检索结果-南通市图书馆

检索条件"主题词=11C-methionine PET"

共 1 条记录，以下是1-10 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

Pathologic Analysis of Glioblastoma Via Stereotactic Biopsies combined with Enhanced MR Images and ~11c-methionine pet

Pathologic Analysis of Glioblastoma Via Stereotactic Biopsie...

引用

中国抗癌协会神经肿瘤专业委员会第八届学术会议

作者： Tae-Young Jung Shin Jung In-Young Kim Kyung-Sub Moon Woo-Youl Jang Seung-Jin Park Young-Hee Kim Hyung-Seok Kim Jung-Joon Min Jahae Kim Departments of Neurosurgery Chonnam National University Research Institute of Medical Sciences chonnam National University Hwasun Hospital & Medical School GwangjuSouth Korea Departments of Brain Tumor Research Laboratory Chonnam National University Research Institute of Medical Sciences Departments of Biomedical Engineering Chonnam National University Research Institute of Medical Sciences Departments of Pathology Chonnam National University Research Institute of Medical Sciences Departments of Nuclear Medicine Chonnam National University Research Institute of Medical Sciences

Objective:To obtain more representative biopsy specimens in glioblastoma,we combined MR stereotactic planning with 11c-methionine pet and analyzed the pathologic ***:From December 2009 to October 2010,we performed stereotactic biopsies in 12 patients with radiologically heterogeneous,ring-enhanced *** biopsied the MR enhanced lesions having higher 11c-methionine uptake and the MR non-enhanced lesions having lower uptake and analyzed differences in pathologic diagnoses between *** pathologic findings,including cell density,Ki-67 LI,microvessel density,and number of endothelial proliferations,were analyzed as correlating factors of the degree of 11c-methionine uptake（T/N ratio）.We performed immunohistochemical staining for L-amino acid transporter 1（LAT1） to demonstrate the correlation with T/N ratio and the pattern of ***:The final diagnosis of each specimen was *** T/N ratio correlated statistically with enhancement（p = 0.000）.The diagnostic failure rate was 33.3%（4/12 patients） when we selected only one MR enhanced,high 11c-methionine uptake lesion,and 40%（4/10 patients） when we selected one MR non-enhanced,low 11c-methionine uptake *** T/N ratio showed a statistical correlation with cell density depending on the degree of necrosis,LAT1 immunopositivity,microvessel density,number of endothelial proliferations,and Ki-67 LI（p = 0.002,0.032,0.057,0.24 and 0.741,respectively）.LAT1 was localized in the tumor cells,vascular endothelium,and the vicinity of endothelial ***:Multiple stereotactic biopsies combined with enhanced MR images and 11cmethionine pet could provide the diagnostic yield in glioblastoma,which mostly differing cell densities depending on the degree of necrosis.

关键词： biopsy 11c-methionine pet enhanced MRI glioblastoma LAT1 stereotaxic

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

全选清除本页清除全部题录导出标记到“检索档案”

共1页 << < 1 > >>

回到顶部

执行限定条件

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：