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Developing macromolecular therapeutics:the future drug-of-choice

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Frontiers of Chemical Science and Engineering 2010年第1期4卷 10-17页

作者： Huining HE Weibing DONG Junbo GONG Jingkang WANG Victor C.YANG Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency Tianjin UniversityTianjin 300072China State Key Laboratory of Chemical Engineering Tianjin UniversityTianjin 300072China School of Chemical Engineering Tianjin UniversityTianjin 300072China Department of Pharmaceutical Sciences College of PharmacyUniversity of Michigan428 Church StreetAnn ArborMI 48109-1065USA

Macromolecular drugs including peptides,proteins,antibodies,polysaccharides and nucleic acids have been widely used for therapy of major diseases such as carcinoma and AIDS as well as cardiovascular and neurodegenerative disorders among other medical *** to their unmatched properties of high selectivity and efficiency,macromolecular drugs have been recognized as the drug-of-choice of the *** worldwide progress on macromolecular therapeutics still remains in the infant stage and is therefore wide open for equalground competition,R&D related to macromolecular drugs should be considered as the main point of focus in China in setting up its strategic plans in pharmaceutical *** this article,research strategies and drug delivery approaches that should be adopted to enhance the therapeutic effects of macromolecular drugs are *** addition,comments concerning how to implement such strategies to excel from competition in this challenging research field,such as the design of innovative and highly effective delivery systems of macromolecular drugs with self-owned intellectual property rights,are provided.

关键词： macromolecular drugs drug delivery systems therapeutic efficacy

Au coated 3-dimensional nanoporous titania layers using polystyrene-b-poly(2-vinylpyridine) block copolymer nanoparticles

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Au coated 3-dimensional nanoporous titania layers using poly...

Utilization of Dredged Sediments from Lumsai Canal with Rice Husks to Produce Bricks

13th Asian Chemical Congress

作者： SHIN WON-JEONG BASARIR FEVZIHAN YOON TAE-HO LEE JAE-SUK Department of Nanobio Materials and Engineering and Department of Materials Science and Engineering Gwangju Institute of Science and Technology(GIST)261 Cheomdan-gwagiro(1-Oryong-dong)

In recent years,considerable effort has been focused on easy fabrication and various applications of porous inorganic materials obtained from colloidal array as a *** this work,new nanoporous structures of Au-coated-titania layers were prepared by using amphiphilic block copolymer nanoparticles as a template.A 3-dimensional(3-D)template composed of self assembled

关键词： nanoporous 3-dimension template nanoparticle block copolymer

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Utilization of Dredged Sediments from Lumsai Canal with Rice...

Structural Study of the Silica Mesoporous Crystals with Hexagonal Close-Packed Structures

作者： W.Tangprasert S.Jaikaew N.Supakata the Department of Environmental Science Faculty of ScienceChulalongkorn University

The laboratory-scale study was conducted to assess the feasibility of using dredged sediments from Lumsai canal with rice husks to produce *** study was investigated into three different proportions of dredged sediments with rice husks ranging from 0, 5, 10, 15, and 20 percent(by weight of rice husks or rice straws) as raw materials in producing *** characteristics of the dredged sediments, rice husks, and fired bricks were analyzed using X-ray fluorescence(XRF) and X-ray diffraction(XRD), *** physical-mechanical properties of fired bricks were found to comply with the criteria for bricks(Thai Industrial Standards 77-2545).The obtained results indicated that major chemical compositions of dredged sediments were silica(SiO) 56.27 percent, alumina(AlO) 11.76 percent and iron oxide(FeO) 7.84 percent, and heavy metal contents including Cr, Cu, Zn, As, Cd, Hg, Pb, Mn, Sr, and Ni were lower than the soil quality *** of this study showed that bricks made from dredged sediments with 5 percent of rice husks were suitable as primary raw materials in the production of bricks without harmfulness.

关键词： Bricks dredged sediments rice husks

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Structural Study of the Silica Mesoporous Crystals with Hexa...

How big are the increments of G-Brownian motion?

