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Neddylation Regulation of Immune Responses

Research 2024年第3期2023卷 545-559页

作者： Hongmei Mao Xin Lin yi sun Cancer Institute(Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education)of the Second Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029China Institute for Immunology School of MedicineTsinghua UniversityBeijing 100084China Changping Laboratory Beijing 102206China Cancer Center of Zhejiang University Hangzhou 310029China Zhejiang Provincial Clinical Research Center for Cancer HangzhouZhejiang ProvinceChina Key Laboratory of Molecular Biology in Medical sciences HangzhouZhejiang ProvinceChina Research Center for Life science and Human Health Binjiang Institute of Zhejiang UniversityHangzhou 310053China.

Neddylation plays a vital role in post-translational modification, intricately.shaping the regulation of diverse biological processes, including those related to cellular immune responses. In fact, neddylation exerts control over both innate and adaptive immune systems via various mechanisms. specifically, neddylation influences the function and survival of innate immune cells, activation of pattern recognition receptors and GMP-AMP synthase–stimulator of interferon genes pathways, as well as the release of various cytokines in innate immune reactions. Moreover, neddylation also governs the function and survival of antigen-presenting cells, which are crucial for initiating adaptive immune reactions. In addition, neddylation regulates T cell activation, proliferation, differentiation, survival, and their effector functions, thereby ensuring an appropriate adaptive immune response. In this review, we summarize the most recent findings in these aspects and delve into the connection between dysregulated neddylation events and immunological disorders, especially inflammatory diseases. Lastly, we propose future directions and potential treatments for these diseases by targeting neddylation.

关键词： activation thereby initiating

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Knockouts of RecA-Like Proteins RadC1 and RadC2 Have Distinct Responses to DNA Damage Agents in sulfolobus islandicus

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Journal of Genetics and Genomics 2013年第10期40卷 533-542页

作者： Peng-Juan Liang Wen-yuan Han Qi-Hong Huang yan-Ze Li Jin-Feng Ni Qun-Xin she yu-Long shen state Key Laboratory of Microbial Technology Shandong University Archaeal Centre Department of BiologyUniversity of CopenhagenOle Maal es Vej 5Copenhagen BiocenterDK-2200 CopenhagenDenmark

RecA family recombinases play essential roles in maintaining genome integrity. A group of RecA-like proteins named RadC are present in all archaea, but their in vivo functions remain unclear. In this study, we performed phylogenetic and genetic analysis of two RadC proteins from sulfolobus islandicus. RadC is closer to the KaiC lineage of cyanobacteria and proteobacteria than to the lineage of the recombinases （RecA, RadA, and Rad51） and the recombinase paralogs （e.g., RadB, Rad55, and Rad51B）. Using the recently- established s. islandicus genetic system, we constructed deletion and over-expression strains of radC1 and radC2. Deletion of radC1 rendered the cells more sensitive to DNA damaging agents, methyl methanesulfonate （MMs）, hydroxyurea （HU）, and ultraviolet （UV） radiation, than the wild type, and a AradCIAradC2 double deletion strain was more sensitive to cisplatin and MMs than the AradC1 single deletion mutant. In addition, ectopic expression of His-tagged RadC 1 revealed that RadC I was co-purified with a putative structure-specific nuclease and ATPase, which is highly conserved in archaea. Our results indicate that both RadCI and RadC2 are involved in DNA repair. RadCl may play a general or primary role in DNA repair, while RadC2 plays a role in DNA repair in response to specific DNA damages.

关键词： RecA-like protein RadA RadC sulfolobus DNA repair

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Plasma metabolomic and lipidomic alterations associated with COVID-19

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national science Review 2020年第7期7卷 1157-1168页

作者： Di Wu Ting shu Xiaobo yang Jian-Xin song Mingliang Zhang Chengye yao Wen Liu Muhan Huang yuan yu Qingyu yang Tingju Zhu Jiqian Xu Jingfang Mu yaxin Wang Hong Wang Tang Tang yujie Ren yongran Wu shu-Hai Lin yang Qiu Ding-yu Zhang you shang Xi Zhou Joint Laboratory of Infectious Diseases and Health Wuhan Institute of Virology & Wuhan Jinyintan Hospital Wuhan Institute of Virology Center for Biosafety Mega-ScienceChinese Academy of Sciences (CAS) state Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-Science CAS Center for Translational Medicine Jinyintan Hospital Joint Laboratory of Infectious Diseases and Health Wuhan Institute of Virology & Wuhan Jinyintan Hospital Wuhan Jinyintan Hospital Department of Critical Care Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Department of Infectious Diseases Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

