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MH-STRALP:A scoring system for prognostication in patients with upper gastrointestinal bleeding

World Journal of Gastrointestinal Surgery 2024年第3期16卷 790-806页

作者： Jun-Nan Hu Fei Xu Ya-Rong Hao Chun-Yan Sun Kai-Ming Wu Yong Lin Lan Zhong Xin Zeng Department of Gastroenterology Shanghai East HospitalTongji University School of MedicineShanghai 200120China Department of Gastroenterology Shanghai Changzheng HospitalNavy Military Medical UniversityShanghai 200003China

BACKGROUND Upper gastrointestinal bleeding(UGIB)is a common medical emergency and early assessment of its outcomes is vital for treatment *** To develop a new scoring system to predict its *** In this retrospective study,692 patients with UGIB were enrolled from two cen-ters and divided into a training(n=591)and a validation cohort(n=101).The clinical data were collected to develop new prognostic prediction *** en-dpoint was compound outcome defined as(1)demand for emergency surgery or vascular intervention,(2)being transferred to the intensive care unit,or(3)death during *** models’predictive ability was compared with previously esta-blished scores by receiver operating characteristic(ROC)*** Totally 22.2%(131/591)patients in the training cohort and 22.8%(23/101)in the validation cohort presented poor *** on the stepwise-forward Lo-gistic regression analysis,eight predictors were integrated to determine a new post-endoscopic prognostic scoring system(MH-STRALP);a nomogram was de-termined to present the *** with the previous scores(GBS,Rock-all,ABC,AIMS65,and PNED score),MH-STRALP showed the best prognostic prediction ability with area under the ROC curves(AUROCs)of 0.899 and 0.826 in the training and validation cohorts,*** to the calibration cur-ve,decision curve analysis,and internal cross-validation,the nomogram showed good calibration ability and net clinical benefit in both *** removing the endoscopic indicators,the pre-endoscopic model(pre-MH-STRALP score)was ***,the pre-MHSTRALP score showed better predictive value(AUROCs of 0.868 and 0.767 in the training and validation cohorts,respectively)than the other pre-endoscopic *** The MH-STRALP score and pre-MH-STRALP score are simple,convenient,and accurate tools for prognosis prediction of UGIB,and may be applied for early decision on its management strategies.

关键词： Upper gastrointestinal bleeding Prognosis prediction Retrospective study Nomogram Post-endoscopic model Pre-endoscopic model

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A BBS4 mutation causes autosomal dominant polycystic liver disease

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Genes & Diseases 2024年第1期11卷 72-75页

作者： Yalu Cui Wenping Xu Jinpei Liu Shuqing Liu Wei Huang Yihai Shi Xin Zhang Cuihua Lu Weifen Xie Department of Gastroenterology Changzheng HospitalNaval Medical UniversityShanghai 200003China Department of Gastroenterology Gongli Hospital of Shanghai Pudong New AreaShanghai 200135China Department of Gastroenterology Affiliated Hospital of Nantong UniversityNantong UniversityNantongJiangsu 226001China

Autosomal dominant polycystic liver disease(ADPLD)refers to a condition characterized by the presence of numerous cholangiocytes-lined and fluid-filled cysts in the liver and the absence of polycystic kidney disease.1 Although patients with ADPLD may be asymptomatic,some patients suffer from abdominal pain,gastroesophageal reflux,and nausea,because of hepatomegaly.

关键词： liver polycystic patients

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Personalized surgical recommendations and quantitative therapeutic insights for patients with metastatic breast cancer: Insights from deep learning

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Cancer Innovation 2024年第3期3卷 65-80页

作者： Enzhao Zhu Linmei Zhang Jiayi Wang Chunyu Hu Qi Jing Weizhong Shi Ziqin Xu Pu Ai Zhihao Dai Dan Shan Zisheng Ai School of Medicine Tongji UniversityShanghaiChina shanghai Engineering Research Center of Tooth Restoration and Regeneration Research Institute of StomatologyStomatological Hospital and Dental School of Tongji UniversityShanghaiChina Tenth People's Hospital of Tongji University School of MedicineTongji UniversityShanghaiChina Department of Anesthesiology and Perioperative Medicine Shanghai Fourth People's HospitalSchool of MedicineTongji UniversityShanghaiChina shanghai Hospital Development Center ShanghaiChina Columbia University New YorkNYUSA School of Medicine Royal College of Surgeons in IrelandUniversity of Medicine and Health SciencesDublinIreland Department of Biobehavioral Sciences Columbia UniversityNew YorkNYUSA Department of medical Statistics School of MedicineTongji UniversityShanghaiChina Clinical Research Center for Mental Disorders Chinese-German Institute of Mental HealthShanghai Pudong New Area Mental Health CenterSchool of MedicineTongji UniversityShanghaiChina