第十七届全国分子筛学术大会

作者： Lu Han Yanhang Ma Osamu Terasaki Shunai Che School of Chemistry and Chemical Engineering State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University Graduate School of EEWS WCU KAIST 335 Gwahangno Yuseong-GuDaejeon 305-701 Republic of Korea

Pure hexagonal close-packed （hcp） mesostructure with P6 3 /mmc symmetry of silica mesoporous crystals （SMCs） has been obtained in the synthetic system of cationic gemini surfactant with the co-structure directing agent （CSDA）. Electrostatic potential distribution 3D map was reconstructed using Fourier analysis of HRTEM images based on electron crystallography and the mechanism of stabilization and favorable growth has been proposed based on synthesis strategy and symmetry support.

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Science China Mathematics 2014年第8期57卷 1687-1700页

作者： HU Feng CHEN ZengJing ZHANG DeFei School of Mathematical Sciences Qufu Normal University School of Mathematics Shandong University Department of Financial Engineering Ajou University Department of Mathematics Honghe University

In this paper,we investigate the problem:How big are the increments of G-Brownian *** obtain the Csrg and R′ev′esz’s type theorem for the increments of G-Brownian *** applications of this result,we get the law of iterated logarithm and the Erds and R′enyi law of large numbers for G-Brownian ***,it turns out that our theorems are natural extensions of the classical results obtained by Csrg and R′ev′esz(1979).

关键词：布朗运动增量 ERD EV 定理铯

Determination of the number of J/ψ events with J/ψ → inclusive decays

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Chinese Physics C 2012年第10期36卷 915-925页

