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Apigenin is an anoikis sensitizer with strong anti-metastatic properties in experimental breast cancer

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Food Science and Human Wellness 2024年第4期13卷 2221-2233页

作者： Ruijie Xu Zhijie Yao Hao Zhang Haitao Li Wei Chen State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China School of Food Science and Technology Jiangnan UniversityWuxi 214122China

Loss of susceptibility to anoikis signals is a crucial step in *** resistance therefore represents a promising adjuvant therapeutic target for cancer *** this study,we have conducted a rationalized screening to search for novel leading anoikis sensitizer from daily *** 19 tested dietary phytochemicals,the best results were obtained with apigenin,a natural component of ***,apigenin sensitized breast cancer cells to anoikis,lowered the number of circulating tumor cells,and protected against breast cancer metastasis to lung in ***,we demonstrated that the thromboxane A_(2)(TXA_(2))-TXA_(2)receptor(TP)axis has a critical role in acquired anoikis resistance by activating PI3K-Akt signaling *** of TXA_(2)signaling up-regulated p53 as well as its target gene p21,caused a G1 phase arrest,and finally led to apoptosis in breast cancer ***_(2)level was positively correlated with breast cancer cell anoikis rate,and apigenin significantly inhibited TXA_(2)biosynthesis in vitro and in ***,we identified apigenin as a potent anoikis sensitizer with anti-metastatic properties in a mouse model of breast cancer,and these findings might provide a rationale for introducing apigenin supplementation to breast cancer patients.

关键词： Apigenin Anoikis Breast cancer metastasis Thromboxane A2

Large contributions of emission reductions and meteorological conditions to the abatement of PM_(2.5)in Beijing during the 24th Winter Olympic Games in 2022

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Journal of Environmental Sciences 2024年第2期136卷 172-188页

作者： Yaping Jiang Shaocai Yu Xue Chen Yibo Zhang Mengying Li Zhen Li Zhe Song Pengfei Li Xiaoye Zhang Eric Lichtfouse Daniel Rosenfeld Key Laboratory of Environmental Remediation and Ecological Health Ministry of EducationResearch Center for Air Pollution and HealthCollege of Environmental and Resource SciencesZhejiang UniversityHangzhou 310058China College of Science and Technology Hebei Agricultural UniversityBaoding 071000China Chinese Academy of Meteorological Sciences China Meteorological AdministrationBeijing 100081China Aix-Marseille Univ CNRSColl FranceCNRSIRDINRAEEuropole Mediterraneen de l’ArboisAvenue Louis Philibert13100 Aix en ProvenceFrance Xi’an Jiaotong University State Key Laboratory of Multiphase Flow in Power EngineeringXi’an 710049China Institute of Earth Sciences The Hebrew University of JerusalemJerusalemIsrael

To guarantee the blue skies for the 2022 Winter Olympics held in Beijing and Zhangjiakou from February 4 to 20,Beijing and its surrounding areas adopted a series of emission control *** provides an opportunity to determine the impacts of large-scale temporary control measures on the air quality in Beijing during this special ***,we applied the WRF-CMAQ model to quantify the contributions of emission reduction measures and meteorological *** show that meteorological conditions in 2022 decreased PM_(2.5)in Beijing by 6.9 and 11.8μg/m^(3)relative to 2021 under the scenarios with and without emission reductions,*** emission reduction measures implemented in Beijing and seven neighboring provinces resulted in an average decrease of 13.0μg/m^(3)(-41.2%)in PM_(2.5)in *** the entire period,local emission reductions contributed more to good air quality in Beijing than nonlocal emission *** the emission reduction scenario,local,controlled regions,other regions,and boundary conditions contributed 47.7%,42.0%,5.3%,and 5.0%to the PM_(2.5)concentrations in Beijing,*** results indicate that during the cleaning period with the air masses from the northwest,the abatements of PM_(2.5)were mainly caused by local emission ***,during the potential pollution period with the air masses from the east-northeast and west-southwest,the abatements of PM_(2.5)were caused by both local and nonlocal emission reductions almost *** implies that regional coordinated prevention and control strategies need to be arranged scientifically and rationally when heavy pollution events are forecasted.

