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Biophysics Reports 2024年第4期10卷 241-253页

作者： Xiaoning Yang Yuwei Zhao Wei Liu Zhongbao Gao Chunlan Wang Changyong Wang Siwei Li Xiao Zhang Beijing Institute of Basic Medical Sciences

The whole heart decellularized extracellular matrix(ECM) has become a promising scaffold material for cardiac tissue engineering. Our previous research has shown that the whole heart acellular matrix possesses the memory function regulating neural stem cells(NSCs) trans-differentiating to cardiac lineage cells. However, the cell subpopulations and phenotypes in the trans-differentiation of NSCs have not been clearly identified. Here, we performed single-cell RNA sequencing and identified 2,765 cells in the recellularized heart with NSCs revealing the cellular diversity of cardiac and neural lineage, confirming NSCs were capable of trans-differentiating into the cardiac lineage while maintaining the original ability to differentiate into the neural lineage. Notably, the trans-differentiated heart-like cells have dual signatures of neuroectoderm and cardiac mesoderm. This study unveils an in-depth mechanism underlying the trans-differentiation of NSCs and provides a new opportunity and theoretical basis for cardiac regeneration.

关键词： Single-cell transcriptomics Neural stem cell Trans-differentiation Decellularized extracellular matrix Cardiac lineage cells

Fabrication and characterization of NiO films for energetic nano-multilayers by direct current reactive sputtering

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Rare Metals 2018年第7期37卷 594-598页

作者： Yi-Chao Yan Wei Shi Hong-Chuan Jiang Jie Xiong Wan-Li Zhang State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China

NiO films were fabricated by reactive direct current magnetron sputtering on glass and alumina substrates for the application in energetic nano-multilayers. The structural and thermal properties of the films were investigated with the volume ratio of oxygen to argon ranging from 1：9 to 3：2, and the optimized ratio value is obtained as 1：3, which was confirmed by X-ray diffraction （XRD）, atomic force microscopy and ultrafast measure- ment system. The effect of the film thickness, varying from 150 to 900 nm, on the structural properties was characterized by XRD and scanning electron microscopy （SEM）. XRD analysis reveals that the （111） lattice plane is the preferred orientation. The intensities of preferential peaks and the grain sizes increase as the film thicknesses increase.

关键词： NiO films Energetic nano-multilayers Thermal properties Volume ratio of oxygen to argon

Si-Assisted Solidification Path and Microstructure Control of 7075 Aluminum Alloy with Improved Mechanical Properties by Selective Laser Melting

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Acta Metallurgica Sinica(English Letters) 2022年第9期35卷 1424-1438页

作者： Junwei Sha Meixian Li Lizhuang Yang Xudong Rong Bowen Pu Dongdong Zhao Simi Sui Xiang Zhang Chunnian He Jianglin Lan Naiqin Zhao School of Materials Science and Engineering and Tianjin Key Laboratory of Composites and Functional Materials Tianjin UniversityTianjin300350China Collaborative Innovation Center of Chemical Science and Engineering Tianjin300350China Key Laboratory of Advanced Ceramics and Machining Technology Ministry of EducationTianjin300350China Central Iron and Steel research Institute(CISRI) Beijing100081China

The construction and application of traditional high-strength 7075 aluminum alloy(Al7075) through selective laser melting(SLM) are currently restricted by the serious hot cracking phenomenon. To address this critical issue, in this study, Si is employed to assist the SLM printing of high-strength Al7075. The laser energy density during SLM is optimized, and the eff ects of Si element on solidification path, relative density, microstructure and mechanical properties of Al7075 alloy are studied systematically. With the modified solidification path, laser energy density, and the dense microstructure with refined grain size and semi-continuous precipitates network at grain boundaries, which consists of fine Si, β-MgSi, Q-phase and θ-AlCu, the hot cracking phenomenon and mechanical properties are eff ectively improved. As a result, the tensile strength of the SLM-processed Si-modified Al7075 can reach 486 ± 3 MPa, with a high relative density of ~ 99.4%, a yield strength of 291 ± 8 MPa, fracture elongation of(6.4 ± 0.4)% and hardness of 162 ± 2(HV) at the laser energy density of 112.5 J/mm~3. The main strengthening mechanism with Si modification is demonstrated to be the synergetic enhancement of grain refinement, solution strengthening, load transfer, and dislocation strengthening. This work will inspire more new design of high-strength alloys through SLM.

