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Enhanced optical imaging and fluorescent labeling for visualizing drug molecules within living organisms

Acta Pharmaceutica Sinica B 2024年第6期14卷 2428-2446页

作者： Ting Sun Huanxin Zhao Luyao Hu Xintian Shao Zhiyuan Lu Yuli Wang Peixue Ling Yubo Li Kewu Zeng Qixin Chen school of Pharmaceutical Sciences National Key Laboratory of Advanced Drug Delivery SystemMedical Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinan 250062China Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingapore 119074Singapore Institute of Biochemical and Biotechnological Drugs School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Key Laboratory of Biopharmaceuticals Postdoctoral Scientific Research WorkstationShandong Academy of Pharmaceutical ScienceJinan 250098China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China school of Life Sciences Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinan 250062China school of Chinese Materia Medica Tianjin University of Traditional Chinese MedicineTianjin 301617China Tianjin Pharmaceutical DA REN TANG Group Corporation Limited Traditional Chinese Pharmacy Research Institute Tianjin 300457China Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemistry Engineering and TechnologyTianjin UniversityTianjin 300072China

The visualization of drugs in living systems has become key techniques in modern *** advancements in optical imaging technologies and molecular design strategies have revolutionized drug *** the subcellular level,super-resolution microscopy has allowed exploration of the molecular landscape within individual cells and the cellular response to *** beyond subcellular imaging,researchers have integrated multiple modes,like optical near-infrared II imaging,to study the complex spatiotemporal interactions between drugs and their *** combining these visualization approaches,researchers gain supplementary information on physiological parameters,metabolic activity,and tissue composition,leading to a comprehensive understanding of drug *** review focuses on cutting-edge technologies in drug visualization,particularly fluorescence imaging,and the main types of fluorescent molecules ***,we discuss current challenges and prospects in targeted drug research,emphasizing the importance of multidisciplinary cooperation in advancing drug *** the integration of advanced imaging technology and molecular design,drug visualization has the potential to redefine our understanding of pharmacology,enabling the analysis of drug micro-dynamics in subcellular environments from new perspectives and deepening pharmacological research to the levels of the cell and organelles.

关键词： Optical imaging Drug visualization Fluorophore labeling Therapeutics

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Highly Elastic,Bioresorbable Polymeric Materials for Stretchable,Transient Electronic Systems

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Nano-Micro Letters 2024年第6期16卷 1-13页

作者： Jeong‑Woong Shin Dong‑Je Kim Tae‑Min Jang Won Bae Han Joong Hoon Lee Gwan‑Jin Ko Seung Min Yang Kaveti Rajaram Sungkeun Han Heeseok Kang Jun Hyeon Lim Chan‑Hwi Eom Amay J.Bandodkar Hanul Min Suk‑Won Hwang KU‑KIST graduate school of Converging Science and technology Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea SK Hynix 2091Gyeongchung‑daeroBubal‑eupIcheon‑siGyeonggi‑do 17336Republic of Korea Hanwha Systems Co. Ltd.188Pangyoyeok‑roBundang‑guSeongnam‑siGyeonggi‑do 13524Republic of Korea Department of Electrical and Computer Engineering North Carolina State UniversityRaleighNC 27606USA Center for Advanced Self‑Powered Systems of Integrated Sensors and Technologies(ASSIST) North Carolina State UniversityRaleighNC 27606USA Department of Integrative Energy Engineering Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea Biomaterials Research Center Korea Institute of Science and Technology(KIST)5 Hwarang‑ro 14‑gilSeongbuk‑guSeoul 02792Republic of Korea Semiconductor R&D Center Samsung Electronics Co.Ltd.Hwaseong‑siGyeonggi‑do 18448Republic of Korea Center for Advanced Biomolecular Recognition Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

Substrates or encapsulants in soft and stretchable formats are key components for transient,bioresorbable electronic systems;however,elastomeric polymers with desired mechanical and biochemical properties are very limited compared to nontransient ***,we introduce a bioresorbable elastomer,poly(glycolide-co-ε-caprolactone)(PGCL),that contains excellent material properties including high elongation-at-break(<1300%),resilience and toughness,and tunable dissolution *** of PGCLs as polymer matrices,in combination with conducing polymers,yields stretchable,conductive composites for degradable interconnects,sensors,and actuators,which can reliably function under external *** of device components with wireless modules demonstrates elastic,transient electronic suture system with on-demand drug delivery for rapid recovery of postsurgical wounds in soft,time-dynamic tissues.

