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APOE、血管病理学和阿尔茨海默病脑部病变

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世界核心医学期刊文摘（神经病学分册） 2005年第11期1卷 57-58页

作者： Yip A.G. McKee A.C. Green R.C. L.A. Farrer 刘凯 Dr. Genetics Program Boston University School of Medicine 715 Albany Street Boston MA 02118 United States

Objective: To use neuropathologic data to examine the association between APOE genotype and cerebrovascular lesions commonly found in Alzheimer disease (AD), as well as neuritic senile plaque (SP) and neurofibrillary tangle (NFT) burden. Methods: The sample comprised brains from 96 men and 3 women who fulfilled NIA-Reagan criteria for intermediate to high likelihood of AD. Region-specific and global measures of gross cerebrovascular disease, arteriolosclerosis, white matter lesions, microinfarcts, amyloid angiopathy, neuritic SP, and NFT burden were compared among those who had at least one APOE-4: vs those who did not. Pairwise rank-order correlations between measures were calculated. The association between APOE 4 status and measures of vascular and AD pathology, adjusting for age at death, sex, brain weight, and Braak stage, were evaluated. Results: APOE-4 was not associated with gross cerebrovascular pathology. Compared to those who were negative, brains from 4 individuals had a greater degree of small vessel arteriolosclerosis (p=0.04) and perivascular macrophage infiltration (p=0.06), but not other markers of small vessel disease or white matter myelin loss. Microinfarcts in the deep nuclei were associated with 4(p=0.009), whereas cortical and subcortical microinfarcts were not. There was a trend toward association between APOE genotype and amyloid angiopathy (p=0.08), and 4 was associated with neuritic SP burden, but not NFT. Conclusion: APOE-4 is associated with small vessel arteriolosclerosis, microinfarcts of the deep nuclei, neuritic senile plaque density, and amyloid angiopathy in patients with autopsy-proven Alzheimer disease (AD). These results suggest a role for 4 in some of the microvascular changes commonly found in AD and are consistent with a potential amyloidogenic role for 4.

关键词：阿尔茨海默病 APOE 血管病理学脑部病变神经纤维缠结淀粉样蛋白微梗死脑血管病阴性样脑白质损伤

对来自Barrett食管的细胞学标本进行荧光原位杂交:初步可行性研究

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世界核心医学期刊文摘（胃肠病学分册） 2005年第2期1卷 32-33页

作者： Falk G.W. Skacel M. Gramlich T.L. 赵丽娜 Ctr. Swallowing Esopha geal Disord. Depts. Gastroenterol.Hepatol. C. Cleveland Clinic Foundation Cl eveland OHUnited StatesDr.

Background Endoscopic brush cytology is a promising surveillance technique for Barrett’s esophagus. However, there is a need for ancillary biomarkers to incr ease the sensitivity of cytology and to allow identification of patients at increased risk for disease progression. The aims of this study were to eval uate the feasibility of fluorescence in situ hybridization of endoscopic brush c ytology specimens and to determine if there are specific chromosomal changes in cytologic specimens from patients with cancer that are not present in patients w ithout dysplasia. Methods Archival cytology slides from 16 patients with Barrett ’s esophagus were studied: 8 negative for dysplasia and 8 positive for adenocar cinoma. Fluorescence in situ hybridization was used to detect two alterations: H ER-2 gene(17q11.2-q12) and 20q13.2 region amplification. Observations For 7 of 8 adenocarcinoma cases, there was amplification/aneusomy of at least one of the two analyzed regions by fluorescence in situ hybridization. None of the samples negative for dysplasia were abnormal for either of the two genomic regions stud *** Fluorescence in situ hybridization is feasible by using routine Barrett’s esophagus cytologic specimens. Differences in genomic makeup can be d etected in cells from patients negative for dysplasia and in those with adenocar cinoma.

关键词： Barrett 荧光原位杂交初步可行性研究不典型增生阴性样阴性患者刷检非整倍体生物标记

澳门地区献血者病毒核酸筛检的分析及跟进调查

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中国输血杂志 2010年第S1期23卷 167-167页

作者：梁婉仪何启桂李国斌许萍澳门特别行政区卫生局捐血中心

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兽药四君子散中药材的鉴别方法

中国畜牧兽医文摘 2017年第5期33卷 231-231,229页

作者：杨强贵州省兽药饲料监察所贵州贵阳550004

四君子散,是源自古方的品种,不违反命名原则,沿用古方名称。四君子散是中医补气的一个代表方剂,方剂组成：党参60g,白术（炒）60g,茯苓60g,炙甘草30g。四君子散以党参之甘温,大补元气为君;白术（炒）之苦温,健脾燥湿为臣;茯苓之甘淡,健... 详细信息

四君子散,是源自古方的品种,不违反命名原则,沿用古方名称。四君子散是中医补气的一个代表方剂,方剂组成：党参60g,白术（炒）60g,茯苓60g,炙甘草30g。四君子散以党参之甘温,大补元气为君;白术（炒）之苦温,健脾燥湿为臣;茯苓之甘淡,健脾渗湿为佐;炙甘草之甘平,益气调中为使。四药相合,补而不滞、温而不燥,是健脾益气的基本方剂。1性状本品为灰黄色的粉末;气微香,味甘。

关键词：君子散方剂组成健脾益气健脾渗湿补元甘温代表方剂苦温阴性样基本方剂

PB Diagnostics公司的自动化AIDS检测法

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生物技术通报 1990年第11期6卷 18-18页

作者：李思经

Polaroid Corp.和 Behringwerke AG 的联合企业 PB Diagnostics Systems(Westwood,MA)希望今年开始对一种自动化 AIDS 抗体测试法进行临床试验.它们声称,这是第一种能在一小时内得出结果的试验方法,而大部分自动化试验法需要两小时或更... 详细信息

Polaroid Corp.和 Behringwerke AG 的联合企业 PB Diagnostics Systems(Westwood,MA)希望今年开始对一种自动化 AIDS 抗体测试法进行临床试验.它们声称,这是第一种能在一小时内得出结果的试验方法,而大部分自动化试验法需要两小时或更多时间才能完成.Cambridge BioScience 公司(Worcester,MA)市场销售了一种手工操作的。

关键词：联合企业 PB Diagnostics 试验方法 Cambridge 临床试验手工操作打印结果司卿随机存取阴性样