经瞳孔温热疗法治疗老年性黄斑变性的隐匿性CNV:前瞻性、随机对照初步研究

作     者：Myint K. Armbrecht A. M. Mon S. Dhillon B. 潘家鸿(译) 

作者机构：Princess Alexandra Eye Pavilion Chalmers Street Edinburgh EH39HA United Kingdom 不详 

出 版 物：《世界核心医学期刊文摘（眼科学分册）》 (Digest of the World Core Medical Journals:Ophthalmology)

年 卷 期：2006年第2卷第9期

页      面：50-51页

学科分类：1010[医学-医学技术（可授医学、理学学位）] 10[医学] 

主　　题：隐匿性脉络膜新生血管 老年性黄斑变性 经瞳孔温热疗法 随机对照 CNV 治疗组 初步 显著性差异 

摘      要：Purpose:To evaluate whether transpupillary thermotherapy(TTT)reduces the risk of moderate visual loss in patients with occult choroidal neovascularization(CNV)secondary to agerelated macular degeneration(AMD).Methods:A group of 25 patients were recruited and randomized in to TTT or placebo *** were included if they had a subfoveal purely or predominantly( 50%)occult CNV secondary to AMD with best corrected visual acuity(BCVA)of 6/60 or better and the lesion was not larger than 4.5 *** was carried out using an 810-nm Oculight diode laser with a fixed spot size covering the whole lesion according to the standard *** same procedure was used for the control group,except that the power was set at *** patients were followed up at 6 weeks,3 months and then every 6 months for up to 2 years.A maximum of three treatments were administered in both groups if there was evidence of persistent leakage from ***:At the 12-month follow-up,there was no significant difference in the mean values for BCVA distance and near or contrast sensitivity between the treatment and control *** Mann-Whitney test was used to assess the differences in BCVA and contrast sensitivity between the groups,both at baseline and at the 12-month *** statistically significant difference was found;both groups lost on average two lines of ***:Transpupillary thermotherapy appeared to have been of no benefit in preventing further visual loss in patients with occult CNV in this pilot study.