关键词： Selective laser melting(SLM) 7075 aluminum alloy High-strength alloy Microstructure control Solidification path

Revealing the Local Microstates of Fe–Mn–Al Medium Entropy Alloy:A Comprehensive First-principles Study

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Acta Metallurgica Sinica(English Letters) 2021年第11期34卷 1492-1502页

作者： Ying Zhang William Yi Wang Chengxiong Zou Rui Bai Yidong Wu Deye lin Jun Wang Xidong Hui Xiubing Liang Jinshan Li State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi'an 710072China State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China CAEP Software Center for High Performance Numerical Simulation Beijing 100088China Defense Innovation Institute Academy of Military Sciences of the PLA of ChinaBeijing 100071China

Entropy-stabilized multi-component alloys have been considered to be prospective structural materials attributing to their impressive mechanical and functional *** local chemical complexions,microstates and configurational transformations are essential to reveal the structure–property relationship,thus,to promote the development of advanced multicomponent *** the present work,effects of local lattice distortion(LLD)and microstates of various configurations on the equilibrium volume(V0),total energy,Fermi energy,magnetic moment(μMag)and electron work function(Φ)and bonding structures of the Fe–Mn–Al medium entropy alloy(MEA)have been investigated comprehensively by first-principles *** is found that theΦandμMag of those MEA are proportional to the V 0,which is dominated by lattice *** terms of bonding charge density,both the strengthened clusters or the so-called short-range order structures and the weakly bonded spots or weak spots are *** the presence of weakly bonded Al atoms implies a large LLD/mismatch,the Fe–Mn bonding pairs result in the formation of strengthened clusters,which dominate the local microstates and the configurational *** variations ofμMag are associated with the enhancement of the nearest neighbor magnetic Fe and Mn atoms,attributing to the LLD caused by Al atoms,the local changes in the electronic *** work provides an atomic and electronic insight into the microstate-dominated solid-solution strengthening mechanism of Fe–Mn–Al MEA.

关键词： Medium entropy alloy Bonding charge density Magnetic moment Microstates

preliminary Study on Cytotoxic Effect of Biodegradation of Magnesium on Cancer Cells

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Journal of Materials Science & Technology 2012年第9期28卷 769-772页

作者： Yu Zhang Ling Ren Mei Li Xiao Lin Huafu Zhao Ke Yang Department of Orthopedic Surgery Guangzhou General Hospital of Guangzhou Military CommandGuangzhou 510010China Institute of Metal research Chinese Academy of SciencesShenyang 110016China

Biodegradation of magnesium （Mg） based metals in body fluid can lead to a strong alkalinity as well as an increase of Mg2＋ concentration in its surrounding environment. In vitro cytotoxic effects of the extracts of pure Mg with and without micro arc oxidation （MAO） coating on osteosarcoma U2-OS cells, a kind of bone cancer cells, were preliminarily studied, independently considering the increase of either alkalinity or Mg2＋ concentration. The results indicated that the high alkalinity, i.e., a great increase of pH value, caused by the degradations of Mg with and without MAO coating in the culture medium all showed strong cytotoxic effects on U2-OS cells. However, the increase of Mg2＋ concentration had no such cytotoxic effect. This finding may provide an alternative way to cure bone cancers through creating a high alkalinity surrounding the cancer cells.

