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EZH2-dependent myelination following sciatic nerve injury

Neural Regeneration Research 2025年第8期20卷 2382-2394页

作者： Hui Zhu Li Mu Xi Xu Tianyi Huang Ying Wang Siyuan Xu Yiting Wang Wencong Wang Zhiping Wang Hongkui Wang Chengbin Xue Research Center of Clinical Medicine Affiliated Hospital of Nantong UniversityKey Laboratory of Neuroregeneration of Jiangsu and Ministry of EducationCo-innovation Center of NeuroregenerationNMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology ProductsNantong UniversityNantongJiangsu ProvinceChina Medical School of nantong University NantongJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Rehabilitation Medicine Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Critical Care Medicine Nantong Fourth People’s HospitalNantongJiangsu ProvinceChina

Demyelination and remyelination have been major focal points in the study of peripheral nerve regeneration following peripheral nerve ***,the gene regulatory network of regenerated myelin differs from that of native *** of enhancer of zeste homolog 2(EZH2)hinders the differentiation,maturation,and myelination of Schwann cells in *** further determine the role of EZH2 in myelination and recovery post-peripheral nerve injury,conditional knockout mice lacking Ezh2 in Schwann cells(Ezh2^(fl/fl);Dhh-Cre and Ezh2^(fl/fl);Mpz-Cre)were *** results show that a significant proportion of axons in the sciatic nerve of Ezh2-depleted mice remain *** highlights the crucial role of Ezh2 in initiating Schwann cell ***,we observed that 21 days after inducing a sciatic nerve crush injury in these mice,most axons had remyelinated at the injury site in the control nerve,while Ezh2^(fl/fl);Mpz-Cre mice had significantly fewer remyelinated axons compared with their wild-type *** suggests that the absence of Ezh2 in Schwann cells impairs myelin formation and *** conclusion,EZH2 has emerged as a pivotal regulatory factor in the process of demyelination and myelin regeneration following peripheral nerve *** EZH2 activity during these processes may offer a promising therapeutic target for the treatment of peripheral nerve injuries.

关键词： demyelination EZH2 myelination peripheral nerve injury PRC2 remyelination Schwann cells sciatic nerve crush sciatic nerve transection

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A Novel Hybrid Data Clustering Algorithm Based on Artificial Bee Colony Algorithm and K-Means

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Chinese Journal of Electronics 2015年第4期24卷 694-701页

作者： TRAN Dang Cong WU Zhijian WANG Zelin DENG Changshou State Key Laboratory of Software Engineering School of Computer Wuhan University Vietnam Academy of science and technology School of Information science and technology Jiujiang University

To improve the performance of K-means clustering algorithm, this paper presents a new hybrid approach of Enhanced artificial bee colony algorithm and Kmeans(EABCK). In EABCK, the original artificial bee colony algorithm(called ABC) is enhanced by a new mutation operation and guided by the global best solution(called EABC). Then, the best solution is updated by Kmeans in each iteration for data clustering. In the experiments, a set of benchmark functions was used to evaluate the performance of EABC with other comparative ABC variants. To evaluate the performance of EABCK on data clustering, eleven benchmark datasets were utilized. The experimental results show that EABC and EABCK outperform other comparative ABC variants and data clustering algorithms, respectively.

关键词： Data clustering K-means Artificial bee colony Mutation operation

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Interleukin 17A deficiency alleviates neuroinflammation and cognitive impairment in an experimental model of diabetic encephalopathy

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Neural Regeneration Research 2022年第12期17卷 2771-2777页

作者： Xiao-Xia Fang Fen-Fen Xu Zhan Liu Bei-Bei Cao Yi-Hua Qiu Yu-Ping Peng Department of Physiology School of Medicineand Co-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina

