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The anti-neoplastic activities of aloperine in HeLa cervical cancer cells are associated with inhibition of the IL-6-JAK1-STAT3 feedback loop

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Chinese Journal of Natural Medicines 2021年第11期19卷 815-824页

作者： CHEN Yao-Dong CAI Fang-Yu MAO Yu-Ze YANG Yong-Sheng XU Kun LIU Xiao-Fang FAN Wen-Wen CHEN Wu JIANG Feng-Qi ZHANG Hui Department of Ultrasonic Imaging the First Hospital of Shanxi Medical UniversityTaiyuan 030001China Department of Radiology the First Clinical Medical CollegeShanxi Medical UniversityTaiyuan 030001China Department of Thoracic Surgery the General Hospital of Heilongjiang Province Land Reclamation BureauHarbin 150088China Department of Cardio-Thoracic Surgery the First Affiliated Hospital of Jiamusi UniversityJiamusi 154000China Department of General Surgery Heilongjiang Provincial HospitalHarbin 150001China

Cervical cancer(CC)is recognized as the most common neoplasm in the female reproductive system *** lack of chemotherapeutic agents with outstanding effectiveness and safety severely compromises the anti-cipated prognosis of ***(ALO)is a natural quinolizidine alkaloid with marked anti-cancer effects on multiple malignancies as well as favorable activity in relieving inflammation,allergies and ***,its therapeutic efficacy and underlying mechanism in CC are still *** the current study,MTT assay was employed to evaluate the viability of HeLa cells exposed to ALO to preliminarily estimate the effectiveness of ALO in ***,the effects of ALO on the proliferation and apoptosis of HeLa cells were further investigated by plate colony formation and flow cytometry,respectively,while the migration and invasion of ALO-treated HeLa cells were evaluated using Transwell ***,nude mice were subcutaneously inoculated with HeLa cells to demonstrate the anti-CC properties of ALO in *** molecular mechanisms underlying these effects of ALO were evaluated by Western blot and immunohistochemical *** study experimentally demonstrated that ALO inhibited the proliferation of HeLa cells via G2 phase cell cycle ***,ALO promoted an increase in the percentage of apoptotic HeLa cells by increasing the Bax/Bcl-2 ***,the migration and invasion of HeLa cells were attenuated by ALO treatment,which was considered to result from inhibition of epithelial-to-mesenchymal *** molecular mechanisms,the expression and activation of the IL-6-JAK1-STAT3 feedback loop were markedly suppressed by ALO *** study indicated that ALO markedly suppresses the proliferation,migration and invasion and enhances the apoptosis of HeLa *** addition,these prominent anti-CC properties of ALO are associated with repression of the IL-6-JAK1-STAT3 feedback loop.

关键词： Cervical cancer Chemotherapy Aloperine Epithelial-mesenchymal transition IL-6-JAK1-STAT3 feedback loop

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Geometric Mean Maximum FSVMI Model and Its Application in Carotid Artery Stenosis Risk Prediction

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Chinese Journal of Electronics 2021年第5期30卷 824-832页

作者： ZHANG Xueying GUO Yuling LI Fenglian WEI Xin HU Fengyun HUI Haisheng JIA Wenhui College of Information and Computer Taiyuan University of Technology Department of Neurology Shanxi Province People's Hospital

Carotid artery stenosis is a serious medical condition that can lead to stroke. Using machine learning method to construct classifier model, carotid artery stenosis can be diagnosed with transcranial doppler data. We propose an improved fuzzy support vector machine model to predict carotid artery stenosis, with the maximum geometric mean as the optimization *** fuzzy membership function is obtained by combining information entropy with the normalized class-center distance. Experimental results showed that the proposed model was superior to the benchmark models in sensitivity and geometric mean criteria.

关键词： blood vessels machine learning method fuzzy set theory improved fuzzy support vector machine model pattern classification geometric mean maximum FSVMI model maximum geometric mean classifier model support vector machines carotid artery stenosis risk prediction geometric mean criteria learning (artificial intelligence) entropy

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RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition

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World Journal of Gastroenterology 2025年第2期31卷 113-127页

作者： Peng-Yu Chen Pei-Yao Wang Bang Liu Yang-Pu Jia Zhao-Xiong Zhang Xin Liu Dao-Han Wang Yong-Jia Yan Wei-Hua Fu Feng Zhu Department of General Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Department of General Surgery Jincheng People’s HospitalJincheng 048000Shanxi ProvinceChina

