The spindle assembly checkpoint:perspectives in tumorigenesis and cancer therapy

作     者：Joana BARBOSA Ana Vanessa NASCIMENTO Juliana FARIA Patrícia SILVA Hassan BOUSBAA 

作者机构：Centro de Investigação em Ciências da Saúde(CICS)Instituto Superior de Ciências da Saúde-NorteCESPURua Central de Gandra13174585-116 Gandra PRDPortugal 

出 版 物：《Frontiers in Biology》 (生物学前沿（英文版）)

年 卷 期：2011年第6卷第2期

页      面：147-155页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 0836[工学-生物工程] 0713[理学-生态学] 10[医学] 

基　　金：H.B.was supported by grant#04-GBMC-CICS-09 from CESPU–Cooperativa de Ensino Superior Politécnico e Universitário 

主　　题：spindle assembly checkpoint mitosis chromosome instability tumor cancer therapy 

摘      要：Loss or gain of chromosomes,a condition known as aneuploidy,is a common feature of tumor cells and has therefore been proposed as the driving force for *** chromosomal instability can arise during mitosis as a result of mis-segregation of the duplicated sister chromatids to the two daughter *** normal cells,missegregation is usually prevented by the spindle assembly checkpoint(SAC),a sophisticated surveillance mechanism that inhibits mitotic exit until all chromosomes have successfully achieved bipolar attachment to spindle *** abrogation of SAC activity is lethal to normal as well as to tumor cells,as a consequence of massive chromosome ***,many human aneuploid tumor cells exhibit a weakened SAC activity that allows them to tolerate gains or losses of a small number of chromosomes;and interfering with this SAC residual activity may constitute a suitable strategy to kill cancer *** review focuses on the potential link between SAC and tumorigenesis,and the therapeutic strategy to target the SAC for cancer treatment.