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Adipose-derived stromal cell in regenerative medicine:A review

World Journal of Stem Cells 2017年第8期9卷 107-117页

作者： Reza Tabatabaei Qomi Mohsen Sheykhhasan Department of Stem Cell the Academic Center for EducationCulture and ResearchPO Box QOM-***QomIran

The application of appropriate cell origin for utilizing inregenerative medicine is the major issue. Various kinds of stem cells have been used for the tissue engineering and regenerative medicine. Such as, several stromal cells have been employed as treat option for regenerative medicine. For example, human bone marrow-derived stromal cells and adipose-derived stromal cells(ADSCs) are used in cell-based therapy. Data relating to the stem cell therapy and processes associated with ADSC has developed remarkably in the past 10 years. As medical options, both the stromal vascular and ADSC suggests good opportunity as marvelous cell-based therapeutics. The some biological features are the main factors that impact the regenerative activity of ADSCs, including the modulation of the cellular immune system properties and secretion of bioactive proteins such as cytokines, chemokines and growth factors, as well as their intrinsic anti-ulcer and anti-inflammatory potential. A variety of diseases have been treated by ADSCs, and it is not surprising that there has been great interest in the possibility that ADSCs might be used as therapeutic strategy to improve a wider range of diseases. This is especially important when it is remembered that routine therapeutic methods are not completely effective in treat of diseases. Here, it was discuss about applications of ADSC to colitis, liver failure, diabetes mellitus, multiple sclerosis, orthopaedic disorders, hair loss, fertility problems, and salivary gland damage.

关键词：脂肪质导出 stromal 房间大肠炎疾病肝失败糖尿病 mellitus 多重硬化矫形混乱头发损失生育力问题唾液的腺损坏

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Cerebellum and neurodegenerative diseases:Beyond conventional magnetic resonance imaging

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World Journal of Radiology 2017年第10期9卷 371-388页

作者： Enricomaria Mormina Maria Petracca Giulia Bommarito Niccolò Piaggio Sirio Cocozza Matilde Inglese Department of Neurology Icahn School of Medicine at Mount Sinai Neuroradiology Unit Department of Biomedical Sciences and Morphological and Functional ImagesUniversity of Messina Department of Neuroscience Reproductive Sciences and OdontostomatologyUniversity of Naples Federico Ⅱ Depart-ment of Neuroscience RehabilitationOphthalmologyGenetics and Maternal and Child Health (DINOGMI)University of Genoa Department of Neuroradiology San Martino Hospital Department of Advanced Biomedical Sciences University of Naples Federico Ⅱ

The cerebellum plays a key role in movement control and in cognition and cerebellar involvement is described in several neurodegenerative diseases.While conventional magnetic resonance imaging(MRI) is widely used for brain and cerebellar morphologic evaluation,advanced MRI techniques allow the investigation of cerebellar microstructural and functional characteristics.Volumetry,voxel-based morphometry,diffusion MRI based fiber tractography,resting state and task related functional MRI,perfusion,and proton MR spectroscopy are among the most common techniques applied to the study of cerebellum.In the present review,after providing a brief description of each technique's advantages and limitations,we focus on their application to the study of cerebellar injury in major neurodegenerative diseases,such as multiple sclerosis,Parkinson's and Alzheimer's disease and hereditary ataxia.A brief introduction to the pathological substrate of cerebellar involvement is provided for each disease,followed by the review of MRI studies exploring structural and functional cerebellar abnormalities and by a discussion of the clinical relevance of MRI measures of cerebellar damage in terms of both clinical status and cognitive performance.

关键词：小脑 Neurodegenerative 疾病混乱多重硬化 Parkinsons 疾病散开磁性的回声成像 Tractography 容量测定功能的磁性的回声成像 Alzheimers 疾病

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