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Nutritional assessment,glycemic indices and anti-diabetic potentials of dough meal generated from optimized blends of matured plantain,soya cake and wheat bran flours

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未来食品学报(英文) 2023年第4期3卷 374-382页

作者： Adedamola Iyioluwa Akinyede Ebenezer Oladipupo Ayibiowu Titilope Fakologbon Olugbenga Olufemi Awolu Tayo Nathaniel Fagbemi Department of Food Science and Technology Federal University of TechnologyAkure 340110Nigeria

Management of blood glucose levels associated with type 2 diabetes using nutrients derived from food without having a harmful effect on one’s health is gradually gaining research *** dough meal blends were developed using optimal mixture design of response surface methodology(RSM).The optimum blends based on the protein and crude fibre contents were as follows:PSW1:mature plantain 70.0%+soya cake 25.0%+wheat bran 5.0%;PSW2:mature plantain 68.0%+soya cake 23.0%+wheat bran 9.00%;PSW3:mature plantain 69.0%+soya cake 24.0%+wheat bran 7.0%,while 100% mature plantain flour(PLNT)and cerolina were used as *** nutritional value,amino acid profile,pasting properties,α-amylase,α-glucosidase inhibition potential,in-vitro glycemic index and consumer acceptability were determined using standard *** showed that the inclusion of soya cake and wheat bran significantly increased(Pα-amylase inhibition and lowest estimated glycaemic index at(P≤0.05).Hence,the study established that PSW3 showed the best potentials to modulate blood sugar level.

关键词： Dough meal Amino acids Glycaemic indices α-amylase inhibition α-Glucosidase inhibition

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Antidiabetic effect of Chrysophyllum albidum is mediated by enzyme inhibition and enhancement of glucose uptake via 3T3-L1 adipocytes and C2C12 myotubes

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Asian Pacific Journal of Tropical Biomedicine 2020年第9期10卷 387-396页

作者： Benjamin Kingsley Harley Rita Akosua Dickson Isaac Kingsley Amponsah Robert A Ngala Dorice Berkoh Theophilus Christian Fleischer Department of Pharmacognosy and Herbal Medicine School of PharmacyUniversity of Health and Allied SciencesHoGhana Department of Pharmacognosy Faculty of Pharmacy and Pharmaceutical SciencesCollege of Health SciencesKwame Nkrumah University of Science and TechnologyKumasiGhana Department of Molecular Medicine School of Medical SciencesCollege of Health SciencesKwame Nkrumah University of Science and TechnologyKumasiGhana Department of Basic and Applied Biology School of SciencesUniversity of Energy and Natural ResourcesSunyaniGhana

Objective:To investigate the in vivo and in vitro antidiabetic potential of Chrysophyllum ***:The effects of oral treatment with hydro-ethanolic extract(125,250 and 500 mg/kg)of the stem bark of Chrysophyllum albidum and glibenclamide for 21 d on glucose level,serum enzyme markers for liver function,lipid profile,total protein,serum urea,serum creatinine,and body weight were evaluated in experimental diabetic rats administered with 45 mg/kg of *** vitro assays including glucose uptake in C2 C12 cells and 3 T3-L1 adipose tissues,α-glucosidase andα-amylase inhibition were employed to evaluate the possible mechanism of hypoglycemic action of the *** and nitric oxide radical antioxidant activity of the extract was also ***:The increased levels of blood glucose,triglycerides,lowdensity lipoprotein,total cholesterol,serum aspartate,and alanine transaminases,creatinine,and urea in the diabetic animals were reduced significantly(Pamylase andα-*** also demonstrated potent antioxidant action by scavenging considerably DPPH and nitric oxide ***:Chrysophyllum albidum stem bark extract exhibits considerable antidiabetic effect by stimulating glucose uptake and utilization in C2 C12 myotubes and 3 T3-L1 adipocytes as well as inhibiting the activities ofα-amylase andα-glucosidase.

关键词： Antidiabetic C2C12 myotubes α-glucosidase inhibition α-amylase inhibition Glucose uptake Chrysophyllum albidum

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