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Mitochondria-targeted Janus mesoporous nanoplatform for tumor photodynamic therapy

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Chinese Chemical Letters 2024年第2期35卷 544-547页

作者： Min Dong Rui Tang Jing Li Jiajia Zhao Yu Wang Lin Ouyang Wei Lu Jun Tao Meng Dang Yuxia Tang Zhaogang Teng Key Laboratory for Organic Electronics & Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced MaterialsJiangsu National Synergetic Innovation Centre for Advanced MaterialsNanjing University of Post and TelecommunicationsNanjing 210023China Laboratory of Molecular Imaging Department of RadiologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Radiology The 909th HospitalSoutheast HospitalSchool of MedicineXiamen UniversityZhangzhou 363000China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringInstitute of Functional MaterialsDonghua UniversityShanghai 201620China

Photodynamic therapy(PDT)is an effective treatment method for *** the specifically accumulated of photosensitizer was very difficult in the tumor site,which greatly limited the efficacy of ***,mitochondria-targeted Janus mesoporous nanoplatform(JPMO-Pt-CTPP-ZnPc)for PDT was prepared,the nanoplatform has uniform size(275 nm)and good dispersion and *** confocal laser scanning microscopy(CLSM)revealed the signal of ZnPc of JPMO-Pt-CTPP-ZnPc were higher than JPMO-Pt-ZnPc in tumor cells,and flow cytometry results showed the cell uptake efficiency of JPMO-Pt-CTPP-ZnPc was 2.5-fold higher than that of *** revealed the modification of CTPP significantly improves the targeting ability of the *** vitro anti-tumor experiment showed the JPMO-Pt-CTPP-ZnPc significantly inhibited the growth of tumor cells upon the irradiation of low-power laser,and the survival rate of cells incubated with 60μg/mL JPMO-Pt-CTPP-ZnPc was only 3%.Simultaneously,compared with JPMO-Pt-ZnPc(not modified with mitochondria targeting molecules CTPP),the PDT efficacy of JPMO-Pt-CTPP-ZnPc was significantly better,as it has targeted mitochondria in cells.

关键词： Mesoporous materials Janus particle Photodynamic therapy Mitochondria targeting Tumor treatment

Effects of drive imbalance on the particle emission from a Bose-Einstein condensate in a one-dimensional lattice

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Chinese Physics B 2024年第3期33卷 238-243页

作者：赖龙泉李照 School of Science Nanjing University of Posts and TelecommunicationsNanjing 210023China School of Electronic Engineering Chengdu Technological UniversityChengdu 611730China

Time-periodic driving has been an effective tool in the field of nonequilibrium quantum dynamics,which enables precise control of the particle *** investigate the collective emission of particles from a Bose-Einstein condensate in a one-dimensional lattice with periodic drives that are separate in modulation amplitudes and relative *** addition to the enhancement of particle emission,we find that amplitude imbalances lead to energy shift and band broadening,while typical relative phases may give rise to similar *** results offer insights into the specific manipulations of nonequilibrium quantum systems with tone-varying drives.

关键词： Bose-Einstein condensate particle emission periodic drive

Trench gate GaN IGBT with controlled hole injection efficiency

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The Journal of China Universities of posts and telecommunications 2024年第2期31卷 10-16页

作者： Huang Yi Li Yueyue Gao Sheng Wang Qi Liu Bin Han Genquan School of Optoelectronic Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065China School of Electronic Science and Engineering Nanjing UniversityNanjing 210008China School of Microelectronics Xidian UniversityXi’an 710126China

In this paper,a novel trench gate gallium nitride(GaN)insulated gate bipolar transistor(GaN IGBT),in which the collector is divided into multiple regions to control the hole injection efficiency,is designed and theoretically *** incorporation of a P+/P-multi-region alternating structure in the collector region mitigates hole injection within the collector *** the device is in forward conduction,the conductivity modulation effect results in a reduced storage of carriers in the drift *** a result,the number of carriers requiring extraction during device turn-off is minimized,leading to a faster turn-off *** results illustrate that the GaN IGBT with controlled hole injection efficiency(CEH GaN IGBT)exhibits markedly enhanced performance compared to conventional GaN IGBT,showing a remarkable 42.2%reduction in turn-off time and a notable 28.5%decrease in turn-off loss.

