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光学相干断层扫描血管成像在隐匿性脉络膜新生血管中的应用

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临床医学研究与实践 2018年第28期3卷 5-7页

作者：武炳慧索琰陆慧琴吴慧琴西安市第一医院眼科医院陕西西安710002

目的探讨光学相干断层扫描血管成像(OCTA)在隐匿性脉络膜新生血管诊断中的优越性。方法回顾我院2016年11月至2017年12月拟诊断为隐匿性脉络膜新生血管的20例患者(共22眼),年龄49～77岁;男性15例,女性5例;分析患者眼底荧光血管造影(FFA)... 详细信息

目的探讨光学相干断层扫描血管成像(OCTA)在隐匿性脉络膜新生血管诊断中的优越性。方法回顾我院2016年11月至2017年12月拟诊断为隐匿性脉络膜新生血管的20例患者(共22眼),年龄49～77岁;男性15例,女性5例;分析患者眼底荧光血管造影(FFA)、吲哚菁绿血管造影(ICGA)检查及OCTA检查的诊断一致性。结果 22眼中,2眼中心性浆液性脉络膜视网膜病变(CSC)患者在OCTA中能够明确的显示高血流信号影,与相应的ICGA中发现的高灌注热点相对应。其余的20眼在OCTA中均清晰的显现出了BVN的形态,与其ICGA相对应,同时较ICGA检查中出现的BVN形态更清晰,细节更明显。结论 OCTA检查技术不仅具有非接触性、扫描速度快、分辨率高的优点,而且与眼底血管造影检查相比,其在隐匿性脉络膜新生血管的诊断中更具有敏感性和特异性。

关键词：隐匿性脉络膜新生血管光学相干断层扫描血管成像(OCTA) 视网膜疾病

经瞳孔温热疗法大光斑治疗年龄相关性黄斑变性的隐匿性脉络膜新生血管

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美国医学会眼科杂志（中文版） 2004年第1期16卷 58-58页

作者： AllenB.Thach JackO.Sipperley PravinU.Dugel ScottR.Sneed DonaldW.Park JenniferCornelius 康洁

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世界核心医学期刊文摘（眼科学分册） 2006年第5期2卷 20-20页

作者： Stolba U. Krebs I. Lamar P.D. 杨秀梅 Department of Ophthalmology Rudolf Foundation Hospital Juchgasse 25 1030 Vienna Austria Dr.

Aim: To evaluate long term results after transpupillary thermotherapy (TTT) in eyes with exudative age related macular degeneration. Methods: In a prospective clinical study eyes with occult or predominantly occult choroidal neovascularisation and no pretreatment were scheduled to have a TTT with a power of 630 mW. Visual acuity for far and near distances as well as contrast sensitivity were evaluated 6, 12, and 24 months postoperatively and statistically analysed. Results: 47 eyes fulfilled the inclusion criteria. Overall, 70%of the patients showed an improved (14%) or had unchanged (56%) ETDRS vision after 24 months. Reading vision was stabilised (51%) or better (5%) in 56%of the eyes at this time. However, the increasing number of eyes with severe deterioration resulted in a significant decrease of both parameters over time (p=0.0002 and p=0.0003, respectively). Contrast sensitivity could be maintained (70%) or improved (9%) in 79%. Statistical analyses indicated a trend but no significant decrease over time (p=0.056). Conclusion: Although in the majority of patients far and near distance acuity could be stabilised on average a significant decrease over time after TTT was observed. Statistical comparison of months 12 and 24 showed no further deterioration.

关键词：隐匿性脉络膜新生血管渗出性年龄相关性黄斑变性经瞳孔温热疗法远期疗效观察治疗试验研究前瞻性临床研究伴发对比敏感度统计学分析

经瞳孔温热疗法治疗老年性黄斑变性的隐匿性CNV:前瞻性、随机对照初步研究

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世界核心医学期刊文摘（眼科学分册） 2006年第9期2卷 50-51页

作者： Myint K. Armbrecht A. M. Mon S. Dhillon B. 潘家鸿(译) Princess Alexandra Eye Pavilion Chalmers Street Edinburgh EH39HA United Kingdom 不详

Purpose:To evaluate whether transpupillary thermotherapy(TTT)reduces the risk of moderate visual loss in patients with occult choroidal neovascularization(CNV)secondary to agerelated macular degeneration(AMD).Methods:A group of 25 patients were recruited and randomized in to TTT or placebo *** were included if they had a subfoveal purely or predominantly(> 50%)occult CNV secondary to AMD with best corrected visual acuity(BCVA)of 6/60 or better and the lesion was not larger than 4.5 *** was carried out using an 810-nm Oculight diode laser with a fixed spot size covering the whole lesion according to the standard *** same procedure was used for the control group,except that the power was set at *** patients were followed up at 6 weeks,3 months and then every 6 months for up to 2 years.A maximum of three treatments were administered in both groups if there was evidence of persistent leakage from ***:At the 12-month follow-up,there was no significant difference in the mean values for BCVA distance and near or contrast sensitivity between the treatment and control *** Mann-Whitney test was used to assess the differences in BCVA and contrast sensitivity between the groups,both at baseline and at the 12-month *** statistically significant difference was found;both groups lost on average two lines of ***:Transpupillary thermotherapy appeared to have been of no benefit in preventing further visual loss in patients with occult CNV in this pilot study.