关键词： Biodegradable elastomer Conductive polymer composites Biomedical device Transient electronics

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Tri-signal colorimetric/electrochemical detection of egg allergen based on boric acid affinity reagent modified CuO nanoparticles

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Food Science and Human Wellness 2024年

作者： Chunlan Chen Fengqi Zhou Hongmin Zhu Ding Ma Yufan Huang Jing Li Linjiang Guo Lin Xiao Guobao Ning Xiaokang Lu Bilian Li Hui Zhao Can-Peng Li school of Chemical Science and technology， Yunnan University Laboratory for Conservation and Utilization of Bio-resource， Yunnan University

A tri-signal ultrasensitive colorimetric/electrochemical detection of ovomucoid （OM） was developed. Herein， copper oxide nanoparticles （CuO NPs） were prepared， which exhibit excellent enzyme-like activity （peroxidase-like and laccase-like） and electrochemical activity. CuO@3-APBA nanoparticles （CuO@3-APBA NPs） were prepared by the coordinating Cu with the amino group on 3-aminophenobenic boric acid （3-APBA） in CuO NPs. 3-APBA of CuO@3-APBA can react with diol structure on sugar chain of OM under alkaline conditions. Then， a tri-signal ultrasensitive biosensing platform for OM was established based on the catalytic activity of CuO@3-APBA nanozyme. For the first signal， CuO@3-APBA can catalyze oxidation of TMB to turn the solution from colorless to blue in the presence of H2O2（absorbance at 652 nm）. For the second signal， CuO@3-APBA can catalyze the oxidation of substrates （2， 4-dichlorophenol and 4-aminoantipyrine） and turn the solution from colorless to pink （absorbance at 510 nm）. For the third signal， electrochemical oxidation peak of copper ion from Cu+to Cu2+of CuO@3-APBA was recorded by differential pulse voltammetry， which was used to determine the OM. The sensing platform exhibited a wide linear range （0.0000316-100 ng/mL） with a low detection limit （0.0105 pg/mL）， as well as showed advantages， such as satisfactory reproducibility， good stability， and excellent selectivity. The assay has the potential applications for ultrasensitive detection of allergen in foods.

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An inorganic liquid crystalline dispersion with 2D ferroelectric moieties

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National Science Review 2024年第05期 254-263页

作者： Ziyang Huang Zehao Zhang Rongjie Zhang Baofu Ding Liu Yang Keyou Wu Youan Xu Gaokuo Zhong Chuanlai Ren Jiarong Liu Yugan Hao Menghao Wu Teng Ma Bilu Liu Shenzhen Graphene Centre Shenzhen Key Laboratory of Advanced Layered Materials for Value-added ApplicationsTsinghua-Berkeley Shenzhen Institute and Institute of Materials ResearchTsinghua Shenzhen International Graduate School Tsinghua University Institute of technology for Carbon Neutrality Faculty of Materials Science and Engineering Shenzhen Institute of Advanced Technology Chinese Academy of Sciences school of Physics and Institute for Quantum Science and Engineering School of Chemistry and Institute of Theoretical ChemistryHuazhong University of Science and Technology Xi'an Research Institute of High technology Shenzhen Institute of Advanced technology Chinese Academy of Sciences Department of Applied Physics Hong Kong Polytechnic University