The pandemic of the coronavirus disease 2019(COVID-19) has become a global public health crisis. The symptoms of COVID-19 range from mild to severe, but the physiological changes associated with COVID-19 are barely understood. In this study, we performed targeted metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 who had experienced different symptoms. We found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients, indicating that the development of COVID-19 affected their whole-body metabolism. In particular, malic acid of the TCA cycle and carbamoyl phosphate of the urea cycle result in altered energy metabolism and hepatic dysfunction, respectively. It should be noted that carbamoyl phosphate is profoundly down-regulated in patients who died compared with patients with mild symptoms. And, more importantly, guanosine monophosphate(GMP), which is mediated not only by GMP synthase but also by CD39 and CD73, is significantly changed between healthy.subjects and patients with COVID-19, as well as between the mild and fatal cases. In addition, dyslipidemia was observed in patients with ***, the disturbed metabolic patterns have been found to align with the progress and severity of COVID-19. This work provides valuable knowledge about plasma biomarkers associated with COVID-19 and potential therapeutic targets, as well as an important resource for further studies of the pathogenesis of COVID-19.

关键词： sARs-Co V-2 COVID-19 metabolome lipidome

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IL-33 drives the antitumor effects of dendritic cells via the induction of Tc9 cells

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Cellular & Molecular Immunology 2019年第7期16卷 644-651页

作者： Ning Liu yuxue Jiang Jintong Chen He Nan yinghua Zhao Xiao Chu Alison Wang Dongjiao Wang Tianxue Qin sujun Gao ying yue siqing Wang Department of Gynecological Oncology The First Hospital of Jilin UniversityChangchun 130061China Department of Cancer Immunology The First Hospital of Jilin UniversityChangchun 130061China Department of Rheumatology and Immunology China-Japan Union Hospital of Jilin UniversityChangchun 130033China Department of Hematology The First Hospital of Jilin UniversityChangchun 130061China and 5 Department of Cancer BiologyLerner Research InstituteCleveland ClinicClevelandOH 44195USA

Dendritic cell(DC)tumor vaccines exert their antitumor effects through the induction of effector T *** recently identified Tc9 cells as a new potent antitumor effector T cell ***,approaches to direct DCs to preferably prime antitumor Tc9 cells should be further ***,we demonstrate that the addition of interleukin(IL)-33 potently promotes the induction of Tc9 cells by DCs in vitro and in ***-33 treatment also drives the cytotoxic activities of DC-induced Tc9 ***,IL-33 treatment enhances cell survival and proliferation of DC-primed CD8+T *** importantly,the addition of IL-33 during in vitro priming of tumor-specific Tc9 cells by DCs increases the antitumor capability of Tc9 *** studies demonstrated that IL-33 treatment inhibits exhaustive CD8+T cell differentiation by inhibiting PD-1 and 2B4 expression and increasing IL-2 and CD127(IL-7 receptor-α,IL-7Rα)expression in CD8+T ***,the addition of IL-33 further promotes the therapeutic efficacy of DC-based tumor vaccines in the OT-I mouse *** study demonstrates the important role of IL-33 in DC-induced Tc9 cell differentiation and antitumor immunity and may have important clinical implications.

关键词： Interleukin-33 Dendritic cells Tc9 Cancer immunology

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Nuclear peripheral chromatin-lamin B1 interaction is required for global integrity of chromatin architecture and dynamics in human cells

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Protein & Cell 2022年第4期13卷 258-280页

作者： Lei Chang Mengfan Li shipeng shao Chen Li shanshan Ai Boxin Xue yingping Hou yiwen Zhang Ruifeng Li Xiaoying Fan Aibin He Cheng Li yujie sun state Key Laboratory of Membrane Biology School of Life Sciencesand Biomedical Pioneering Innovation Center(BIOPIC)Peking UniversityBeijing 100871China Peking-Tsinghua Center for Life sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Center for Bioinformatics School of Life SciencesPeking UniversityBeijing 100871China Institute of Molecular Medicine Beijing Key Laboratory of Cardiometabolic Molecular MedicinePeking UniversityBeijing 100871China Center for statistical science Peking UniversityBeijing 100871China Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) Guangzhou 510530China

The eukaryotic genome is folded into higher-order conformation accompanied with constrained dynamics for coordinated genome ***,the molecular machinery underlying these hierarchically organized three-dimensional(3D)chromatin architecture and dynamics remains poorly *** by combining imaging and sequencing,we studied the role of lamin B1 in chromatin architecture and *** found that lamin B1 depletion leads to detachment of lamina-associated domains(LADs)from the nuclear periphery accompanied with global chromatin redistribution and ***,the interchromosomal as well as inter-compartment interactions are increased,but the structure of topologically associating domains(TADs)is not *** live-cell genomic loci tracking,we further proved that depletion of lamin B1 leads to increased chromatin dynamics,owing to chromatin decompaction and redistribution toward *** together,our data suggest that lamin B1 and chromatin interactions at the nuclear periphery promote LAD maintenance,chromatin compaction,genomic compartmentalization into chromosome territories and A/B compartments and confine chromatin dynamics,supporting their crucial roles in chromatin higher-order structure and chromatin dynamics.