作者：麦迪娜 M. N. Achasov D. J. Ambrose 安芬芬安琪安正华白景芝班勇 J. Becker N. Berger M. Bertani 边渐鸣 E. Boger O. Bondarenko I. Boyko R. A. Briere V. Bytev 蔡啸 A. Calcaterra 曹国富常劲帆 G. Chelkov 陈刚陈和生陈江川陈玛丽陈申见陈晔陈元柏程和平初元萍 D. Cronin-Hennessy 代洪亮代建平 D. Dedovich 邓子艳 A. Denig I. Denysenko M. Destefanis 丁伟民丁勇董燎原董明义杜书先方建房双世 L. Fava F. Feldbauer 封常青 R. B. Ferroli 傅成栋傅金林高原宁耿聪 K. Goetzen 龚文煊 W. Gradl M. Greco 顾旻皓顾运厅管颖慧郭爱强郭立波郭玉萍韩艳良郝喜庆 F. A. Harris 何康林何苗何振亚 T. Held 衡月昆侯治龙胡海明胡继峰胡涛黄彬黄光明黄金书黄性涛黄燕萍 T. Hussain 姬长胜纪全季晓斌季筱璐贾卢魁姜丽丽江晓山焦健斌焦铮金大鹏金山景繁凡 N. Kalantar-Nayestanaki M. Kavatsyuk W. Kuehn 赖蔚 J. S. Lange 潘振声李春花李澄李翠李德民李飞李刚李海波李家才李康李蕾李宁博李秋菊李绍莉李卫东李卫国李晓玲李小男李学潜李秀荣李志兵梁昊梁勇飞梁羽铁廖广瑞廖小涛刘北江 C. L. Liu 刘春秀刘春燕刘福虎刘芳刘峰刘虎刘宏邦刘汇慧刘怀民刘红薇刘觉平刘魁勇刘凯刘坤刘佩莲刘树彬刘翔刘晓海刘勇刘豫斌刘振安刘志强刘智青 H. Loehner 鲁公儒吕海江吕军光吕绮雯吕晓睿卢云鹏罗成林罗民兴罗涛罗小兰吕蒙马长利马凤才马海龙马秋梅马斯马天马晓妍 Y. Ma F. E. Maas M. Maggiora Q. A. Malik 毛虎冒亚军毛泽普 J. G. Messchendorp 闵建闵天觉 R. E. Mitchell 莫晓虎 C. Morales Morales C. Motzko N. Yu. Muchnoi Y. Nefedov 宁洁 I. B. Nikolaev 宁哲马鹏欧阳群 S. Pacetti 卞正烷 M. Pelizaeus 彭海平 K. Peters 平加伦平荣刚 R. Poling E. Prencipe C. S. J. Pun 祁鸣钱森乔从丰秦小帅秦瑶秦中华邱进发 K. H. Rashid 荣刚阮向东 A. Sarantsev B. D. Schaefer J. Schulze 邵明沈成平沈肖雁盛华义 M. R. Shepherd 宋新颖 S. Spataro B. Spruck 孙德辉孙功星孙俊峰孙胜森孙晓东孙勇杰孙永昭孙志嘉孙振田唐昌建唐晓 E. H. Thorndike 田浩来 D. Toth M. Ullrich G. S. Varner 王斌王博群王科王亮亮王灵淑王萌王平王佩良王强王庆娟王思广王雄飞汪晓莲王雅迪王贻芳王亚乾王铮王志刚王至勇魏代会 P. Weidenkaff 文群刚文硕频 M. Werner U. Wiedner 伍灵慧吴宁吴硕星吴蔚吴智夏力钢肖振军谢宇广修青磊许国发徐光明徐昊徐庆君徐新平徐晔许志蕊薛飞薛镇严亮鄢文标颜永红杨洪勋杨涛杨迎杨永栩叶桦叶梅叶铭汉俞伯祥喻纯旭俞洁晟于帅鹏苑长征袁文龙袁野 A. A. Zafar A. Zallo 曾云张丙新张炳云张长春张达华张宏浩章红宇张杰张金国张敬庆张家文张建勇张景芝张雷张书华张太锐张晓杰张学尧张瑶张银鸿张艳硕张子平张振宇赵光赵海升赵京伟赵凯旋赵雷赵玲赵明刚赵强赵书俊赵天池赵祥虎赵豫斌赵政国 A. Zhemchugov 郑建平郑阳恒郑志鹏钟彬 J. Zhong 周莉周晓康周小蓉朱程朱凯朱科军朱世海朱相雷朱兴旺朱亚敏朱永生朱自安庄建邹冰松邹佳恒左嘉旭 Institute of High Energy Physics G.I. Budker Institute of Nuclear Physics SB RAS (BINP) Novosibirsk 630090 Russia University of Rochester Rochester New York 14627 USA University of Science and Technology of China Peking University Bochum Ruhr-University INFN Laboratori Nazionali di Frascati University of Minnesota Minneapolis Joint Institute for Nuclear Research also at the Moscow Institute of Physics and Technology Moscow Russia KVI/University of Groningen 9747 AA Groningen The Netherlands Carnegie Mellon University Nanjing University Huangshan College University of Minnesota Minneapolis MN 55455 USA Johannes Gutenberg University of Mainz Johann-Joachim-Becher-Weg 45 55099 Mainz Germany on leave from the Bogolyubov Institute for Theoretical Physics Kiev Ukraine University of Turin and INFN Turin Italy Shandong University Liaoning University Zhengzhou University University of Piemonte Orientale and INFN (Turin) Bochum Ruhr-University 44780 Bochum Germany Tsinghua University GSI Helmholtzcentre for Heavy Ion Research GmbH D-64291 Darmstadt Germany GuangXi University Graduate University of Chinese Academy of Sciences Nankai University Nanjing Normal University University of Hawaii Honolulu Hawaii 96822 USA Huazhong Normal University Henan Normal University University of the Punjab Universitaet Giessen 35392 Giessen Germany The University of Hong Kong Pokfulam Hong Kong China Hangzhou Normal University Seoul National University Sun Yat-Sen University Sichuan University The Chinese University of Hong Kong Shatin N.T. Hong Kong China Carnegie Mellon University Pittsburgh PA 15213 USA Shanxi University Henan University of Science and Technology Luoyang 471003 China Wuhan University Lanzhou University Zhejiang University Helmholtz Institute Mainz J.J. Becherweg 45D 55099 Mainz Germany Indiana University Bloomington Indiana 47405 USA University of Perugia and INFN I-06100 Perugia Italy also at the PNPI Gatchina Russia now at Nagoya University Nagoya Japan China Center o

The number of J/ψ events collected with the BES detector at the BEPC from June 12 to July 28, 2009 is determined to be （225.3 ± 2.8） × 10^ 6 using J/ψ→inclusive events, where the uncertainty is the systematic e... 详细信息

