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Brain circuits for retching-like behavior

national Science Review 2024年第1期11卷 145-160页

作者： Lifang Huo Zhimin Ye Meiling Liu Ziqing He Meizhu Huang Dapeng Li Qian Wu Qian Wang Xiaoqun Wang Peng Cao Ji Dong Congping Shang School of Basic Medical Sciences Guangzhou National Laboratory The Fifth Afflliated Hospital Guangzhou Medical University Bioland laboratory (guangzhou Regenerative Medicine and Health Guangdong laboratory) Department of Neurobiology School of Basic Medical Sciences Beijing Key Laboratory of Neural Regeneration and Repair Advanced Innovation Center for Human Brain Protection Capital Medical University State Key laboratory of Cognitive Neuroscience and Learning IDG/McGovern Institute for Brain Research Beijing Normal University Changping Life Science laboratory national Institute of Biological Sciences

Nausea and vomiting are important defensive responses to cope with pathogens and toxins that invade the body. The nucleus of the solitary tract(NTS) is important for initiating these responses. However, the molecular heterogeneities and cellular diversities of the NTS occlude a better understanding of these defensive responses. Here, we constructed the single-nucleus transcriptomic atlas of NTS cells and found multiple populations of NTS neurons that may be involved in these defensive responses. Among these, we identified Calbindin1-positive(Calb1+) NTS neurons that are molecularly distinct from Tac1+*** Calb1+neurons are critical for nausea and retching induced by cereulide; an emetic toxin secreted by Bacillus Cereus. Strikingly, we found that cereulide can directly modulate vagal sensory neurons that innervate Calb1+NTS neurons, a novel mechanism distinct from that for nausea and retching induced by Staphylococcal enterotoxin A. Together, our transcriptomic atlas of NTS neurons and the functional analyses revealed the neural mechanism for cereulide-induced retching-like behavior. These results demonstrate the molecular and cellular complexities in the brain that underlie defensive responses to the diversities of pathogens and toxins.

关键词： vomiting nausea nucleus of the solitary tract Calbindin1 neural circuits

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Preparation and Tribological Properties of Onion-like Carbon/Waterborne Polyurethane Coatings

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China Petroleum Processing & Petrochemical Technology 2024年第2期26卷 108-120页

作者： Fei Xingpeng Jiang Wuhao Wen Maosheng Xu Yong Hu Kunhong Hu Enzhu Department of Energy Materials and Chemical Engineering Hefei UniversityHefei 230601China Anhui Province Key laboratory of Critical Friction Pair for advanced Equipment Hefei 230088China

Rice husk powder was used as a carbon source in a high-temperature carbonization reaction for the production of rice husk ash(RHA).Under the catalysis of ferric nitrate,onion-like carbon(OLC)nanomaterial with a particle size of approximately 200 nm was successfully prepared and incorporated into waterborne polyurethane(WPU).The tribological properties of the coatings were determined using a controlled-atmosphere tribometer(WMT-2E)under dry-friction *** the friction test,the friction mechanism was investigated by characterizing the abrasive spot surfaces of the test samples using 3D laser microscopy and scanning electron microscopy/energy dispersive *** final results demonstrated that the thermal stability of WPU composite coatings containing various concentrations of OLC nanoparticles was significantly enhanced,binding forces between coatings and steel sheets increased,and hardness improved compared to pure WPU *** tests revealed a notable enhancement in the anti-wear properties of WPU coatings due to the presence of OLC ***,the wear rate of the 1.5%OLC/WPU coating was reduced by 45.3%.The coating’s anti-wear mechanism was attributed to the improvement in the mechanical properties of WPU due to OLC,as well as OLC’s participation in the formation of a transfer film under induced friction,which protected the matrix.