关键词： lamin B1 3D genome Hi-C chromatin dynamics chromosome territories A/B compartments livecell imaging super-resolution imaging

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Tooth number abnormality:from bench to bedside

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International Journal of Oral science 2023年第1期15卷 1-15页

作者： Han Zhang Xuyan Gong Xiaoqiao Xu Xiaogang Wang yao sun Department of Implantology Stomatological Hospital and Dental School of Tongji UniversityShanghai Engineering Research Center of Tooth Restoration and RegenerationShanghaiChina Key Laboratory of Big Data-Based Precision Medicine School of Engineering MedicineBeihang UniversityBeijingChina

Tooth number abnormality is one of the most common dental developmental diseases,which includes both tooth agenesis and supernumerary *** development is regulated by numerous developmental signals,such as the well-known Wnt,BMP,FGF,shh and Eda pathways,which mediate the ongoing complex interactions between epithelium and *** expression of these crutial signalling during this process may eventually lead to the development of anomalies in tooth number;however,the underlying mechanisms remain *** this review,we summarized the major process of tooth development,the latest progress of mechanism studies and newly reported clinical investigations of tooth number *** addition,potential treatment approaches for tooth number abnormality based on developmental biology are also *** review not only provides a reference for the diagnosis and treatment of tooth number abnormality in clinical practice but also facilitates the translation of basic research to the clinical application.

关键词： abnormality diagnosis epithelium

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strain Gradient Finite Element Formulation of Flexoelectricity in Ferroelectric Material Based on Phase-Field Method

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Acta Mechanica solida sinica 2024年第4期37卷 570-579页

作者： shuai Wang Hengchang su Min yi Li-Hua shao national Key Laboratory of strength and structural Integrity Institute of Solid MechanicsSchool of Aeronautic Science and EngineeringBeihang UniversityBeijing100191People’s Republic of China state Key Laboratory of Mechanics and Control for Aerospace structures and Institute for Frontier science and Key Laboratory for Intelligent Nano Materials and Devices of Ministry of Education and College of Aerospace Engineering Nanjing University of Aeronautics and AstronauticsNanjing210016People’s Republic of China

Flexoelectricity is a two-way coupling effect between the strain gradient and electric field that exists in all dielectrics,regardless of point group ***,the high-order derivatives of displacements involved in the strain gradient pose challenges in solving electromechanical coupling problems incorporating the flexoelectric *** this study,we formulate a phase-field model for ferroelectric materials considering the flexoelectric effect.A four-node quadrilateral element with 20 degrees of freedom is constructed without introducing high-order shape *** microstructure evolution of domains is described by an independent order parameter,namely the spontaneous polarization governed by the time-dependent Ginzburg–Landau *** model is developed based on a thermodynamic framework,in which a set of microforces is introduced to construct the constitutive relation and evolution *** the flexoelectric part of electric enthalpy,the strain gradient is determined by interpolating the mechanical strain at the node via the values of Gaussian integration points in the isoparametric *** model is shown to be capable of reproducing the classic analytical solution of dielectric materials incorporating the flexoelectric *** model is verified by duplicating some typical phenomena in flexoelectricity in cylindrical tubes and truncated pyramids.A comparison is made between the polarization distribution in dielectrics and *** model can reproduce the solution to the boundary value problem of the cylindrical flexoelectric tube,and demonstrate domain twisting at domain walls in ferroelectrics considering the flexoelectric effect.

