a seasonal rhythm consisting of elevation during the summer and reduction during the winter(P5-HT and GABA)consisted of elevation during the summer and reduction during the *** the winter,the pineal gland exhibited a reverse regulatory effect on the secretion of 5-HT and GABA in the hippocampus,and it exhibited seasonal selectivity with regard to the regulation of 5-HT.

关键词： Melatonin 5-hydroxytryptamine γ-aminobutyric acid Photoperiod Rats Seasonal rhythm Pineal excision

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INFLUENCE OF 5-hydroxytryptamine MICRO INJECTED INTO PREOPTIC AREA ON ELECTRO ACTIVITIES OF PAIN RESPONSE NEURONS IN PARAFASCICULAR NUCLEUS OF THALAMUS IN RAT

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Chinese Science Bulletin 1990年第16期35卷 1369-1373页

作者：张丽娟徐屯 Department of Physiology Harbin Medical University Harbin 150086 PRC

Many research works through out the world show that the preoptic area(POA) is a region concerned with analgesia. Electric stimulation to this region could enhance markedly pain threshold and exert an analgesic effect. Central 5-hydroxytryptamine (5-HT) plays an important role in pain mediation. Acupuncture could accelerate the synthe-

关键词： 5-hydroxytryptamine preoptic area parafascicular nucleus of thalamus pain response neurons.

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Role of 5-hydroxytryptamine expression in cerebellar Purkinje cells in obstructive sleep apnea syndrome

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Neural Regeneration Research 2012年第8期7卷 606-610页

作者： Liping Peng Jinghua Wang Lihong Zhang Pan Liu Min Wang Min Huang Shengnan Liu Pingping He Li Cui Mingxian Li Shao Wang Department of Pneumology First Affiliated Hospital of Jilin University Changchun 130021 Jilin Province China Key Laboratory of Pathobiology Ministry of Education Jilin University Changchun 130021 Jilin Province China Department of Physiology Norman Bethune College of Medicine Jilin University Changchun 130021 Jilin Province China Department of Neurology First Affiliated Hospital of Jilin University Changchun 130021 Jilin Province China

In the present study, electrical stimulation to the rat insular cortex induced apnea or respiratory disturbance, reduced amplitude of genioglossal electromyogram, and decreased electromyogram integrals. In addition, arterial blood gas analysis showed arterial blood acidosis, reduced pH values, increased alkali reserve negative values, decreased peripheral blood 5-hydroxytryptamine content, and increased 5-hydroxytryptamine expression in cerebellar Purkinje cells. Following lidocaine injection to block the habenular nucleus, abnormalities in breath, genioglossal electromyogram, and blood gas values disappeared, and peripheral blood 5-hydroxytryptamine content returned to levels prior to electric stimulation. However, 5-hydroxytryptamine expression in cerebellar Purkinje cells remained high. The results suggested that 5-hydroxytryptamine expression in Purkinje cells did not correlate with ventilation function involving insular cortex and habenular nucleus.

关键词： sleep apnea obstructive cerebellum 5-hydroxytryptamine insular cortex habenular nucleus Purkinje cells

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Orbitofrontal cortex action of 5-hydroxytryptamine and its receptor in an acute forced swimming stress-induced depression model

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Neural Regeneration Research 2009年第7期4卷 530-535页

作者： Huipeng Li Fengli An Shucheng An College of Life Science Shaanxi Normal University Xi'an 710062 Shaanxi Province China