Interleukin 17A(IL-17A)was previously shown to be a key pro-inflammatory factor in diabetes mellitus and associated ***,the role of IL-17A in diabetic encephalopathy remains poorly *** this study,we established a mouse model of diabetic encephalopathy that was deficient in IL-17A by crossing Il17a-/-mice with spontaneously diabetic Ins2^(Akita)(Akita)*** glucose levels and body weights were monitored from 2-32 weeks of *** mice were 32 weeks of age,behavioral tests were performed,including a novel object recognition test for assessing short-term memory and learning and a Morris water maze test for evaluating hippocampus-dependent spatial learning and ***-17A levels in the serum,cerebrospinal fluid,and hippocampus were detected with enzyme-linked immunosorbent assays and real-time quantitative polymerase chain ***,proteins related to cognitive dysfunction(amyloid precursor protein,β-amyloid cleavage enzyme 1,p-tau,and tau),apoptosis(caspase-3 and-9),inflammation(inducible nitric oxide synthase and cyclooxygenase 2),and occludin were detected by western blot ***-inflammatory cytokines including tumor necrosis factor-α,interleukin-1β,and interferon-γin serum and hippocampal tissues were measured by enzyme-linked immunosorbent *** activation and hippocampal neuronal apoptosis were detected by immunofluorescent *** with that in wild-type mice,mice with diabetic encephalopathy had higher IL-17A levels in the serum,cerebrospinal fluid,and hippocampus;downregulation of occludin expression;lower cognitive ability;greater loss of hippocampal neurons;increased microglial activation;and higher expression of inflammatory factors in the serum and ***-17A knockout attenuated the abovementioned changes in mice with diabetic *** findings suggest that IL-17A participates in the pathological process of diabetic ***,IL-17A deficiency reduces

关键词： Akita mice apoptosis cognitive impairment diabetic encephalopathy hippocampus interleukin 17A mice microglia neuroinflammation neuron targeted treatment

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Enhancing Differential Evolution with Commensal Learning and Uniform Local Search

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Chinese Journal of Electronics 2017年第4期26卷 725-733页

作者： PENG Hu WU Zhijian DENG Changshou State Key Laboratory of Software Engineering School of Computer Wuhan University School of Information science and technology Jiujiang University

Differential evolution(DE) is a popular and powerful evolutionary algorithm for global optimization problems. However, the combination of mutation strategies and parameter settings of DE is problem dependent and choosing the suitable one is a challenge work and timeconsuming. In addition, the deficiency in local exploitation also has a significant influence on the performance of *** order to solve these problems, a DE variant with Commensal learning and uniform local search(CUDE) has been proposed in this paper. In CUDE, commensal learning is proposed to adaptively select optimal mutation strategy and parameter setting simultaneously under the same criteria. Moreover, uniform local search enhances exploitation ability. Comprehensive experiment results on all the CEC2013 test suite and comparison with the state-of-the-art DE variants indicate that the CUDE is very competitive.

关键词： Differential evolution Commensal learn ing Uniform local search Global optimization

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Proteolysis targeting chimera technology:a novel strategy for treating diseases of the central nervous system

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Neural Regeneration Research 2021年第10期16卷 1944-1949页

作者： Ke Ma Xiao-Xiao Han Xiao-Ming Yang Song-Lin Zhou Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury RepairCo-Innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina College of Life science Nantong UniversityNantongJiangsu ProvinceChina

Neurological diseases such as stroke,Alzheimer’s disease,Parkinson’s disease,and Huntington’s disease are among the intractable diseases for which appropriate drugs and treatments are *** targeting chimera(PROTAC)technology is a novel strategy to solve this *** technology uses the ubiquitin-protease system to eliminate mutated,denatured,and harmful proteins in *** can be reused,and utilizes the protein destruction mechanism of the cells,thus making up for the deficiencies of traditional protein degradation *** can effectively target and degrade proteins,including proteins that are difficult to identify and ***,it has extremely important implications for drug development and the treatment of neurological *** present,the targeted degradation of mutant BTK,mHTT,Tau,EGFR,and other proteins using PROTAC technology is gaining *** is expected that corresponding treatment of nervous system diseases can be *** review first focuses on the recent developments in PROTAC technology in terms of protein degradation,drug production,and treatment of central nervous system diseases,and then discusses its *** review will provide a brief overview of the recent application of PROTAC technology in the treatment of central nervous system diseases.