关键词： number of J/ψ events BES detector J/ψ →inclusive events

Precision measurement of the integrated luminosity of the data taken by BESIII at center-of-mass energies between 3.810 GeV and 4.600 GeV

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Chinese Physics C 2015年第9期39卷 1-7页

作者：麦迪娜 M.N.Achasov 艾小聪 O.Albayrak M.Albrecht D.J.Ambrose A.Amoroso 安芬芬安琪白景芝 R.Baldini Ferroli 班勇 D.W.Bennett J.V.Bennett M.Bertani D.Bettoni 边渐鸣 F.Bianchi E.Boger O.Bondarenko I.Boyko R.A.Briere 蔡浩蔡啸 O.Cakir A.Calcaterra 曹国富 S.A.Cetin 常劲帆 G.Chelkov 陈刚陈和生陈海云陈江川陈玛丽陈申见谌炫陈旭荣陈元柏程和平褚新坤 G.Cibinetto D.Cronin-Hennessy 代洪亮代建平 A.Dbeyssi D.Dedovich 邓子艳 A.Denig I.Denysenko M.Destefanis F.De Mori 丁勇董超董静董燎原董明义杜书先段鹏飞范荆州方建房双世方馨方易 L.Fava F.Feldbauer G.Felici 封常青 E.Fioravanti M.Fritsch 傅成栋高清高原宁高榛 I.Garzia 耿聪 K.Goetzen 龚文煊 W.Gradl M.Greco 顾旻皓顾运厅管颖慧郭爱强郭立波郭玥 Y.P.Guo Z.Haddadi A.Hafner 韩爽韩艳良郝喜庆 F.A.Harris 何康林何振亚 T.Held 衡月昆侯治龙胡琛胡海明胡继峰胡涛胡誉黄光明黄光顺黄海鹏黄金书黄性涛黄勇 T.Hussain 纪全姬清平季晓斌季筱璐姜丽丽姜鲁文江晓山焦健斌焦铮金大鹏金山 T.Johansson A.Julin N.Kalantar-Nayestanaki 康晓琳康晓珅 M.Kavatsyuk B.C.Ke R.Kliemt B.Kloss O.B.Kolcu B.Kopf M.Kornicer W.Kuehn A.Kupsc 赖蔚 J.S.Lange M.Lara P.Larin C.Leng 李春花李澄李德民李飞李刚李海波李家才李瑾李康李科李蕾李培荣李腾李卫东李卫国李晓玲李小梅李小男李学潜李志兵梁昊梁勇飞梁羽铁廖广睿 D.X.Lin(Lin) 刘北江刘春秀刘福虎刘芳刘峰刘宏邦刘汇慧刘欢欢刘怀民刘杰刘觉平刘晶译刘凯刘魁勇刘兰雕刘佩莲刘倩刘树彬刘翔刘晓霞刘玉斌刘振安刘志强 Zhiqing Liu H.Loehner 娄辛丑吕海江吕军光鲁睿其卢宇卢云鹏罗成林罗民兴 T.Luo 罗小兰吕蒙吕晓睿马凤才马海龙马连良马秋梅马斯马天马旭宁马晓妍 F.E.Maas M.Maggiora Q.A.Malik 冒亚军毛泽普 S.Marcello J.G.Messchendorp 闵建闵天觉 R.E.Mitchell 莫晓虎莫玉俊 C.Morales Morales K.Moriya N.Yu.Muchnoi H.Muramatsu Y.Nefedov F.Nerling I.B.Nikolaev 宁哲 S.Nisar 牛顺利牛讯伊馬鵬欧阳群 S.Pacetti P.Patteri M.Pelizaeus 彭海平 K.Peters 平加伦平荣刚 R.Poling 濮亚男祁鸣钱森乔从丰秦丽清覃拈秦小帅秦瑶秦中华邱进发 K.H.Rashid C.F.Redmer 任海龙 M.Ripka 荣刚阮向东 V.Santoro A.Sarantsev M.Savrié K.Schoenning S.Schumann 单葳邵明沈成平沈培迅沈肖雁盛华义宋维民宋欣颖 S.Sosio S.Spataro 孙功星孙俊峰孙胜森孙勇杰孙永昭孙志嘉孙振田唐昌建唐晓 I.Tapan E.H.Thorndike M.Tiemens D.Toth M.Ullrich I.Uman G.S.Varner 王斌王滨龙王东王大勇王科王亮亮王灵淑王萌王平王佩良王庆娟王思广王炜王雄飞王雅迪王贻芳王亚乾王铮王志刚王志宏王至勇 T.Weber 魏代会韦江波 P.Weidenkaff 文硕频 U.Wiedner M.Wolke 伍灵慧吴智夏力钢夏宇肖栋肖振军谢宇广修青磊许国发徐雷徐庆君徐庆年徐新平严亮鄢文标闫文成颜永红杨洪勋杨柳杨迎杨永栩叶桦叶梅叶铭汉殷俊昊俞伯祥喻纯旭于海旺俞洁晟苑长征袁文龙袁野 A.Yuncu A.A.Zafar A.Zallo 曾云张丙新张炳云张驰张长春张达华张宏浩章红宇张佳佳张杰磊张 Institute of High Energy Physics G.I.Budker Institute of Nuclear Physics SB RAS (BINP) the Novosibirsk State University Carnegie Mellon University Bochum Ruhr-University University of Rochester Rochester University of Turin INFN University of Science and Technology of China INFN Laboratori Nazionali di Frascati Peking University Indiana University INFN Sezione di Ferrara University of Minnesota Joint Institute for Nuclear Research the Moscow Institute of Physics and Technology KVI-CART University of Groningen Wuhan University Istanbul Aydin University Ankara University Dogus University the Functional Electronics Laboratory Tomsk State University Beihang University Nanjing University Lanzhou University Huangshan College Shanghai Jiao Tong University Helmholtz Institute Mainz Johannes Gutenberg University of Mainz Liaoning University Nankai University Zhengzhou University Tsinghua University University of Eastern Piedmont GSI Helmholtzcentre for Heavy Ion Research GmbH Guang Xi University Nanjing Normal University Henan Normal University University of Hawaii Central China Normal University Shandong University University of the Punjab Uppsala University Currently at Istanbul Arel University Justus Liebig University Giessen II.Physikalisches Institut Seoul National University Hangzhou Normal University Beijing Institute of Petrochemical Technology University of Chinese Academy of Sciences Sun Yat-Sen University Sichuan University Guangxi Normal University Shanxi University Henan University of Science and Technology University of Texas at Dallas Hunan University Zhejiang University COMSATS Institute of Information Technology INFN and University of Perugia the NRC "Kurchatov Institute" University of Ferrara Uludag University Soochow University China Center of Advanced Science and Technology Bogazici University University of South China

