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The spindle assembly checkpoint:perspectives in tumorigenesis and cancer therapy

Frontiers in Biology 2011年第2期6卷 147-155页

作者： Joana BARBOSA Ana Vanessa NASCIMeNTO Juliana FARIA Patrícia SILVA Hassan BOUSBAA Centro de Investigação em Ciências da Saúde(CICS) Instituto Superior de Ciências da Saúde-NorteCESPURua Central de Gandra13174585-116 Gandra PRDPortugal

Loss or gain of chromosomes,a condition known as aneuploidy,is a common feature of tumor cells and has therefore been proposed as the driving force for *** chromosomal instability can arise during mitosis as a result of mis-segregation of the duplicated sister chromatids to the two daughter *** normal cells,missegregation is usually prevented by the spindle assembly checkpoint(SAC),a sophisticated surveillance mechanism that inhibits mitotic exit until all chromosomes have successfully achieved bipolar attachment to spindle *** abrogation of SAC activity is lethal to normal as well as to tumor cells,as a consequence of massive chromosome ***,many human aneuploid tumor cells exhibit a weakened SAC activity that allows them to tolerate gains or losses of a small number of chromosomes;and interfering with this SAC residual activity may constitute a suitable strategy to kill cancer *** review focuses on the potential link between SAC and tumorigenesis,and the therapeutic strategy to target the SAC for cancer treatment.

关键词： spindle assembly checkpoint mitosis chromosome instability tumor cancer therapy

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Neurocognitive sequelae of cerebral malaria in adults: A pilot study in Benguela Central Hospital, Angola

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Asian Pacific Journal of Tropical Biomedicine 2013年第7期3卷 532-535页

作者： Bruno Peixoto Isabel Kalei Sciences department of the Instituto superior de Ciências da Saúde-Norte (cespu) Research Unit on Psychology and HealthGandra Portugal Central Hospital of Benguela Benguela Angola

Objective:To characterize the neurocognitive sequelae of cerebral malaria(CM)in an adultsample of the city of Benguela,***:A neuropsychological assessment was carriedout in 22 subjects with prior history of CM ranging from 6 to 12 months after the *** results were compared to a control group with no previous history of cerebral *** study was conducted in Benguela Central Hospital,Angola in ***:CM groupobtained lower results on the two last trials of a verbal learning task and on an abstract ***:CM is associated to a slower verbal learning rate and to difficulties in theability to discriminate and perceive relations between new elements.

关键词： Cognition Neuropsychological assessment Verbal learning Abstract reasoning Plasmodium falciparum Angola

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