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Blood-brain barrier and cerebral blood flow: Age differences in hemorrhagic stroke

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Journal of Innovative Optical Health sciences 2015年第6期8卷 101-110页

作者： Semyachkina-Glushkovskaya Oxana Sindeeva Olga Abdurashitov Arkady Sindeev Sergey Zinchenko Ekaterina Gekaluk Artem Ulanova Maria Mohanad Kassim Yankovskaya Ludmila Tuchin Valery Department of Physiology of Human and Animals Saratov State University Astrakhanskaya Str.83 Saratov 410012Russia Department of Optics and Biophotonics Saratov State University Astrakhanskaya Str.83 Saratov 410012Russia Department of Therapy Grodno Medical State University Limozha Str.23Grodno 230005Byelorussia Laboratory of Biophotonics Tomsk State University Tomsk 634050Russia

Neonatal stroke is similar to the stroke that occurs in adults and produces a significant morbidity and long-term neurologic and cognitive *** are important differences in the factors,clinical events and outcomes associated with the stroke in infants and ***,mechanisms underlying age differences in the stroke development remain largely ***,treatment guidelines for neonatal stroke must extrapolate from the adult data that is often not suitable for *** new information about differences between neonatal and adult stroke is essential for identification of significant areas for future treatment and effective prevention of neonatal ***,we studied the development of stress-induced hemorrhagic stroke and possible mechanisms underlying these processes in newborn and adult *** histological methods and magnetic resonance imaging,we found age differences in the type of intracranial *** rats demonstrated small superficial bleedings in the cortex while adult rats had more severe deep bleedings in the *** Doppler optical coherent tomography,we found higher stress-reactivity of the sagittal sinus to deleterious effects of stress in newborn *** rats suggesting that the cerebral veins are more vulnerable to negative stress factors in neonatal *** brain in ***,adult but not newborn rats demonstrated the stroke-induced breakdown of blood brain barrier(BBB)*** one of possible mechanisms underlying the higher resistance to stress-related stroke injures of cerebral vessels in newborn rats compared with adult animals is the greater expression of two main tight junction proteins of BBB(occludin and claudin-5)in neonatal *** brain in rats.

关键词： Stroke age di®erences cerebral blood flow brain blood barrier

Thermally stimulated exciton emission in Si nanocrystals

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Light(science & Applications) 2017年第1期6卷 228-234页

作者： Elinore MLD de Jong Huub Rutjes Jan Valenta M Tuan Trinh Alexander N Poddubny Irina N Yassievich Antonio Capretti Tom Gregorkiewicz Van der Waals-Zeeman Institute University of AmsterdamScience Park 9041098 XHAmsterdamThe Netherlands Department of Chemical Physics and Optics Faculty of Mathematics and PhysicsCharles UniversityKe Karlovu 312116 Prague 2Czech Republic Department of Electrical Engineering and Computer science University of Michigan2200 Bonisteel BlvdAnn ArborMI 48109USA Ioffe Institute Russian Academy of Sciences26 Polytechnicheskaya194021 St PetersburgRussia

Increasing temperature is known to quench the excitonic emission of bulk silicon,which is due to thermally induced dissociation of ***,we demonstrate that the effect of temperature on the excitonic emission is reversed for quantumconfined silicon *** laser-induced heating of silicon nanocrystals embedded in SiO2,we achieved a more than threefold(4300%)increase in the radiative(photon)emission *** theoretically modeled the observed enhancement in terms of the thermally stimulated effect,taking into account the massive phonon production under intense *** results elucidate one more important advantage of silicon nanostructures,illustrating that their optical properties can be influenced by *** also provide an important insight into the mechanisms of energy conversion and dissipation in ensembles of silicon nanocrystals in solid *** practice,the radiative rate enhancement under strong continuous wave optical pumping is relevant for the possible application of silicon nanocrystals for spectral conversion layers in concentrator photovoltaics.

关键词： micro-photoluminescence nanocrystal optical spectroscopy silicon thermal

The morphological changes in the internal organs of laboratory animals after prolonged oral administration of gold nanoparticles

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Journal of Innovative Optical Health sciences 2016年第4期9卷 74-84页

作者： Alla B.Bucharskaya Galina N.Maslyakova Svetlana S.Pakhomy Olga V.Zlobina Irina O.Bugaeva Nikita A.Navolokin Boris N.Khlebtsov Vladimir A.Bogatyrev Nikolai G.Khlebtsov Valery V.Tuchin Saratov State Medical University n.a.V.I.Razumovsky 410012 Saratov Russia Institute of Biochemistry and Physiology of Plants and Microorganisms RAS 410049 Saratov Russia Research-Educational Institute of Optics and Biophotonics Saratov National Research State University 410012 Saratov Russia Institute of Precision Mechanics and Control RAS 410028 Saratov Russia Interdisciplinary Laboratory of Biophotonics Tomsk National Research State University 634050 TomskRussia