BACKGROUND Regulator of G protein signaling(RGS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric G *** speci-fic effect of RGS,particularly RGS4,on the progression of gastric cancer(GC)is not yet *** To explore the role and underlying mechanisms of action of RGS4 in GC *** The prognostic significance of RGS4 in GC was analyzed using bioinformatics based public databases and verified by immunohistochemistry and quantitative polymerase chain reaction in 90 patients with *** assays were employed to assess the carcinogenic impact of RGS4,and the mechanism of its possible influence was detected by western blot analysis.A nude mouse xenograft model was established to study the effects of RGS4 on GC growth in *** RGS4 was highly expressed in GC tissues compared with matched adjacent normal *** RGS4 expression was correlated with increased tumor-node-metastasis stage,increased tumor grade as well as poorer overall survival in patients with *** experiments demonstrated that RGS4 knockdown suppressed GC cell proliferation,migration and ***,xenograft experiments confirmed that RGS4 silencing significantly inhibited tumor ***,RGS4 knockdown resulted in reduced phosphorylation levels of focal adhesion kinase,phosphatidyl-inositol-3-kinase,and protein kinase B,decreased vimentin and N-cadherin,and elevated *** High RGS4 expression in GC indicates a worse prognosis and RGS4 is a prognostic ***4 influences tumor progression via the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition.

关键词： Gastric cancer Prognosis Regulator of G protein signaling 4 Focal adhesion kinase Epithelial-mesenchymal transition

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Spatial Heterogeneity and Risk Factors of Dental Caries in 12-Year-Old Children in shanxi Province,China

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Biomedical and Environmental Sciences 2024年第10期37卷 1173-1183页

作者： Ruxia Hou Tingting Yang Jiajia Liu Hao Chen Wen Kang Junming Li Xiaotong Shi Yi Liang Junyu Liu Bin Zhao Xiangyu Wang shanxi Medical University School and Hospital of Stomatology Taiyuan 030001ShanxiChina shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials Taiyuan 030001ShanxiChina School of Statistics Shanxi University of Finance and EconomicsTaiyuan 030006ShanxiChina

Objective This study aimed to explore the spatial heterogeneity and risk factors for dental caries in 12-year-old children in shanxi province,*** The data encompassed 3,721 participants from the two most recent oral health surveys conducted across 16 districts in shanxi Province in 2015 and *** specific variables were analyzed to examine the interplay between socioeconomic factors,medical resources and environmental *** Geo-detector model was employed to assess the impacts and interactions of these ecological *** Socioeconomic factors(Q=0.30,Pshanxi Province,China,influenced by socioeconomic factors,medical resources,and environmental conditions to varying extents.

关键词： Caries Socioeconomic factors Natural environment Oral health services Spatial heterogeneity analysis Risk factors

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Nucleus-targeting orange-emissive carbon dots delivery adriamycin for enhanced anti-liver cancer therapy

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Chinese Chemical Letters 2024年第6期35卷 421-426页

作者： Qiang Li Jiangbo Fan Hongkai Mu Lin Chen Yongzhen Yang Shiping Yu The Second Hospital of shanxi Medical University Taiyuan 030001China shanxi Medical University Taiyuan 030001China Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of EducationTaiyuan University of TechnologyTaiyuan 030024China shanxi-Zheda Institute of Advanced Materials and Chemical Engineering Taiyuan 030032China

Carbon dots(CDs)with precise targeting function show great potential in the field of drug delivery *** this study,the functionalized nucleus-targeting orange-emissive CDs with nuclear localization sequence(NLS)were loaded with adriamycin(DOX)to obtain a nucleus-targeting orange-emissive CDs drug delivery system(CDs-NLS-DOX),which delivered DOX to tumor cell nuclei to enhance its anti-tumor *** drug carrier orange-emissive CDs showed excitation-independent behavior,stable and enhanced imaging capability and good biocompatibility in vitro and in ***,the CDs-NLS could target the nuclei efficiently,and the CDs-NLS-DOX complexes had a high drug loading rate(59.4%)after loading DOX,exhibiting p H-dependent DOX release behavior through breaking acylhydrazone bond in a weak acidic *** addition,the CDs-NLS-DOX complexes exhibited an enhanced killing activity against human hepatoma cells(HepG2).The in vivo therapeutic effects on HepG2 nude mice transplanted tumors indicated the CDs-NLS-DOX had a stronger ability to inhibit tumor growth compared to free *** short,CDs-NLS-DOX is expected to be a precise and efficient nucleus-targeting nano-drug delivery system for tumor treatment.

