检索结果-南通市图书馆

Improvement of a SARS-CoV-2 vaccine by enhancing the conjugation efficiency of the immunogen to self-assembled nanoparticles

引用

Cellular & Molecular Immunology 2021年第8期18卷 2042-2044页

作者： Xiantao Zhang Yaochang Yuan Bolin Wu Xuemei Wang Yingtong Lin Yuewen Luo Rong Li Tao Chen Jieyi Deng Xu Zhang Fan Zou Xin He Hui Zhang Institute of Human Virology Key Laboratory of Tropical Disease Control of the Ministry of EducationGuangdong Engineering Research Center for Antimicrobial Agents and ImmunotechnologyEngineering Research Center of Gene Vaccines of the Ministry of EducationZhongshan School of MedicineSun Yat-Sen UniversityGuangzhou510080GuangdongChina Qianyang Biomedical Research Institute GuangzhouGuangdong510063China

To the Editor:Coronavirus disease 2019(COVID-19)has become a worldwide public health emergency,threatening public health and global stability[1].The development of a safe and effective vaccine is urgently needed to co... 详细信息

关键词： vaccine vaccines assembled

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The challenge of emerging SARS-CoV-2 mutants to vaccine development

引用

Journal of Genetics and Genomics 2021年第2期48卷 102-106页

作者： Rong Li Jun Liu Hui Zhang Institute of Human Virology Key Laboratory of Tropical Disease Control of Ministry of EducationGuangdong Engineering Research Center for Antimicrobial Agent and ImmunotechnologyZhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 570080China

Since the outbreak of the pandemic,waves of epidemics caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)variants that harbor novel mutations have never ***,it undergoes rapid mutations that involve single-nucleotide polymorphism(SNP)dominantly,whereas ORF1ab and spike genes contain the most of more than 20,000 mutation sites reported within a year(Fang et al.,2021).Mutations inside spike protein are highly concerned for their potential impact on viral transmissibility and immune evasion,as spike protein is responsible for the interaction with the viral receptor angiotensin-converting enzyme 2(ACE2)to mediate viral entry to the target cells.D614G identified in early 2020 is a globally dominant mutation(Korber et al.,2020).In late 2020,several variants were reported,which had caused continental and eventually worldwide *** notable variants include B.1.1.7 lineage(501Y.V1,Variant of Concern[VOC]202012/01),501Y.V2 variant(known as B.1.351 lineage),and P.1 lineage(also named 501Y.V3).In comparison with the D614G and D614 lineages identified in early 2020,they contain a large number of mutations within spike protein(Fig.1).

关键词： respiratory acute eventually

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：