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长期炎症性结肠炎患者的结肠直肠不典型增生发生率低:荧光内镜检查结果

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世界核心医学期刊文摘（胃肠病学分册） 2006年第10期2卷 23-23页

作者： Ochsenkühn T. Tillack C. Stepp H. 程妍 Department of Medicine II University of Munich-GrosshadernMarchioninistrasse 1581366 MunichGermany.Dr

Background and Study Aim: Patients with long-standing in-flammatory bowel disease (IBD) have an increased risk of developing colonic dysplasias. Dysplastic changes in flat mucosa are likely to be missed by conventional colonoscopy. Endoscopic fluorescence imaging, using 5-aminolevulinic acid (5-ALA) as photosensitizer, has evolved as a new technique to differentiate between normal colonic mucosa and dysplasia. We combined this technique with random biopsies to prospectively evaluate the occurrence of dysplasias in patients with long-standing IBD. Patients and Methods: 52 colonoscopies were performed in 42 consecutive patients (n = 28 with ulcerative colitis, n = 11 with Crohn’s colitis, n = 3 with indeterminate colitis; mean age 43 years, range 21-78) with long-standing IBD colitis (median disease duration 14 years, range 3-40). All patients were in clinical remission. Patients were examined using both conventional white light and by fluorescence colonoscopy using oral 5-ALA. Four biopsies were taken every 10cm frommucosa of normal appearance. In addition, macroscopically suspicious and fluorescence-positive areas were biopsied. Results: A total of 688 biopsies of red-fluorescent (n = 20) and nonfluorescent (n = 662) areas of mucosa were taken. Dysplasia was detected histopathologically in only two of the biopsies. These biopsies were taken from two polypoid lesions which were fluorescence-negative. Conclusions: The rate of colonic dysplasia in patients with long-standing IBD colitis may be lower than previously reported.

关键词：内镜检查结果结肠直肠不典型增生常规结肠镜检查克罗恩病息肉状正常结肠黏膜临床缓解期氨基

服用小剂量阿司匹林的无症状患者的内镜检查结果

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世界核心医学期刊文摘（胃肠病学分册） 2005年第8期1卷 8-8页

作者： Niv Y Battler A Abuksis G 朱国栋 Department of Gastroenterology Rabin Medical Center Beilinson CampusPetach Tiqva 49100 Israel .Dr

Aspirin is widely used for its antiplatelet activity, but it harbors a risk of severe adverse gastrointestinal effects, such as bleeding and perforation, espe cially in elderly people. Our aim to assess the prevalence of upper gastrointest inal lesions and the effect of aspirin on the gastrointestinal mucosa in asympto matic subjects taking minid- ose aspirin (100 to 325 mg per day) for more than 3 mon- ths. A prospective, open design was used. Patients attending the ophthalmology and cardiology outpatient clinics who had a medical history of more than 3 mont hs of regular aspirin consumption were referred for esophagogastroduodenoscopy(E GD). Of the 90 patients referred for EGD, 44 were symptomatic (epigastric pain o r dyspepsia) and were excluded from the study. The 46 asymptomatic patients incl uded 22 men and 24 women of mean age 70 ±10 years (range, 36 to 87 years); 32% were current or former smokers. Mean daily aspirin dose was 129.34 ±76.61 mg. O nly 24%were taking a gastroprotective agent. EGD revealed ulcer or erosions in 47.83%of the patients: erosive gastroduodenitis in 13 patients,gastric ulcer in 14, duodenal ulcer in 2, and gastric and duodenal ulcers in 2. Urease test for Helicobacter pylori infection was positive in 26%. Univariate and multivariate analysis revealed no factor other than aspirin predictive of a positive endoscop - *** aspirin treatment is associated with a high prevalence of ulceratio ns of the stomach and duodenum.