关键词： Carbon dots Nucleus-targeting Adriamycin Drug delivery system Liver cancer therapy

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Mediating function of heart failure in the causal relationship between diastolic blood pressure and hypertensive renal disease with renal failure:a mediated Mendelian randomization study

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Frontiers of Nursing 2024年第3期11卷 285-294页

作者： Lei Pang Zi-Jun Ding Hong-Qiang Chai Fei Li Ming Wu Wei-Bing Shuang Department of Urology The Fifth Hospital of Shanxi Medical University(Shanxi Provincial People’s Hospital)TaiyuanShanxi 030012China First Clinical Medical College of shanxi Medical University TaiyuanShanxi 030012China Department of Neonatology Shanxi Children’s HospitalTaiyuanShanxi 030013China Department of Urology The First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030012China

Objective:To study the causality relationship between diastolic blood pressure(DBP)and hypertensive renal disease with renal failure(HRDRF)and the mediating role of hear t failure(HF)in the causality relationship by network Mendelian randomization(MR).Methods:Genome-wide analysis of DBP,HRDRF,and HF was downloaded from the public database(Genome-Wide Analysis Study[GWAS])and was used to analyze the results and to conduct mediated MR ***:Analysis showed that DBP was positively correlated with HRDRF(OR=1.0002,95%CI:1.0001–1.0003,P=1.8076e-05)and DBP was positively correlated with HF(OR=1.0295,95%CI:1.0221–1.0370,P=2.5292e-15).HF and HRDRF had a positive causal effect(OR=1.0001,95%CI:1.0000–1.0001,P=0.0152).Mediation analysis showed that the contribution ratio of HF to the combined effect of DBP and HRDRF was 24.69%.Conclusions:DBP can increase the risk of renal disease with renal failure,and HF may play an impor tant role in mediating this causal relationship.

关键词： atherosclerotic heart disease diastolic blood pressure heart arrhythmia heart failure hypertensive renal disease with renal failure Mendelian randomization

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Visualization analysis of the study of fund-sponsored clinical nursing papers

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Frontiers of Nursing 2018年第2期5卷 127-137页

作者： Xi Tan Jin-Lian Cheng Yu-Jiao Li School of Nursing Shanxi Medical UniversityTaiyuanShanxi 030001 China First Hospital of shanxi Medical University TaiyuanShanxi 030001China

Objective： The aims of this study were to understand the status quo of authors, collaborations between institutions, research hotspots, and research frontiers of fund-sponsored clinical nursing papers and to provide a reference for Chinese scholars to conduct clinical nursing studies in the ***： The visualization software CiteSpace was used to analyze fund-sponsored clinical nursing papers published between 2012 and 2016 in 12 core journals of ***： In the clinical nursing field, there are many co叩erative author groups; however, the collaborations between institu加 not close and exist mainly within the same province or city. High-frequency keywords have revealed the four clinical nursing research hotspots of population, diseases, nursing intervention, and others. Chinese medicine nursing, prevention, treatment and nursing, and new technology-aided nursing of ventilator-associated pneumonia are the study frontiers of clinical ***： Clinical nursing studies are rich in content and cover a wide range of areas, and their hotspots and frontiers are closely related to the requirements of clinical nursing. Collaborations across regions, provinces, and cities are not adequate; there is an urgent need to strengthen the cross-regional exchanges and collaborations to promote the further development of clinical nursing.

关键词： clinical nursing fund-sponsored papers CiteSpace visualization analysis research hotspot research frontiers

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Successful leadless pacemaker implantation in a patient with dextroversion of the heart:A case report

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World Journal of Clinical Cases 2023年第33期11卷 8089-8093页

作者： Na Li Hai-Xiong Wang Yue-Hui Sun Yan Shu Department of Cardiology Shanxi Cardiovascular HospitalTaiyuan 030000Shanxi ProvinceChina

BACKGROUND Dextroversion is defined as the presence of dextrocardia with situs solitus,dextroloop ventricles,and normally related great *** can pose technical challenges when interventional treatments are ***,the challenges posed by dextroversion can be amplified due to the disruption of typical anatomical relationships,the unpredictable positioning and boundaries of cardiac structures resulting from the shift,and the pathological processes influencing *** SUMMARY A 73-year-old woman with cardiac dextroversion suffered from a recurrence of atrial fibrillation after her radiofrequency catheter ablation and Despite the cessation of antiarrhythmic medications,there were episodes of sinus pauses and symptomatic bradycardia,with heart rates dropping as low as 28 beats per *** Dextroversion makes the implantation of leadless pacemakers more challenging,and appropriate adjustments in fluoroscope angles may be crucial for intracardiac ***,when advancing delivery systems,attention should be paid to rotational direction during valve-crossing procedures;changes in the perspective of posture angle between normal cardiac position and dextroversion can serve as references.