Electro-optical effect-based liquid crystal devices have been extensively used in optical modulation techniques, in which the Kerr coefficient reflects the sensitivity of the liquid crystals and determines the strength of the device's operational electric field. The Peterlin–Stuart theory and the O'Konski model jointly indicate that a giant Kerr coefficient could be obtained in a material with both a large geometrical anisotropy and an intrinsic polarization, but such a material is not yet reported. Here we reveal a ferroelectric effect in a monolayer two-dimensional mineral vermiculite. A large geometrical anisotropy factor and a large inherent electric dipole together raise the record value of Kerr coefficient by an order of magnitude, till 3.0 × 10-4mV-2. This finding enables an ultra-low operational electric field of10～2–10～4V m-1and the fabrication of electro-optical devices with an inch-level electrode separation, which has not previously been practical. Because of its high ultraviolet stability（decay <1% under ultraviolet exposure for 1000 hours）, large-scale production, and energy efficiency, prototypical displayable billboards have been fabricated for outdoor interactive scenes. This work provides new insights for both liquid crystal optics and two-dimensional ferroelectrics.

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Pseudospectral method for optimal propellantless rendezvous using geomagnetic Lorentz force

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Applied Mathematics and Mechanics(English Edition) 2015年第5期36卷 609-618页

作者： Xu HUANG Ye YAN Yang ZHOU Hua ZHANG College of Aerospace Science and Engineering National University of Defense Technology Department of Communication Beijing Aerospace Control Center

A charged spacecraft is subject to the Lorentz force when it orbits a central body with a magnetic field. The induced Lorentz force provides a new mean of propellantless electromagnetic propulsion for orbital control. Modeling the Earth magnetic field as a tilted dipole that co-rotates with the Earth, this paper develops a nonlinear dynamical model that describes the relative motion of the Lorentz spacecraft about an arbitrary reference orbit. Based on the proposed dynamical model, feasibility of Lorentz-propelled rendezvous with no restrictions on the initial states is investigated. The rendezvous problem is then formulated as an optimal control problem, and solved with the Gauss pseudospectral method（GPM）. Numerical simulations substantiate the validity of proposed model and method, and results show that the propellantless rendezvous is achieved at both fixed and free final time.

关键词： Lorentz dynamical dipole spacecraft propulsion validity orbital integer formulated constraints

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基于靶点和活性成分的筛选探讨连翘抗病毒作用机制

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Journal of Chinese Pharmaceutical Sciences 2024年第6期33卷 543-558页

作者：孙娜马烁靳琳萱张新周苗杨欢欢李文倩吴欣茹侯艳艳袁宇涵张玉舒朋华许昌学院食品与药学院河南许昌461000

连翘作为传统中药,具有显著的抗病毒作用,尤其是在治疗新冠肺炎方面。然而,其抗病毒有效化合物及其靶点尚不清楚。本论文利用网络药理学技术筛选连翘中的抗病毒成分和靶标,并利用分子对接技术分析了它们之间的相互作用。最终,从连翘中... 详细信息

连翘作为传统中药,具有显著的抗病毒作用,尤其是在治疗新冠肺炎方面。然而,其抗病毒有效化合物及其靶点尚不清楚。本论文利用网络药理学技术筛选连翘中的抗病毒成分和靶标,并利用分子对接技术分析了它们之间的相互作用。最终,从连翘中筛选出11个活性化合物(1–11)和7个抗病毒靶标(AKT1、TP53、MYC、PTEN、CASP8、MMP9和VEGFA),并利用基因本体论分析预测了潜在靶标可能的生物信号通路。基于分子对接结果,我们讨论了活性化合物的构效关系。此外,对活性化合物的吸收、分布、代谢、排泄和毒性(ADMET)特性进行了预测和分析。本研究阐明了连翘多个靶点和途径在治疗病毒性疾病中的协同作用,以及活性化合物的可药用性。本研究为开发和设计新型抗病毒药物提供了依据。

关键词：连翘抗病毒中药靶点活性成分

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基于靶点和活性成分的筛选探讨连翘抗病毒作用机制（英文）

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Journal of Chinese Pharmaceutical Sciences 2024年第6期 543-558+587-604页

作者：孙娜马烁靳琳萱张新周苗杨欢欢李文倩吴欣茹侯艳艳袁宇涵张玉舒朋华许昌学院食品与药学院

关键词：连翘抗病毒中药靶点活性成分

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(3+1)-dimensional localized self-accelerating Airy elegant Ince-Gaussian wave packets and their radiation forces in free space

