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Glycyrrhiza uralensis flavonoids inhibit brain microglial cell TNF-α secretion,p-IκB expression,and increase brain-derived neurotropic factor(BDNF)secretion

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Journal of Traditional Chinese Medical Sciences 2014年第1期1卷 28-37页

作者： Sangita P.Patil Changda Liu Joseph Alban Nan Yang Xiu-Min Li Department of Pediatrics Division of Pediatric Allergy and ImmunologyJaffe Food Allergy InstituteCenter for Integrative Medicine for Allergies and WellnessIcahn School of Medicine at Mount Sinai1425 Madison AvenueBox 1089New YorkNY 10029-6574USA

Objective:Asthma sufferers exhibit high prevalence of anxiety/*** tumor-necrosis factor-alpha(TNF-α)levels in peripheral system and central nervous system(CNS)are associated with anxiety/depression,whereas brain-derived neurotropic factor(BDNF)has anti-depressant *** anti-asthma herbal medicine intervention ASHMI inhibits peripheral TNF-αsecretion in an animal model of *** hypothesize that ASHMI and its compounds may have modulatory effects on CNS TNF-αand BDNF *** sought to determine the effect of ASHMI and individual herb constituents on brain microglial cell TNF-αproduction,and identify the active compounds that suppress TNF-αand increase ***:BV-2 mouse microglial cells were pre-treated with ASHMI or extracts of Ganoderma lucidum(***),Sophora flavescens Ait(***),and Glycyrrhiza uralensis Fischer(***),the herbal constituents in ASHMI,or individual compounds isolated from *** at different concentrations and then stimulated with ***-αlevels in culture supernatants were measured by *** effect of active compounds on NFkB signaling pathway and on BDNF production were determined by western blotting and ELISA,***:ASHMI produced dose-dependent inhibition of TNF-αsecretion by cultured-mousemicroglia BV2 *** the three herb extracts in ASHMI,only *** significantly and dosedependently inhibited TNF-α*** the 5 flavonoids isolated from ***,isoliquiritigeninwas themost *** suppression of TNF-αproduction was associated with attenuation of p-NF-kB expression,andwas accompanied by increased BDNF ***:ASHMI and its effective flavonoid,isoliquiritigenin,inhibited TNF-αproduction by LPS stimulatedmicroglial cells and elevated BDNF levels,which may prove to have anti-CNS inflammatory and anti-anxiety effects.

关键词： Anti-asthma herbal medicine intervention Anxiety and asthma Flavonoids TNF-α BDNF

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