关键词： Flexoelectricity Phase-field method Ferroelectrics Domain configuration

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spaceflight and simulated microgravity.suppresses macrophage development via altered RAs/ERK/NFκB and metabolic pathways

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Cellular & Molecular Immunology 2021年第6期18卷 1489-1502页

作者： Lu shi Hongling Tian Peng Wang Ling Li Zhaoqi Zhang Jiayu Zhang yong Zhao state Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina University of Chinese Academy of sciences BeijingChina Institute for stem Cell and Regeneration Chinese Academy of SciencesBeijingChina

spaceflight-associated immune system weakening ultimately limits the ability of humans to expand their presence beyond the earth's orbit. A mechanistic study of microgravity-regulated immune cell function is necessary to overcome this challenge. Here, we demonstrate that both spaceflight (real) and simulated microgravity.significantly reduce macrophage differentiation, decrease macrophage quantity and functional polarization, and lead to metabolic reprogramming, as demonstrated by changes in gene expression profiles. Moreover, we identified RAs/ERK/NFκB as a major microgravity-regulated pathway. Exogenous ERK and NFκB activators significantly counteracted the effect of microgravity on macrophage differentiation. In addition, microgravity also affects the p53 pathway, which we verified by RT-qPCR and Western blot. Collectively, our data reveal a new mechanism for the effects of microgravity on macrophage development and provide potential molecular targets for the prevention or treatment of macrophage differentiation deficiency in spaceflight.

关键词： Microgravity Hematopoietic progenitor cells Macrophage differentiation Macrophage polarization RAs/ERK/NFκB pathway

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Customizable Ligand Exchange for Tailored surface Property of Noble Metal Nanocrystals

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Research 2020年第1期2020卷 292-303页

作者： Qikui Fan Hao yang Juan Ge shumeng Zhang Zhaojun Liu Bo Lei Tao Cheng youyong Li yadong yin Chuanbo Gao Frontier Institute of science and Technology State Key Laboratory of Multiphase Flow in Power EngineeringXi’an Jiaotong UniversityXi’anShaanxi 710054China Institute of Functional Nano&soft Materials(FUNsOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesJoint International Research Laboratory of Carbon-Based Functional Materials and DevicesSoochow UniversitySuzhouJiangsu 215123China Department of Chemistry University of CaliforniaRiversideCalifornia 92521USA

It is highly desirable,while still challenging,to obtain noble metal nanocrystals with custom capping ligands,because their colloidal synthesis relies on specific capping ligands for the shape control while conventional ligand exchange processes suffer from“the strong replaces the weak”limitation,which greatly hinders their ***,we report a general and effective ligand exchange approach that can replace the native capping ligands of noble metal nanocrystals with virtually any type of ligands,producing flexibly tailored surface *** key is to use diethylamine with conveniently.switchable binding affinity to the metal surface as an intermediate *** a strong ligand,it in its original form can effectively remove the native ligands;while protonated,it loses its binding affinity and facilitates the adsorption of new ligands,especially weak ones,onto the metal *** this means,the irreversible order in the conventional ligand exchange processes could be *** efficacy of the strategy is demonstrated by mutual exchange of the capping ligands among cetyltrimethylammonium,citrate,polyvinylpyrrolidone,and *** novel strategy.significantly expands our ability to manipulate the surface property of noble metal nanocrystals and extends their applicability to a wide range of fields,particularly biomedical applications.

关键词： properties replace mutual

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Prediction of Van Hove singularity.systems in ternary borides

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npj Computational Materials 2023年第1期9卷 247-257页

作者： yang sun Zhen Zhang Andrew P.Porter Kirill Kovnir Kai-Ming Ho Vladimir Antropov Department of Physics Xiamen University361005 XiamenChina Department of Physics and Astronomy Iowa State UniversityAmesIA 50011USA Department of Chemistry Iowa State UniversityAmesIA 50011USA Ames national Laboratory U.S.Department of EnergyAmesIA 50011USA

A computational search for stable structures among bothαandβphases of ternary ATB4 borides(A=Mg,Ca,sr,Ba,Al,Ga,and Zn,T is 3d or 4d transition elements)has been *** found thatα-ATB4 compounds with A=Mg,Ca,Al,and T=V,Cr,Mn,Fe,Ni,and Co form a family of structurally.stable or almost stable *** systems are metallic in non-magnetic states and characterized by the formation of the localized molecular-like state of 3d transition metal atom dimers,which leads to the appearance of numerous Van Hove singularities in the electronic *** closeness of such singularities to the Fermi level can be easily tuned by electron *** the atoms in the middle of the 3d row(Cr,Mn,and Fe),these singularities led to magnetic instabilities and magnetic ground states with a weakly metallic or semiconducting *** states appear as non-trivial coexistence of the different spin ladders formed by magnetic dimers of 3d *** magnetic states can be characterized as an analog of the spin glass *** attempts to produce MgFeB4 and associated challenges are discussed,and promising directions for further synthetic studies are formulated.

关键词： metallic ternary magnetic

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