检索结果-南通市图书馆

expression of p27,cyclin e and cyclin A in hepatocellular carcinoma and its clinical significance

World Journal of Gastroenterology 2003年第11期9卷 2450-2454页

作者： Qi Zhou Qiang He Li-Jian Liang, Department of Hepatobilliary Surgery, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guandong Province, China Department of Hepatobilliary Surgery the First Affiliated Hospital of Sun Yat-Sen University Guangzhou 510080 Guandong Province China.

AIM: TO investigate the expression of p27, cyclin e andcyclin A in hepatocellular carcinoma (HCC) and its potential clinical ***: expression of p27, cyclin e and cyclin A in 45 HCC specimens and 30 adjacent noncancerous lesions obtained from 45 patients during surgery was examined by immunohistochemical SABC assay. The diameter of tumor ranged from 1 cm to 19 cm (d≤5 cm, 9 samples; 5 cmes; d>10 cm, 17 samples). The tumors were graded according to the criteria described by edmondsonSteiner: well-differentiated HCC group (Grade Ⅰ+Ⅱ), 26 samples; poorly-differentiated HCC group (Grade Ⅲ+Ⅳ),19 samples. According to the clinical-pathologic features,19 samples were poorly encapsulated, 15 samples had portal invasion of cancer, 11 samples had extrahepatic metastasis,and 12 samples had intrahepatic metastasis. All of the samples were classified as the invasive and metastatic group,while the remaining was classified as the non-invasive and non- metastatic ***: The average labeling index (LI) of p27 in HCC lesions was significantly higher than that in adjacent noncancerous lesions (45.87±14.21 vs33.77±12.92, t=3.745,Pe LI of p27 was associated with differentiation,invasiveness and metastasis of the tumors (34.46±12.29 vs 52.80±11.36, t=5.17; 41.42±12.86 vs51.44±14.10, t=2.48;Pe was overexpressed in 16 cases (35.6 %)while cyclin A was overexpressed in 21 cases (46.7 %) in HCC lesions. No overexpression of cyclin e or cyclin A could be observed in adjacent non-carcinoma lesions and normal liver tissues. The overexpressions of cyclin e and cyclin A were correlated with differentiation, tumor thrombus,invasiveness and metastasis (Pexpression of cyclin e was significantly correlated with expression of cyclin A (r=0.329, Pe LI of p27 was significantly decreased in cyclin e, cyclin A positive groups (40.33±11.91 vs 49.50±13.76, t=3.05; 38.86±11.19 vs 52.57±12.62,t=3.89; P<0.05).CONCLUSION: p27,

关键词：细胞周期调节蛋白e 细胞周期调节蛋白A p27 肝细胞癌基因表达临床意义肿瘤侵袭肿瘤转移

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：