BACKGROUND： The orbitofrontal cortex （OFC） is a brain region closely associated with emotion. 5-hydroxytryptamine （5-HT） has been shown to be involved in human depression. OBJECTIVE： To investigate OFC actions and mechanisms of 5-HT and 5-HT1A receptor （5-HT1AR） in stress-induced depression.DESIGN, TIME AND SETTING： A randomized, controlled, animal experiment was performed at Laboratory of Neurobiology, College of Life Science, Shaanxi Normal University between May 2006 and March 2008. MATERIALS： 5-HT, p-chlorophenylalanine （PCPA, an inhibitor to tryptophan hydroxylase） and spiperone （5-HT1AR antagonist） were provided by Sigma, USA; rabbit anti-rat 5-HT1AR antibody was provided by Tianjin Haoyang Biological Manufacture. METHODS： A total of 40 male Sprague Dawley rats, aged 3 months, were randomly divided into five groups： control, model, 5-HT, spiperone ＋ 5-HT, and PCPA, with 8 rats in each group. Except for control group, rats in the other four groups were used to establish depression models by forced swimming for 15 minutes. At 30 minutes before forced swimming test, 0.5 pL of 5-HT （12.5 pg/pL）, PCPA （20 pg/pL）, spiperone （1.3 pg/pL）＋ 5-HT （12.5 pg/pL, 10 minutes later）, and saline were respectively injected into the OFC of 5-HT, PCPA, spiperone ＋ 5-HT, and model groups, respectively. The control group received a saline microinjection into the OFC.MAIN OUTCOME MEASURES： Forced swimming and open field tests were employed to measure animal behaviors, and immunohistochemistry was used to analyze 5-HT1AR expression in the OFC, cingulate cortex, and piriform cortex. RESULTS：（1） Compared with the model group, 5-HT microinjection into the OFC prominently reduced immobility time in the forced swimming test and rearing in open field test （P 〈 0.05）; locomotion and grooming in open field test were increased, although there was no significance （P 〉 0.05）. Furthermore, following PCPA microinjection into the OFC （PCPA ＋ forced swimming stress）, immobility time in f

关键词： depression orbitofrontal cortex 5-hydroxytryptamine forced swimming test open field test

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Effects of 5-hydroxytryptamine ascending pathways of dorsal raphe nuclei and habenular nucleus on the respiration and blood pressure of rats

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Chinese Medical Journal 2007年第24期120卷 2308-2310页

作者： YU Lei HUANG Min XU Hai-yan ZHAO Hua Department of Physiology School of Basic Medical Sciences JilinUniversity Changchun 130021 China

Obstructive sleep apnea syndrome （OSAS） was a disease of breath obstacle happened in the process of sleep. The central mechanism of OSAS has not yet been fully elucidated. Most of studies focused on raphe nuclei and 5-hydroxytryptamine （5-HT）, and showed that brain serotonergic activity might be decreased in OSAS. It is well known that the dorsal and medial raphe nuclei provide almost all the serotonergic innervation to the forebrain. A previous study evaluated the stimulation of the dorsal raphe nuclei （DRN） in the rat inducing mainly pressor and sympathoexcitatory responses.

关键词： habenular nucleus dorsal raphe nuclei respiration blood pressure lidocaine 5-hydroxytryptamine

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Tong xie yao fang relieves irritable bowel syndrome in rats via mechanisms involving regulation of 5-hydroxytryptamine and substance P

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World Journal of Gastroenterology 2015年第15期21卷 4536-4546页

作者： Yue Yin Lei Zhong Jian-Wei Wang Xue-Ying Zhao Wen-Jing Zhao Hai-Xue Kuang Chinese Medicine Teaching and Research Office Basic Medical College of Heilongjiang University of Chinese Medicine Heilongjiang Chinese Medicine key Laboratory Department of Breast Surgery Second Affiliated Hospital of Harbin Medical University Basic and Applied Research Key Laboratory Heilongjiang University of Chinese Medicine and Department of Education Natural Drug Efficacy Material Basic Research Key Laboratory Heilongjiang Traditional Chinese Medicine

AIM: To investigate whether the Chinese medicine Tong Xie Yao Fang(TXYF) improves dysfunction in an irritable bowel syndrome(IBS) rat model. METHODS: Thirty baby rats for IBS modeling were separated from mother rats(1 h per day) from days 8 to 21, and the rectum was expanded by angioplasty from days 8 to 12. Ten normal rats were used as normal controls. We examined the effects of TXYF on defection frequency, colonic transit function and smooth muscle contraction, and the expression of 5-hydroxytryptamine(5-HT) and substance P(SP) in colonic and hypothalamus tissues by Western blot and RT-PCT techniques in both normal rats and IBS model rats with characterized visceral *** normal rats and 4.5 ± 1.58 in IBS model rats(P 5 vs 4.5 ± 1.58, P 5), while the time(in seconds) of colon transit function was significantly increased(256.88 ± 20.32 vs 93.36 ± 17.28, P 5-HT and SP down-regulation. CONCLUSION: TXYF can modulate the activity of the enteric nervous system and alter 5-HT and SP activities, which may contribute to the symptoms of IBS.

关键词： Tong Xie Yao Fang Irritable bowel syndrome 5-hydroxytryptamine Substance P Traditional Chinesemedicine

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