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A Visual Feedback Control Framework Oriented to Lung Branching Pattern Formation Simulation

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A Visual Feedback Control Framework Oriented to Lung Branchi...

RBAP96 Mediates Radiosensitivity of Breast Cancer Cells via Interacting with Retinoblastoma Protein

2015年中国智能自动化学术会议

作者： Hui Xu Mingzhu Sun Jianda Han Xin Zhao Institute of Robotics and Automatic Information System Nankai University tianjin Key Laboratory of Intelligent Robotics Nankai University State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of Sciences

Mathematical modeling based on reaction-diffusion partial differential equations,is a well-known way to study the mechanism of lung branching pattern ***,model parameter identification is one of the key problems in the research,which is both labor-intensive and of low *** work out this problem,a visual feedback control framework is proposed in this *** framework based on automatic control theory is built,by means of pattern feature feedback,to identify model *** results suggest that this framework is effective and feasible.

关键词： Visual feedback control framework Lung branching pattern formation Model parameter identification Pattern feature extraction

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国际放射医学核医学杂志 2016年第5期40卷 323-328页

作者： Junling Zhang Xiaolei Xue Qinghui Meng Lu Lu Ming Cui Saijun Fan tianjinKeyLaboratoryofRadiationMedicineandMolecularNuclearMedicine InstituteofRadiationMedicineChineseAcademyofMedicalSciencesandPekingUnionMedicalCollegeTianjin300192China DepartmentofOncology LombardiComprehensiveCancerCenterGeorgetownUniversityWashingtonDC20079USA

ObjectiveTo identify a novel retinoblastoma protein(RB)-associated protein(RBAP 96) and to explore the impact of RBAP96 on radiosensitivity of human breast cancer cells.MethodsAn in vivo and in vitro association of RBAP96 with RB was determined by immunoprecipitation-Western blotting and GST pull-down assay. Protein expression was measured by Western blot assay. Cellular survival was evaluated by using a colony formation assay. ResultsIn both in vitro and in vivo assays, we found that the RBAP96 and RB interaction required a 513LXCXE 517 motif on the RBAP96 protein and an intact A/B binding pocket of RB. RBAP96 enhances RB-mediated transcriptional repression. Finally, enforced expression of RBAP96 caused an elevated radiosensitivity of human breast cancer cells bearing wtRB, but did not affect radiosensitivity of breast cancer cells bearing mutant RB. Expression of a full-length RBAP96 with an 513LXCXE 517 inactivating mutation(LXCXE→RXRXH) failed to result in any radiosensitivity alteration. ConclusionThis study for the first time characterizes a novel RB-interacting protein RBAP96 and demonstrates that enforced expression of RBAP96 causes an increase of RBAP96-mediated transcription activation and radiosensitivity via a RB-interacting dependent manner.

关键词：视网膜医学研究临床分析乳腺癌细胞

美式回望期权定价的有限元超收敛分析(英文)

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应用泛函分析学报 2009年第1期11卷 20-32页

作者：林群张书华中国科学院数学与系统科学研究院北京100190 天津财经大学数学经济研究中心天津300222

考虑美式回望看跌期权的有限元方法.在把原问题转化成等价的变分不等式的基础上,研究了半离散格式在L2和L∞范数意义下的最优误差估计.此外,为了进一步提高逼近解的精度,借助超收敛分析技术和插值后处理方法,研究了H1范数意义下的整体... 详细信息

考虑美式回望看跌期权的有限元方法.在把原问题转化成等价的变分不等式的基础上,研究了半离散格式在L2和L∞范数意义下的最优误差估计.此外,为了进一步提高逼近解的精度,借助超收敛分析技术和插值后处理方法,研究了H1范数意义下的整体超收敛以及后验误差估计.

关键词：美式回望期权变分不等式有限元方法最优和超收敛估计插值后处理后验误差估计子

Self-trapping and oscillation of quadruple beams in high band gap of 2D photonic lattices

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Chinese Optics Letters 2013年第9期11卷 21-24页

作者：夏世强宋道红唐莉勤楼慈波李乙刚 The MOE Key Laboratory of Weak Light Nonlinear Photonics TEDA Applied Physics School and School of PhysicsNankai University

through single-site excitation. By changing the initial to the lattices, periodic oscillations of the localized quadruple state becomes a rotating doubly charged undergo charge-flipping when the rotating direction is orientation of the incident quadruple beam related quadruple mode may be obtained. The localized optical vortex （DCV） during rotation and should reversed.

关键词： Self-trapping and oscillation of quadruple beams in high band gap of 2D photonic lattices high

蓝宝石CMP工艺中粗糙度的控制技术(英文)

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蓝宝石CMP工艺中粗糙度的控制技术(英文)

2008全国功能材料科技与产业高层论坛

作者：刘玉岭檀柏梅牛新环赵海涛河北工业大学

蓝宝石是第三代半导体材料GaN的主要衬底材料,其表面质量直接影响器件的性能。对蓝宝石衬底片进行CMP研究,系统分析了影响CMP效果的多种因素,讨论了CMP机理模型,采用自制的小粒径(20～30nm)、低分散度的SiO水溶胶磨料,避免由粒径不均匀... 详细信息

蓝宝石是第三代半导体材料GaN的主要衬底材料,其表面质量直接影响器件的性能。对蓝宝石衬底片进行CMP研究,系统分析了影响CMP效果的多种因素,讨论了CMP机理模型,采用自制的小粒径(20～30nm)、低分散度的SiO水溶胶磨料,避免由粒径不均匀造成的划伤,在抛光过程中向CMP浆料中加入复合表面活性剂,降低了表面张力,实现了高凹凸选择性和低粗糙度。质量传递和温度成正向关系,温度愈高,传递速度越快、速率差愈大,通过控制适当的温度实现了粗糙度达亚纳米级,最佳值达到0.2nm,获得了比较完美的蓝宝石表面状态。

