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Exploitation of the nicotinic anti-inflammatory pathway for the treatment of epithelial inflammatory diseases

World Journal of Gastroenterology 2006年第46期12卷 7451-7459页

作者： David A Scott Michael Martin Oral Health and Systemic Disease Research Group and Department of Pharmacology and Toxicology University of Louisville Kentucky United States Oral Health and Systemic Disease Research Group and Department of Microbiology and Immunology University of Louisville Kentucky United States

Discoveries in the first few years of the 21st century have led to an understanding of important interactions between the nervous system and the inflammatory response at the molecular level, most notably the acetylcholine （ACh）- triggered,α7-nicotinic acetylcholine receptor （α7nAChR）- dependent nicotinic antinflammatory pathway. Studies using the α7nAChR agonist, nicotine, for the treatment of mucosal inflammation have been undertaken but the efficacy of nicotine as a treatment for inflammatory bowel diseases remains debatable. Further understanding of the nicotinic anti-inflammatory pathway and other endogenous anti-inflammatory mechanisms is required in order to develop refined and specific therapeutic strategies for the treatment of a number of inflammatory diseases and conditions, including periodontitis, psoriasis, sarcoidosis, and ulcerative colitis.

关键词： α7-nicotinic acetylcholine receptor Inflammation Mucosa Nicotine nicotinic anti-inflammatory pathway Tobacco smoking

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Effect of differential rearing environments on nicotine-stimulated locomotor activity and nicotinic acetylcholine receptor subtypes

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中国药理学与毒理学杂志 2017年第10期31卷 1014-1014页

作者： CS BOCKMAN M QUAST DJ STAIRS Department of Pharmacology Creighton University School of MedicineCreighton University School of Arts & Sciences Department of Psychology Creighton University School of Arts & Sciences

OBJECTIVE Individuals vary in sensitivity to the behavioral effects of nicotine,resulting in differences in their vulnerability to *** role of rearing environment in determining individual sensitivity to nicotine is *** neuropharmacological mechanisms mediating the effect of rearing environment on the actions of nicotine are also ***,the contribution of rearing environment in determining the sensitivity to the locomotor effects of nicotine and regulating α4β2*-and α7-nicotinic acetylcholine(n ACh) receptor expressionwas determined in rats reared in isolated(IC) or enriched(EC) *** To measure locomotor activity,adolescent rats(postnatal day 21-51)were injected with saline(1 mL·kg^(-1)) or nicotine(0.3 mg·kg^(-1)) subcutaneously,then placed in chamberswhere ambulatory activity was monitored for 30-min by computer for 14 daily sessions.α4β2*-andα7-n ACh receptor expression in the mesolimbic dopamine pathway was determined by quantitative autoradiography of [125 I]-epibatidine and [125 I]-bungarotoxinbinding,respectively,in 16 μmol·L^(-1) coronal *** for receptor expression in fmol are ±s of 8 brains and compared by two-tailed,unpaired t-test with P7-n ACh receptor expression in the mesolimbic dopamine *** Rearing environment differentially regulates n ACh receptor subtypes in EC and IC *** data suggest regulation of n ACh receptors by environmental factors may be a mechanism for the protective effect of enrichment against altered sensitivity to nicotine in genetically vulnerable *** characterization of these mechanisms will aid in develo

关键词： nicotine addiction environmental enrichment α4β2*-nicotinic acetylcholine receptor α7-nicotinic acetylcholine receptor

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