From December 2011 to May 2014, about 5 fb^-1 of data were taken with the BESIII detector at center-of- mass energies between 3.810 GeV and 4.600 GeV to study the charmonium-like states and higher excited charmonium states. The time-integrated luminosity of the collected data sample is measured to a precision of 1% by analyzing events produced by the large-angle Bhabha scattering process.

关键词： precision measurement luminosity Bhabha scattering charmonium

Evidence for e^+e^-→γχ_(c1,2) at center-of-mass energies from 4.009 to 4.360 GeV

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Chinese Physics C 2015年第4期39卷 1-9页

作者：麦迪娜 M.N.Achasov 艾小聪 O.Albayrak M.Albrecht D.J.Ambrose A.Amoroso 安芬芬安琪白景芝 R.Baldini Ferroli 班勇 D.W.Bennett J.V.Bennett M.Bertani D.Bettoni 边渐鸣 F.Bianchi E.Boger O.Bondarenko I.Boyko R.A.Briere 蔡浩蔡啸 O.Cakir A.Calcaterra 曹国富 S.A.Cetin 常劲帆 G.Chelkov 陈刚陈和生陈海云陈江川陈玛丽陈申见谌炫陈旭荣陈元柏程和平褚新坤 G.Cibinetto D.Cronin-Hennessy 代洪亮代建平 A.Dbeyssi D.Dedovich 邓子艳 A.Denig I.Denysenko M.Destefani F.De Mori 丁勇董超董静董燎原董明义杜书先段鹏飞范荆州方建房双世方馨方易 L.Fava F.Feldbauer G.Felici 封常青 E.Fioravanti M.Fritsch 傅成栋高清高原宁高榛 I.Garzia K.Goetzen 龚文煊 W.Gradl M.Greco 顾旻皓顾运厅管颖慧郭爱强郭立波郭墩郭玥 Y.P.Guo Z.Haddadi A.Hafner 韩爽韩艳良 F.A.Harris 何康林何振亚 T.Held 衡月昆侯治龙胡琛胡海明胡继峰胡涛胡誉黄光明黄光顺黄海鹏黄金书黄性涛黄勇 T.Hussain 纪全姬清平季晓斌季筱璐姜丽丽姜鲁文江晓山焦健斌焦铮金大鹏金山 T.Johansson A.Julin N.Kalantar-Nayestanaki 康晓琳康晓珅 M.Kavatsyuk B.C.Ke R.Kliemt B.Kloss O.B.Kolcu B.Kopf M.Kornicer W.Kuehn A.Kupsc 赖蔚 J.S.Lange M.Lara P.Larin 李春花李澄李德民李飞李刚李海波李家才李瑾李康李科李培荣李腾李卫东李卫国李晓玲李小梅李小男李学潜李志兵梁昊梁勇飞梁羽铁廖广睿 Lin 刘北江 C.L.Liu 刘春秀刘福虎刘芳刘峰刘宏邦刘汇慧刘欢欢刘怀民刘杰刘觉平刘晶译刘凯刘魁勇刘兰雕刘佩莲刘倩刘树彬刘翔刘晓霞刘玉斌刘振安刘志强 Zhiqiang Liu H.Loehner 娄辛丑吕海江吕军光鲁睿其卢宇卢云鹏罗成林罗民兴 T.Luo 罗小兰吕蒙吕晓睿马凤才马海龙马连良马秋梅马斯马天马旭宁马骁妍 F.E.Maas M.Maggiora Q.A.Malik 冒亚军毛泽普 S.Marcello J.G.Messchendorp 闵建闵天觉 R.E.Mitchell 莫晓虎莫玉俊 C.Morales Morale K.Moriya N.Yu.Muchnoi H.Muramatsu Y.Nefedov F.Nerling I.B.Nikolaev 宁哲 S.Nisar 牛顺利牛讯伊马鹏欧阳群 S.Pacetti P.Patteri M.Pelizaeus 彭海平 K.Peters 平加伦平荣刚 R.Poling 濮亚男祁鸣钱森乔从丰秦丽清覃拈秦小帅秦瑶秦中华邱进发 K.H.Rashid C.F.Redmer 任海龙 M.Ripka 荣刚阮向东 V.Santoro A.Sarantsev M.Savrié K.Schoenning S.Schumann 单葳邵明沈成平沈培迅沈肖雁盛华义 M.R.Shepherd 宋维民宋欣颖 S.Sosio S.Spataro B.Spruck 孙功星孙俊峰孙胜森孙勇杰孙永昭孙志嘉孙振田唐昌建唐晓 I.Tapan E.H.Thorndike M.Tiemens D.Toth