关键词： gallium nitride insulated gate bipolar transistor(GaN IGBT) hole injection trench gate turn-off loss

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Enhancing the electrochemical performance of Na metal anodes via local eutectic melting in porous Al-Cu alloy hosts

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Nano research 2024年第7期17卷 6111-6118页

作者： Tao Hu Qiang Wu Cheng Wang Jialu Chen Fu Su Zibo Chen Yizhou Wang Jianyu Chen Yanwen Ma Jin Zhao State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts&Telecommunications9 Wenyuan RoadNanjing 210023China Materials Science and Engineering King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia Suzhou Vocational Institute of Industrial Technology 1 Zhineng AvenueSuzhou International Education ParkSuzhou 215104China

Sodium(Na)metal batteries(SMBs)have emerged as promising alternatives to lithium metal batteries for large-scale energy storage applications,owing to their cost-effectiveness,abundance,and favorable redox ***,the practical implementation of SMBs faces several challenges associated with the Na metal anode,including the formation of dendrites,low Coulombic efficiency,and capacity ***,we propose a novel approach to enhance the electrochemical performance of Na metal anodes through a porous Al-Cu alloy host(PAC)fabricated by a local eutectic melting *** local eutectic melting facilitates the development of a conductive network,offering mechanical support,and the porous structure provides abundant channels for the diffusion of Na ions and accommodates volume fluctuations in the Na metal during charge–discharge ***,the PAC exhibits a high average Coulombic efficiency of 99.8%at 1 mA·cm^(−2)for 1 mAh·cm^(−2)and a low voltage polarization of 19 mV during 500 *** study provides valuable insight into the design and fabrication of highperformance Na metal anodes,which hold significant promise for the advancements of next-generation energy storage systems.

关键词： Na metal anode porous Al-Cu alloy porous current collector local eutectic melting

Attack-Resilient Distributed Cooperative Control of Virtually Coupled High-Speed Trains via Topology Reconfiguration

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 1066-1068页

作者： Shunyuan Xiao Xiaohua Ge Qing Wu the Institute of Advanced Technology Nanjing University of Posts and TelecommunicationsNanjing 210023China the School of Science Computing and Engineering TechnologiesSwinburne University of TechnologyMelbourne VIC 3122Australia the School of Engineering and Technology Central Queensland UniversityRockhampton QLD 4701Australia

Dear Editor,This letter addresses the resilient distributed cooperative control problem of a virtually coupled train convoy under stochastic disturbances and cyber *** main purpose is to achieve distributed coordinati... 详细信息

关键词： prescribed Speed trains

An injectable,self-healable,and reusable PEDOT:PSS/PVA hydrogel patch electrode for epidermal electronics

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Nano research 2024年第6期17卷 5479-5490页

作者： Yang Li Yuzhe Gu Sheng Qian Shuwen Zheng Yuncong Pang Lele Wang Baoguang Liu Shujuan Liu Qiang Zhao College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023China State Key Laboratory of Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts and Telecommunications(NJUPT)Nanjing 210023China