关键词：化学机械抛光蓝宝石粗糙度控制

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InP外延材料的MBE生长模式

Journal of Semiconductors 2007年第Z1期28卷 28-32页

作者：皮彪舒永春林耀望徐波姚江宏邢晓东曲胜春王占国南开大学弱光非线性光子学材料先进技术及制备教育部重点实验室天津300457 中国科学院半导体研究所半导体材料科学重点实验室北京100083

采用固态磷源分子束外延技术,在不同的生长条件下生长了InP外延材料,并用原子力显微镜对样品表面形貌进行了系统研究.实验结果表明,样品表面形貌的显著变化与生长模式发生变化有关;二维(2D)生长模式和三维(3D)生长模式之间存在转换的临... 详细信息

采用固态磷源分子束外延技术,在不同的生长条件下生长了InP外延材料,并用原子力显微镜对样品表面形貌进行了系统研究.实验结果表明,样品表面形貌的显著变化与生长模式发生变化有关;二维(2D)生长模式和三维(3D)生长模式之间存在转换的临界工艺条件.通过对实验数据的分析,绘制了InP外延生长模式对应工艺条件的区域分布图;在2D生长区域获得了高质量的InP/InP外延材料.

关键词：固态源分子束外延 InP 生长模式

The structure of WbnH in a near active state

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Protein & Cell 2015年第8期6卷 615-618页

作者： Fengzhi Li Siwei Li Xiaofen Liu Xue Yang Peng Wang Yuequan Shen State Key Laboratory of Medicinal Chemical Biology Nankai University Tianjin 300071 China College of Life sciences Nankai University Tianjin 300071 China tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences Tianjin 300308 China Synergetic Innovation Center of Chemical science and Engineer- ing Tianjin 300071 China

Dear Editor, Gram-negative bacteria possess a complicated membrane system that plays an essential role in interactions between bacteria and the envJronment （Reeves and Wang, 2002）. The inner leaflet of the membrane is composed of various glycerophospholipids, and the outer leaflet consists primarily of lipopolysaccharide （LPS） molecules.

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Pulmonary complications and respiratory management in neurocritical care:a narrative review

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Chinese Medical Journal 2022年第7期135卷 779-789页

作者： Junxian Wen Jia Chen Jianbo Chang Junji Wei Department of Neurosurgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeDongcheng DistrictBeijing 100730China

Neurocritical care(NCC)is not only generally guided by principles of general intensive care,but also directed by specific goals and *** review summarizes the common pulmonary diseases and pathophysiology affecting NCC patients and the progress made in strategies of respiratory support in *** review highlights the possible interactions and pathways that have been revealed between neurological injuries and respiratory diseases,including the catecholamine pathway,systemic inflammatory reactions,adrenergic hypersensitivity,and dopaminergic *** complications of neurocritical patients include pneumonia,neurological pulmonary edema,and respiratory *** aspects of respiratory management include prioritizing the protection of the brain,and the goal of respiratory management is to avoid inappropriate blood gas composition levels and intracranial *** with the traditional mode of protective mechanical ventilation with low tidal volume(V_(t)),high positive end-expiratory pressure(PEEP),and recruitment maneuvers,low PEEP might yield a potential benefit in closing and protecting the lung *** neuromonitoring can ensure the safety of respiratory maneuvers in clinical and scientific *** studies are required to develop guidelines for respiratory management in NCC.

关键词： Neurocritical care Pneumonia Respiratory management Multimodel neuromonitoring Tracheostomy Mechanical ventilation Positive end-expiratory pressure

一个新型三硫醚配体-银(Ⅰ)配位聚合物的合成、表征与晶体结构(英文)

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天津师范大学学报（自然科学版） 2005年第2期25卷 1-4页

作者：郭亚梅赵小军杜淼天津大学化学系天津300072 天津师范大学化学与生物科学学院天津300074

报道了一个基于柔性三硫醚配体(L=1 ,3,5 -三(苯基硫代亚甲基) - 2 ,4,6-三甲基苯)的新型Ag 配合物{[Ag3 (L ) 2 (Cl O4) 2 ](Cl O4) }∞(1 )的合成与结构表征.X-射线单晶衍射结果表明,配合物1为单斜晶系,C2 /c空间群,晶胞参数为a=3.49... 详细信息

报道了一个基于柔性三硫醚配体(L=1 ,3,5 -三(苯基硫代亚甲基) - 2 ,4,6-三甲基苯)的新型Ag 配合物{[Ag3 (L ) 2 (Cl O4) 2 ](Cl O4) }∞(1 )的合成与结构表征.X-射线单晶衍射结果表明,配合物1为单斜晶系,C2 /c空间群,晶胞参数为a=3.4931 (7) nm,b=2 .1 5 84(8) nm,c=2 .8782 (4)nm,β=1 2 3.688(1 0 ) o,V=1 8.0 5 6(3) nm3 ,Z=8.配合物1的不对称单元中存在3个晶体学独立的Ag 离子,其中一个为四配位,另外两个具有线性二配位模式.每个配体中的3个硫原子通过与其邻近的3个Ag 离子配位,形成由6个金属离子和6个配体所组成的六边形48元大环重复单元,并且通过这种重复单元构成具有(6,3)

关键词：晶体结构银(I)配合物三硫醚配体配位聚合物