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Chinese Physics B 2017年第12期26卷 248-256页

作者：李冬冬彭喜彭玉莲张丽萍陈星宇庄经立赵方杨湘波邓冬梅 Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices South China Normal University CAS Key Laboratory of Geospace Environment University of Science & Technology of China Chinese Academy of Sciences

We construct analytically linear self-accelerating Airy elegant Ince-Gaussian wave packet solutions from （3＋1）-dimensional potential-free Schr？dinger equation. These wave packets have elliptical geometry and show different characteristics when the parameters （p, m） and ellipticity ε are adjusted. We investigate these characteristics both analytically and numerically and give the 3-dimensional intensity and phase distribution of these wave packets. Lastly, we analyze the radiation forces on a Rayleigh dielectric particle. In addition, we also find an interesting phenomenon that if the energy distribution between every part of wave packets is uneven at the input plane, the energy will be transferred between every part in the process of transmission.

关键词： wave propagation beam optics computer-generated holograms

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Estimation on structural responses using multi scale measurements

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Science China(Technological Sciences) 2014年第9期57卷 1707-1713页

作者： LU Wei WU FengQi TENG Jun ZHOU QiuShi Department of Civil and Environmental Engineering Harbin Institute of Technology Shenzhen Graduate School Shenzhen Capol International & Associates Group

Different measurands from the different types of sensors can obtain different information regarding the structural behavior in a real structural health monitoring *** enrich information and estimate the structural responses based on much more known information,the estimation on structural responses using multi scale measurements from multi-type sensors is proposed in this *** identification is constructed with the pattern library given by strain measurements and deformation *** the uncertainty of the measurements as well as to enhance the robustness of the proposed algorithm,more than one best pattern is selected to synthesize the finally estimated stress *** validate the capacity of the proposed acquisition method using multi scale measurements,finite element model analysis is conducted to estimate the structural stress response in Shenzhen Bay Stadium as an *** performance of the pattern identifications,constructed by two kinds of pattern libraries captured by sole strain measurement,and multi scale measurements which are constructed by both kinds of strain measurements and deformation measurements,respectively,are compared in this paper to observe measurements constructed from strain measurements and deformation measurements outperformed *** analysis for a series of parametric studies in which noise at different levels has also included in the measurements are further carried out,and robustness of the proposed information acquisition scheme under noisy measurement is demonstrated.

关键词： structural health monitoring multi scale sensor measurements pattern identification information fusion

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Effects of the vegetation restoration years on soil microbial community composition and biomass in degraded lands in Changting County,China

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Journal of Forestry Research 2020年第4期31卷 1295-1308页

作者： Yonghui Bai Xuan Zha Shifa Chen Key Laboratory for Subtropical Mountain Ecology(Ministry of Science and technology and Fujian Province Funded) School of Geographical SciencesFujian Normal UniversityFuzhou 350007China College of Tourism and Geography Shaoguan UniversityShaoguan 512005China

We evaluated the effects of the number of years of restoration of vegetation on soil microbial community structure and biomass in degraded *** investigated the microbial community structure by analyzing their phospholipid fatty acids then examined microbial biomass carbon and nitrogen by chloroform fumigation extraction of restoration soils over several *** data were compared with those of highly degraded lands and native vegetation *** results show that the duration of vegetation on the sites substantially increased microbial biomass and shifted the microbial community structure even after only 4 ***,microbial communities and biomass did not recover to the status of native vegetation even after 35 years of vegetation cover.A redundancy analysis and Pearson correlation analysis indicated that soil organic carbon,total nitrogen,available potassium,soil water content,silt content and soil hardness explained 98.4%of total variability in the microbial community *** organic carbon,total nitrogen,available potassium and soil water content were positively correlated with microbial community structure and biomass,whereas,soil hardness and silt content were negatively related to microbial community structure and *** study provides new insights into microbial community structure and biomass that influence organic carbon,nitrogen,phosphorus and potassium accumulation,and clay content in soils at different stages of restoration.

关键词： Vegetation restoration Soil microorganisms Environmental factors PLFA Degraded red soil lands

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