关键词： biomass carbon onion-like carbon waterborne polyurethane wear transfer films

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Novel C_(sf)/SiBCN composites prepared by densifying C_(sf)/MA-SiBCN with the PIP process:Oxidation behavior and damage mechanism

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Journal of advanced Ceramics 2024年第5期13卷 666-678页

作者： Wenhao Dou Daxin Li Bingzhu Wang Zhihua Yang Jun Chen Dechang Jia Ralf Riedel Yu Zhou Institute for advanced Ceramics School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001China Key laboratory of advanced Structural-Functional Integration Materials and Green Manufacturing Technology Harbin Institute of TechnologyHarbin 150001China Chongqing research Institute of HIT Chongqing 401135China Beijing Institute of Control Engineering Beijing 100094China Institut für Materialwissenschaft Technische Universität DarmstadtDarmstadt D-64287Germany School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)Shenzhen 518055China

To improve the oxidation resistance of short carbon fiber(C_(sf))-reinforced mechanically alloyed SiBCN(MA-SiBCN)(C_(sf)/MA-SiBCN)composites,dense amorphous C_(sf)/SiBCN composites containing both MA-SiBCN and polymer-derived ceramics SiBCN(PDCs-SiBCN)were prepared by repeated polymer infiltration and pyrolysis(PIP)of layered C_(sf)/MA-SiBCN composites at 1100℃,and the oxidation behavior and damage mechanism of the as-prepared C_(sf)/SiBCN at 1300–1600℃ were compared and discussed with those of C_(sf)/*** C_(sf)/MA-SiBCN composites resist oxidation attack up to 1400℃ but fail at 1500℃ due to the collapse of the porous framework,while the PIP-densified C_(sf)/SiBCN composites are resistant to static air up to 1600℃.During oxidation,oxygen diffuses through preexisting pores and the pores left by oxidation of carbon fibers and pyrolytic carbon(PyC)to the interior of the *** to the oxidative coupling effect of the MA-SiBCN and PDCs-SiBCN matrices,a relatively continuous and dense oxide layer is formed on the sample surface,and the interfacial region between the oxide layer and the matrix of the as-prepared composite contains an amorphous glassy structure mainly consisting of Si and O and an incompletely oxidized but partially crystallized matrix,which is primarily responsible for improving the oxidation resistance.

关键词： mechanically alloyed SiBCN(MA-SiBCN) polymer-derived ceramics SiBCN(PDCs-SiBCN) short carbon fiber-reinforced SiBCN(C_(sf)/SiBCN)composites polymer infiltration and pyrolysis(PIP) oxidation damage mechanism

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Enriched electrophilic oxygen species facilitate acidic oxygen evolution on Ru-Mo binary oxide catalysts

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Nano research 2024年第3期17卷 1165-1172页

作者： Yaya Wang Yunzhou Wen Yumeng Cheng Xinhong Chen Mengjiao Zhuansun Tongbao Wang Jun Li Debora Meira Huarui Sun Jun Wei Jia Zhou Yuhang Wang Sisi He Shenzhen Key laboratory of Flexible Printed Electronics Technology Harbin Institute of Technology(Shenzhen)University TownShenzhen 518055China School of Science Harbin Institute of Technology(Shenzhen)University TownShenzhen 518055China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory of Advanced Negative Carbon TechnologiesSoochow UniversitySuzhou 215123China Frontiers Science Center for Transformative Molecules Shanghai Jiao Tong UniversityShanghai 200240China Science Division Canadian Light SourceSaskatoonSKS7N 2V3Canada Photon Science Division Argonne National LaboratoryLemontIL60439USA School of Materials Science and Engineering Harbin Institute of Technology(Shenzhen)University TownShenzhen 518055China

The polymer electrolyte membrane(PEM)electrolyzers are burdened with costly iridium(Ir)-based catalysts and high operation overpotentials for the oxygen evolution reaction(OER).The development of earth-abundant,highly active,and durable electrocatalysts to replace Ir is a critical step in reducing the cost of green hydrogen *** we develop a Ru5Mo4Ox binary oxide catalyst that exhibits high activity and stability in acidic *** electron-withdrawing property of Mo enriches the electrophilic surface oxygen species,which promotes acidic OER to proceed via the adsorbate evolution *** a result,we achieve a 189 mV overpotential at 10 mA·cm^(-2) and a Tafel slope of 48.8 mV·dec^(-1).Our catalyst demonstrates a substantial 18-fold increase in intrinsic activity,as evaluated by turnover frequency,compared to commercially available RuO_(2) and IrO_(2) ***,we report a stable OER operation at 10 mA·cm^(-2) for 100 h with a low degradation rate of 2.05 mV·h^(-1).