Injectability empowers conductive hydrogels to transcend traditional limitations,unlocking a realm of possibilities for innovative medical,wearable,and therapeutic applications that can significantly enhance patient care and quality of ***,we report an injectable,self-healable,and reusable hydrogel obtained by mixing the concentrated poly(3,4-ethylenedioxythiophene)doped with polystyrene sulfonate(PEDOT:PSS)suspension(~2 wt.%solid content),polyvinyl alcohol(PVA),and *** the presence of reversible borax/hydroxyl bonds and multiple hydrogen bonds,this PEDOT:PSS/PVA hydrogel exhibits notable shear-thinning behavior and self-healing capabilities,enabling it to be injected as a gel fiber from a ***-prepared injectable hydrogel also demonstrates an ultra-low modulus(~2.5 MPa),reduced on-skin impedance(~45%of commercial electrodes),and high signal-to-noise ratio(SNR)(~15-22 dB)in recording of electrocardiography(ECG),electromyography(EMG),and electroencephalogram(EEG)***,the injectable hydrogels can be remolded and reinjected as the reusable electrodes,maintaining nearly identical electrophysiological recording capabilities and brain-computer interface(BCI)performance compared to commercial wet *** their straightforward fabrication,excellent material properties and electronic performance,ease of cleaning,and remarkable reusability,our injectable PEDOT:PSS/PVA hydrogels hold promise for advancements in BCI based electronics and wearable bioelectronics.

关键词： epidermal hydrogel electrodes reusability injectability self-healing electrophysiological recording brain-computer interface

Nanowire-mediated miR NA delivery

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Science China Life Sciences 2024年

作者： Yuan Wang Bing Chen Laboratory for Biomaterials and Drug Delivery Department of Anesthesiology Division of Critical Care Medicine Boston Children's Hospital Harvard Medical School College of Electronic and Optical Engineering and College of Flexible Electronics (Future Technology) Nanjing University of Posts and Telecommunications

In the ever-evolving nanomedicine and biotechnology, the pursuit of advanced drug delivery systems that induce precise positioning and targeting in the complex biological landscape for personalized and efficient therapies has become a paramount endeavor (Vargason et al., 2021).Central to this trend is the delivery of functional microRNAs (miRNAs), which play crucial roles in regulating gene expression (Li et al., 2021).

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Reversible generation of dissipative Kerr solitons in a microresonator by the backward tuning method

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Chinese Optics Letters 2024年第7期 58-63页

作者：郑继辉倪菱蔓谷望航贾琳华翟宇润牛琼张福民曲兴华 Advanced Photonic Technology Laboratory College of Electronic and Optical Engineering&College of MicroelectronicsNanjing University of Posts and Telecommunications State Key Laboratory of Precision Measurement Technology and Instruments Tianjin University

Soliton generation schemes have attracted considerable scholarly attention. This paper introduces a novel backward tuning method for the reversible generation of dissipative Kerr solitons(DKSs). Reversible soliton generation relies on the thermal stabilization of the auxiliary laser, coupled with backward tuning of the pump laser, significantly increasing the range of soliton steps by over 10 times. Moreover, the method alleviates the stringent auxiliary laser detuning requirement. By adjusting the detuning of the auxiliary laser, diverse numbers of solitons can be deterministically generated, enhancing both flexibility and precision.

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Two-grid Method of Expanded Mixed Finite Element Approximations for Parabolic Integro-differential Optimal Control Problems

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Acta Mathematicae Applicatae Sinica 2024年

作者： Yan-ping CHEN Jian-wei ZHOU Tian-liang HOU School of Science Nanjing University of Posts and Telecommunications School of Mathematics and Statistics Linyi University School of Mathematics and Statistics Beihua University

This paper aims to construct a two-grid scheme of fully discretized expanded mixed finite element methods for optimal control problems governed by parabolic integro-differential equations and discuss a priori error estimates. The state variables and co-state variables are discretized by the lowest order Raviart-Thomas mixed finite element, and the control variable is approximated by piecewise constant functions. The time derivative is discretized by the backward Euler method. Firstly, we define some new mixed elliptic projections and prove the corresponding error estimates which play an important role in subsequent convergence ***, we derive a priori error estimates for all variables. Thirdly, we present a two-grid scheme and analyze its convergence. In the two-grid scheme, the solution of the parabolic optimal control problem on a fine grid is reduced to the solution of the parabolic optimal control problem on a much coarser grid and the solution of a decoupled linear algebraic system on the fine grid and the resulting solution still maintains an asymptotically optimal accuracy. At last, a numerical example is presented to verify the theoretical results.

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