服用小剂量阿司匹林的无症状患者的内镜检查结果

作     者：Niv Y Battler A Abuksis G 朱国栋 

作者机构：Department of Gastroenterology Rabin Medical Center Beilinson CampusPetach Tiqva 49100 Israel .Dr 

出 版 物：《世界核心医学期刊文摘（胃肠病学分册）》 (Core Journals in Gastroenterology)

年 卷 期：2005年第1卷第8期

页      面：8-8页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：内镜检查结果 无症状患者 胃黏膜保护剂 血小板活性 十二指肠镜 胃肠道黏膜 胃十二指肠炎 上消化道疾病 心脏内科 脲酶试验 

摘      要：Aspirin is widely used for its antiplatelet activity, but it harbors a risk of severe adverse gastrointestinal effects, such as bleeding and perforation, espe cially in elderly people. Our aim to assess the prevalence of upper gastrointest inal lesions and the effect of aspirin on the gastrointestinal mucosa in asympto matic subjects taking minid- ose aspirin (100 to 325 mg per day) for more than 3 mon- ths. A prospective, open design was used. Patients attending the ophthalmology and cardiology outpatient clinics who had a medical history of more than 3 mont hs of regular aspirin consumption were referred for esophagogastroduodenoscopy(E GD). Of the 90 patients referred for EGD, 44 were symptomatic (epigastric pain o r dyspepsia) and were excluded from the study. The 46 asymptomatic patients incl uded 22 men and 24 women of mean age 70 ±10 years (range, 36 to 87 years); 32% were current or former smokers. Mean daily aspirin dose was 129.34 ±76.61 mg. O nly 24%were taking a gastroprotective agent. EGD revealed ulcer or erosions in 47.83%of the patients: erosive gastroduodenitis in 13 patients,gastric ulcer in 14, duodenal ulcer in 2, and gastric and duodenal ulcers in 2. Urease test for Helicobacter pylori infection was positive in 26%. Univariate and multivariate analysis revealed no factor other than aspirin predictive of a positive endoscop - *** aspirin treatment is associated with a high prevalence of ulceratio ns of the stomach and duodenum.