Background:The role of surgery in metastatic breast cancer(MBC)is currently *** novel statistical and deep learning(DL)methods promise to infer the suitability of surgery at the individual ***:The objective of this study was to identify the most applicable DL model for determining patients with MBC who could benefit from surgery and the type of surgery ***:We introduced the deep survival regression with mixture effects(DSME),a semi-parametric DL model integrating three causal inference *** models were trained to make individualized treatment *** who received treatments in line with the DL models'recommendations were compared with those who underwent treatments divergent from the *** probability weighting(IPW)was used to minimize *** effects of various features on surgery selection were visualized and quantified using multivariate linear regression and causal ***:In total,5269 female patients with MBC were *** was an independent protective factor,outperforming other models in recommending surgery(IPW-adjusted hazard ratio[HR]=0.39,95%confidence interval[CI]:0.19–0.78)and type of surgery(IPW-adjusted HR=0.66,95%CI:0.48–0.93).DSME was superior to other models and traditional guidelines,suggesting a higher proportion of patients benefiting from surgery,especially breast-conserving *** debiased effect of patient characteristics,including age,tumor size,metastatic sites,lymph node status,and breast cancer subtypes,on surgery decision was also ***:Our findings suggested that DSME could effectively identify patients with MBC likely to benefit from surgery and the specific type of surgery *** method can facilitate the development of efficient,reliable treatment recommendation systems and provide quantifiable evidence for decision-making.

关键词： breast surgery causal inference deep learning metastatic breast cancer

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Mesenchymal stem/stromal cells-derived exosomes for osteoporosis treatment

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World Journal of Stem Cells 2023年第3期15卷 83-89页

作者： Kai-Lun Huo Tie-Yi Yang Wei-Wei Zhang Jin Shao Postgraduate Training Base in shanghai Gongli Hospital Ningxia Medical UniversityYinchuan 750004the Ningxia Hui Autonomous RegionChina Department of Orthopedics Pudong New Area Gongli HospitalSchool of Medical TechnologyUniversity of Shanghai for Science and TechnologyShanghai 200135China Department of Urology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China

Osteoporosis is a systemic bone disease,which leads to decreased bone mass and an increased risk of fragility ***,there are many anti-resorption drugs and osteosynthesis drugs,which are effective in the treatment of osteoporosis,but their usage is limited due to their contraindications and side *** regenerative medicine,the unique repair ability of mesenchymal stem cells(MSCs)has been favored by *** exosomes secreted by MSCs have signal transduction and molecular delivery mechanisms,which may have therapeutic *** this review,we describe the regulatory effects of MSCs-derived exosomes on osteoclasts,osteoblasts,and bone *** aim to summarize the preclinical studies of exosome therapy in ***-ermore,we speculate that exosome therapy can be a future direction to improve bone health.

关键词： Mesenchymal stem cells Exosome Osteoporosis Osteoblasts Osteoclasts Bone immunity

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Effect of micro/nano-sheet array structures on the osteo-immunomodulation of macrophages

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Regenerative Biomaterials 2022年第1期9卷 888-899页

作者： Xinhui Zheng Lan Chen Ji Tan Jianhua Miao Xuanyong Liu Tieyi Yang Zhihong Ding Department of Orthopedics Gongli Hospital of Shanghai Pudong New AreaShanghai 200135China Department of Orthopedics Zhengzhou Central Hospital Affiliated Zhengzhou UniversityZhengzhou 450007China State Key Laboratory of High-Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China School of Materials Science and Engineering&Henan Key Laboratory of Advanced Magnesium Alloy&Key Laboratory of Materials Processing and Mold Technology(Ministry of Education) Zhengzhou UniversityZhengzhou 450001China

The immune response induced by surface topography crucially determines the implant ***,how the immune response is mediated by the size of surface topography remains ***,various biocompatible Mg-Al layered double hydroxides sheet-array films with different sizes(nano,micro and nano/micro mixture)were constructed on the biomedical titanium,and their osteo-immunomodulation effects on the macrophages were *** nano-sheet array structures significantly promoted the polarization of M2 macrophages by activating the PI3K-AKT-mTOR signaling pathway with high gene expressions of integrin b2 and *** the micro-sheet array structures enhanced osteogenic differentiation of mouse bone marrow mesenchymal stem cells(mBMSCs)via ROCK-YAP/TAZ-mediated ***,the nano-sheet array structures promoted the osteogenic differentiation of mBMSCs with a high proportion of M2 macrophages through a shared *** study gave further information concerning integrin-induced focal adhesions in cells of different sheet array structures and their role in macrophage polarization and osteogenic differentiation of mBMSCs,which might help to design biomaterial surfaces with optimal geometry for a desired immunemodulation.