Recently gold nanoparticles(GNPs)have been actively studied as photot hermal converters,drug carriers,and imaging agents in a wide range of applications in cancer diagnosis and ther *** prolonged peroral administration of GNPs in a range of sizes was performed to investigate the morphological changes and their reversibility in the internal organs of laboratory *** this study,GNP's with average diameters of 2 nm,15 nm and 50nm were administered during 30 days,and the reversibility of morphological changes was investigated 14 days after *** the prolonged administration of GNPs,the severity of morphological changes in the liver,kidney,spleen and lymph nodes depended on the nanoparticle ***,50 nm nano-particles caused the most pronounced dystrophic and necrobiotic effects,whereas the smallest 2 nm nanoparticles caused proliferative *** importantly,the development of patho-logical processes was reversible,as evidenced by the gradual restoration of the organ structure at 14 days after the end of GNPs administration.

关键词： Gold nanoparticles prolonged peroral administration morphological changes reversibility.

Pendulum-type laser strainmeter

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Earthquake science 2015年第4期28卷 311-317页

作者： Grigory Ivanovich Dolgikh V.I.Il'ichev Pacific Oceanological Institute of the Far Eastern Branch Russian Academy of Sciences

Constructive disposition principles of the basic optical units of Michelson interferometers are used in making one-coordinate laser strainmeters of unequal-arm type. The fundamental advantages of pendulurn-type laser ... 详细信息

关键词： Amplitude-frequency characteristic Classical-type laser strainmeter Elastic wave Infrasound Pendulum-type laser strainmeter

维普期刊数据库

The bactericidal effect of continuous wave laser with strongly absorbing coating at the fiber tip

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Journal of Innovative Optical Health sciences 2018年第5期11卷 51-58页

作者： Vadim Elagin Anton Smirnov Vladimir Yusupov Alexey Kirillov Nadezhda Ignatova Olga Streltsova Evgeniy Grebenkin Vladislav Kamensky Institute of Biomedical Technologies Privolzhsky Research Medical University 10/1 Minina Square Nizhny Novgorod 603005Russia Laboratory of Laser Nanomodification of Materials Institute of Applied Physics russian Academy of sciences 46 Ulyanova Street Nizhny Novgorod 603950Russia Institute of Photon Technologies of Federal Scientific Research Centre"Crystallography and Photonics"of the russian Academy of sciences 2 Pionerskaya Street MoscowTroitsk 108840Russia Department of Innovative Program Institute of Applied Physics russian Academy of sciences 46 Ulyanova Street Nizhny Novgorod 603950Russia

The bactericidal effect of laser radiation with a quartz fiber-based transmission system with a strong absorption coating converter against bacteria associated with urological stones has been *** am-negative rod Escherichia coli and the Gram-positive coccus Staphylococcus epi-dermidis,Staphylococcus aureus,Enterococcus faecalis and Enterococcus faecium were used in this *** bacterial species was treated by continuous-wave near infrared laser coupled with bare fiber tip or strongly absorption coating fiber *** treatment,the temperature of bacterial suspension was *** addition,the temperature dist ribution was *** has been shown that using laser with a strongly absorption coating fiber tip results in significant bactericidal *** decrease of the amount of *** and *** was 100%after treatment with an output power of6 W of radiation at a wavelength of 0.97 pum for *** of *** and *** colony-forming unit was reduced to 70%after same *** peak temperature of bacterial suspension was 86℃ after treatment by laser with a strongly absorption coating fiber *** with a strongly absorpt ion coating fiber tip provides large scale hydrodynamic flows directed away from the fiber *** laser with a strongly absorption coating fiber tip has bactericidal *** main role is associated with the effect of high temperature,which,in the form of flow in a liquid medium,afects bacteria.

关键词： Laser strongly absorbing coating bacteria bacterididal efect laserinduced hydrodynamic

Effect of 0.3% Sc on microstructure, phase composition and hardening of Al-Ca-Si eutectic alloys

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Transactions of Nonferrous Metals Society of China 2017年第4期27卷 741-746页

作者： Nikolay BELOV Evgenia NAUMOVA Torgom AKOPYAN National University of science and Technology MISIS 4 Leninskiy pr. 4 Moscow 119049 Russia Institute of russian Academy of sciences A. A. Baikov Institute of Metallurgy and Material Science RASLeninskiy pr. 49 Moscow 119991 Russia