关键词： Alzheimer’s disease disease treatment drug development Huntington’s disease proteolysis targeting chimera stroke targeted degradation

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Long non-coding RNA GAS5 promotes PC12 cells differentiation into Tuj1-positive neuron-like cells and induces cell cycle arrest

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Neural Regeneration Research 2019年第12期14卷 2118-2125页

作者： He-Yan Zhao Sheng-Tong Zhang Xiang Cheng Hao-Ming Li Lei Zhang Hui He Jian-Bing Qin Wei-Ye Zhang Yan Sun Guo-Hua Jin Department of Human Anatomy the Jiangsu Key Laboratory of Neuroregeneration Medical School Nantong University

Growth arrest-specific 5 (GAS5) is an anti-oncogene that has been extensively studied in tumors. However, research on GAS5 in the context of nervous system disease is rare at present. This study aimed to investigate the role of the long non-coding RNA GAS5 in rat pheochromocytoma cells (PC12 cells). GAS5-overexpressing lentivirus was transfected into PC12 cells, and expression levels of GAS5 and C-myc were detected by real-time PCR. Ratios of cells in S phase were detected by 5-ethynyl-2′-deoxyuridine. Immunohistochemical staining was used to detect the immunoreactivity of neuron microtubule markers Tuj1, doublecortin, and microtubule-associated protein 2. Apoptosis was detected by flow cytometry, while expression of acetylcholine in cells was detected by western blot assay. We found that GAS5 can promote PC12 cells to differentiate into Tuj1-positive neuron-like cells with longer processes. In addition, cell proliferation and cell cycle were significantly suppressed by GAS5, whereas it had no effect on apoptosis of PC12 cells. Our results indicate that GAS5 could increase the expression of choline acetyltransferase and acetylcholine release. Thus, we speculate that GAS5 is beneficial to the recovery of neurons and the cholinergic nervous system.

关键词： nerve regeneration growth arrest-specific 5 PC12 cell neuron proliferation cell cycle choline acetyltransferase acetylcholine Alzheimer's disease neural regeneration

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A Survey on Heliumspeech Communications in Saturation Diving

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china Communications 2020年第6期17卷 68-79页

作者： Shibing Zhang Lili Guo Hongjun Li Zhihua Bao Xiaoge Zhang Yonghong Chen School of Information science and technology Nantong UniversityNantong 226019China nantong Research Institute for Advanced Communication technology Nantong 226019China Xinglin College Nantong UniversityNantong 226019China

With the development of society and the progress of technology,more and more ocean activities are carried *** results in booming of deep-sea *** use of helium-oxygen mixture(as a kind of breathing gas)solves the physiological problems of divers in saturated diving,but it brings about the Heliumspeech voice communication problem,the drop of speech *** is no doubt that the effective speech communication must be provided for supporting the life and work of divers in *** paper describes the mechanism of forming heliumspeech,discusses the effects of pressure and helium environment on the speech spectrum,compares the pros and cons of the time-domain and frequency-domain unscrambling techniques,shows the challenges in heliumspeech ***,it briefly introduces the deep learning,and points out that deep learning/machine learning may be a perfectly unscrambling technique.

关键词： maritime communications saturation diving heliumspeech unscrambling challenging deep learning

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Multi-Objective Bacterial Foraging Optimization Algorithm Based on Effective Area in Cognitive Emergency Communication Networks

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china Communications 2021年第12期18卷 252-269页

作者： Shibing Zhang Xue Ji Lili Guo Zhihua Bao School of Information science and technology Nantong UniversityNantong 226019China Xinglin College Nantong UniversityNantong 226008China

Cognitive emergency communication net-works can meet the requirements of large capac-ity,high density and low delay in emergency *** paper analyzes the properties of emergency users in cognitive emergency communi-cation networks,designs a multi-objective optimiza-tion and proposes a novel multi-objective bacterial foraging optimization algorithm based on effective area(MOBFO-EA)to maximize the transmission rate while maximizing the lifecycle of the *** the algorithm,the effective area is proposed to prevent the algorithm from falling into a local optimum,and the diversity and uniformity of the Pareto-optimal solu-tions distributed in the effective area are used to eval-uate the optimization ***,the dynamic preservation is used to enhance the competitiveness of excellent individuals and the uniformity and diversity of the Pareto-optimal solutions in the effective ***,the adaptive step size,adaptive moving direc-tion and inertial weight are used to shorten the search time of bacteria and accelerate the optimization *** simulation results show that the pro-posed MOBFO-EA algorithm improves the efficiency of the Pareto-optimal solutions by approximately 55%compared with the MOPSO algorithm and by approx-imately 60%compared with the MOBFO algorithm and has the fastest and smoothest convergence.