关键词：内镜检查结果无症状患者胃黏膜保护剂血小板活性十二指肠镜胃肠道黏膜胃十二指肠炎上消化道疾病心脏内科脲酶试验

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老年上消化道出血的观察及护理

华南国防医学杂志 1993年第4期7卷 348-349页

作者：李宇慧 187医院

老年上消化道出血是临床常见的急症,且并发症较多。因此,做好老年上消化道出血的观察及护理,对降低老年病的发病率及死亡率至关重要。现将我院自1987年—1990年收治的46例老年上消化道出血观察及护理体会介绍如下。

关键词：上消化道出血十二指肠粘膜消化性溃疡出血内镜检查结果溃疡病出血十二指肠炎输血量消化道息肉窦房结功能低下浅表性胃炎

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自身免疫性胰腺炎的胃肠道表现

世界核心医学期刊文摘（胃肠病学分册） 2006年第3期2卷 33-34页

作者： Kamisawa T. Egawa N. Nakajima H. 廖新华 Department of Internal Medicine Tokyo Metropolitan Komagome Hospital 3-18-22 Honkomagome Bunkyo-ku Tokyo 113-8677 Japan.Dr

Background and study aims: Autoimmune pancreatitis (AIP) is a condition that has been proposed as a clinical entity only fairly recently. Its pathogenesis involves autoimmune mechanisms. Although the radiological findings in patients with AIP have been well evaluated, few studies have focused on the gastrointestinal findings in these patients. The aim of this study was to explore the endoscopic and histological findings in the gastrointestinal tract in patients with autoimmune pancreatitis. Patients and methods: The endoscopic findings in the stomach (n = 10), the duodenum (n = 18), the major duodenal papilla (n = 18), and the colon (n = 5) in 24 patients with AIP were reviewed. These were compared with the results of histological examination of gastric mucosa (n = 13), duodenal mucosa (n = 9), the major duodenal papilla (n = 3), and colonic mucosa (n = 3) in these patients. All these specimens were subjected to immunohistochemical study using anti-IgG4 antibody. Results: Foci of slightly pale, thickened mucosa with loss of visible vascular pattern were observed in the stomach in four patients and in the colon in two patients on endoscopy. Slight or moderate swelling of the major duodenal papilla was detected in five patients. Slight to moderate lymphoplasmacytic infiltration was observed in the lamina propria of the gastric and colonic mucosa, and of the major duodenal papilla. Heavy infiltration with IgG4-positive plasma cells (>10 cells per high-power field)was observed in the lamina propria of the stomach in seven patients, of the colon in two patients, and of the major duodenal papilla in three patients; this was not observed in the control patients, who had other diseases. Conclusions: Although there were no specific endoscopic findings in the stomach or colon in patients with autoimmune pancreatitis, foci of slightly pale, thickened mucosa with loss of visible vascular pattern were observed in some cases. This indistinct change seen on endoscopy appears to be

关键词：十二指肠大乳头内镜检查结果肠黏膜组织学检查黏膜固有层非特异性改变血管结构自身免疫高倍

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大肠镜检查诊断回盲部鞭虫感染

西南国防医药 1994年第S1期4卷 72-73页

作者：郑冬青田学明赵锦秀成都军区昆明总医院消化内科 650032

我院内镜室自1984年至1994年间行纤维结肠镜及电子结肠镜检查4530例,发现105例回盲部鞭虫感染,现报告如下: 一、对象以下消化道症状就诊行结肠镜检查男性2900例,女性1630例;年龄最大88岁,最小23岁。主要临床症状为:下腹痛、腹泻、便血... 详细信息

我院内镜室自1984年至1994年间行纤维结肠镜及电子结肠镜检查4530例,发现105例回盲部鞭虫感染,现报告如下: 一、对象以下消化道症状就诊行结肠镜检查男性2900例,女性1630例;年龄最大88岁,最小23岁。主要临床症状为:下腹痛、腹泻、便血、腹胀等,病程为15天至十年不等。实验室检查:大便培养(一),常规检查正常。

关键词：鞭虫感染大肠镜检查结肠镜检查下消化道纤维结肠镜大便培养内镜室常规检查临床症状内镜检查结果

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非类固醇抗炎药与消化不良

临床消化病杂志 1990年第3期2卷 141-142页

作者： Richard Heatley 张青 MD FRCP

非溃疡性消化不良是一种最常见的症状群,其发病机理尚未完全明瞭,治疗用药多而杂乱,疗效较难评价,然而,每年耗资甚大,严重影响社会劳动力.因此,本征的严重性,已开始引起我国消化系病临床工作者的重视。中美合资天津史克制药有限公司提... 详细信息

非溃疡性消化不良是一种最常见的症状群,其发病机理尚未完全明瞭,治疗用药多而杂乱,疗效较难评价,然而,每年耗资甚大,严重影响社会劳动力.因此,本征的严重性,已开始引起我国消化系病临床工作者的重视。中美合资天津史克制药有限公司提供本刊一书(Practical Approaches to the Management of Dyspepsia),汇集了国际上知名学者对本症的诊治经验,对提高我们对本病的认识甚有助益.本刊特组织人员参加翻译,后经编辑部审校删节,以专辑形式刊出,供读者参考,并向史克公司表示谢忱.