关键词： electrocatalysis oxygen evolution reaction(OER) ruthenium(Ru)-based oxide molybdenum electrophilic oxygen

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The multi-kingdom microbiome catalog of the chicken gastrointestinal tract

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Biosafety and Health 2024年第2期6卷 101-115页

作者： Yanan Wang Mengqi Qu Yuhai Bi William J.Liu Sufang Ma Bo Wan Yongfei Hu Baoli Zhu Gaiping Zhang George F.Gao International Joint research Center of national Animal Immunology College of Veterinary MedicineHenan Agricultural UniversityZhengzhou 450046China CAS Key laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences(CAS)Beijing 100101China Longhu laboratory Zhengzhou 450046China University of Chinese Academy of Sciences Beijing 100049China NHC Key laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China State Key laboratory of Animal Nutrition and Feeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Chicken is an important food animal worldwide and plays an important role in human life by providing meat and *** recent significant advances in gut microbiome studies,a comprehensive study of chicken gut bacterial,archaeal,and viral genomes remains *** this study,we constructed a chicken multi-kingdom microbiome catalog(CMKMC),including 18,201 bacterial,225 archaeal,and 33,411 viral genomes,and annotated over 6,076,006 protein-coding genes by integrating 135 chicken gut metagenomes and publicly available metagenome-assembled genomes(MAGs)from ten *** found that 812 and 240 MAGs in our dataset were putative novel species and genera,respectively,far beyond what was previously *** newly unclassified MAGs were predominant in Phyla Firmicutes_A(n=263),followed by Firmicutes(n=126),Bacteroidota(n=121),and Proteobacteria(n=87).Most of the classified species-level viral oper-ational taxonomic units belong to ***,63.24%of chicken gut viromes are predicted to infect two or more hosts,including complete circular ***,we found that diverse auxiliary metabolic genes and antibiotic resistance genes were carried by ***,our CMKMC provides the largest integrated MAGs and viral genomes from the chicken gut to date,functional insights into the chicken gastrointestinal tract microbiota,and paves the way for microbial interventions for better chicken health and productivity.

关键词： Chicken Microbiome Metagenome assembled genomes Archaeome Virome Antibiotic resistance gene

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Multi-omics joint analysis revealed the metabolic profile of retroperitoneal liposarcoma

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Frontiers of Medicine 2024年第2期18卷 375-393页

作者： Fu’an Xie Yujia Niu Lanlan Lian Yue Wang Aobo Zhuang Guangting Yan Yantao Ren Xiaobing Chen Mengmeng Xiao Xi Li Zhe Xi Gen Zhang Dongmei Qin Kunrong Yang Zhigang Zheng Quan Zhang Xiaogang Xia Peng Li Lingwei Gu Ting Wu Chenghua Luo Shu-Hai Lin Wengang Li Cancer research Center Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China State Key laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life SciencesXiamen UniversityXiamen361102China Xiamen University research Center of Retroperitoneal Tumor Committee of Oncology Society of Chinese Medical Association Xiamen UniversityXiamen361102China Department of laboratory Medicine Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China Department of Retroperitoneal Tumor Surgery Peking University International HospitalBeijing102206China School of Public Health Harvard UniversityBostonMA02115USA laboratory of Biochemistry and Molecular Biology research Department of Clinical LaboratoryFujian Medical University Cancer HospitalFuzhou350014China Surgery Department Affiliated Fuzhou First Hospital of Fujian Medical UniversityFuzhou350009China national Institute for Data Science in Health and Medicine Xiamen UniversityXiamen361102China Department of Hepatobiliary Surgery Xiang’an Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamen361102China

Retroperitoneal liposarcoma(RLPS)is the main subtype of retroperitoneal soft sarcoma(RSTS)and has a poor prognosis and few treatment options,except for *** proteomic and metabolic profiles of RLPS have remained *** aim of our study was to reveal the metabolic profile of ***,we performed proteomic analysis(n=10),metabolomic analysis(n=51),and lipidomic analysis(n=50)of retroperitoneal dedifferentiated liposarcoma(RDDLPS)and retroperitoneal well-differentiated liposarcoma(RWDLPS)tissue and paired adjacent adipose tissue obtained during *** analysis mainly revealed that glycolysis,purine metabolism,pyrimidine metabolism and phospholipid formation were upregulated in both RDDLPS and RWDLPS tissue compared with the adjacent adipose tissue,whereas the tricarboxylic acid(TCA)cycle,lipid absorption and synthesis,fatty acid degradation and biosynthesis,as well as glycine,serine,and threonine metabolism were *** particular importance,the glycolytic inhibitor 2-deoxy-D-glucose and pentose phosphate pathway(PPP)inhibitor RRX-001 significantly promoted the antitumor effects of the MDM2 inhibitor RG7112 and CDK4 inhibitor *** study not only describes the metabolic profiles of RDDLPS and RWDLPS,but also offers potential therapeutic targets and strategies for RLPS.

