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Immunopotentiality of Ayurvedic polyherbal formulations “saribadi” and “Anantamul Salsa” with augmentation of IgM production and lymphocytes proliferation:A preliminary study

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Asian Pacific Journal of Tropical Biomedicine 2016年第7期6卷 568-573页

作者： Md.Moklesur Rahman Sarker Long Chiau Ming Md.Zaidul Islam Sarker M Shahabuddin Kabir Choudhuri Department of Immunochemistry Division of Pharmaceutical SciencesOkayama University Graduate School of MedicineDentistry and Pharmaceutical Sciences Department of Pharmacology Faculty of PharmacyLincoln University College Faculty of Pharmacy Brain Degeneration and Therapeutics GroupPharmaceutical and Life Sciences Co Re Universiti Teknologi MARA Department of Pharmaceutical Technology Faculty of PharmacyInternational Islamic University Malaysia Department of Pharmacy Faculty of Biological ScienceJahangirnagar University

Objective:To assess the immunopotentiality of Ayurvedic polyherbal preparations,"saribadi" and "Anantamul Salsa".Methods: Freshly prepared BALB/c mice splenocytes were cultured with "saribadi" or"Anantamul Salsa" treatment [doses of 0.25%, 0.50%, 0.75%, 1.00%, 1.50%, 2.00%,3.00% and 4.00%(v/v)] at 37C for 5 days. The immunoglobulin M(IgM) production and lymphocytes proliferation were determined by ELISA and MTT methods, *** contamination was assessed by treating the preparations with polymyxin ***: The doses of "saribadi" [0.25%, 0.50%, 0.75% and 1.00%(v/v)] significantly increased IgM productions(0.966, 0.728, 0.695 and 0.615 mg/m L vs. control 0.265 mg/m L)and lymphocytes proliferation [absorbance 0.311, 0.394, 0.372 and 0.334 optical density(OD) vs. control 0.162 OD]. Similarly, the doses of "Anantamul Salsa" [0.50%, 0.75%,1.00% and 1.50%(v/v)] promoted IgM productions(0.933, 0.919, 0.917 and 0.892 mg/m L vs. control 0.502 mg/m L) and the doses of "Anantamul Salsa" [0.50%, 0.75%, 1.00%,1.50%, 2.00%, and 3.00%(v/v)] stimulated lymphocytes proliferation(absorbance 0.395,0.326, 0.440, 0.398, 0.452 and 0.355 OD vs. control 0.199 OD). The activity of "saribadi"and "Anantamul Salsa" was not retarded by the treatment of preparations with polymyxin ***: Immunomodulatory activity of "saribadi" and "Anantamul Salsa" was unveiled for the first time. "saribadi" and "Anantamul Salsa" possess immunostimulating potential acting through the induction of lymphocyte proliferation and IgM *** preparations may be useful in strengthening immune responses. However, further cellular and in vivo studies are required.

关键词： "saribadi" "Anantamul Salsa" Ayurvedic medicine Immunostimulant Lymphocytes Splenocytes Immunoglobulin M antibody Proliferation Differentiation

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