关键词： PM_(2.5) WRF-CMAQ Meteorological conditions Emission reductions Winter Olympic games

Reversing Conventional Site-Selectivity:Electrochemically Driven C(sp^(2))-H/C(sp^(3))-H Coupling with H_(2)Evolution

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CCS Chemistry 2023年第5期5卷 1086-1095页

作者： Xuelian Zheng Pan Peng Cheng Huang Qingquan Lu The Institute for Advanced Studies Wuhan UniversityWuhan 430072

Sustainable and site-selective C–H functionalization is still a challenge because of the comparable properties of bonds of the same ***,an electrochemical C(sp^(2))–H/C(sp^(3))–H coupling with aryl iodides is reported for the first *** C(sp^(2))–H bond outperformed the much weaker C(sp^(2))–I bond participating in C(sp^(2))–H/C(sp^(3))–H *** protocol features mild reaction conditions,good functional group tolerance,and *** products with C–I bonds are versatile moieties for further synthetic manipulation,that can undergo Suzuki,Sonogashira,Ullmann-Ma,Catellani,Heck reactions,and so on to introduce new functional groups into target molecules with good *** investigations showed that the site selectivity of the reaction is enabled by an iodineassisted[3,3]-sigmatropic rearrangement,and the interaction of hypervalent iodine generated in situ with an enolate is the rate-determining step.

关键词： electrosynthesis electrooxidation C–H functionalization oxidative coupling alkylation

gem-Difluorovinylation of alkynyl bromoarenes via dual nickel-/palladium-catalyzed crosselectrophile coupling

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Organic Chemistry Frontiers 2022年第2期9卷 305-310页

作者： Haotian Sun Baojian Xiong Yuan Yang Jiangjun Liu Xuemei Zhang Zhong Lian Department of Dermatology State Key Laboratory of Biotherapy and Cancer CenterNational Clinical Research Center for GeriatricsWest China Hospital and West China School of PharmacySichuan UniversityChengdu 610041China

A dual nickel-/palladium-catalyzed gem-difluorovinylation of alkynyl bromoarenes is *** method proceeds smoothly to afford various dihydrobenzofuran compounds containing gem-difluorovinyl fragments with excellent stere-oselectivities in moderate to excellent *** strategy also features good functional group *** studies reveal that the C-OTs bond and C-Br bond are selectively oxidative-added by nickel and palladium complexes respec-tively,and palladium is the center metal in the reductive elimination step.

关键词： palladium nickel vinyl

Dual-template synthesis of defect-rich mesoporous Co_(3)O_(4) for low temperature CO oxidation

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Chinese Chemical Letters 2023年第7期34卷 368-372页

作者： Shuhua Song Jian Liang Wei Xiao Dong Gu The Institute for Advanced Studies Wuhan UniversityWuhan 430072China College of Chemistry and Molecular Sciences Wuhan UniversityWuhan 430072China

CO oxidation is a benchmark in heterogeneous catalysis for evaluation of redox catalysts due to its practical relevance in many applications and the fundamental problems associated with its very high activity at low *** which,Co_(3)O_(4) is one of the most active non-precious metal *** crystal planes and cobalt sites are considered to be important for its high catalytic ***,we demonstrate an enhanced CO oxidation activity by a defect-rich mesoporous Co_(3)O_(4) that prepared by a designed dual-template *** different kinds of silicas are used as hard-templates at the same time,resulting in a defect-rich mesoporous Co_(3)O_(4) with a surface area as high as 169 m^(2)/*** catalyst exhibited a very high catalytic activity for low temperature CO oxidation with a light-off temperature at -73℃ under the space velocity of 80,000 mL h^(-1)g^(-1)_(cat).Further studies reveal that the high surface area promotes the lattice oxygen mobility,surface rich of Co^(2+)species and active oxygen species are crucial for the high catalytic ***,the dual-template approach paves a way towards the design and construction of high-surface-area mesoporous metal oxides for various applications.

关键词： Mesoporous Dual-template Co_(3)O_(4) CO oxidation Defect

Sulfur-doped CMK-5 with expanded lattice for high-performance lithium ion batteries

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Chinese Chemical Letters 2023年第7期34卷 279-283页

作者： Zhenjin Liang Yuhao Peng Xing Zhang Kewei Cao Wei Xiao Dong Gu The Institute for Advanced Studies Wuhan UniversityWuhan 430072China College of Chemistry and Molecular Sciences Hubei Key Laboratory of Electrochemical Power SourcesWuhan UniversityWuhan 430072China

Heteroatom-doped porous carbon materials are very attractive for lithium ion batteries(LIBs) owing to their high specific surface areas, open pore structures, and abundant active sites. However, heteroatomdoped porous carbon with very high surface area and large pore volume are highly desirable but still remain a big challenge. Herein, we reported a sulfur-doped mesoporous carbon(CMK-5-S) with nanotubes array structure, ultrahigh specific surface area(1390 m^(2)/g), large pore volume(1.8 cm^(3)/g), bimodal pore size distribution(2.9 and 4.6 nm), and high sulfur content(2.5 at%). The CMK-5-S used as an anode material for LIBs displays high specific capacity, excellent rate capability and highly cycling stability. The initial reversible specific capacity at 0.1 A/g is as high as 1580 mAh/g and simultaneously up to 701 mAh/g at 1A/g even after 500 cycles. Further analysis reveals that the excellent electrochemical storage performances is attributed to its unique structures as well as the expanded lattice by sulfur-doping.