M.Ullrich I.Uman G.S.Varner 王斌王滨龙王东王大勇王科王亮亮王灵淑王萌王平王佩良王庆娟王思广王炜王雄飞 Yadi 王贻芳王亚乾王铮王志刚王志宏王至勇 T.Weber 魏代会韦江波 P.Weidenkaff 文硕频 U.Wiedner M.Wolke 伍灵慧吴智夏力钢夏宇肖栋肖振军谢宇广许国发徐雷徐庆君徐庆年徐新平严亮鄢文标闫文成颜永红杨洪勋杨柳杨迎杨永栩叶桦叶梅叶铭汉殷俊昊俞伯祥喻纯旭于海旺俞洁晟苑长征袁文龙袁野 A.Yuncu A.A.Zafar A.Zallo 曾云张丙新张炳云张驰张长春张达华张宏浩章红宇张佳佳张杰 Institute of High Energy Physics Chinese Academy of Sciences G.I. Budker Institute of Nuclear Physics SB RAS (BINP) the Novosibirsk State University Carnegie Mellon University Bochum Ruhr-University University of Rochester University of Turin INFN University of Science and Technology of China INFN Laboratori Nazionali di Frascati Peking University Indiana University INFN Sezione di Ferrara University of Minnesota Joint Institute for Nuclear Research the Moscow Institute of Physics and Technology KVI-CART University of Groningen Wuhan University Istanbul Aydin University Ankara University Dogus University the Functional Electronics Laboratory Tomsk State University Beihang University Nanjing University Lanzhou University Huangshan College Shanghai Jiao Tong University Helmholtz Institute Mainz Johannes Gutenberg University of Mainz Liaoning University Nankai University Zhengzhou University Tsinghua University University of Eastern Piedmont GSI Helmholtzcentre for Heavy Ion Research Gmb H D-64291 Darmstadt Germany Guangxi University Nanjing Normal University University of Hawaii Central China Normal University Henan Normal University Shandong University University of the Punjab Uppsala University Currently at Istanbul Arel University Justus Liebig University Giessen Ⅱ. Physikalisches Institut Seoul National University Hangzhou Normal University University of Chinese Academy of Sciences Sun Yat-Sen University Sichuan University Guangxi Normal University Shanxi University Henan University of Science and Technology University of Texas at Dallas Hunan University Zhejiang University COMSATS Institute of Information Technology INFN and University of Perugia GSI Helmholtzcentre for Heavy Ion Research Gmb H the PNPI University of Ferrara Indiana University Bloomington Uludag University Soochow University China Center of Advanced Science and Technology Bogazici University University of South China