关键词： micro-nano topography immunomodulation macrophages osteogenesis

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Knockdown of RNA N6-methyladenosine methyltransferase METTL3 represses Warburg effect in colorectal cancer via regulating HIF-1a

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Signal Transduction and Targeted Therapy 2021年第3期6卷 624-626页

作者： Zhou Yang Yingjun Quan Yusheng Chen Yijun Huang Renhong Huang Weiping Yu Dejun Wu Min Ye Zhijun Min Bo Yu Department of General Surgery Shanghai Key Laboratory of Vascular Lesions Regulation and RemodelingShanghai Pudong HospitalFudan University Pudong Medical CenterShanghaiChina Department of General Surgery Tongren HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of General Surgery Huashan Hospital Affiliated to Fudan UniversityShanghaiChina

Dear Editor,Colorectal cancer(CRC)is an important digestive tract tumor with high *** one million people suffer from CRC every year with a mortality rate of 33%.Therefore,it is urgent to determine the mechanism for the development of CRC,in order to find more effective diagnosis markers and therapeutic *** RNA modifications have been identified in both mRNA and non-coding RNAs,with RNA methylation being the most common mRNA modification in eukaryotes.

关键词： cancer diagnosis mortality

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Acute histopathological responses and long-term behavioral outcomes in mice with graded controlled cortical impact injury

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Neural Regeneration Research 2019年第6期14卷 997-1003页

作者： Si-Yi Xu Min Liu Yang Gao Yang Cao Jin-Gang Bao Ying-Ying Lin Yong Wang Qi-Zhong Luo Ji-Yao Jiang Chun-Long Zhong Department of Neurosurgery Ren Ji HospitalSchool of MedicineShanghai Jiao Tong University Department of Neurosurgery Shanghai East HospitalTongji University School of Medicine

While animal models of controlled cortical impact often display short-term motor dysfunction after injury, histological examinations do not show severe cortical damage. Thus, this model requires further improvement. Mice were subjected to injury at three severities using a Pin-Point^(TM)-controlled cortical impact device to establish secondary brain injury mouse models. Twenty-four hours after injury, hematoxylin-eosin staining, Fluoro-Jade B histofluorescence, and immunohistochemistry were performed for brain slices. Compared to the uninjured side, we observed differences of histopathological findings, neuronal degeneration, and glial cell number in the CA2 and CA3 regions of the hippocampus on the injured side. The Morris water maze task and beam-walking test verified long-term(14–28 days) spatial learning/memory and motor balance. To conclude, the histopathological responses were positively correlated with the degree of damage,as were the long-term behavioral manifestations after controlled cortical impact. All animal procedures were approved by the Institutional Animal Care and Use committee at shanghai Jiao Tong University School of Medicine.

关键词： nerve regeneration traumatic brain injury controlled cortical impact histopathology behavioral manifestations neural regeneration

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Multidisciplinary and Comprehensive Chinese Medicine for Advanced Non-Small Cell Lung Cancer Patients:A Retrospective Study of 855 Cases

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Chinese Journal of Integrative Medicine 2021年第7期27卷 490-495页

作者： HUANG Xian-ge ZHU Li-hua ZHOU Lei XU Wei-jie YAO Yi-lin ZHOU Zhi-yi LI He-gen The Third Department of Oncology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200032China

Objective To investigate the effects of multidisciplinary and comprehensive Chinese medicine(CM)treatments on progression-free survival(PFS)and median survival time(MST)in patients with advanced non-small cell lung cancer(NSCLC)and identify factors that influence progression and *** Clinical data of 855 patients with advanced NSCLC who received multidisciplinary and comprehensive CM treatments at Longhua Hospital from January 2009 to December 2018 were retrospectively *** analysis was performed by the Kaplan-Meier method and log-rank sequential *** analysis of significant variables from the univariate analysis was performed with Cox regression *** factors correlated to progression and prognosis were screened out,and a Cox proportional hazard model was established to calculate the prognostic *** The PFS and MST of 855 advanced NSCLC patients were 9.0 and 26.0 months,*** 1-,2-,3-,and 5-year survival rates were 79.2%,54%,36.2%,and 17.1%,***,pathologic type,and clinical stage were independent prognostic risk factors;surgical history,radiotherapy,treatment course of Chinese patent medicine,intravenous drip of Chinese herbal preparation,duration of oral administration of Chinese herbal decoction(CHD),and intervention measures were independent prognostic protective *** was an independent risk factor for progression,while operation history and oral CHD administration duration were independent protective factors(all P<0.05).Women with stage IIIb–IIIc lung adenocarcinoma had the best *** Female patients have lower progression risk and better prognoses than male patients,younger patients have higher progression risk but better long-term prognoses than the elderlys,and patients with lower performance status scores are at lower risk for progression and have better *** CM treatments could significantly reduce progression risk,improve pr

关键词： advanced non-small cell lung cancer prognostic factor progression factor survival analysis Chinese medicine

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