关键词： Mesoporous material CMK-5 Hollow structure Sulfur-doping Lithium ion batteries

Stable one dimensional(1D)/three dimensional(3D)perovskite solar cell with an efficiency exceeding 23%

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InfoMat 2022年第5期4卷 187-195页

作者： Qinghua Chen Kaimo Deng Ying Shen Liang Li School of Physical Science and Technology Jiangsu Key Laboratory of Thin FilmsSoochow UniversitySuzhouP.R.China

The interface properties of organic–inorganic mixed halide perovskite solar cells play a significant role in their photovoltaic *** states at the interface can decrease the power conversion efficiency through defect-assisted charge recombination and degrade the long-term ***-dimensional perovskites exhibit excellent *** can be combined with three dimensional(3D)perovskites to utilize their advantages for fabrication of highperformance *** this study,we successfully construct a robust interface for perovskite films through mixed-dimensional *** the introduction of a one dimensional(1D)-structured capping layer on the 3D perovskite through post-treatment,the number of defect states in the perovskite film is significantly decreased,while the lifetime of the photocarriers is *** addition,the 1D capping layer can serve as a diffusion barrier to reduce the ion migration and protect the vulnerable 3D perovskite against *** solar cells based on stacked 1D/3D structures exhibit a power conversion efficiency of 23.3%and maintain 80%of the initial efficiency after storage for over 800 h under ambient conditions with a humidity of 50%.Their performances are superior to those of the 3D *** study provides a simple approach to simultaneously enhance the efficiency and stability of perovskite solar cells and may guide the development of other solar cells.

关键词： interface passivation ion migration perovskite solar cells stability

Recent advances in Ni-Al bimetallic catalysis for unreactive bond transformation

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Science China Chemistry 2018年第8期61卷 1004-1013页

作者： Yin-Xia Wang Mengchun Ye State Key Laboratory and Institute of Elemento-Organic Chemistry Nankai University Tianjin 300071 China Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin 300071 China

Ni-Al bimetallic catalysis proves to be an efficient catalytic strategy for unreactive bond transformations. Recently, chiral bifunctional ligands, especially amphoteric secondary phosphine oxide(SPO) ligand, are used for a more powerful synergistic effect in the bimetal-catalyzed reactions, providing not only milder reaction conditions and higher reactivity but also excellent reaction selectivity. Herein, we give a brief review on the development of Ni-Al bimetallic catalytic system and highlight recent advances in enantioselective Ni-Al bimetallic catalysis for unreactive bond transformation.

关键词： Ni-Al 催化作用金属片反应选择氢氧化物反应条件催化系统膨胀率

Semi-closed synthesis of nitrogen and oxygen Co-doped mesoporous carbon for selective aqueous oxidation

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Green Energy & Environment 2022年第1期7卷 43-52页

作者： Chen Xing Daihui Yang Yan Zhang Tian Sun Junfei Duan Hussein A.Younus Shiguo Zhang College of Materials Science and Engineering Hunan Province Key Laboratory for Advanced Carbon Materials and Applied TechnologyHunan UniversityChangsha410082China School of Materials Science and Engineering Changsha University of Science and TechnologyChangsha410004China Chemistry Department Faculty of ScienceFayoum UniversityFayoum63514Egypt

Heteroatom-doped meso/micro-porous carbon materials are conventionally produced by harsh carbonization under an inert atmosphere involving specific precursors,hard/soft templates,and heteroatom-containing ***,we report a facile synthesis of N and O co-doped meso/micro-porous carbon(NOMC)by template-free carbonization of a small-molecule precursor in a semi-closed *** semi-closed carbonizaiton process yields hydrophilic NOMCs with large surface area in a high *** porous structure as well as the elemental composition of NOMCs can be modulated by changing the holding time at a particular *** as metal-free heterogeneous catalysts can selectively oxidize benzyl alcohol and its derivatives into aldehydes/ketones with>85%conversion in aqueous solution,which is much higher than that of the control sample obtained in tube furnace(21%conversion),mainly due to their high N content,high percentage of pyridinic N,and large surface *** presence of O-containing moieties also helps to improve the hydrophilicity and dispersion ability of catalysts and thus facilitates the mass transfer process during aqueous *** NOMC catalysts also dispayed excellent activity for a wide range of substrates with a selectivity of>99%.

关键词： Semi-closed carbonization Nitrogen and oxygen doping Mesoporous carbon Metal-free catalyst Selective aqueous oxidation