Using data samples collected at center-of-mass energies of √s=4.009, 4.230, 4.260, and 4.360 GeV with the BES0 detector operating at the BEPC/ collider, we perform a search for the process e＋e-→γχc,j （J =0, 1, 2） and find evidence for e＋e-→γχc1 and e＋e-→γχc2 with statistical significances of 3.0σ and 3.4σ, respectively. The Born cross sections σB（e＋e-→γχc,j）, as well as their upper limits at the 90% con dence level （C.L.） are determined at each center-of-mass energy.

关键词： heavy quarkonia decays of hadronic electron-positron collisions hadron production by

Hepatitis E virus infection: Epidemiology and treatment implications

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World Journal of Virology 2015年第4期4卷 343-355页

作者： Ga Young Lee Kittiyod Poovorawan Duangnapa Intharasongkroh Pattaratida Sa-nguanmoo Sompong Vongpunsawad Chintana Chirathaworn Yong Poovorawan Department of Clinical Tropical Medicine Faculty of Tropical Medicine Mahidol University Center of Excellence in Clinical Virology Department of Pediatrics Faculty of Medicine Chulalongkorn University National Blood Centre Thai Red Cross Society Department of Microbiology Faculty of Medicine Chulalongkorn University

Hepatitis E virus(HEV) infection is now established as an emerging enteric viral hepatitis. Standard treatments in acute and chronic hepatitis E remain to be established. This study undertakes a review of the epidemiology, treatment implication and vaccine prevention from published literature. HEV infection is a worldwide public health problem and can cause acute and chronic hepatitis E. HEV genotypes 1 and 2 are primarily found in developing countries due to waterborne transmission, while the zoonotic potential of genotypes 3 and 4 affects mostly industrialized countries. An awareness of HEV transmission through blood donation, especially in the immunocompromised and solid organ transplant patients, merits an effective anti-viral therapy. There are currently no clear indications for the treatment of acute hepatitis E. Despite concerns for side effects, ribavirin monotherapy or in combination with pegylatedinterferon alpha for at least 3 mo appeared to show significant efficacy in the treatment of chronic hepatitis E. However, there are no available treatment options for specific patient population groups, such as women who are pregnant. Vaccination and screening of HEV in blood donors are currently a global priority in managing infection. New strategies for the treatment and control of hepatitis E are required for both acute and chronic infections, such as prophylactic use of medications, controlling large outbreaks, and finding acceptable antiviral therapy for pregnant women and other patient groups for whom the current options of treatment are not viable.

关键词： Treatments Blood donors Adverse effects Vaccination Pegylated-interferon Ribavirin Hepatitis E