关键词： Leadless pacemaker Dextroversion Pacemaker implantation Case report

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Forecast of peak infection and estimate of excess deaths in COVID-19 transmission and prevalence in Taiyuan City,2022 to 2023

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Infectious Disease Modelling 2024年第1期9卷 56-69页

作者： Jia-Lin Wang Xin-Long Xiao Fen-Fen Zhang Xin Pei Ming-Tao Li Ju-Ping Zhang Juan Zhang Gui-Quan Sun Complex Systems research Center Shanxi UniversityTaiyuan030006China School of Mathematical Sciences Shanxi UniversityTaiyuan030006China School of Mathematics North University of ChinaTaiyuan030051China College of Mathematics Taiyuan University of TechnologyTaiyuan030024China Complex Systems and Data Science Key Laboratory of Ministry of Education Taiyuan030006China

In this paper,with the method of epidemic dynamics,we assess the spread and prevalence of COVID-19 after the policy adjustment of prevention and control measure in December 2022 in Taiyuan City in China,and estimate the excess population deaths caused by *** on the transmission mechanism of COVID-19 among individuals,a dynamic model with heterogeneous contacts is established to describe the change of control measures and the population's social behavior in Taiyuan *** model is verified and simulated by basing on reported case data from November 8th to December 5th,2022 in Taiyuan city and the statistical data of the questionnaire survey from December 1st to 23rd,2022 in Neijiang *** with reported numbers of permanent residents and deaths from 2017 to 2021 in Taiyuan city,we apply the dynamic model to estimate theoretical population of 2022 under the assumption that there is no effect of *** addition,we carry out sensitivity analysis to determine the propagation character of the Omicron strain and the effect of the control *** a result of the study,it is concluded that after adjusting the epidemic policy on December 6th,2022,three peaks of infection in Taiyuan are estimated to be from December 22nd to 31st,2022,from May 10th to June 1st,2023,and from September 5th to October 13th,2023,and the corresponding daily peaks of new cases can reach 400000,44000 and 22000,*** the end of 2022,excess deaths can range from 887 to 4887,and excess mortality rate can range from 3.06%to 14.82%.The threshold of the infectivity of the COVID-19 variant is estimated 0.0353,that is if the strain infectivity is above it,the epidemic cannot be control with the previous normalization measures.

关键词： Taiyuan city COVID-19 Dynamic model Epidemic scale Epidemic peak Excess death

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Assessing the effectiveness of the intervention measures of COVID-19 in China based on dynamical method

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Infectious Disease Modelling 2023年第1期8卷 159-171页

作者： Xiaomeng Wei Mingtao Li Xin Pei Zhiping Liu Juan Zhang Complex Systems research Center Shanxi University030006ShanxiChina shanxi Key Laboratory of Mathematical Techniques and Big Data Analysis on Disease Control and Prevention 030006ShanxiChina School of Mathematical Sciences Shanxi University030006ShanxiChina College of Mathematics Taiyuan University of Technology030024ShanxiChina School of Data Science and Technology North University of China030051ShanxiChina

Normalized interventions were implemented in different cities in China to contain the outbreak of COVID-19 before December ***,the differences in the intensity and timeliness of the implementations lead to differences in final size of the *** the outbreak of COVID-19 in three representative cities Xi'an,Zhengzhou and Yuzhou in January 2022,as examples,we develop a compartmental model to describe the spread of novel coronavirus and implementation of interventions to assess concretely the effectiveness of Chinese interventions and explore their impact on epidemic *** applying reported human confirmed cases to verify the rationality of the model,we apply the model to speculate transmission trend and length of concealed period at the initial spread phase of the epidemic(they are estimated as 10.5,7.8,8.2 days,respectively),to estimate the range of basic reproduction number(2.9,0.7,1.6),and to define two indexes(transmission rate vt and controlled rate vc)to evaluate the overall effect of the *** is shown that for Zhengzhou,vc is always more than v t with regular interventions,and Xi'an take 8 days to achieve vc>v t twice as long as Yuzhou,which can interpret the fact that the epidemic situation in Xi'an was more *** carrying out parameter values,it is concluded that in the early stage,strengthening the precision of close contact tracking and frequency of large-scale nucleic acid testing of non-quarantined population are the most effective on controlling the outbreaks and reducing final ***,if the close contact tracking strategy is sufficiently implemented,at the late stage largescale nucleic acid testing of non-quarantined population is not essential.

关键词： COVID-19 Close contact tracking Large-scale nucleic acid testing Dynamics The basic reproduction number Sensitivity analysis

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