关键词： wireless communications emergency communications cognitive radio networks multi-objective optimization algorithm effective areas self-adaption

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Adaptive Multi-layer Particle Swarm Optimization with Neighborhood Search

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Chinese Journal of Electronics 2016年第6期25卷 1079-1088页

作者： TRAN Dang Cong WU Zhijian State Key Lab of Software Engineering School of ComputerWuhan University Vietnam Academy of science and technology

Particle swarm optimization(PSO) has shown a good performance on solving global optimization problems. Traditional PSO has two main drawbacks of premature convergence and low convergence speed, especially on complex problems. This paper presents a new approach called Adaptive multi-layer particle swarm optimization with neighborhood search(AMPSONS), where the traditional PSO is improved by employing an adaptive multi-layer search and neighborhood search strategy to achieve a trade-off between exploitation and exploration abilities. In order to evaluate the performance of the proposed AMPSONS algorithm, the performance of AMPSONS is compared with five other PSO family algorithms,namely, CLPSO, DNLPSO, DNSPSO, global MLPSO and local MLPSO on a set of benchmark functions. The comparison results show that AMPSONS has a promising performance on ma jority of the test functions.

关键词： Particle swarm optimization Global optimization Neighborhood search Adaptive multi-layer search

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Bionic peptide scaffold in situ polarization and recruitment of M2 macrophages to promote peripheral nerve regeneration

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Bioactive Materials 2023年第12期30卷 85-97页

作者： Pengxiang Yang Yong Peng Xiu Dai Jing Jie Deling Kong Xiaosong Gu Yumin Yang Key Laboratory of Neuroregeneration of Jiangsu Province and Ministry of Education Co-Innovation Center of NeuroregenerationNMPA Key Laboratory for Researchand Evaluation of Tissue Engineering Technology ProductsNantong University226001NantongPR China Institute of Cancer Prevention and Treatment Heilongjiang Academy of Medical ScienceHarbin Medical University150081HarbinPR China Department of Clinical Laboratory The Second Affiliated Hospital of Nantong University226001NantongPR China State Key Laboratory of Medicinal Chemical Biology College of Life SciencesNankai UniversityTianjin300071PR China

Tissue regeneration requires exogenous and endogenous signals,and there is increasing evidence that the exogenous microenvironment may play an even more dominant role in the complex process of coordinated multiple *** short-distance peripheral nerve showed a spontaneous regenerative phenomenon,which was initiated by the guiding role of ***,it cannot sufficiently restore long-distance nerve injury by *** on this principle,we firstly constructed a proinflammatory model to prove that abnormal M2 expression reduce the guidance and repair effect of long-distance ***,a bionic peptide hydrogel scaffold based on self-assembly was developed to envelop M2-derived regenerative cytokines and extracellular vesicles(EVs).The cytokines and EVs were quantified to mimic the guidance and regenerative microenvironment in a direct and mild *** bionic scaffold promoted M2 transformation in situ and led to proliferation and migration of Schwann cells,neuron growth and motor function ***,the peptide scaffold combined with CX3CL1 recruited more blood-derived M2 macrophages to promote long-distance nerve recon***,we systematically confirmed the important role of M2 in regulating and restoring the injury peripheral *** bionic peptide hydrogel scaffold mimicked and remodeled the local environment for M2 transformation and recruitment,favoring long-distance peripheral nerve *** can help to explicate regulative effect of M2 may be a cause not just a consequence in nerve repair and tissue integration,which facilitating the development of pro-regenerative biomaterials.

关键词： Bionic peptide scaffolds Peripheral nerve regeneration Macrophages Conditional media Immune microenvironment

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