Role of 5-hydroxytryptamine expression in cerebellar Purkinje cells in obstructive sleep apnea syndrome
Role of 5-hydroxytryptamine expression in cerebellar Purkinje cells in obstructive sleep apnea syndrome作者机构：Department of Pneumology First Affiliated Hospital of Jilin University Changchun 130021 Jilin Province China Key Laboratory of Pathobiology Ministry of Education Jilin University Changchun 130021 Jilin Province China Department of Physiology Norman Bethune College of Medicine Jilin University Changchun 130021 Jilin Province China Department of Neurology First Affiliated Hospital of Jilin University Changchun 130021 Jilin Province China
出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)
年 卷 期：2012年第7卷第8期
页 面：606-610页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 07[理学] 08[工学] 071006[理学-神经生物学] 10[医学]
基 金：supported by the National Natural Science Foundation of China No. 30270502
主 题：sleep apnea obstructive cerebellum 5-hydroxytryptamine insular cortex habenular nucleus Purkinje cells
摘 要：In the present study, electrical stimulation to the rat insular cortex induced apnea or respiratory disturbance, reduced amplitude of genioglossal electromyogram, and decreased electromyogram integrals. In addition, arterial blood gas analysis showed arterial blood acidosis, reduced pH values, increased alkali reserve negative values, decreased peripheral blood 5-hydroxytryptamine content, and increased 5-hydroxytryptamine expression in cerebellar Purkinje cells. Following lidocaine injection to block the habenular nucleus, abnormalities in breath, genioglossal electromyogram, and blood gas values disappeared, and peripheral blood 5-hydroxytryptamine content returned to levels prior to electric stimulation. However, 5-hydroxytryptamine expression in cerebellar Purkinje cells remained high. The results suggested that 5-hydroxytryptamine expression in Purkinje cells did not correlate with ventilation function involving insular cortex and habenular nucleus.
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