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Study on Preparation of Temperature-sensitive Injectable Hydrogel

Chinese Journal of Biomedical Engineering(English Edition) 2010年第2期19卷 66-76页

作者： LIU Ling-xiu HU Guo-yin LIU Xin GU Han-qing Biomedical Engineering Department Tianjin Medical University Tianjin 300070 China Tianjin Institute of Urological Surgery Tianjin 300211 China

To get a sort of new scaffold material for soft tissue reconstruction,we have prepared XLHA-PNIPAAm and XLHA-MC injectable hydrogels through blending crosslinked HA(XLHA) and two temperature-sensitive materials differed in degradation poly(N-isopropylacrylamide)(PNIPAAm) and methylcellulose(MC),*** tested the injectablility,enzymatic biodegradability,temperature-sensitivity,structure cytotoxicity and hemolysis of the two injectable *** research has successfully obtained the preparation condition of XLHA-PNIPAAm injectable hydrogel,and verified that adding non-degradable material PNIPAAm can postpone the degradation of HA more effectively than degradable material *** prepared with 5 kGy dose radiation,MBAAm/NIPAAm(M/M)=0.015,monomer concentration=3% produced XLHA-PNIPAAm with slowest enzymatic *** results showed that temperature-sensitivity of the XLHA-PNIPAAm was more stable than that of *** composite hydrogels were qualified in cytotoxicity and hemolysis tests and the biocompatibility of XLHA-PNIPAAm hydrogel showed better than XLHA-MC hydrogel.

关键词： hyaluronan poly(N-isopropylacrylamide) methylcellulose injectable hydrogel tissue engineering

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维普期刊数据库

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Crosslinking of Bovine Pericardia Using Procyanidins

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Chinese Journal of Biomedical Engineering(English Edition) 2011年第2期20卷 83-89页

作者： WAN Rong-xin TIAN Cong GU Han-qing LIU Xin Tianjin Medical University Tianjin 300070 China Tianjin Institute of Urological Surgery Tianjin 300211 China

The aim of this study was to evaluate the crosslinking effect of a naturally crosslinking reagent-procyanidins （PA）-on the materials of bioprosthetic heart valves. After fixing bovine pericardial tissues by procyanidins, crosslikng characteristics, mechanical properties, in vitro enzymatic degradation resistance, the hydrophilicity and hemolysis tests were examined. The results showed that the fixation of biological tissue with glutaraldehyde （GA） or procyanidins increased its denaturation temperature, the surface hydrophilieity and mechanical properties as well as in vitro enzymatic degradation resistance. There were no significant differences in denaturation temperature, mechanical properties, the hydrophilicity and the in vitro enzymatic degradation between the glutaraldehyde and procyanidins fixed tissues. However, the ultimate tensile strength of the procyanidins fixed tissues was significantly superior to the glutaraldehyde fixed tissues. The hemolysis tests showed that hemolysis rate of the proeyanidins fixed tissues was lower than that of the glutaraldehyde fixed tissues. This study shows that procyanidins can crosslink which bovine pericardiaa effectively without toxicity. Our results suggest that this method might be a useful approach for the preparation of bioprosthetic heart valve.

关键词： bovine pericardia bioprosthetic heart valves glutaraldehyde procyanidins

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Study on Characteristics of Acellular Bovine Pericardium Crosslinked with Genipin

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Chinese Journal of Biomedical Engineering(English Edition) 2011年第1期20卷 10-18页

作者： TIAN Cong WAN Rong-xin GU Han-qing LIU Xin Department of Biomedical Engineering Tianjin Medical University Tianjin 300070 China Tianjin Institute of Urological Surgery Tianjin 300211 China

The study used a naturally occurring crosslinking reagent-genipin to chemically modify acellular bovine pericardium, prepare cardiac valve tissue engineering scaffold material,and evaluated genipin crosslinked acellular matrix of bovine pericardium by investigating the physical and chemical properties of the tissues, such as the surface properties, crosslinking characteristics, mechanical properties, resistance to enzymatic capacity in vitro, and hemolysis tests. The results showed that acellular bovine pericardium matrix erosslinked with genipin was strong hydrophilicity, high crosslinking index, and stable structure, which can maintain good mechanical properties. As a kind of scaffold material for valve tissue engineering, it has wide application prospect.

关键词： acellular bovine pericardium genipin glutaraldehyde crosslinking characteristics mechanical properties

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