关键词：隐匿性脉络膜新生血管老年性黄斑变性经瞳孔温热疗法随机对照 CNV 治疗组初步显著性差异

“热点”的吲哚青绿血管造影表现及其临床意义

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中华眼底病杂志 2003年第2期19卷 133-136页

作者：匡丽晖文峰广州市第一人民医院眼科 510180 中山大学中山眼科中心

“热点”( hot spots or focal spots)是吲哚青绿血管造影 ( indocyanine green angiography,ICGA)过程中出现的一种异常荧光征象。它与隐匿性脉络膜新生血管 ( choroidal neovascularization,CNV )、视网膜 -脉络膜吻合 ( retinal- choriodal anastomosis ,RCA)、视网膜激光光凝术后的效果及其评价有着非常密切的关系。现就有关热点的造影特征和临床意义作一综述。

关键词：吲哚青绿血管造影临床意义热点隐匿性脉络膜新生血管视网膜血管视网膜激光光凝术

手术祛除黄斑下脉络膜新生血管后2D重建与荧光血管造影表现的对照研究:15号SST报道

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世界核心医学期刊文摘（眼科学分册） 2006年第6期2卷 50-51页

作者： Grossniklaus H. E. Bressler S. B. Miskala P. H. 安胜(译) 不详 L. F. Montgomery Ophthalmic Pathology Laboratory BT428 Emory Eye Center1365 Clifton Road Atlanta GA 30322 United States

Objectives: To compare topographic features of surgically excised subfoveal choroidal neovascularization with preoperative and postoperative fluorescein angiographic features from Submacular Surgery Trials (SST) patients,and to compare histological and angiographic features with preoperative and postoperative visual acuities (VAs). Methods: Patients enrolled in the SST GroupsN,B,and H trials between October 1999 and September 2001 and assigned to the surgery arm had surgically removed choroidal neovascularization sent to the SST Pathology Center. Grossly intact specimens were sectioned serially for 2-dimensional reconstruction and were assigned to growth pattern groups based on topographic mapping of the location of cellular components relative to the retinal pigment epithelium (RPE): sub-RPE,subretinal,combined,or indeterminate. These features were compared with preoperative fluorescein angiographic features. The histological choroidal neovascularization growth pattern was compared with preoperative VAs. Results: Two-dimensional reconstructions of surgically excised choroidal neovascularization could not be matched point for point to fluorescein angiographic features. Among the 52 specimens selected,the growth pattern could be determined by 2-dimensional reconstruction in 34 instances (65% ),including 28 (80% ) of 35 Group N specimens,2 (40% ) of 5 Group B specimens,and 4 (33% ) of 12 Group H specimens. Among the choroidal neovascularization growth patterns that could be determined from specimens submitted,the majority of GroupN specimens were combined,and the majority of Group H specimenswere subretinal. In most instances for GroupBspecimens,the growth pattern was indeterminate. The postoperative abnormalities on fluorescein angiography were generally larger than measurements of excised specimens. The subretinal growth pattern was associated with the smallest decrease in 3-month postoperative average VA. Conclusions: Among the 52 specimens from the SST with adequa

关键词：黄斑下脉络膜新生血管荧光血管造影血管造影表现对照研究 SST 手术隐匿性脉络膜新生血管祛除血管组织学生长模型

玻璃体腔pegaptanib注射后发生视网膜色素上皮撕裂

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世界核心医学期刊文摘（眼科学分册） 2006年第9期2卷 16-17页

作者： Dhalla M. S. Blinder K. J. Tewari A. 曹绪胜(译) Dhalla Barnes Retina Institute St Louis MO United States 不详

PURPOSE:To report two cases of a retinal pigment epithelial tear after intravitreal injection of pegaptanib *** our knowledge,this is the first report of this finding after intraocular antivascular endothelial growth factor ***:Observational case ***:Two patients presented with occult choroidal neovascularization and associated serous pigment epithelial detachment that was a result of agerelated macular *** patients were treated with an intravitreal injection of pegaptanib ***:One patient developed a retinal pigment epithelium tear one week after the intravitreal *** second patient developed a retinal pigment epithelium tear eight weeks after ***:Although these cases may represent natural history,there should be a high index of suspicion for retinal pigment epithelium tears in patients who report significant visual deterioration after intravitreal injection of pegaptanib *** studies are needed to determine whether angiographic subtypes of choroidal neovascular membranes are more susceptible to developing retinal pigment epithelium tears after treatmentwith antivascular endothelial growth factor agents.

关键词：色素上皮撕裂玻璃体腔视网膜注射后隐匿性脉络膜新生血管抗血管内皮生长因子老年性黄斑变性色素上皮脱离