关键词：非类固醇抗炎药天津史克症状群 NSAID 史克公司社会劳动力消化性溃疡胃肠症状内镜检查结果甲氰咪呱

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小儿消化性溃疡39例分析

丽水学院学报 1993年第5期18卷 71-72页

作者：袁林生王澄根虞惠康浙江省丽水地区医院

小儿消化性溃疡并非少见。我院自1986年5月—1991年4月应用国产sx—4型纤维胃镜对107例因上腹不适、恶心、呕吐、黑便等主诉的小儿进行上消化道内镜检查,证实消化性溃疡39例(占36.4％),现分析如下:1 临床资料:男30例,女9例,男女之比3.4:... 详细信息

小儿消化性溃疡并非少见。我院自1986年5月—1991年4月应用国产sx—4型纤维胃镜对107例因上腹不适、恶心、呕吐、黑便等主诉的小儿进行上消化道内镜检查,证实消化性溃疡39例(占36.4％),现分析如下:1 临床资料:男30例,女9例,男女之比3.4:1。年龄6—15岁,平均12.6岁。病程最短4天,最长6年,平均10个月左右。Ⅰ级亲属有溃疡史6例。临床表现:上腹痛30例。

关键词：消化性溃疡消化道内镜检查纤维胃镜 Ⅰ级亲属上腹内镜检查结果十二指肠粘膜胃镜检查硫糖铝临床资料

中度高原地区雷尼替丁治疗消化性溃疡近期疗效观察

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青海医药杂志 1993年第2期23卷 27-28页

作者：于进彩青海石油管理局职工总医院内科

雷尼替丁(Ranitidine又名呋喃硝胺)是现代治疗消化性溃疡的高效药物。国内已有数篇报道,但是否适应于高原地区,尚未见报道,值得进一步探讨。冷湖属高原寒冷地区(海拔2800米),消化性溃疡病人占住院内科总人数的5.43％,较山东、广东平原... 详细信息

雷尼替丁(Ranitidine又名呋喃硝胺)是现代治疗消化性溃疡的高效药物。国内已有数篇报道,但是否适应于高原地区,尚未见报道,值得进一步探讨。冷湖属高原寒冷地区(海拔2800米),消化性溃疡病人占住院内科总人数的5.43％,较山东、广东平原地区消化性溃疡占内外科住院总人数的1.04％、5.23％偏高。

关键词：消化性溃疡近期疗效观察高原地区呋喃硝胺现代治疗雷尼内镜检查结果平原地区溃疡愈合率十二指肠球部

食管贲门癌切除食管、胃肠线吻合术后的内镜观察

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中国肿瘤临床 1994年第S1期21卷 37-37页

作者：智会先韩孝存曹景峰梅平周美宏耿明飞郝安林苏文忠河南省安阳市肿瘤医院胸科安阳市445000

报告我院1990年8月至1991年10月施行食管、贲门癌切除食管、胃肠线吻合28例,丝线吻合21例的内镜检查结果。食管、胃吻合口多为类圆形占83.7％。术后3周丝线残留率为100％,肠线为10.7％;3和6个月丝线残留率分别为70.6％和35.7％。而肠线... 详细信息

报告我院1990年8月至1991年10月施行食管、贲门癌切除食管、胃肠线吻合28例,丝线吻合21例的内镜检查结果。食管、胃吻合口多为类圆形占83.7％。术后3周丝线残留率为100％,肠线为10.7％;3和6个月丝线残留率分别为70.6％和35.7％。而肠线则全部吸收。丝线吻合口有糜烂者14例占66.6％,触血者12例占57.1％,线周围脓肿10例占47.6％,而肠线有糜烂者3例占10.7％,触血者2例占7.1％,无线周脓肿。

关键词：食管贲门癌切除胃肠线胃吻合口内镜检查结果内镜观察残留率轻度糜烂缝线吻合息肉样缝合材料