关键词： RLPS proteomics metabolomics lipidomics metabolism

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深冷循环热处理下锆基金属玻璃的回春行为调控

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Transactions of Nonferrous Metals Society of China 2024年第2期34卷 582-591页

作者：郭威余圣丁俊吕书林吴树森赵觅华中科技大学材料科学与工程学院材料成形与模具技术全国重点实验室武汉430074 深圳华中科技大学研究院深圳518057 西安交通大学金属材料强度国家重点实验室材料创新设计中心西安710049 华中科技大学航空航天学院武汉430074

研究Zr_(55)Cu_(30)Ni_(5)Al_(10)(摩尔分数,%)金属玻璃在深冷循环处理过程中的回春行为。实验发现,随着循环次数的增加,样品的回春程度更高,表现为更高的弛豫焓与更低的密度。回春程度经200次循环后逐渐饱和,这可能与非晶结构中有限的... 详细信息

研究Zr_(55)Cu_(30)Ni_(5)Al_(10)(摩尔分数,%)金属玻璃在深冷循环处理过程中的回春行为。实验发现,随着循环次数的增加,样品的回春程度更高,表现为更高的弛豫焓与更低的密度。回春程度经200次循环后逐渐饱和,这可能与非晶结构中有限的自由体积含量有关。同时,高循环次数下的样品硬度更低,塑性更好,这与其剪切转变区体积增大有关。此时,更低的剪切面形成能有利于多重剪切带的形成。此外,还发现自由体积含量与样品塑性应变及剪切转变区体积呈线性关系。分子动力学模拟结果还表明,在高冷速下回春程度高的样品会发生原子体积的饱和。

关键词：金属玻璃回春深冷循环热处理循环次数塑性

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May Traditional Chinese Medicine Reduce the Risk of Developing Rheumatoid Arthritis?An One-armed Prospective Study

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 10-18页

作者： Kaixin Gao Qi Liang Dongyun Li Chuanning Li Maojie Wang Xiumin Chen Qingchun Huang Zehuai Wen Per-Johan Jakobsson Runyue Huang The Second Affiliated Hospital of guangzhou University of Chinese Medicine(Guangdong Provincial Hospital of Chinese Medicine) Guangzhou 510006GuangdongChina The Second Clinical Medical College Guangzhou University of Chinese MedicineGuangzhou 510006GuangdongChina State Key laboratory of Dampness Syndrome of Chinese Medicine The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120GuangdongChina Guangdong Provincial Key laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases Guangzhou 510403GuangdongChina Guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease research Guangzhou 510000GuangdongChina The key unit of methodology of clinical research The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510000GuangdongChina Rheumatology Unit Department of Medicine SolnaKarolinska InstituteKarolinska University HospitalStockholm 17177Sweden Department of Doctor-Patient Relationship The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630GuangdongChina

Background:Rheumatoid arthritis(RA)is a worldwide public health *** and prevention before the onset of rheumatic diseases is a new direction in current ***:The aim of this study was to evaluate the potential and feasibility of traditional Chinese medicine(TCM)in the prevention of ***:This was a single-armed prospective clinical *** participants were recruited from a single center in Guangdong,*** who were tested positive for anti-cyclic citrullinated peptide antibody(anti-CCP)and/or rheumatoid factor(RF),had no synovitis and never been treated with disease-modifying anti-rheumatic drugs(DMARDs),were enrolled to take the Huayu-Qiangshen-Tongbi(HQT)decoction orally twice daily,200 mL each time for 24 *** outcome was the proportion of patients who met 2010 ACR(American College of Rheumatology)/EULAR(European League Against Rheumatism)classification criteria of RA during *** outcomes included levels of anti-CCP,RF,erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),assessment of signs and symptoms,and radiographic progression by magnetic resonance imaging(MRI).Results:19 individuals were enrolled in the study,4 of which withdrew because of the epidemic of *** the observation period,3 individuals(20%)developed RA and they had longer morning stiffness(P=0.009)and more obvious synovial enhancement in MRI(P=0.041)at baseline when compared with those who did not develop *** 24 weeks of intervention,there were improvements in 28-swollen joint count(SJC28)(P=0.046),Visual Analog Scale(VAS)(P=0.019),Patient’s Global Assessment(PtGA)(P=0.019)and Physician’s Global Assessment(PGA)(P=0.031),but no statistical significance was observed in the levels of anti-CCP,RF,ESR,CRP,morning stiffness,28-tender joint count(TJC28),Health Assessment Questionnaire(HAQ)and magnetic resonance imaging(MRI)analysis(P>0.05).Conclusion:The HQT formula is safe and could improve joint symptoms and s