关键词： Magnesium Biodegradation Alkalinity Cancer cell

Tensile deformation behavior of coarse-grained Ti-55 titanium alloy with different hydrogen additions

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Rare Metals 2021年第8期40卷 2092-2098页

作者： Xi-Feng Li Fang-Fei Xu Lan Hu Fu-Hui Zhu Jun Chen Department of Plasticity Technology School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200030China Shanghai Aerospace Equipments Manufacturer Co. Ltd.Shanghai200245China

The effect of hydrogen addition on the deformation behavior of coarse-grained Ti-55 alloys(~20μm)was studied by uniaxial tension tests at high *** elongation of hydrogenated Ti-55 titanium alloy firstly increases and then decreases with hydrogen content increasing at 8750 *** highest elongation of 243.8%is obtained in the hydrogenated alloy with 0.1 wt%H,and the peak stress reaches a minimum value of 29.0 MPa in the hydrogenated alloy with 0.3 wt%*** with that of the unhydrogenated alloy,the elongation of the hydrogenated alloy with 0.1 wt%H increases by 41.3%and its peak stress decreases by 40.6%at 875℃.Hydrogen addition can promote the transformation of β phase and the dislocation *** hydrogen content can evidently improve the deformation properties of coarse-grained Ti-55 titanium alloy.

关键词： Coarse-grained Ti-55 titanium alloy Hydrogen addition Plastic deformation

Cytotoxic Effect on Osteosarcoma MG-63 Cells by Degradation of Magnesium

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Journal of Materials Science & Technology 2014年第9期30卷 888-893页

作者： Mei Li Ling Ren LiHua Li Peng He GuoBo Lan Yu Zhang Ke Yang Hospital of Orthopedics Guangzhou General Hospital of Guangzhou Military Command Institute of Metal research Chinese Academy of Sciences

Biocompatible and biodegradable magnesium （Mg） based metals have attracted great interest for use in orthopedic implants and devices. Based on our previous study that Mg with and without micro-arc oxidation （MAO） coating showed obvious cytotoxic effect on tumor cells due to the increase of pH value during the degradation of Mg, this study further evaluated the cytotoxic effect of Mg and MAO coated Mg on osteosarcoma （MG-63） cells by analyzing the cell adhesion, morphology and number through observation of scanning electron microscope, as well as live/dead staining, lactate dehydrogenase （LDH） activity and 4, 6- diamidino-2-phenylindole （DAPI） assay. The results indicated that, compared to titanium, Mg could strongly inhibit the cell adherence, morphology and number of MG-63 on the surface of the naked Mg, whereas the MAO coated Mg showed relative weak cytotoxic effect on MG-63 cells, expecting that magnesium based metals with suitable coating can be designed to be applied as tumor prosthesis in the clinical practice.

关键词： Magnesium Biodegradation Osteosarcoma Cytotoxicity

Cracking behavior and control of β-solidifying Ti-40Al-9V-0.5Y alloy produced by selective laser melting

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Journal of Materials Science & Technology 2020年第4期39卷 144-154页

作者： Piao Gao Wenpu Huang Huihui Yang Guanyi Jing Qi Liu Guoqing Wang Zemin Wang Xiaoyan Zeng Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China China Academy of Launch Vehicle Technology Beijing 100076China

Aβ-solidifying Ti-40 Al-9 V-0.5 Y(at.%)alloy with a high cracking sensitivity has been successfully fabricated by selective laser melting(SLM)in this *** influence factors for cracking sensitivity,cracking behavior and crack inhibition mechanism were *** results show that the effects of process parameters on cracking sensitivity strongly depend on the cooling rate in molten pool with different heat transfer *** conduction mode with higher cooling rates exhibits a higher cracking sensitivity in comparison to the keyhole *** characteristics and phase transformations controlled by cooling rate determine the inherent ductility ofβ-solidifyingγ-Ti Al alloys during *** this basis,the formation and inhibition mechanism of solidification and cold cracking are ***,the crackfree Ti-40 Al-9 V-0.5 Y sample with fine equiaxed microstructures and favorable mechanical properties(microhardness of 542±19 HV,yield strength of 1871±12 MPa,ultimate strength of 2106±13 MPa and ultimate compressive strain of 10.89±0.57%)can be produced by *** strengthening mechanism can be attributed to grain refinement and precipitation strengthening.

