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EZH2-, CHD4-, and IDH-linked epigenetic perturbation and its association with survival in glioma patients

Journal of Molecular Cell Biology 2017年第6期9卷 477-488页

作者： Le Zhang Ying Liu Mengning Wang Zhenhai Wu Na Li Jinsong Zhang Chuanwei Yang College of Computer Science Sichuan University Chengdu China College of Computer and Information Science Southwest University Chongqing China The Vivian Smith Department of Neurosurgery Center for Stem Cell and Regenerative Medicine The University of Texas Health Science Center at Houston Houston TX USA Harvard Stem Cell Institute Harvard University Cambridge MA USA Department of neurosurgery ShouGuang People's Hospital Shandong China Pharmacological & Physiological Science School of Medicine Saint Louis University St. Louis MO USA Breast Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA Systems Biology The University of Texas MD Anderson Cancer Center Houston TX USA

GUoma is a complex disease with limited treatment options. Recent advances have identified isocitrate dehydrogenase （IDH） mutations in up to 80% lower grade gUomas （LGG） and in 76% secondary gUoblastomas （GBM）. IDH mutations are also seen in 10%-20% of acute myeloid leukemia （AML）. In AML, it was determined that mutations of IDH and other genes involving epigenetic regulations are early events, emerging in the pre-leukemic stem cells （pre-LSCs） stage, whereas mutations in genes propa- gating oncogenic signal are late events in leukemia. IDH mutations are also early events in gUoma, occurring before TP53 mutation, 1p/19q deletion, etc. Despite these advances in gUoma research, studies into other molecular alterations have lagged considerably. In this study, we analyzed currently available databases. We identified EZH2, KMT2C, and CHD# as important genes in glioma in addition to the known gene IDH1/2. We also showed that genomic alterations of PIK3CA, CDKN2A, CDK#, FIPIL1, or FUBP1 collaborate with IDH mutations to negatively affect patients＇ survival in LGG. In LGG patients with TP53 mutations or IDH1/2 mutations, additional genomic alterations of EZH2, KMC2C, and CHD4 individually or in combination were associated with a markedly decreased disease-free survival than patients without such alterations. Alterations of EZH2, KMT2C, and CHD4, at gen- etic level or protein level could perturb epigenetic program, leading to malignant transformation in glioma. By reviewing current literature on both AML and gUoma and performing bioinformatics analysis on available datasets, we developed a hypothetical model on the tumorigenesis from premaUgnant stem cells to gUoma.

关键词： glioma epigenetics bioinformatics prognosis gene mutation

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Contribution of PHD2 to therapeutic angiogenesis through HIF-dependent and HIF-independent manner

Contribution of PHD2 to therapeutic angiogenesis through HIF...

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第十届全国生物力学学术会议暨第十二届全国生物流变学学术会议

作者： Shou-rong Wu Vivi Kasim Yang-he Huang Er-fu Liu Zhi-ling Xu Li Yang The "111 Project"Laboratory of Biomechanics and Molecular Medicine College of BioengineeringUniversity of Chongqing

Ischemia occurs when blood vessels in tissues are blocked,and affects hundreds of millions of people *** vascular diseases include peripheral arterial disease,inferior limb ischemia,ischemic heart, *** strategy so far aims to improve neovascularization in ischemic tissues by delivering angiogenic factor proteins or DNA vectors encoding *** make the cells well adaptive to low oxygen tension(hypoxia) the cellular hypoxic response includes various alterations in gene *** them Hypoxia-in-

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