关键词： Rheumatoid arthritis(RA) Prevention Traditional Chinese medicine(TCM) Huayu-Qiangshen-Tongbi decoction(HQT) Clinical trial

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蛋白活化原子层沉积用于超强原油排斥的层级纳米装甲膜（英文）

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Science Bulletin 2024年第2期 218-226页

作者：杨晓彬孙盼温雅洁 Anil U.Mane Jeffrey W.Elam 马军刘少敏 Seth B.Darling 邵路 MIIT Key laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Laboratory of Urban Water Resource and Environment School of Chemistry and Chemical Engineering Harbin Institute of Technology Chemical Sciences and Engineering Division Argonne National Laboratory advanced Materials for Energy-Water Systems Energy Frontier research Center Argonne National Laboratory School of Environment Harbin Institute of Technology Pritzker School of Molecular Engineering University of Chicago Department of Physics University of Illinois at Chicago Applied Materials Division Argonne National Laboratory WA School of Mines: Minerals Energy and Chemical Engineering Curtin University

Atomic layer deposition(ALD) offers unique capabilities to fabricate atomically engineered porous materials with precise pore tuning and multi-functionalization for diverse applications like advanced membrane separations towards sustainable energy-water systems. However, current ALD technique is inhibited on most non-polar polymeric membranes due to lack of accessible nucleation sites. Here, we report a facile method to efficiently promote ALD coating on hydrophobic surface of polymeric membranes via novel protein activation/sensitization. As a proof of concept, TiO2ALD-coated membranes activated by bovine serum albumin exhibit remarkable superhydrophilicity, ultralow underwater crude oil adhesion, and robust tolerance to rigorous environments including acid, alkali, saline, and *** importantly, excellent cyclable crude oil-in-water emulsion separation performance can be achieved. The mechanism for activation/sensitization is rooted in reactivity for a particular set of amino acids. Furthermore, the universality of protein-sensitized ALD is demonstrated using common egg white,promising numerous potential usages in biomedical engineering, environmental remediation, lowcarbon manufacturing, catalysis, and beyond.

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In-situ preparation of robust self-lubricating composite coating from thermally sprayed ceramic template

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Journal of advanced Ceramics 2023年第2期12卷 357-372页

作者： Zhichao WU Shuangjian LI Xiujuan FAN Florian VOGEL Jie MAO Xiaohui TU Institute of advanced Wear&Corrosion Resistant and Functional Materials Jinan UniversityGuangzhou 510632China Institute of New Materials Guangdong Academy of SciencesNational Engineering Laboratory of Modern Materials Surface Engineering TechnologyGuangzhou 510650China

The self-lubricating ceramic coatings that can control friction and wear have attracted researchers’widespread ***,the poor interfacial bonding between lubricants and ceramics and the deterioration of mechanical properties due to a tribological design limit their practical ***,a robust self-lubricating coating was fabricated by an in-situ synthesis of MoS_(2)/C within inherent defects of thermally sprayed yttria-stabilized zirconia(YSZ)*** edge-pinning by noncoherent endows hybrid coatings with excellent interfacial strength,increasing their hardness(HV)and cohesive ***,owing to the formation of a well-covered robust lubricating film at a frictional interface,a coefficient of friction(COF)can be reduced by 79.6%to 0.15,and a specific wear rate(W)drops from 1.36×10^(−3) to 6.27×10^(−7) mm^(3)·N^(−1)·m^(−1).Combining outstanding mechanical properties and tribological performance,the hybrid coating exhibits great application potential in controlling friction and ***,this strategy of introducing the target materials into the inherent defects of the raw materials to improve the relevant properties opens new avenues for the design and preparation of composite materials.

关键词： self-lubricating ceramic coatings thermal spray in-situ synthesis MoS_(2)/C friction and wear mechanical properties

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