关键词： Selective laser melting β-solidifyingγ-TiAl alloy Cracking behavior Cracking control Microstructure Phase transformation

Microstructure evolution and crystallography of directionally solidified Al2O3/Y3Al5O12 eutectic ceramics prepared by the modified Bridgman method

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Journal of Materials Science & Technology 2019年第9期35卷 1982-1988页

作者： Xu Wang Nan Zhang Yujie Zhong BailingJiang Langhong Lou Jian Zhang Jingyang Wang Shool of Material Science and Engineering Xi'an University of TechnologyXi'an710048China School of Materials Science and Engineering Xi'an Shiyou UniversityXi'an710065China Institute of Metal research. Chinese Academy of Sciences Shenyang110016China

Large size,high-density(99.97%)and well-organized Al2O3/Y3Al5O12(YAG)eutectic ceramics were prepared by the modified Bridgman *** evolution of the three dimensional microstructure and micropores were *** diameter of the micro-pores and the porosity decreased during directional *** average equivalent diam eter of the micro-pores was 2.41μm in the well-prepared eutectic *** of the pores(98.07%)were smaller than 4μ*** data are comparable to those prepared by the optical floating zone *** as-grown eutectic ceramics were polycrystalline,but the interfaces were well-bonded and there were no amorphous phases in the *** misfits of the different crystallographic relationships were calculated,and the bottleneck of the single-crystal preparation was *** results could provide theoretical guidance for the preparation of large,single-crystal Al2O3/YAG eutectic ceramics by the modified Bridgman method.

关键词： Al2O3/YAG eutectic ceramics Crystallography Interfaces Bridgman method

Metal matrix nanocomposites in tribology: Manufacturing, performance, and mechanisms

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Friction 2022年第10期10卷 1596-1634页

作者： Shuaihang PAN Kaiyuan JIN Tianlu WANG Zhinan ZHANG Long ZHENG Noritsugu UMEHARA Department of Mechanical and Aerospace Engineering University of California Los Angeles(UCLA)Los AngelesCA 90095USA Physical Intelligence Department Max Planck Institute for Intelligent SystemsStuttgart 70569Germany Stake Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong UniversityShanghai 200240China Key Laboratory of Bionic Engineering(Ministry of Education) College of Biological and Agricultural EngineeringJilin UniversityChangchun 130022China Micro-Nano Mechanical Science Laboratory Department of Micro-Nano Mechanical Science and EngineeringGraduate School of EngineeringNagoya UniversityChikisa-ku Furo-choNagoyaAichi 464-8601Japan

Metal matrix nanocomposites(MMNCs)become irreplaceable in tribology industries,due to their supreme mechanical properties and satisfactory tribological ***,due to the dual complexity of MMNC systems and tribological process,the anti-friction and anti-wear mechanisms are unclear,and the subsequent tribological performance prediction and design of MMNCs are not easily possible:A critical up-to-date review is needed for MMNCs in *** review systematically summarized the fabrication,manufacturing,and processing techniques for high-quality MMNC bulk and surface coating materials in ***,important factors determining the tribological performance(mainly anti-friction evaluation by the coefficient of friction(CoF)and anti-wear assessment with wear rate)in MMNCs have been investigated thoroughly,and the correlations have been analyzed to reveal their potential coupling/synergetic roles of tuning tribological behavior of *** importantly,this review combined the classical metal/alloy friction and wear theories and adapted them to give a(semi-)quantitative description of the detailed mechanisms of improved anti-friction and anti-wear performance in *** guarantee the universal applications of these mechanisms,their links with the analyzed influencing factors(e.g.,loading forces)and characteristic features like tribo-film have been *** approach forms a solid basis for understanding,predicting,and engineering MMNCs’tribological behavior,instead of pure phenomenology and experimental ***,the pathway to achieve a broader application for MMNCs in tribo-related fields like smart materials,biomedical devices,energy storage,and electronics has been concisely discussed,with the focus on the potential development of modeling,experimental,and theoretical techniques in MMNCs’tribological *** general,this review tries to elucidate the complex tribo-performances of MMNCs in a fundamentally universal yet straightfor

关键词： metal matrix nanocomposites nanophases tribology manufacturing processes anti-wear performance strengthening effects anti-wear mechanisms