The phase composition,microstructure and hardening of aluminum-based experimental alloys containing0.3%Sc,0?14%Si and0?10%Ca(mass fraction)were *** experimental study(electron microscopy,thermal analysis and hardnessmeasurements)was combined with Thermo-Calc software simulation for the optimization of the alloy *** wasdetermined that the maximum hardening corresponded to the annealing at300?350°С,which was due to the precipitation of Al3Scnanoparticles with their further *** alloys falling into the phase region(Al)+Al4Ca+Al2Si2Ca have demonstrated asignificant hardening *** ternary eutectic(Al)+Al4Ca+Al2Si2Ca had a much finer microstructure as compared to the Al?Sieutectic,which suggests a possibility of reaching higher mechanical properties as compared to commercial alloys of the *** commercial alloys of the A356type,the model alloy does not require quenching,as hardening particles are formed in thecourse of annealing of castings.

关键词： Al-Ca-Si-Sc system alloy eutectic Al3Sc nanoparticles phase composition microstructure heat treatment hardening

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Combined effect of surface microgeometry and adhesion in normal and sliding contacts of elastic bodies

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Friction 2017年第3期5卷 339-350页

作者： Irina GORYACHEVA Yulia MAKHOVSKAYA Institute for Problems in Mechanics of the russian Academy of sciences Pr.Vernadskogo 101-1 Moscow 119526 Russia

In this study,models are proposed to analyze the combined effect of surface microgeometry and adhesion on the load-distance dependence and energy dissipation in an approach-separation cycle,as well as on the formation and rupture of adhesive bridges during *** models are based on the Maugis-Dugdale approximation in normal and frictional (sliding and rolling) contacts of elastic bodies with regular surface *** the normal adhesive contact of surfaces with regular relief,an analytical solution,which takes into account the mutual effect of asperities,is *** contribution of adhesive hysteresis into the sliding and rolling friction forces is calculated for various values of nominal pressure,parameters of microgeometry,and adhesion.

关键词： adhesion roughness discrete contact rolling friction sliding friction

A novel role for mitochondrial fission in macrophages: trained innate immunity induced by beta-glucan

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Cellular & Molecular Immunology 2023年第8期20卷 864-866页

作者： Anna Brichkina Hans-Uwe Simon Institute of Systems Immunology Center for Tumor Biology and ImmunologyPhilipps University of Marburg35043MarburgGermany Member of the German Center for Lung Research(DZL) Philipps University of Marburg35043MarburgGermany Laboratory of Molecular Immunology Institute of Fundamental Medicine and BiologyKazan Federal University420012KazanRussia Institute of Pharmacology University of Bern3010BernSwitzerland Institute of Biochemistry Brandenburg Medical School16816NeuruppinGermany

In a recent paper published in Nature Immunology,Ding et *** new insights into the mechanism of how trained innate immunity could eradicate *** authors demonstrated that yeast-derived whole beta-glucan particles(WGP)increased the responsiveness of lung interstitial macrophages to tumor-derived factors associated with the subsequent inhibition of tumor metastasis through enhanced cytotoxicity to cancer *** authors identified the metabolic sphingolipid–mitochondrial fission axis in WGP-trained macrophages as the key pathway responsible for this phenomenon and categorized it as a mechanism of trained innate immunity[1].

关键词： subsequent insight immunity

Discovery of Japalura chapaensis Bourret,1937(Reptilia:Squamata:Agamidae)from Southeast Yunnan Province,China

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Zoological Research 2018年第2期39卷 105-113页

作者： Kai Wang Ke Jiang Yu-Fan Wang Nikolay A.Poyarkov Jr. Jing Che Cameron D.Siler Sam Noble Oklahoma Museum of Natural History & Department of Biology University of Oklahoma Kunming Institute of Zoology Chinese Academy of Sciences Southeast Asia Biodiversity Research Institute Chinese Academy of Sciences Zhejiang Forest Resource Monitoring Center Department of Vertebrate Zoology Biological Faculty Lomonosov Moscow State University

Due to a paucity of surveys in northern Indochina and lack of international collaborations among neighboring countries, recognized distributional ranges for many amphibian and reptile species end at the political borders for some countries, despite seemingly continuous suitable habitat spanning the region. Combining both morphological and genetic data, we report the first discovery of Japalura chapaensis, a rare agamid lizard believed previously to be endemic to northern Vietnam only, along the border region of southeastern Yunnan Province,China. To facilitate future research on the genus Japalura sensu lato in Indochina, we provide detailed descriptions of additional specimens of this rare species, including the first description of coloration in life and an expanded diagnosis, and discuss the species boundary of J. chapaensis with respect to its congeners.

关键词： Draconinae Indochina Morphological Variation New record Range extension Systematics Taxonomy