Improvement of a SARS-CoV-2 vaccine by enhancing the conjugation efficiency of the immunogen to self-assembled nanoparticles

作     者：Xiantao Zhang Yaochang Yuan Bolin Wu Xuemei Wang Yingtong Lin Yuewen Luo Rong Li Tao Chen Jieyi Deng Xu Zhang Fan Zou Xin He Hui Zhang 

作者机构：Institute of Human VirologyKey Laboratory of Tropical Disease Control of the Ministry of EducationGuangdong Engineering Research Center for Antimicrobial Agents and ImmunotechnologyEngineering Research Center of Gene Vaccines of the Ministry of EducationZhongshan School of MedicineSun Yat-Sen UniversityGuangzhou510080GuangdongChina Qianyang Biomedical Research InstituteGuangzhouGuangdong510063China 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2021年第18卷第8期

页      面：2042-2044页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：This work was supported by the National Special Research Program of China for Important Infectious Diseases(2017ZX10202102 and 2018ZX10302103) the Special 2019-nCoV Project of the National Key Research and Development Program of China(2020YFC0841400) the First Panel of 2021 Emergency Key Program of Guangzhou Laboratory(EKPG21-24) the Special 2019-nCoV Program of the Natural Science Foundation of China(NSFC)(82041002) the Special Research and Development Program of Guangzhou(202008070010) the Important Key Program of NSFC(81730060) the Joint-Innovation Program in Healthcare for Special Scientific Research Projects of Guangzhou(201803040002)to H.Z 

主　　题：vaccine vaccines assembled 

摘      要：To the Editor:Coronavirus disease 2019(COVID-19)has become a worldwide public health emergency,threatening public health and global stability[1].The development of a safe and effective vaccine is urgently needed to control the ***,nanoparticle(NP)vaccines can generate a more potent immune response than mRNA vaccines[2].