Study on Preparation of Temperature-sensitive Injectable Hydrogel

作     者：LIU Ling-xiu HU Guo-yin LIU Xin GU Han-qing 

作者机构：Biomedical Engineering Department Tianjin Medical University Tianjin 300070 China Tianjin Institute of Urological Surgery Tianjin 300211 China 

出 版 物：《Chinese Journal of Biomedical Engineering(English Edition)》 (中国生物医学工程学报（英文版）)

年 卷 期：2010年第19卷第2期

页      面：66-76页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0703[理学-化学] 

基　　金：The Nattional Key Scientific Program-Nanoscience and Nanotechnology grant number:2009CB930000 

主　　题：hyaluronan poly(N-isopropylacrylamide) methylcellulose injectable hydrogel tissue engineering 

摘      要：To get a sort of new scaffold material for soft tissue reconstruction,we have prepared XLHA-PNIPAAm and XLHA-MC injectable hydrogels through blending crosslinked HA(XLHA) and two temperature-sensitive materials differed in degradation poly(N-isopropylacrylamide)(PNIPAAm) and methylcellulose(MC),*** tested the injectablility,enzymatic biodegradability,temperature-sensitivity,structure cytotoxicity and hemolysis of the two injectable *** research has successfully obtained the preparation condition of XLHA-PNIPAAm injectable hydrogel,and verified that adding non-degradable material PNIPAAm can postpone the degradation of HA more effectively than degradable material *** prepared with 5 kGy dose radiation,MBAAm/NIPAAm(M/M)=0.015,monomer concentration=3% produced XLHA-PNIPAAm with slowest enzymatic *** results showed that temperature-sensitivity of the XLHA-PNIPAAm was more stable than that of *** composite hydrogels were qualified in cytotoxicity and hemolysis tests and the biocompatibility of XLHA-PNIPAAm hydrogel showed better than XLHA-MC hydrogel.